Chiral phosphine ligands

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4E)-5-(3-Pyridyl)-4-penten-2-ol. A mixture of 3-bromopyridine (7.50 g, 47.46 mmol), 4-penten-2-ol (4.90 g, 56.96 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (575 mg, 1.89 mmol), triethylamine (28.4 mL, 204.11 mmol) and acetonitrile (25 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (7.50 g, 81.0%).

6163-58-2 Tri-o-tolylphosphine 80271, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Caldwell, William S.; Dull, Gary M.; Bhatti, Balwinder S.; Hadimani, Srishailkumar B.; Park, Haeil; Wagner, Jared M.; Crooks, Peter A.; Lippiello, Patrick M.; Bencherif, Merouane; US2003/125345; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OEt)), trans-C777: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OEt) (0.607 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from toluene/pentane at -35 C affording trans-C777 (1.48 g, 67.2%, >95% purity). ?H NMR (400 MHz, CD2C12, ppm): oe18.39 (d, J= 11.2 Hz, 1H), 7.34 – 7.26 (m, 2H), 7.24 – 7.14 (m, 8H), 7.03 – 6.95 (m, 1H), 6.89 (s, 2H), 6.79 (s, 2H), 4.08 – 3.88 (m, 4H), 3.36 (pseudo pentet, J= 6.9 Hz, 2H), 2.56 (s, 6H), 2.36 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.11 (s, 3H), 1.07 (t, J= 6.9 Hz, 3H), 1.03 (s, 3H). 3?PNIVIR(161.8 IVIHz, CD2C12, ppm): oe 129.8 (s).

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

2622-14-2, Tricyclohexylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

As the paragraph descriping shows that 2622-14-2 is playing an increasingly important role.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

Example 253 0.031 mL of indoline, 0.12 g of cesium carbonate, 1.7 mg of tris(dibenzylideneacetone)dipalladium(0), 0.8 mg of palladium acetate and 4.4 mg of 2-dicyclohexylphosphino -2′,4′,6′-triisopropylbiphenyl were added to 1.4 mL of toluene solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 3 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain 77 mg of tert-butyl 2-(benzamido)-4-(indolin-1-yl)benzoate as yellow oil. 1H-NMR (CDCl3) delta: 1.63 (9H, s), 3. 17 (2H, t, J = 8.4 Hz), 4.10 (2H, t, J = 8.4 Hz), 6.86 (1H, td, J = 7.4, 0.8 Hz), 6.96 (1H, dd, J = 8.9, 2.5 Hz), 7.16-7.24 (2H, m), 7.46-7.57 (4H, m), 7.97 (1H, d, J = 8.9 Hz), 8.06-8.10 (2H, m), 8.81 (1H, d, J = 2.5 Hz), 12.40 (1H, s).

The synthetic route of 564483-18-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-20-8, Cyclohexyldiphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a screw capped vial with a spinvane triangular-shaped Teonstir bar were added indicated arylphosphine oxide (0.20 mmol),[IrCp*Cl2]2 (3.2 mg, 0.0040 mmol, 2.0 mol %), AgNTf2 (6.6 mg,0.017 mmol, 8.5 mol %), O,O-dipivaloyl-L-tartaric acid (2.6 mg,0.040 mmol), 1,2-dichloroethane (0.5 mL), and p-toluenesulfonylazide (43.4 mg, 0.22 mmol) under atmospheric conditions. Thereaction mixture was stirred in a pre-heated oil bath at 60 C for18 h, and then ltered through a pad of Celite washing with EtOAc(10 mL3). Solvents were removed under reduced pressure and theresidue was puried by column chromatography to give the ami-dated product. Enantiomeric excess (ee) of amidated products ofthe crude reaction mixture was determined by chiral HPLC analysisusing ChiralPak IB-3 column with ethanol/hexane as eluents. 4.8.4. Compound 5d. White solid; mp 225e227 C; 1H NMR(600 MHz, CDCl3) d 11.52 (s,1H), 7.80 (dd, J8.5, 4.0 Hz,1H), 7.69 (d,J8.2 Hz, 2H), 7.65e7.58 (m, 2H), 7.50 (td, J7.4,1.6 Hz,1H), 7.42 (td,J7.7, 2.9 Hz, 2H), 7.41e7.34 (m, 1H), 7.20 (ddd, J12.4, 7.7, 1.6 Hz,1H), 7.07 (d, J8.0 Hz, 2H), 7.06e7.00 (m,1H), 2.30 (s, 3H), 2.21e2.11(m,1H),1.82e1.76 (m,1H),1.76e1.66 (m, 2H),1.60 (ddd, J12.3, 6.2,3.2 Hz, 1H), 1.55e1.37 (m, 3H), 1.26e1.16 (m, 3H); 13C NMR(150 MHz, CDCl3) d 144.4,143.1,136.8,132.7 (d, JCP2.3 Hz),131.8 (d,JCP2.7 Hz), 131.1 (d, JCP96.5 Hz), 130.8 (d, JCP9.9 Hz), 130.7 (d,JCP8.9 Hz, 2C), 129.3 (2C), 128.6 (d, JCP11.4 Hz, 2C), 127.2 (s, 2C),122.9 (d, JCP11.6 Hz), 120.3 (d, JCP7.0 Hz), 116.2 (d, JCP90.3 Hz),37.2 (d, JCP72.9 Hz), 26.1 (d, JCP10.2 Hz), 26.0 (d, JCP10.2 Hz),25.5, 24.2 (d, JCP2.9 Hz), 23.8 (d, JCP2.7 Hz), 21.4; 31P NMR(243 MHz, CDCl3) d 44.1; IR (diamond) 2930, 2853, 2807, 2746,1594,1573,1491,1448,1439,1418,1339,1266,1161,1131,1106,1089,943, 872, 812, 779, 712, 695 cm1; HRMS (EI) m/z calcd forC25H28NO3PS [M]: 453.1528, found: 453.1526.

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gwon, Donghyeon; Park, Sehoon; Chang, Sukbok; Tetrahedron; vol. 71; 26-27; (2015); p. 4504 – 4511;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

To a Schlenk flask charged with a solution of [Ph2P(o-tolyl)] (1 g, 3.61 mmol) in hexane (40 mL),tetramethylethylenediamine, TMEDA (0.54 mL, 3.61 mmol) and nBuLi (1.44 mL of a hexane solution,3.61 mmol) were added at -78 C with stirring. The reaction mixture was then kept at 0 C for 16 h,after which it was filtered and dried under reduced pressure yielding an extremely air and moisturesensitive yellow-orange solid. Crystals for the X-ray experiment were obtained from benzene. Yield:(1.24 g, 86%). m.p.: 146-148 C. 1H NMR (500 MHz, C6D6, 298 K): delta 7.57 (m, 4H, CH arom), 7.36 (m, 1H,CH arom), 7.16 (m, 1H, CH arom), 7.09 (m, 3H, CH arom), 7.03 (m, 2H, CH arom), 6.99 (m, 1H, CH arom),6.73 (m, 1H, CH arom), 6.19 (m, 1H, CH arom), 2.35 (br, 2H, CH2Li), 1.85 (s, 12H, CH3N), 1.65 (s, 4H,CH2N). 13C{1H} NMR (100.68 MHz, C6D6, 298 K): delta 43.71 (d, CH2-Li, 3JP,C = 17.5 Hz), 45.57 (s, CH3N),56.87 (s, CH2N), 108.12 (s, CH, o-tolyl), 120.68 (s, CH, o-tolyl), 127.94 (s, CH, Phenyl), 128.03 (d, CH,3JP,C = 7.4 Hz, Phenyl), 128.3 (s, CH, o-tolyl), 128.80 (s, CH, Phenyl), 132.79, (s, CH, o-tolyl), 133.9 (d, CH,2JP,C = 20.1 Hz, o-tolyl), 134.2 (s, CH, 2JP,C = 17.5 Hz, Phenyl), 136.27 (d, C-P, 1JP,C = 12.57 Hz, o-tolyl),136.66 (d, C-P, 1JP,C = 11.3 Hz, Phenyl), 157.5 (d, C-P, 1JP,C = 26.39 Hz, o-tolyl). 31P{1H} NMR (161.92MHz, C6D6, 298 K): delta 15.30 (s, w1/2 4 Hz).). 7Li NMR (155.45 MHz, C6D6, 298 K): delta 1.59 (s). IR(KBr/cm-1): 3059 (m), 2962 (m), 1585 (m), 1470 (m), 1434 (m), 1258 (m), 1176 (m), 1088 (m), 1026 (m),803 (m), 742 (s), 693 (s), 551 (m), 511 (m).

The synthetic route of 5931-53-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rufino-Felipe, Ernesto; Mu Oz-Hernandez, Miguel-Angel; Montiel-Palma, Virginia; Molecules; vol. 23; 1; (2018);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Example 3 Dinaphthylphosphine-borane complex Under an argon atmosphere, 4 mL of toluene was added to dinaphthylphosphine oxide synthesised in Reference Example 2 (0.6061 g, 2.00 mmol) at a room temperature (25C) and the mixture was stirred to obtain a suspension. Then, to the suspension was added 1.02 mol/L of a borane-tetrahydrofuran complex (5 mL, 2.55 equivalents). The reaction mixture was purified by silica gel column chromatography (silica gel 15 g, toluene) and the desired fraction was concentrated under reduced pressure. The residue was dried (under reduced pressure at 40C) to obtain the titled compound (0.4577 g, white powder). The yield was 76.2%. 1H-NMR (300 MHz, CDCl3, TMS) delta: 0.60-1.85 (m, 3 H), 6.56 (dq, 1 H, JH-P= 378.7 Hz, J = 6.9 Hz), 7.52-8.31 (m, 14H). 13C-NMR (75 MHz, CDCl3, CDCl3) delta: 124.40, 125.16, 128.53, 129.22, 129.31, 129.61, 129.96, 130.30, 130.43, 134.20, 134.36, 135.91, 135.94, 135.99, 136.14. 31P-NMR (121 MHz, CDCl3, 85% H3PO4) delta: 1.10-2.21 (m), 3.92-4.95 (m).

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1626052; (2006); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 12 (mu-SCH2CH2CH2S-mu)Fe2(CO)6 (0.193g, 0.5mmol) and 13 2-(diphenylphosphino)benzaldehyde (0.145g, 0.5mmol) in 14 CH2Cl2 (20mL) was added a solution of 15 Me3NO¡¤2H2O (0.056g, 0.5mmol) in 16 MeCN (10mL). The mixture was stirred at room temperature for 1h and then the solvent was reduced on a rotary evaporator and the residue was subjected to TLC separation using CH2Cl2/17 petroleum ether=1:1 (v/v) as eluent.

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Reference£º
Article; Sheng, Yu-Dong; Yu, Xiao-Yong; Liu, Xu-Feng; Li, Yu-Long; Polyhedron; vol. 137; (2017); p. 134 – 139;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 50 mL four-necked round-bottom flask, a magnetic stirrer bar, a Claisen distillation apparatus, a condenser, a thermometer, and a three-way stopcock were attached, and the inside was purged with nitrogen. Then, [RuCl2(p-cymene)]2 (459 mg, 0.75 mmol, 1.0 equivalents), tris(4-methoxyphenyl)phosphine (11-6) (581 mg, 1.65 mmol, 2.2 equivalents), and anhydrous THF (5 mL) were introduced sequentially, and the obtained dark red suspension was stirred at room temperature for 5 minutes. Subsequently, 2-diphenylphosphino-N-[2-(methylthio)ethyl]ethylamine (1D-1) (500 mg, 1.65 mmol, 2.2 equivalents) obtained in Example 1/Example 2 and 3M1B (10 mL) were added, and THF was removed by distillation at normal pressure using the Claisen distillation apparatus, followed by stirring for 1 hour under reflux in 3M1B.The reaction liquid was cooled to 5 C., and MeOH (20 mL) was added to the obtained yellowish orange suspension, followed by filtration by suction. Then, the crystals obtained by filtration were washed with MeOH, and dried by heating under reduced pressure to obtain 922 mg of title compound (8S-10) as a yellowish orange powder. Isolated yield: 73.5%, Purity: 99.0% by weight. Note that the major impurity was 3M1B.1H NMR (400 MHz, CD2Cl2): 31P NMR (161 MHz, CD2Cl2): delta=47.0-45.6 (m, 1P), 40.1-39.4 (m, 1P).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; NAKAYAMA, Yuji; OGATA, Osamu; (72 pag.)US2017/233418; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78percent).2

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate