Chiral phosphine ligands

13885-09-1, 2-(Diphenylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

101.4 mg (0.3 mmol) was added to the reaction kettle.2-diphenylphosphine-biphenyl (compound I-2),141 muL of tert-butyl acrylate (Compound II-2), 9.3 mg of cymene dichloride dimer, 15.8 mg of N-Boc-glycine, 5.3 mg of tris(4-methoxyphenyl)phosphine,58.8 mg of potassium acetate and 1.5 mL of n-hexane,After stirring and mixing uniformly, argon gas is introduced into the reaction system to control the reaction in an argon atmosphere.The temperature was reacted at 120 C for 24 h and then cooled to room temperature.Separation of diatomaceous earth by vacuum filtration and column chromatography101 mg of the desired product in a yield of 72%.

As the paragraph descriping shows that 13885-09-1 is playing an increasingly important role.

Reference£º
Patent; Hubei University; Liu Yuejin; Wang Liangneng; Li Jiawei; Zeng Minghua; Li Ming; Tang Panting; (17 pag.)CN109851635; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.

25 mL of Schlenk tube, and 2-diphenylphosphino-2 ‘- (N, N-dimethylamino) biphenyl was added to a solution of 76.3 mg (0.2 mmol), (1,5-cyclooctadiene) chloride2.5 mg of rhodium (I) dimer (2.5% of moles of raw material), and 32 mg of lithium tert-butoxide (0.4 mmol), argon was replaced three times, and 1 mL of 1,4-dioxane and 47.1 mg (0.3 mmol) of bromobenzene were added under argon. 120 C for 36 hours, cooled to room temperature and evaporated under reduced pressure. The solvent was separated on a 200-300 mesh silica gel column. The petroleum ether: Ester = 100: 1 and dried in vacuo to give 56.9 mg of product as a white solid in 62% yield,

240417-00-9 2-Diphenylphosphino-2’-(N,N-dimethylamino)biphenyl 2734939, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nanjing University; Qiu Xiaodong; Wang Minyan; Zhao Yue; Pu Xinghui; Hu Jiefeng; Shi Zhuangzhi; (26 pag.)CN106674279; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 317 Production of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}amino)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide A mixture of N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (330 mg, 1.0 mmol), N-(3-aminophenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide (280 mg, 1.2 mmol), tris(dibenzylideneacetone)dipalladium (0) (46 mg, 0.050 mmol), 2-dicyclohexylphosphino-2′,4′,6′-tri-isopropyl-1,1′-biphenyl (48 mg, 0.10 mmol), potassium tert-butoxide (170 mg, 1.5 mmol) and tert-butanol was heated under reflux for 2 days. Ethyl acetate/tetrahydrofuran and saturated aqueous sodium hydrogencarbonate solution were added to the mixture, the aqueous layer was extracted with ethyl acetate/tetrahydrofuran (*4). Combined organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=30/70?100/0) to give the title compound (37 mg, 9%) as a brown solid. 1H-NMR (DMSO-d6, 300 MHz) delta 0.74-0.88 (4H, m), 1.86-1.98 (1H, m), 2.22 (3H, s), 4.01 (3H, s), 6.85 (1H, s), 6.89 (1H, d, J=9.6 Hz), 7.24-7.36 (2H, m), 7.45-7.53 (1H, m), 7.75 (1H, d, J=9.6 Hz), 8.00 (1H, s), 8.21 (1H, s), 9.37 (1H, s), 10.15 (1H, s), 10.93 (1H, s).

As the paragraph descriping shows that 564483-18-7 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. 4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-1-benzoic acid methyl ester To a solution of trifluoro-methanesulfonic acid 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-phenyl ester (10.0 g, 19.8 mmol) in a Parr pressure bottle in MeOH (69 mL) were added DMSO (62 mL) and triethylamine (21.8 mL, 157 mmol). To the reaction mixture were added palladium acetate (2.2 g, 9.1 mmol) and 1,3-bis(diphenylphosphino)propane(3.75 g, 9.1 mmol). The mixture was shaken under 40 psi of CO at 70 C. for 4 hours. The reaction mixture was cooled to room temperature and was diluted with diethyl ether (600 mL). The ether layer was washed with water (5*60 mL), dried (MgSO4) and concentrated. The crude residue was purified by flash chromatography with hexanes/EtOAc (1:1) to afford 6.9 g (85% yield) of 4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester. 1H-NMR (400 MHz, CDCl3) delta 7.91 (d, 2H), 7.32 (d, 2H), 7.28-7.16 (comp, 6H),), 6.82 (d,, 1H), 6.79 (s, 1 H), 6.68 (dd, 1H), 3.86 (s, 3H), 3.74 (s, 3H), 3.38 (s, 2H), 2.47-2.44 (comp, 8H); MS (M+1) 416.2.

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Liras, Spiros; US2002/13321; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 296.4 mg of tricyclohexylphosphorus oxide and 188.5 mg of DyCl3 ¡¤6H2O was added to a beaker, 15 mL of ethanol and 5 mL of water were added, and the mixture was stirred at room temperature for 4 hours. Then, the mixed solution was allowed to stand at room temperature for 3 days to obtain colorless rectangular crystals. The resulting crystals were washed with iced ethanol to purify the resulting product. The calculated yield based on the metal Dy was 52%.

The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nankai University; Cheng Peng; Wang Yuxia; Shi Wei; (8 pag.)CN107556341; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Potassium tetrachloropalladate(II) was prepared by the procedure described in [26]. Potassium chloride, 2 equiv, was added to a solution of palladium(II) chloride in 25 mL of distilled water with stirring over a period of 30 min. The mixture was cooled with ice, and yellowish-brown crystals of potassium tetrachloropalladate(II) separated in a few minutes. The crystals were collected by filtration and recrystallized from water containing a few drops of aqueous HCl. The complexes were prepared by adding 2 equiv of the corresponding phosphine in 15 mL of acetonitrile to a solution of 0.326 g of K2[PdCl4] in15 mL of water, followed by stirring. After 30 min, a solution of 2 equiv of N,N-dimethylthiourea in 15 mL of methanol was added, and the mixture was stirred for one hour. The resulting yellow or red solution was filtered, and the filtrate was kept at room temperature for three to five days. Slow evaporation of the acetonitrile-methanol solution afforded solid complex 1-3. The overall reaction is shown in Scheme 1.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aziz; Sirajuddin; Munir; Tirmizi; Nadeem; Tahir; Sajjad; Russian Journal of General Chemistry; vol. 88; 3; (2018); p. 551 – 559;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

A solution of tyramine (239 mg, 1.74 mmol) in hot EtOH (8 mL) was added dropwise to a solution of 2-(diphenylphosphino)benzaldehyde (505 mg, 1.69 mmol) in hot EtOH (8 mL). The mixture was left stirring at 45 C for 2 h (31P NMR monitoring). Solvent was removed in vacuum to afford 1 in 84percent yield (603 mg,1.47 mmol) as a pale yellow powder. 31P{1H} NMR (121.25 MHz,CDCl3, d (ppm)): 14.1 (s, PIII). 1H NMR (300 MHz, CDCl3, d(ppm)): 2.73 (t, JHH = 7.55 Hz, 2H, CH2Cx4), 3.75 (t, JHH = 7.55 Hz,2H, NCH2), 6.72 (d, JHH = 8.25 Hz, 2H, Cx2H), 6.97 (d, JHH = 8.25 Hz,2H, Cx2H), 6.9?7.0 (m, 1H, Cy3H), 7.20?7.75 (m, 12H, Harom), 7.97(br s, 1H, OH), 8.04 (dd, JHH = 6.9 Hz, JHH = 3.9 Hz, 1H, Cy8H), 8.97(d, JHP = 4.8 Hz, 1H, CHN). 13C{1H} NMR (75.5 MHz, CDCl3, d(ppm)): 36.42 (s, CH2Cx4), 62.98 (s, CH2N), 115.61 (s, Cx2), 127.79(d, JCP = 4.0 Hz, Cy5), 128.79 (d, JCP = 7.2 Hz, Cm), 128.97 (s, Cx4),129.09 (s, Cp), 129.23 (s, Cy6), 129.84 (s, Cx3), 130.64 (s, Cy4),133.32 (s, Cy3), 134.13 (d, JCP = 20.4 Hz, Co), 136.19 (d, JCP = 9.2 Hz,Ci), 137.73 (d, JCP = 18.6 Hz, Cy1), 138.95 (d, JCP = 17.2 Hz, Cy2),155.02 (s, Cx1), 161.31 (d, JCP = 23 Hz, CHN). MS (DCI/NH3, CHCl3,positive) m/z: 410.4 [M+1].

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Tristany, Mar; Laurent, Re?gis; Dib, Hanna; Gonsalvi, Luca; Peruzzini, Maurizio; Majoral, Jean-Pierre; Caminade, Anne-Marie; Inorganica Chimica Acta; vol. 409; PART A; (2014); p. 121 – 126;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The crude solid was treated with 1.31 mL of thionyl chloride and heated on a steam bath for 1 hour. After cooling to room temperature, the crude mixture was taken up in water and extracted with ether. The ether was washed with water and dried(MgSO4), and concentrated to give an oily residue which was purified by silica gel chromatography (25% methylene chloride/75% hexane) to give 2.70 grams (85.6%) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride as a solid. 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150 C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography (10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the above-titled compound. MP 109-111 C.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US5935945; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61.0mg mesityl -Cu and 3ml of toluene were added to 100.0mg(0.33 mmol) of 7-BTpCa and 149.3mg (0.33 mmol) of dppb in a glove box. It formsa yellow solution. It was filtered and was coated with a layer of hexane. itforms yellow crystals. under UV (356nm), these emit a strong green and thesolution in the same way emits a strong green. Yield: 83%.

As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate