Category: 829-85-6

Some tips on 829-85-6

As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.829-85-6,Diphenylphosphine,as a common compound, the synthetic route is as follows.

829-85-6, General procedure: MCM-41-3N-Pd(0) (21mg, 0.01mmol), KOAc (1.5mmol) and aryl iodide 1 (1.0mmol) (if solid) were placed in an oven-dried 20mL Schlenk tube, the reaction vessel was evacuated and filled with argon for three times. Then aryl iodide 1 (1.0mmol) (if liquid), diphenylphosphine (1.2mmol) and DMAc (1mL) were added with a syringe under a counter flow of argon. The reaction mixture was stirred at 130C for 3h. After completion of the reaction, the mixture was cooled to room temperature and diluted with CH2Cl2 (20mL) and filtered. The MCM-41-3N-Pd(0) catalyst was washed with distilled water (2¡Á5mL) and ethanol (2¡Á5mL), and reused in the next run. The filtrate was concentrated in vacuo and the residue was purified by flash column chromatography on silica gel to provide the product 2.

As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.

Reference£º
Short Survey; Xu, Zhaotao; Wang, Pingping; Chen, Qiurong; Cai, Mingzhong; Journal of Organometallic Chemistry; vol. 866; (2018); p. 50 – 58;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Analyzing the synthesis route of 829-85-6

As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.829-85-6,Diphenylphosphine,as a common compound, the synthetic route is as follows.

1.86 g (10 mmol) of diphenyl phosphane and 10 ml of tetrahydrofuran were introduced into a four-neck flask of 100 ml in capacity that had been fully replaced with nitrogen. Into this mixture, 7.63 g of 1.4 mol/kg isopropyl magnesium chloride/lithium chloride-THF solution was dripped over 30 minutes at a constant temperature between 0 C. and 2 C. After the entire solution had been dripped, the mixture was agitated for 4 hours at a temperature of 0 C., to manufacture a diphenyl phosphanyl magnesium chloride/lithium chloride complex. Into this complex, a solution prepared from 0.99 g (7.8 mmol) of benzoyl chloride and 5 ml of tetrahydrofuran was dripped over 1 hour at a constant temperature of 0 C. After the entire solution had been dripped, the mixture was agitated for 8 hours at a temperature of 0 C. Thereafter, 8.5 g of toluene was added to the reaction liquid, after which 10 ml of 5% aqueous sulfuric acid solution was added to the reaction liquid to separate out the organic layer which was then washed with 10 g of water, 10 g of 5% sodium bicarbonate water, and 10 g of water, in this order. The solvent was distilled away from the obtained organic layer under reduced pressure and the residue was dissolved in 5 ml of methanol at 50 C., after which the solution was cooled to 0 C., and thus 1.83 g of benzyl diphenyl phosphine (purity: 98%) was obtained as white crystal. The yield was 85%.

As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.

Reference£º
Patent; HOKKO CHEMICAL INDUSTRY CO., LTD.; SUZUKI, Kenta; KUMAMOTO, Nobumichi; ITO, Nobuhiro; HATAE, Shinji; SUZUKI, Hiroyuki; US2019/248815; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate