Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: To a diethyl ether solution (20 mL) of AgCF3SO3 (51 mg,0.2 mmol) was added the corresponding phosphinobenzoic acid(61 mg, 0.2 mmol), and the reaction stirred for 2 h protected fromthe light. The insoluble compounds were filtered off, washed anddried. A second fraction was obtained by evaporation ca. 2 ml and addition of hexane. Compounds 1?2 were obtained as whitesolids. Yield of 1: 78 mg, 70percent. Anal. Calc. for C40H30Ag2F6O10P2S2:C, 42.65; H, 2.68; N, 0. Found: C, 42.37; H, 2.75; N, 0percent. 1H NMR(d6-acetone): d 8.37 (d, JHH = 7.6 Hz, 1H, H6), 7.76 (td, JHH = 7.6 Hz,JHP = 1.4 Hz, 1H, H5), 7.70 (td, JHH = 7.6 Hz, JHP = 1.4 Hz, 1H, H4),7.59?7.45 (m, 10H, Ph), 7.04 (t, JHP = JHH = 7.8 Hz, 1H, H3). 1HNMR (50 C, d6-acetone): d 12.49 (brs, 1H, COOH), 8.40 (ddd,JHH = 7.5 and 1.5 Hz, JHP = 4.4 Hz, 1H, H6), 7.82 (t, JHH = 7.5 Hz, 1H,H5), 7.77 (t, JHH = 7.5 Hz, 1H, H4), 7.60?7.43 (m, 10H, Ph),6.94 (ddd, JHP = 9.2 and 1.2 Hz, JHH = 7.5 Hz, 1H, H3). 19F NMR(d6-acetone): 77.58 (s). 31P NMR (d6-acetone): 15.6 (brs).31P NMR (50 C, d6-acetone): 15.5 (d, 1J107Ag?31P = 736 and1J109Ag?31P = 849 Hz). IR (KBr): 3060 m(O?H), 1673 m(CO), 1257,1223, 1209, 635 (CF3SO3) cm?1. Yield of 2: 91 mg, 81percent. Anal. Calc.for C20H15AgF3O5PS: C, 42.65; H, 2.68; N, 0. Found: C, 42.60; H,2.84; N, 0percent. 1H NMR (d6-acetone): d 11.5 (brs, 1H, COOH), 8.13(d, JHH = 8.0 Hz, 2H, H2), 7.68?7.55 (m, 12H, H3+Ph). 1H NMR(50 C, d6-acetone): d 12.54 (brs, 1H, COOH), 8.15 (dd, JHP =1.6 Hz, JHH = 8.4 Hz, 2H, H2), 7.68?7.53 (m, 12H, H3+Ph). 19F NMR(d6-acetone): 77.6 (s). 31P NMR (d6-acetone): 14.5 (d, 1JAg?P =721 Hz). 31P NMR (50 C, d6-acetone): 13.8 (d, 1J107Ag-31P = 690and 1J109Ag-31P = 795 Hz). IR (KBr): 3054 m(O?H), 1687 m(CO),1223, 635 (CF3SO3) cm1.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Miguel-Coello, Ana B.; Bardaji, Manuel; Inorganica Chimica Acta; vol. 423; PA; (2014); p. 219 – 224;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657408-07-6,Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Step 1. A mixture of 8.1 g (51.5 mmol) of 2-bromopyridine, 7 g (51.5 mmol) o-tolylboronic acid, 0.47 g (0.51 mmol) of Pd2(dba)3, 0.84 g (2.06 mmol) of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl and 32 g (154.5 mmol) of potassium phosphate tribasic, 100 mL of toluene and 30 mL of water was purged with nitrogen. The solution was heated to reflux for 12 hours. Upon cooling, the organic layer was separated, and dried with MgSO4. The product was separated by column chromatography using hexanes/ethyl acetate (5% ethyl acetate) as the eluent. The solvent was removed by rotary evaporation, and the product was dried under vacuum resulting in 6 g (35.5 mmol) of 2-(o-tolyl)pyridine.

657408-07-6 Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 11269872, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Alleyne, Bert; US2009/124805; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

Under argon a solution of 2-(ethylthio)ethanamine (0.36 g, 3.44 mmol) in THF (3 ml) is added to a solution of 2-(diphenylphosphino)benzaldehyde (1.00 g, 3.44 mmol) in THF (10 ml). After stirring for 12 h at 72¡ã C. the reaction mixture is cooled to 0¡ã C., DCM (3 ml) is added and the solvents are evaporated under vacuo. SNP-ligand N-(2-(diphenylphosphino)benzylidene)-2-(ethylthio)ethan-amine is obtained as an orange solid (1.20 g, 92percent). Analytical data: 1H-NMR (400 MHz, CDCl3): 8.92 (d, J=4.80, 1H), 8.00 (m, 1H), 7.41 (m, 1H), 7.38-7.28 (m, 11H), 6.91 (m, 1H), 3.70 (dt, J=1.26, 7.07, 2H), 2.62 (t, J=7.33, 2H), 2.50 (q, J=7.33, 2H), 1.23 (t, J=7.33, 3H). 13C-NMR (400 MHz, CDCl3): 161.12, 139.67, 137.93, 136.96, 136.87, 134.42, 133.77, 130.74, 129.28, 129.01, 128.13, 61.64, 32.56, 26.49, 15.28. 31P-NMR (500 MHz, CDCl3): ?13.55 (s, 1P). GC/MS: 377 (6percent, M+), 348 (54percent, [M?29]+), 288 (100percent), 226 (20percent), 208 (14percent), 183 (28percent), 165 (14percent), 107 (11percent), 89 (34percent), 61 (14percent).

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Reference£º
Patent; GIVAUDAN SA; GEISSER, Roger Wilhelm; OETIKER, Juerg Daniel; SCHROeDER, Fridtjof; (17 pag.)US2016/326199; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 6 (526.211 eq) was added to the Schlenk tube,After evacuation of nitrogen,The system was cooled to 0 C,And the reaction vessel was added at this temperatureP (NMe2) 3 (1.3 eq),Reaction at 0 C for 10 min,Then rose to 110 C,TLC detection to complete reaction,Separation by column chromatography to give a white solid,The yield was 80%

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shangqiu Teachers College; Zhengzhou University; Zhao, Wenxian; Chao, Ruiqing; Li, Gaowei; Xu, Kai; Wang, Tao; Wang, Xiaojuan; Zhao, Ruijuan; Liu, Lantao; (16 pag.)CN104530122; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate