Category: 7650-91-1

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, A 25 mL flask was charged with IrCl3.3H2O (210 mg, 0.6 mmol) and benzyldiphenyl phosphine (331 mg, 1.2 mmol) then dry and degassed 2-methoxyethanol (10 mL) was added as solvent. The reaction mixture was heated at 120 C. for 12 hour. After cooling to room temperature, fppzH (86 mg, 0.4 mmol) and Na2CO3 (636 mg, 6.0 mmol) were added into the flask, followed by stirring at RT for another 3 hour. The reaction was quenched by addition of excess water which resulted in the pale yellow precipitate. The precipitate was collected by the filtration and then washed with ice MeOH and diethyl ether. Purification by flash column using CH2Cl2 as eluent gave a chloride intermediate which could be further purified by recrystallization in mixed CH2Cl2 and hexane solution with 40% yield (240 mg, 0.24 mmol). After then, a mixture of chloride intermediate (99 mg, 0.1 mmol), AgOTf (28 mg, 0.12 mmol) and dry 2-methoxyethanol (5 mL) was refluxed in the dark for 2 hour and then cooled to room temperature. After removal of the white precipitate by filtration, the collected filtrate was added excess water. The resulting white precipitate could be collected by filtration, followed by washing with ice methanol and diethyl ether. Purification was conducted by flash column using CH2Cl2 as eluent and then recrystallization in mixed solution of CH2Cl2 and hexane gave 5a as white powder with 37% yield (70 mg, 0.037 mmol).Spectral data of 5a: MS (FAB, 192Ir), 955 [M+]. 1H NMR (500 MHz, CDCl3, 294K): delta 7.89 (d, J=8.0 Hz, 1H), 7.87 (d, J=8.0 Hz, 1H), 7.50 (d, J=6.5 Hz, 1H), 7.43 (t, J=9.0 Hz, 2H), 7.33-7.25 (m, 3H), 7.21 (d, J=7.5 Hz, 1H), 7.16-7.13 (m, 3H), 7.11-7.08 (m, 5H), 6.96 (t, J=7.5 Hz, 1H), 6.85 (t, J=7.5 Hz, 1H), 6.82-6.79 (m, 3H), 6.77 (s, 1H), 6.72 (t, J=7.3 Hz, 1H), 6.69-6.66 (m, 3H), 6.61 (t, J=8.8 Hz, 2H), 6.43 (t, J=6.8 Hz, 1H), 6.32 (t, J=8.5 Hz, 2H), 6.18 (t, J=5.8 Hz, 1H), 4.05 (dd, J=15.0, 8.8 Hz, 1H), 3.77 (dd, J=15.0, 8.8 Hz, 1H), 3.46 (dd, J=16.5, 9.7 Hz, 1H), 2.17 (dd, J=16.5, 9.7 Hz, 1H). 19F {1H} NMR (470 MHz, CDCl3, 294K): delta -60.27 (s, 3F).31P {1H} NMR (202 MHz, CDCl3, 294K): delta 6.29 (d, J=11.1 Hz, 1P), 6.18 (d, J=11.1 Hz, 1P).

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YUN CHI; US2008/161568; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: The following procedure was used in place of the general procedure for this reaction: SiO2 (0.0561 g) and di-(mu-acetato)bis-{2-[(N,N-dimethylamino)methyl]phenyl-C,N}dipalladium(II) 1a (0.0222 g, 0.0370 mmol) were mixed first in a small round-bottomed flask. A stir bar was inserted and the flask, septum, and stirring spatula were all transferred to a glove box with an atmosphere of N2. Benzyldiphenylphosphine 7 (0.020 g, 0.072 mmol) was then added to the flask and thoroughly mixed with the spatula. The reaction was allowed to stir at room temperature in the glove box. The flask was capped with the septum before being removed from the glove box and put in a preheated oil bath (100 C) for 2 h. No CaCl2-filled syringe was used in this reaction. The reaction mixture was filtered into a flask with LiCl as described in the general procedure and purified using preparative TLC in CH2Cl2., 7650-91-1

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lamb, Jessica R.; Stepanova, Valeria A.; Smoliakova, Irina P.; Polyhedron; vol. 53; (2013); p. 202 – 207;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-trifluoromethyl-1H-pyrazol-5-yl)pyridine (61 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:n-hexane=1:1 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E5 (60.8% yield; 102 mg). The reaction scheme for producing the complex E5 is represented as follows: The spectrum analysis for the complex E5 is: 1H NMR (400 MHz, CDCl3, 298 K) delta 8.89 (d, J=8.3 Hz, 1H), 7.83 (dd, J=8.1, 11.7 Hz, 4H), 7.61 (d, J=1.4 Hz, 1H), 7.56 (d, J=6.1 Hz, 1H), 7.42-7.51 (m, 6H), 7.11 (t, J=6.4 Hz, 2H), 6.98 (t, J=7.4 Hz, 1H), 6.94 (s, 1H), 6.64 (dd, J=2.1, 6.1 Hz, 1H), 3.77 (d, J=11.4 Hz, 2H), 1.26 (s, 9H), 19F NMR (400 MHz, CDCl3, 298 K) delta -60.7, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.24, FAB-MS m/z 738.7 M+

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, General procedure: The following procedure was used in place of the general procedure for this reaction: SiO2 (0.0561 g) and di-(mu-acetato)bis-{2-[(N,N-dimethylamino)methyl]phenyl-C,N}dipalladium(II) 1a (0.0222 g, 0.0370 mmol) were mixed first in a small round-bottomed flask. A stir bar was inserted and the flask, septum, and stirring spatula were all transferred to a glove box with an atmosphere of N2. Benzyldiphenylphosphine 7 (0.020 g, 0.072 mmol) was then added to the flask and thoroughly mixed with the spatula. The reaction was allowed to stir at room temperature in the glove box. The flask was capped with the septum before being removed from the glove box and put in a preheated oil bath (100 C) for 2 h. No CaCl2-filled syringe was used in this reaction. The reaction mixture was filtered into a flask with LiCl as described in the general procedure and purified using preparative TLC in CH2Cl2.

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Lamb, Jessica R.; Stepanova, Valeria A.; Smoliakova, Irina P.; Polyhedron; vol. 53; (2013); p. 202 – 207;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, A mixture of Fe2(l-pdt)(CO)6 (0.097 g, 0.25 mmol), Ph2P(CH2Ph) (0.083 g, 0.3 mmol) and Me3NO2H2O (0.034 g, 0.3 mmol) was dissolved in MeCN (15 mL). The mixture was stirred at room temperature for 0.5 h to give a brown-red solution. The solvent was removed on a rotary evaporator and the residue was subject to preparative TLC separationusing CH2Cl2/petroleum ether (v/v1:5) as eluent. From the main red band, 1(0.076 g, 48%) was obtained as a red solid. Anal. Calcd for C27H23Fe2O5PS2: C, 51.13; H,3.66%. Found: C, 50.95; H, 3.87%. FT-IR (KBr disk, cm-1): mCO 2041 (vs.), 1979 (vs.),1954 (s), 1922 (m). 1H NMR (600 MHz, CDCl3, TMS, ppm): 7.68 (s, 4H, 2xPPhH-o), 7.44 (s,6H, 2xPPhH-m,p), 7.17 (s, 1H, CH2PhH-p), 7.11 (s, 2H, CH2PhH-o), 6.71 (s, 2H, CH2PhHm),3.87 (s, 2H, CH2Ph), 1.86 (s, 2H, 2xSCHeHa), 1.65-1.51 (m, 2xSCHeHa and CH2).31P{1H} NMR (243 MHz, CDCl3, 85% H3PO4, ppm): 63.14 (s).

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Zhao, Pei-Hua; Ma, Zhong-Yi; Hu, Meng-Yuan; Jing, Xing-Bin; Wang, Yan-Hong; Liu, Xu-Feng; Journal of Coordination Chemistry; vol. 71; 16-18; (2018); p. 2941 – 2952;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate