Chiral phosphine ligands

Michon, Christophe; Bethegnies, Aurelien; Capet, Frederic; Roussel, Pascal; de Filippis, Arnault; Gomez-Pardo, Domingo; Cossy, Janine; Agbossou-Niedercorn, Francine published the artcile< Catalytic Asymmetric Allylic Alkylation of 3-Arylated Piperidin-2-ones>, HPLC of Formula: 152140-65-3, the main research area is preparation chiral allyl pyrimidine derivative asym alkylation catalysis.

The preparation of optically active lactams from 3-aryl-2-piperidinone is reported. The quaternary carbon stereo-centers were formed using palladium-catalyzed asym. allylic alkylation reactions. The resulting enantio-enriched compounds are useful intermediates for the synthesis and development of neurokinin antagonists.

European Journal of Organic Chemistry published new progress about Alkylation, stereoselective (allylic). 152140-65-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C54H42N2O2P2, HPLC of Formula: 152140-65-3.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Shintani, Ryo; Maciver, Eleanor E.; Tamakuni, Fumiko; Hayashi, Tamio published the artcile< Rhodium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Dibenzooxasilines via Enantioselective Transmetalation>, Recommanded Product: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is rhodium catalyzed asym synthesis dibenzooxasiline enantioselective transmetalation; diarylsilylbiphenylol preparation rhodium diphosphine catalyzed cyclization enantioselectivity; crystal mol structure dibenzooxasiline.

A rhodium-catalyzed asym. synthesis of silicon-stereogenic dibenzooxasilines has been developed. High enantioselectivities have been achieved by employing (S,S)-Me-Duphos as the ligand through “”enantioselective transmetalation””.

Journal of the American Chemical Society published new progress about Crystal structure. 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Recommanded Product: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Kita, Yusuke; Kavthe, Rahul D.; Oda, Hiroaki; Mashima, Kazushi published the artcile< Asymmetric Allylic Alkylation of β-Ketoesters with Allylic Alcohols by Nickel/Diphosphine Catalyst>, Safety of (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is enantioselective allylic alkylation nickel diphosphine catalyst; alkylation beta ketoester allylic alc; alkylation; allylic compounds; asymmetric catalysis; enantioselectivity; nickel.

Asym. allylic alkylation of β-ketoesters with allylic alcs. catalyzed by [Ni(cod)2]/(S)-H8-BINAP was found to be a superior synthetic protocol for constructing quaternary chiral centers at the α-position of β-ketoesters. The reaction proceeded in high yield and with high enantioselectivity using various β-ketoesters and allylic alcs., without any addnl. activators. The versatility of this methodol. for accessing useful and enantioenriched products was demonstrated.

Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Safety of (S)-(-)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Oonishi, Yoshihiro; Masusaki, Shuichi; Sakamoto, Shunki; Sato, Yoshihiro published the artcile< Rhodium(I)-Catalyzed Enantioselective Cyclization of Enynes by Intramolecular Cleavage of the Rh-C Bond by a Tethered Hydroxy Group>, Safety of (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is acyl heterocyclic compound enantioselective preparation; enynol preparation enantioselective cyclization rhodium catalyst; cyclization; enantioselectivity; enyne; rhodium; σ-bond metathesis.

Rhodium(I)-catalyzed enantioselective intramol. cyclization of enynes having a hydroxy group in the tether was investigated, and various cyclic compounds possessing a chiral quaternary carbon center were obtained in high yields with high ees. In this cyclization, a Rh-C(sp2) bond in the rhodacyclopentene intermediate, which was formed by enantioselective oxidative cycloaddition of enynes to a chiral rhodium(I) complex, was intramolecularly cleaved by σ-bond metathesis of a tethered O-H bond in the substrate. Furthermore, it was found that the cyclic compounds were obtained with high ees even when the starting materials having a racemic secondary alc. moiety were used in this reaction.

Angewandte Chemie, International Edition published new progress about Alcohols, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Safety of (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Oonishi, Yoshihiro; Hato, Yoshio; Sato, Yoshihiro published the artcile< Rhodium(I)-Catalyzed Diastereoselective Cycloisomerization of Enynes with Tethered (S)-2-Methyl-2-propanesulfinyl Imine>, Application of C44H40P2, the main research area is enyne tethered sulfinyl imine rhodium catalyst cycloisomerization; cyclic diene enantioselective diastereoselective preparation dienophile Diels Alder reaction; spiroamide diastereoselective enantioselective preparation.

The rhodium(I)-catalyzed cycloisomerization of enynes with tethered (S)-2-methyl-2-propanesulfinyl imine afforded 5- or 6-membered cyclic compounds containing exocyclic 1,3-diene moieties in a stereoselective manner. The reaction proceeded through β-hydride elimination of a 7-membered azarhodacycle intermediate, which was generated from three unsaturated bonds (i.e., alkene, alkyne, and C-N bonds) and an Rh(I) complex. The resultant cyclic compounds could be reacted with various dienophiles to afford spiroamides as single isomers through the Diels-Alder reaction.

Advanced Synthesis & Catalysis published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 139139-93-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Application of C44H40P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Kashima, Kenichi; Ishii, Masahiro; Tanaka, Ken published the artcile< Synthesis of Pyridylphosphonates by Rhodium-Catalyzed [2+2+2] Cycloaddition of 1,6- and 1,7-Diynes with Diethyl Phosphorocyanidate>, Quality Control of 139139-86-9, the main research area is diyne cycloaddition enantioselective phosphorocyanidate preparation pyridylphosphonate fluorescence.

The convenient and atom-economical synthesis of substituted bicyclic pyridylphosphonates was achieved by the cationic Rh(I)/H8-binap-complex-catalyzed [2+2+2] cycloaddition of 1,6- and 1,7-diynes with di-Et phosphorocyanidate. These reactions may proceed via an azarhodacyclopentadiene intermediate in addition to the rhodacyclopentadiene intermediate.

European Journal of Organic Chemistry published new progress about Alkadiynes Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Quality Control of 139139-86-9.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Yu, Chang-Bin; Wang, Jie; Zhou, Yong-Gui published the artcile< Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles>, Recommanded Product: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, the main research area is indoline enantioselective preparation; butoxycarbonyloxoalkylaniline cascade condensation hydrogenation.

A concise and enantioselective procedure for the synthesis of optically active indolines I [R = Me, n-Bu, Bn, etc.; R1 = H, 2-Me, 2-OMe, 4-OMe, 2,4-di-Me] was developed through intramol. condensation, deprotection and palladium-catalyzed asym. hydrogenation in a one-pot process with up to 96% ee. A strong Bronsted acid played an important role in both the formation of indoles and asym. hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity.

Organic Chemistry Frontiers published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 139139-86-9 belongs to class chiral-phosphine-ligands, and the molecular formula is C44H40P2, Recommanded Product: (R)-2,2′-Bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Lautens, M.; Fagnou, K. published the artcile< Rhodium-catalyzed asymmetric ring opening reactions with carboxylate nucleophiles>, Product Details of C32H40FeP2, the main research area is stereoselective ring opening oxabenzonorbornadiene carboxylate; rhodium stereoselective ring opening oxabenzonorbornadiene carboxylate; epoxynaphthalene stereoselective ring opening carboxylate.

An asym. ring opening reaction of oxabenzonorbornadiene with carboxylate nucleophiles to generate enantiomerically enriched naphthalene-derived products containing an allylic carboxylate moiety was developed. These reactions occur in good yield and excellent enantioselectivity (>90% ee). The allylic carboxylate functionality was found to be stable towards reaction with the rhodium catalyst under the reaction conditions. In order to obtain these results, two advancements were required. First, the use of protic additives was necessary for good reactivity. Second, the exchange of the halide ligand on the catalyst from chloride to iodide was required to obtain high ee.

Tetrahedron published new progress about Nucleophiles. 277306-29-3 belongs to class chiral-phosphine-ligands, and the molecular formula is C32H40FeP2, Product Details of C32H40FeP2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Ludwig, Janet C.; Misiorowski, Ronald L.; Chvapil, Milos; Seymour, Michael D. published the artcile< Interaction of zinc ions with electron carrying coenzymes NADPH and NADH>, Related Products of 606-68-8, the main research area is zinc NADH drug metabolism inhibition.

The substrate for the drug-oxidizing system, NADPH, binds to Zn2+, but NADH does not. Equilibrium gel filtration and acid titrations of Zn2+ and NADPH tetrasodium salt indicated a molar ratio of metal to nucleotide of 2:1 and a formation constant of 106.75. 31P-NMR, UV, and fluorescence spectra of the complex indicated the possible binding sites of Zn2+ to NADPH. Since Zn2+ is known to inhibit the metabolism of drugs by mixed function oxidases in liver microsomes, the formation of the Zn2+-NADPH complex suggests the mechanism by which Zn2+ may inhibit the drug-oxidizing system.

Chemico-Biological Interactions published new progress about Drug-metabolizing enzymes Role: BIOL (Biological Study). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Related Products of 606-68-8.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Tominaga, Masato; Iwaoka, Ayako; Kawai, Daisuke; Sakamoto, Shingo published the artcile< Correlation between carbon oxygenated species of SWCNTs and the electrochemical oxidation reaction of NADH>, Product Details of C21H27N7Na2O14P2, the main research area is oxygenated carbon nanotube correlation electrochem oxidation NADH.

The correlation between carbon oxygenated species as a defect in single-walled carbon nanotubes (SWCNTs) and the oxidation reaction behavior of the reduced form of β-nicotinamide dinucleotide (NADH) was investigated. The two main oxidation peaks of NADH at the SWCNTs were due to adsorbed and diffused species, resp. The peak current ratio showed a good relationship to the intensity ratio of the G-band/D-band obtained from the Raman spectra of the SWCNTs.

Electrochemistry Communications published new progress about Carbon nanotubes (oxygenated). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Product Details of C21H27N7Na2O14P2.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate