Category: 855-38-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

General procedure: General procedures for the synthesis of 2-6: To a solution of 1 (0.2mmol) and monophosphines (0.2mmol) in MeCN, a solution of Me3NO¡¤2H2O (0.2mmol) in MeCN was added. The mixture was stirred at room temperature for 1h (Scheme 3 ). Then the solvent was removed on a rotary evaporator and the residue was subjected to TLC by using CH2Cl2/ petroleum ether as eluent. From the main red band, 2-6 were obtained as red solids with high yields, varying from 67% to 96%. Although complex 2 was reported in the literature [14], we prepared it by a different method and further studied its electrochemical and photochemical properties

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Article; Li, Rui-Xia; Liu, Xu-Feng; Liu, Ting; Yin, Yi-Bing; Zhou, Ying; Mei, Shun-Kang; Yan, Jing; Electrochimica Acta; vol. 237; (2017); p. 207 – 216;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

To azide 6 [8a,14] (436?mg, 0.832?mmol) in Et2O (2.1?mL) under argon atmosphere was added tris(4-methoxyphenyl)phosphine (293?mg, 0.832?mmol) at rt. Stirring was maintained at rt for 24?h and then pentane (2.0?mL) was added and the resultant thick precipitate was filtered. The precipitate was washed with pentane/Et2O 1:1 (1?mL) and dried in vacuo to obtain the title compound 1d as a colourless solid (630?mg, 90%). MP 168-170?C; [alpha]D24?=?-18.0 (c?=?0.59, CHCl3); 1H NMR (500?MHz, CDCl3) delta ppm 2.99 (br. s, 1H), 3.10 (br. s, 1H), 3.82 (s, 9H), 3.97-4.09 (m, 1H), 5.11 (br. s, 1H), 6.88 (d, J?=?5.5?Hz, 6H), 7.11-7.21 (m, 6H), 7.22-7.31 (m, 7H), 7.31-7.45 (m, 6H), 7.63 (s, 2H); 13C NMR (125?MHz, CDCl3) delta ppm 50.3, 55.0, 55.6, 59.9, 115.0 (d, JPC?=?11.4?Hz), 123.8 (q, JFC?=?272.8?Hz), 126.6, 126.9 (br. s), 128.1, 128.5, 128.8, 128.9 (br. s), 130.6 (q, JFC?=?32.4?Hz), 134.9 (JPC?=?11.5?Hz), 142.9, 163.7; 31P NMR (162?MHz, CDCl3) delta ppm 27.6 (br s); 19F NMR (376?MHz, CDCl3) delta ppm – 62.6; IR numax/cm-1 3027, 2963, 1624, 1594, 1499, 1471, 1388, 1258, 1118, 1028, 804, 700; HRMS (ESI+): calcd. for C45H40F6N3O3PS [M+H]+ 848.2505, found 848.2492.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Farley, Alistair J.M.; Jakubec, Pavol; Goldys, Anna M.; Dixon, Darren J.; Tetrahedron; vol. 74; 38; (2018); p. 5206 – 5212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 20 N-(2,2,2-Trifluoroethyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide Analogously to Example 14, 1.39 g (5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)-pyrazol-5-yloxy]pyridine, 0.75 g (7.57 mmol, 98 percent content) of 2,2,2-trifluoroethylamine, 0.80 g (7.55 mmol) of anhydrous sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 88 mg (0.25 mmol) of tris(4-methoxyphenyl)phosphine in 20 ml of methylcyclohexane were reacted under a CO pressure of 21 bar. The yield was 0.96 g (75.4 percent) of a white solid. The melting point was 135.8 to 136.3 C. (from methylcyclohexane). Other data concerning the product was: MS; m/z: 368 (M+); 242 (100 percent) 1 H NMR (CDCl3): delta=3.82 (s, 3H); 4.05 (m, 2H); 6.29 (s, 1H); 7.27 (dt, J=8.1/0.6 Hz, 1H); 7.64 (br. s, 1H); 8.01 (dd, J=7.3/0.5 Hz, 1H); 8.07 (d, J=7.3 Hz, 1H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: To a CH2Cl2 solution of [Cp*Ir(S2C2B10H10)] (B or C) (107mg, 0.2mmol) PR3 (0.2mmol) was added and the mixture was stirred for 10minat ambient temperature. The resulting yellow solution was evaporated in vacuo and the residue was washed with hexanes to give B1-B4, C1-C4, respectively. Single crystals suitable for X-ray analysis were obtained by slow evaporation of a CH2Cl2/hexane solution. (Note: for the preparation of B4 and C4, slight excess of PMe3 was added.)

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Article; Zou, Wenli; Zhang, Xiaolei; Dai, Humin; Yan, Hong; Cremer, Dieter; Kraka, Elfi; Journal of Organometallic Chemistry; vol. 865; (2018); p. 114 – 127;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

General procedure: To a CH2Cl2 solution of [Cp*Ir(S2C2B10H10)] (B or C) (107mg, 0.2mmol) PR3 (0.2mmol) was added and the mixture was stirred for 10minat ambient temperature. The resulting yellow solution was evaporated in vacuo and the residue was washed with hexanes to give B1-B4, C1-C4, respectively. Single crystals suitable for X-ray analysis were obtained by slow evaporation of a CH2Cl2/hexane solution. (Note: for the preparation of B4 and C4, slight excess of PMe3 was added.)

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zou, Wenli; Zhang, Xiaolei; Dai, Humin; Yan, Hong; Cremer, Dieter; Kraka, Elfi; Journal of Organometallic Chemistry; vol. 865; (2018); p. 114 – 127;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: A solution of (mu3-S)FeCo2(CO)9 (0.069 g, 0.15 mmol) and tris(4-fluorophenyl)phosphane(0.063 g, 0.2 mmol) in CH2Cl2 (10 mL) was added to a solution of Me3NO2H2O (0.022 g,0.2 mmol) and stirred at room temperature for 1 h. The solvent was reduced in vacuo andthe residue was subjected to TLC separation using CH2Cl2:petroleum ether = 1:5 (v/v) aseluent. From the first main brown band, 1 (0.039 g, 35%) was obtained as a black solid. Fromthe second main brown band, 2 (0.040 g, 26%) was obtained as a black solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Article; Zhao, Peng; Liu, Xu-Feng; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 70; 17; (2017); p. 3080 – 3094;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: To a solution of [Fe2(CO)6{mu-SCH(CH3)CH(CH3)S}] (0.040 g, 0.10 mmol) and tris(4-fluorophenyl)phosphine (0.032 g, 0.10 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h, and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 2:5 (v/v) as eluent.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lin, Hui-Min; Wang, Ling-Hui; Liu, Xu-Feng; Liu, Xing-Hai; Jiang, Zhong-Qing; Transition Metal Chemistry; vol. 45; 1; (2020); p. 47 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

A mixture of 12-bromododecanoic acid (302 mg, 1.08 mmol) and tris(4-methoxyphenyl)phosphine (400 mg, 1.14 mmol) in degassed MeCN (5 mL) under N2 was heated at 80 00 for 3 d. On cooling the solvent was removed in vacuo and the resultingresidue purified by column chromatography eluting with 0-10% MeOH in DCM to give (11-carboxyundecyl)tris(4-methoxyphenyl)phosphonium bromide (545 mg, 80%) as a white solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; NOVINTUM BIOTECHNOLOGY GMBH; SPAREY, Tim; RATCLIFFE, Andrew; COCHRANE, Edward; STEVENSON, Brett; HALLETT, David; LAGASSE, Franz; LASSALLE, Gilbert; FROIDBISE, Alexandre; (106 pag.)WO2018/193113; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 3 N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-pyridine-2-carboxamide 10.26 g (37.5 mmol) of 2-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine (content: 99.5 percent, prepared according to Example 1), 6.25 g (56.2 mmol) of 4-fluoroaniline, 4.37 g (41.3 mmol) of sodium carbonate, 26.3 mg (37.5 mumol) of dichlorobis(triphenylphosphine)palladium(II) and 0.40 g (1.125 mmol) of tris(4-methoxyphenyl)phosphine (IV, R8 =R9 =R10 =methoxy) in 37.5 ml of xylene were placed in an autoclave at room temperature. The autoclave was flushed with inert gas, a carbon monoxide pressure of 5 bar was then applied and the mixture was heated to 150 C. The CO pressure was raised to 18 bar and the mixture was stirred for 21 hours at 150 C. After cooling to room temperature and depressurization, 50 ml of xylene and 50 ml of water were added to the reaction mixture, which was filtered. The aqueous phase was extracted with 25 ml of xylene and the combined organic phases were washed with 30 ml of water. Neither unconverted educt nor by-products were detectable by GC in the xylene phase. After distillation of the solvent, the crude product (15.83 g) was obtained in the form of a yellow solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;; ; Patent; Lonza AG; US5892032; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate