Chiral phosphine ligands

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-(diphenylphosphino)benzaldehyde (0.290g, 1mmol) and 2-thiophene carboxylic acid hydrazide (0.126g, 1mmol) in ethanol (20mL) were added 2?3 drops of glacial acetic acid. The resulting solution was heated under reflux over a 3h period, and then concentrated to ca. 3mL. The white crystalline precipitate was filtered off, washed with diethyl ether (2¡Á5mL), and dried under vacuo. Yield: 87percent (0.36g). Mp: 197?199¡ãC. Anal. Calcd for C24H19N2OPS: C, 69.55; H, 4.62; N, 6.76; S, 7.74. Found: C, 69.67; H, 4.58; N, 6.86; S, 7.69. IR (KBr disks, cm?1): 3195 (m, nuNH); 1685 (s, nuC=O); 1583+1474 (s, nuC=N+nuC?N). 1H NMR (400MHz, DMSO?d6, ppm): 6.83?7.50 (m, 14H, Ar H), 7.57 (t, 1H, J=6.24, Hz Ar H), 8.05 (s, 1H, Ar H), 8.15 (s, 1H, Ar H), 8.85 (d, IH, J=3.6Hz, ?CH=N), 9.13 (s, 1H, Ar H), 11.98 (s, IH, ?NH). 13C NMR (100MHz, DMSO?d6, ppm): 125.78 (Ar C), 128.91 (Ar C), 129.15 (Ar C), 129.47 (Ar C), 130.07 (Ar C), 133.30 (Ar C), 133.49 (Ar C), 134.12 (Ar C), 135.62 (Ar C), 138.25 (Ar C), 149.52 (?CH=N), 158.12 (C=O). 31P NMR (162MHz, DMSO?d6, ppm): ?17.14.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Ramachandran; Prakash; Viswanathamurthi; Malecki; Inorganica Chimica Acta; vol. 477; (2018); p. 122 – 129;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Similar procedure described for 1c was used in the synthesis of 5c by using dppbz instead of dppm to obtain a pale yellow solid. Yield: 94%. 31P-NMR (121.42 MHz, 298 K, CDCl3):62.4 ppm (d, 1J(Rh-P) = 134 Hz). 1H-NMR (300 MHz,298 K, CDCl3): 7.38-6.75 (m, 24H, Ph). ESI-MS(?):501.3 (M?-CO-Ph, calc.: 501.3). IR (KBr, cm-1) 1970,m(C:O); 1103, 1032 (OTf-).

The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arcau, Julia; Ferrer, Montserrat; Aguilo, Elisabet; Rodriguez, Laura; Transition Metal Chemistry; vol. 42; 1; (2017); p. 57 – 67;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl diphenyl phosphinite (12.6 g, 55 MMOL) is added, at 60C and under argon, to a solution of the compound of formula (37) (15.2 g, 36.6 MMOL) IN toluene (370 ml). The reaction mixture is stirred at 60C for 3 hours and then concentrated. The residue is dissolved in 10 ml of toluene, and 10 ml of hexane are added, the product precipitating out in the form of a colourless powder, which is filtered off. In that manner, 14.3 G (73 %) of the phosphine oxide (38) can be obtained. aH NMR (300 MHz, CDCI3) : 1.22 (d, J = 6.7 Hz, 6H); 3.32-3. 45 (m, 1H); 3.41 (s, 3H); 3.47 (s, 3H); 3.89 (d, J = 12.9 Hz, 2H); 6.86 (dd, J = 8.7, 8.7 Hz, 2H); 7.09 (dd, J = 8.6, 5.3 Hz, 2H); 7.27-7. 45 (m, 10H). 13C NMR (75 MHz, CDCI3) : 22.1, 30.0 (JCP = 64.8 Hz), 33.1, 33.5, 42.7, 114.1 (Jcp = 8.2 Hz), 115.5 (JCF = 21.7 Hz), 128.8 (Jcp = 11. 8 Hz), 130.9 (Jcp = 9.3 Hz), 132.1 (JCF = 8.4 Hz), 132.1 (Jcp = 2.9 Hz), 133.3, 134.7 (Jcp = 2.3 Hz), 157.3 (Jcp = 2.3 Hz), 162.9 (JCF = 249 Hz), 166.3 (Jcp = 4.6 Hz). 3’P NMR (121 MHz, CD13) : 27.7.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; CIBA SPECIALTY CHEMICALS HOLDING INC.; WO2004/103977; (2004); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Embodiment 1 Synthesis of Compounds 8 and 9 Ammonium chloride (0.01 g) and Compound 7 (1 mmol) were charged to a 30 mL flask. The mixture was dissolved in toluene (10 mL), hexamethyl phosphorus triamide was added, and the mixture was refluxed for 12 hours. After allowing the mixture to cool to room temperature, the solvent was distilled off. The residue was recrystallized from methylene chloride/pentane (yield 75 percent, R=Me).

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Patent; Japan Science and Technology Agency; EP1854802; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.30 methyl 2-phenyl-5-(4-methoxylphenyl)oxazole-4-carboxylate (4j) A suspension of Pd(OAc)2 (10 mol %), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 72 mg (47%). White solid, mp 131-132.5 C; 1H NMR (300 MHz, CDCl3) delta 3.87 (s, 3H), 3.97 (s, 3H), 7.01 (d, J=8.9 Hz, 2H), 7.46-7.48 (m, 3H), 8.12-8.15 (m, 4H) ppm; 13C NMR (75 MHz, CDCl3) delta 162.4, 160.7, 158.6, 155.1, 130.4, 129.7, 128.3, 126.2, 126.0, 119.0, 113.4, 54.9, 51.8 ppm; IR (KBr) 2962, 2926, 2855, 1729, 1465, 1330, 1261, 1108, 1069, 1020, 802, 761, 686 cm-1; HRMS (ESI) calcd for [C18H15NO4+H]+ 310.1074, found 310.1066.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 Preparation of N,N’-bis{[2-(diphenylphosphino)phenyllmethvlenel-2,2-dimethyl-1,3-propanediamine (L-5) Under argon, a solution of 2-(diphenylphosphino)benzaldehyde (522.7 mg, 1.8 mmol) and 2,2-dimethyl-1,3-propanediamine (93.3 mg, 0.9 mmol) in toluene (15 mL) was stirred at room temperature for 15 h. Then the reaction mixture was heated at 80; C. (oil bath) for 2,5 h. Next, the solvent was removed in vacuo, and an orange solid was recovered (476.8 mg, 0.74 mmol, 82percent). 1H NMR (CD2Cl2, 400 MHz): delta 8.78 (d, J=4.6 Hz, 2H), 7.96 (dd, J=7.7, 4.1 Hz, 2H), 7.3-7.2 (m, 24H), 6.87 (dd, J=7.7, 4.1Hz, 2H), 3.19 (s, 4H), 0.69 (s, 6H). 13C NMR (CD2CL2, 100 MHz): delta 160 (d, J=20.2 Hz, CH=N), 140.3 (d, J=17.8 Hz, Carom), 137.7 (d, J=20.2 Hz, Carom), 137.4 (d, J=10.5 Hz, Carom), 134.4 (d, J=20.2 Hz, CHarom), 134.1 (d, J=20.2 Hz, CHarom), 133.7 (CHarom), 130.2 (CHarom), 129.1 (CHarom), 128.9 (d, J=7.3 Hz, CHarom), 128.4 (d, J=4.8 Hz, CHarom), 70.7 (CH2), 36.9 (C), 24.4 (CH3). 31P{1H}NMR (CD2CL2, 100 MHz): delta -12.8.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SAUDAN, Lionel; Dupau, Philippe; Riedhauser, Jean-Jacques; Wyss, Patrick; US2008/71098; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

29949-84-6, Tris(3-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under a N2 atmosphere, phosphine ligand (2 mmol) (L) was added to a stirred solution of Co2(CO)8 (1 mmol) in tetrahydrofuran or toluene (10 mL). The reaction mixture was stirred for 1 h under CO bubbling at 50 C. The organic solvent was evaporated under reduced pressure. The resulting solid was washed several times with diethyl ether and pentane, finally dried under vacuum to give the desired complex.

As the paragraph descriping shows that 29949-84-6 is playing an increasingly important role.

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Article; Amezquita-Valencia, Manuel; Ramirez-Garavito, Ricardo; Toscano, Ruben A.; Cabrera; Catalysis Communications; vol. 33; (2013); p. 29 – 33;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of [Fe2(CO)6{mu-SC6H3(CH3)S}] (0.043 g,0.1 mmol) and ethyl diphenylphosphinite (0.023 g,0.1 mmol) in CH2Cl2(5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 1:4(v/v) as eluent. From the main red band, 0.056 g (88%) of complex 2 was obtained as a red solid. IR (CH2Cl2, cm-1):nuC?O 2048 (vs), 1991 (vs), 1937 (m). 1H NMR (500 MHz,CDCl3):7.55 (q, J = 9 Hz, 4H, PhH), 7.40-7.32 (m, 6H,PhH), 6.57 (d, J = 7.5 Hz, 1H, C6H3H),6.30 (s, 1H, C6H3H),6.17 (d, J = 7.5 Hz, 1H, C6H3H),3.92-3.83 (m, 2H, OCH2),1.93 (s, 3H, C6H3CH3),1.28 (t, J = 7 Hz, 3H, CH2CH3)ppm.31P{1H} NMR (200 MHz, CDCl3,85% H3PO4):162.12 (s)ppm. Anal. Calcd. for C26H21Fe2O6PS2:C, 49.08; H, 3.33.Found: C, 48.88; H, 3.56%.

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Lin, Hui-Min; Mu, Chao; Li, Ao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Transition Metal Chemistry; vol. 44; 5; (2019); p. 491 – 498;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Example 221A 6-(tert-butyl)-2-methoxynicotinaldehyde A 500 mL flask was charged with palladium acetate (0.511 g, 2.277 mmol), 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (1.933 g, 4.55 mmol), and cesium carbonate (37.1 g, 114 mmol). After purging the flask with N2, toluene (75 mL) was added, and the mixture was heated in a preheated heating block to 80 C. After 5 minutes, the flask was cooled to room temperature, and 6-(tert-butyl)-2-chloronicotinaldehyde (15 g, 76 mmol) was added as a solution in methanol (75 mL). The mixture was heated at 67 C. for 2 hours, and cooled to room temperature. The reaction was quenched by the addition of saturated aqueous ammonium chloride solution, the mixture was partitioned between water and methyl tert-butyl ether, and the organic phase was washed with brine and dried over sodium sulfate. After filtration, the mixture was concentrated in vacuo, and the residue was purified by silica gel chromatography, eluting with 0 to 10% ethyl acetate/heptanes, to afford the title compound. 1H NMR (501 MHz, CDCl3) delta ppm 10.35 (s, 1H), 8.06 (d, J=7.8 Hz, 1H), 7.06-6.99 (m, 1H), 4.09 (s, 3H), 1.38 (s, 9H); MS (ESI+) m/z 194.1 (M+H)+.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Desroy, Nicolas; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (247 pag.)US2018/99932; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate