Category: 849924-49-8

Quality Control of (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphineOn March 14, 2019, Wei, Xiao-Feng; Wakaki, Takayuki; Itoh, Taisuke; Li, Hong-Liang; Yoshimura, Takayoshi; Miyazaki, Aya; Oisaki, Kounosuke; Hatanaka, Miho; Shimizu, Yohei; Kanai, Motomu published an article in Chem. The article was 《Catalytic Regio- and Enantioselective Proton Migration from Skipped Enynes to Allenes》. The article mentions the following:

Here, a copper(I)-catalyzed enantioselective proton migration from skipped enynes to allenes I [R1 = Ph, 3-MeC6H4, 3-thienyl, etc.; R2 = H, Me, Bn, etc.] as an efficient approach in chiral allene synthesis was reported. With catalyst loading as low as 0.5 mol %, the reaction proceeded smoothly under mild conditions without the need for addnl. stoichiometric reagents or generation of waste. Novel chiral ligand containing diphenylphosphine moiety plays a critical role in furnishing high catalyst activity, promoting regioselective protonation to produce allenes instead of conjugated enynes and inducing axial chirality of allenes. The multiple roles of the chiral ligand were rationalized by d. functional theory calculations In the experimental materials used by the author, we found (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8Quality Control of (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine)

(R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Quality Control of (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

In 2018,Angewandte Chemie, International Edition included an article by Itoh, Taisuke; Kanzaki, Yamato; Shimizu, Yohei; Kanai, Motomu. Recommanded Product: (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine. The article was titled 《Copper(I)-catalyzed enantio- and diastereodivergent borylative coupling of styrenes and imines》. The information in the text is summarized as follows:

We report copper(I)-catalyzed enantio- and diastereodivergent borylative coupling of styrenes Ar1CH:CH2 with imines RCH:HP(S)Ar22 and B2pin2 to produce enantiomerically-enriched α,β-dibranched γ-boryl amine derivatives RCH(NHPSAr22)CHAr1CH2Bpin (3). Each of the four possible stereoisomers of the products, derived from the two contiguous stereocenters, was selectively accessible by choosing a proper chiral ligand for the copper catalyst. This method, which combines catalyst-controlled stereodivergency and constitutional divergency derived from the lynchpin motif (i.e., the C-B bond), offers a strategy for addressing the construction of mol. structural diversity concomitant with precise chirality control. The results came from multiple reactions, including the reaction of (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8Recommanded Product: (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine)

(R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Recommanded Product: (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Category: chiral-phosphine-ligandsOn October 4, 2017 ,《Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts》 was published in Journal of the American Chemical Society. The article was written by Garcia-Morales, Cristina; Ranieri, Beatrice; Escofet, Imma; Lopez-Suarez, Laura; Obradors, Carla; Konovalov, Andrey I.; Echavarren, Antonio M.. The article contains the following contents:

The enantioselective intermol. gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes was achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach was applied to the enantioselective total synthesis of rumphellaone A. After reading the article, we found that the author used (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8Category: chiral-phosphine-ligands)

(R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Category: chiral-phosphine-ligands These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis