Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6737-42-4,1,3-Bis(diphenylphosphino)propane,as a common compound, the synthetic route is as follows.

6737-42-4, 4-[Isopropyl-(7-isopropyl-3,3,6-trimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid methyl ester (Compound 67) Following general procedure O and using 7-isopropyl-5-[isopropyl-(4-trifluoromethanesulfonyloxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 63, 0.052 g, 0. 107 mmol), triethyl amine (0.4 mL, 0.28 mmol), palladium(II)acetate (0.030 g, 0.13 mmol) and 1,3-bis(diphenylphosphino)propane (0.041 g, 0.1 mmol) in a mixture of 3 mL of methanol, 2 mL of dimethylsulfoxide and 1 mL of 1,2-dichloroethane, the title compound (0.037 g, 84%) was obtained as a brown oil. 1 H NMR (300 MHz, CDCl3): delta 7.81 (d, 2H, J=9.2 Hz), 6.59 (s, 1H), 6.40 (d, 2H, J=9.2 Hz), 4.32 (heptet, 1H, J=6.6 Hz), 4.24 (s, 2H), 3.83 (s, 3H), 3.19 (heptet, 1H, J=7.0 Hz), 2.00 (s, 3H), 1.36-1.26 (m, 15H), 0.98 (d, 3H, J=6.6 Hz).

The synthetic route of 6737-42-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan Sales, Inc.; US6093838; (2000); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

80 g (199.8 mmol in terms of sulfur trioxide) of fuming sulfuric acid containing 20% by mass of sulfur trioxide was placed in a 3-neck flask having an internal capacity of 200 ml, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line, and 27.65 g (100.07 mmol) of diphenyl(2-methylphenyl)phosphine (hereinafter referred to as a DPOTP) was added thereto for 1 hour. Further, the liquid temperature was controlled to a range of 25 C. to 30 C. After completion of the addition, the reaction was carried out at the same temperature for 2 hours. (0220) While controlling the liquid temperature to a range of 25 C. to 30 C., the reaction solution was diluted with 600 g of ion exchange water and then transferred to a separatory funnel, and 250 g of toluene and 250 g of tetrahydrofuran were added thereto, thereby acquiring an organic phase. To the organic phase was added 20 g of an aqueous 20%-by-mass sodium hydroxide solution to separate the organic phase, thereby acquire a lower phase. The lower phase was concentrated until the liquid amount reached 95 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration by natural filtering, thereby acquiring 23.53 g of a pale yellow solid. (0221) To this acquisition was added 120 g of ion exchange water to obtain an aqueous solution, and then 24 g of an aqueous 50%-by-mass sulfuric acid solution was added dropwise thereto. Further, 70 g of toluene and 70 g of tetrahydrofuran were added thereto, followed by sufficiently mixing, thereby acquiring an organic phase. To the organic phase was added 10.52 g (103.96 mmol) of triethylamine, followed by stirring in the range of 20 C. to 30 C. for 1 hour. This liquid was concentrated until the liquid amount reached 50 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration by natural filtering, thereby acquiring 15.36 g of a pale yellow solid. (0222) 31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) delta: a diphenyl(6-methyl-3-sulfonatophenyl)phosphine triethylammonium salt as a mono-form showed a peak at -13.19, and an oxide formed by oxidation of the phosphorous atoms showed a peak at 28.73. (0223) The acquisition was a mixture including 14.63 g (31.98 mmol, 95.42% by mole) of a diphenyl(6-methyl-3-sulfonatophenyl)phosphine triethylammonium salt and 0.73 g (1.54 mmol, 4.58% by mole) of an oxide formed by oxidation of the phosphorous atoms. From the viewpoint that 15.36 g (33.52 mmol in terms of phosphorous atoms) of a desired product could be acquired using 27.65 g (100.07 mmol in terms of phosphorous atoms) of DPOTP, the yield based on phosphorous atoms was 33.5%. This phosphorous compound was referred to as a ligand K.

5931-53-3 Diphenyl(o-tolyl)phosphine 80040, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; KURARAY CO., LTD.; YOSHIKAWA, Tatsuya; TSUJI, Tomoaki; (30 pag.)US2016/46549; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

787618-22-8, REFERENCE EXAMPLE 584 Preparation of (2S)-1-[4-({[t-butyl(dimethyl)silyl]oxy}methyl)phenyl]-2-(trifluoromethyl)pyrrolidine A suspension of [(4-bromobenzyl)oxy](t-butyl)dimethylsilane (1.0 g), (2S)-2-(trifluoromethyl)pyrrolidine (695 mg), tris(dibenzylideneacetone)palladium(0) (302 mg), 2-dicyclohexyl-phosphino-2′,6′-diisopropoxybiphenyl (308 mg) and sodium t-butoxide (638 mg) in 1,2-dimethoxyethane (50 mL) was stirred for 2 hours at 90 C. under nitrogen atmosphere. NH-silica gel and ethyl acetate were added to the reaction mixture, and the insoluble materials were removed by filtration. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (solvent: hexane/ethyl acetate=100/0 to 50/50), followed by silica gel column chromatography (solvent: hexane/ethyl acetate=90/10 to 20/80) to yield the titled compound (1.12 g, 94% yield). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.21 (d, J=8.70 Hz, 2H), 6.74 (d, J=8.70 Hz, 2H), 4.65 (s, 2H), 4.21 (m, 1H), 3.60-3.69 (m, 1H), 3.16-3.26 (m, 1H), 2.12-2.29 (m, 2H), 1.95-2.11 (m, 2H), 0.93 (s, 9H), 0.08 (s, 6H).

As the paragraph descriping shows that 787618-22-8 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei; US2015/239889; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

[0139] Under argon atmosphere, tris(3-sulfonatophenyl)phosphine hydrate sodium salt (c) (42.6 mg, 0.075 mmol) and acetylacetonato iridium(1,5-cyclooctadiene) (10.0 mg, 0.025 mmol) were placed in a Schlenk flask. One-half milliliters of a degassed aqueous formic acid solution (98 vol %) was added thereto with a syringe, and the flask was tightly sealed, followed by stirring the resulting mixture at 60 C. for 1 hour. Thereafter, the aqueous formic acid solution was removed under reduced pressure, and the resultant was washed with ethanol, to obtain the iridium hydride complex C as white powder (46.6 mg). Spectroscopic Data of the Iridium Hydride Complex C: [0140] 1H NMR (D2O), delta: 6.97-8.00 (m, 24H), [fac: -10.64 (t, JH-P=18.4 Hz, 1H), -11.83 (ddd, JH-P=102.7, 20.4 Hz, JH-H=4.8 Hz, 2H)]

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY; Muranaka, Makoto; Oshiki, Toshiyuki; US2013/244865; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

n an air atmosphere containing 200mL to gauge stainless steel autoclave was charged with [Rh (acac) (CO)2] (0.07mmol, 18.1mg) and 0.28mmol of a single phosphine ligands L2 and L12, 0.14mmol bidentate phosphite ligand, and 70mL of anhydrous toluene, connecting the gas line to a synthesis gas (hydrogen: carbon monoxide = 1: 1) after the autoclave was replaced three times the gas, the electromagnetic drive a mechanical stirrer, temperature of the autoclave was heated to 100 deg.] C, passed into the synthesis gas to a total pressure of 2.0MPa, at 100 , 2.0MPa reaction conditions 1h, to obtain a rhodium / (bidentate phosphite – single phosphine ligand) complex catalyst HRh (L12) (L2) (CO)

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Huayi (Group) Company; Lai, Chunbo; Fan, Manman; Yang, Xushi; Li, Yuan; Gao, Shanlin; Huang, Xiaoyun; Liao, Benren; Chen, Jianwei; Gao, Huimin; Zhang, Chunlei; (21 pag.)CN105566081; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

A sample of1 (0.531 g, 1.99 mmol) was dissolved in approximately 8 ml ofTHF. Cyclohexyldiphenylphosphine (1.07 g, 3.98 mmol) wasadded to the solution as a solid, causing effervescence of dinitrogen.The reaction was stirred overnight, at which pointthe volume of THF was reduced to approximately 1-2 ml toprecipitate the product. The colorless residue was filtered offon a fritted filter, rinsed with cold hexanes, and dried for 2 hunder vacuum, leading to isolation of a white powder in 60.8%yield (0.905 g). 1H NMR (CDCl3): 1.13-1.41 (m, 10H), 1.67(d, J = 12.2 Hz, 2H), 1.79 (d, J = 8.7 Hz, 4H), 1.98 (br s, 4H),2.48 (br q, J = 10.9 Hz, 2H), 4.31 (d, J = 16.4 Hz, 4H), 7.41-7.44(m, 13H), 7.56-7.81 (m, 8H), 8.01 (d, J = 7.5 Hz, 2H). 13C{1H}NMR (CDCl3): 26.19, 26.80 (d, J = 13.4 Hz), 37.29 (d, JP-C =77.0 Hz), 49.65, 123.19, 126.66, 126.87, 128.51 (d, J = 10.51 Hz),130.18, 131.01, 131.25, 132.28 (d, J = 7.7 Hz), 143.68 (d, J =18.8 Hz). 31P{1H} NMR (CDCl3): 19.41. Elemental analysiscalculated (%) for C44H49BrN2P2: C 70.68, H 3.75, N 6.61;found: C 70.68, H 3.73, N 6.56.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Guillet, Gary L.; Pitts, Skyler L.; Sheriff, Kirkland W.; Rucker, Donna N.; Rogers, Aaryn L.; Acta Crystallographica Section C: Structural Chemistry; vol. 75; (2019); p. 1381 – 1388;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Under argon protection,Add to 50mLSchlenk bottle1 ¡¤ 56 mmol of (SO3Na+) 3-R6,4 ¡¤ 73 mmol of [CH3 (EO) 42N + H = C (N (CH3) 2) 2] [CH3SO3-] and 25 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours, filtered,The filtrate was removed under reduced pressure to give an orange yellow viscous liquid acetonitrile, yield 96%.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

The labeling method was as follows: to a 10 mL vial was added tricine solution (0.5 mL, 80 mg/mLin saline), HYNIC-D1-FA2 solution (100 L, 1 mg/mL in PBS, pH 7.4), TPPTS (0.2 mL, 5 mg/mL insaline), SnCl2 solution (20 L, 2 mg/mL) in 0.1 N HCl and about 1 mL of 99mTcO4 (370 MBq) in saline.The vial was heated at 100 C for 30 min in a heating module. After cooling to room temperature,a sample of the resulting solution was purified and analyzed by Sep-Pak C18 cartridge and radio-HPLC.In further experiments, a kit formulation was developed for preparation of 99mTc-HYNIC-D1-FA2 usingthis ternary ligand system.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Guo, Zhide; Gao, Mengna; Song, Manli; Shi, Changrong; Zhang, Pu; Xu, Duo; You, Linyi; Zhuang, Rongqiang; Su, Xinhui; Liu, Ting; Du, Jin; Zhang, Xianzhong; Molecules; vol. 21; 6; (2016);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Under argon protection, add in a 50 mL Schlenk bottle(S03Na) 3-R6,4.73 mmol of [C6H5 (EO) 16N + H = C (N (CH3) 2) 2] [CH3SO3-] and (SO3Na)3-R6 10 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours, filtered and the filtrate was removed under reduced pressure to give an orange yellow viscous liquid in 90% yield.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate