Category: 89544-83-2

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Facile synthetic approaches to 1-thiocyclopropanecarboxylates, published in 2017, which mentions a compound: 89544-83-2, Name is Ethyl 1-bromocyclopropanecarboxylate, Molecular C6H9BrO2, Reference of Ethyl 1-bromocyclopropanecarboxylate.

1-(Alkylthio) and 1-(arylthio)cyclopropanecarboxylates were prepared by two different methods from the parent thiols. Reaction of thiols with α-bromo-γ-butyrolactone, lactone hydrolysis, O-methylation, mesylation of the free alc., and base-mediated cyclization yielded 1-(alkylthio) and 1-(arylthio)cyclopropanecarboxylates; a (bromoquinolinylthio)cyclopropanecarboxylate and a [(bromonaphthylmethyl)triazolyl]cyclopropanecarboxylate could not be prepared by this route. Alternatively, reaction of thiols with Me bromoacetate followed by double alkylation with the cyclic sulfate of ethylene glycol yielded 1-(alkylthio) and 1-(arylthio)cyclopropanecarboxylates; the previous (bromoquinolinylthio)cyclopropanecarboxylate was prepared using this method, while a [(bromonaphthylmethyl)triazolyl]cyclopropanecarboxylate could not be prepared by this route. The first route uses inexpensive reagents and is easier to perform but requires five steps and is incompatible with acidic and basic functionalities, while the second route uses more expensive reagents and is incompatible with acidic functionality.

《Facile synthetic approaches to 1-thiocyclopropanecarboxylates》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 1-bromocyclopropanecarboxylate)Reference of Ethyl 1-bromocyclopropanecarboxylate.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Facile synthetic approaches to 1-thiocyclopropanecarboxylates, published in 2017, which mentions a compound: 89544-83-2, Name is Ethyl 1-bromocyclopropanecarboxylate, Molecular C6H9BrO2, Reference of Ethyl 1-bromocyclopropanecarboxylate.

1-(Alkylthio) and 1-(arylthio)cyclopropanecarboxylates were prepared by two different methods from the parent thiols. Reaction of thiols with α-bromo-γ-butyrolactone, lactone hydrolysis, O-methylation, mesylation of the free alc., and base-mediated cyclization yielded 1-(alkylthio) and 1-(arylthio)cyclopropanecarboxylates; a (bromoquinolinylthio)cyclopropanecarboxylate and a [(bromonaphthylmethyl)triazolyl]cyclopropanecarboxylate could not be prepared by this route. Alternatively, reaction of thiols with Me bromoacetate followed by double alkylation with the cyclic sulfate of ethylene glycol yielded 1-(alkylthio) and 1-(arylthio)cyclopropanecarboxylates; the previous (bromoquinolinylthio)cyclopropanecarboxylate was prepared using this method, while a [(bromonaphthylmethyl)triazolyl]cyclopropanecarboxylate could not be prepared by this route. The first route uses inexpensive reagents and is easier to perform but requires five steps and is incompatible with acidic and basic functionalities, while the second route uses more expensive reagents and is incompatible with acidic functionality.

《Facile synthetic approaches to 1-thiocyclopropanecarboxylates》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 1-bromocyclopropanecarboxylate)Reference of Ethyl 1-bromocyclopropanecarboxylate.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Copper-Catalyzed Three-Component Difunctionalization of Aromatic Alkenes with 2-Amino-1,4-naphthoquinones and α-Bromocarboxylates, Author is Shangguan, Yu; Yang, Fazhou; Deng, Hao; Liu, Hao; Liu, Ziyan; Zhuang, Wanyue; Qiao, Chenxi; Wang, Aizheng; Xiao, Yumei; Zhang, Cheng, which mentions a compound: 89544-83-2, SMILESS is O=C(C1(Br)CC1)OCC, Molecular C6H9BrO2, SDS of cas: 89544-83-2.

A copper-catalyzed three-component difunctionalization of aromatic alkenes to access 1,4-naphthoquinone derivatives with diverse structures is described. The difunctionalization reaction is accompanied by ester exchange reaction with the solvent. In this method, α-bromocarboxylates were used as radical precursors and 2-amino-1,4-naphthoquinones as radical trapping reagents. The substrate scope is broad because various aromatic alkenes, 2-amino-1,4-naphthoquinones, and α-bromocarboxylates were employed in the reaction, and corresponding products were obtained in moderate to good yields.

This literature about this compound(89544-83-2)SDS of cas: 89544-83-2has given us a lot of inspiration, and I hope that the research on this compound(Ethyl 1-bromocyclopropanecarboxylate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 1-bromocyclopropanecarboxylate( cas:89544-83-2 ) is researched.Application In Synthesis of Ethyl 1-bromocyclopropanecarboxylate.Peng, Jianbiao; Hu, Qiyue; Gu, Chunyan; Liu, Bonian; Jin, Fangfang; Yuan, Jijun; Feng, Jun; Zhang, Lei; Lan, Jiong; Dong, Qing; Cao, Guoqing published the article 《Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model》 about this compound( cas:89544-83-2 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: uric acid transporter inhibitor; 3D pharmacophore; Gout; Hyperuricemia; URAT1 homology model; URAT1 inhibitors. Let’s learn more about this compound (cas:89544-83-2).

This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore anal. resulted in compound (I). With an IC50 of 33.7 nM, I also demonstrated good oral bioavailability in rat (74.8%) and displayed a consistent PK profile across all species tested (rat, dog and monkey).

From this literature《Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model》,we know some information about this compound(89544-83-2)Application In Synthesis of Ethyl 1-bromocyclopropanecarboxylate, but this is not all information, there are many literatures related to this compound(89544-83-2).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 89544-83-2, is researched, Molecular C6H9BrO2, about A facile route to gem-dibromocyclopropane, the main research direction is cyclopropane bromo; cyclopropanedicarboxylate Hunsdiecker Cristol reaction; bromination cyclopropanedicarboxylate; bromocyclopropane.SDS of cas: 89544-83-2.

Hunsdiecker-Cristol reaction of cyclopropanedicarboxylate I (R = CO2Et, R1 = CO2H) gave 85% I (R = CO2Et, R1 = Br), which was hydrolyzed to give 85% I (R = CO2H, R1 = Br), which underwent a 2nd Hunsdiecker-Cristol reaction to give 88% title compound I (R = R1 = Br).

This literature about this compound(89544-83-2)SDS of cas: 89544-83-2has given us a lot of inspiration, and I hope that the research on this compound(Ethyl 1-bromocyclopropanecarboxylate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate