Category: 7650-91-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

The complex was obtained from benzyldiphenylphosphine in 54% yield by using a reported procedure [41]. M.p. 196-199C (dec.) [lit. [42] 198C (dec.)]. The 1H and 31P{1H} NMR data for the synthesized complex were consistent with the literature data [30]., 7650-91-1

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Korte, Nicholas J.; Stepanova, Valeria A.; Smoliakova, Irina P.; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 356 – 362;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, General procedure: The following procedure was used in place of the general procedure for this reaction: SiO2 (0.0561 g) and di-(mu-acetato)bis-{2-[(N,N-dimethylamino)methyl]phenyl-C,N}dipalladium(II) 1a (0.0222 g, 0.0370 mmol) were mixed first in a small round-bottomed flask. A stir bar was inserted and the flask, septum, and stirring spatula were all transferred to a glove box with an atmosphere of N2. Benzyldiphenylphosphine 7 (0.020 g, 0.072 mmol) was then added to the flask and thoroughly mixed with the spatula. The reaction was allowed to stir at room temperature in the glove box. The flask was capped with the septum before being removed from the glove box and put in a preheated oil bath (100 C) for 2 h. No CaCl2-filled syringe was used in this reaction. The reaction mixture was filtered into a flask with LiCl as described in the general procedure and purified using preparative TLC in CH2Cl2.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lamb, Jessica R.; Stepanova, Valeria A.; Smoliakova, Irina P.; Polyhedron; vol. 53; (2013); p. 202 – 207;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1,7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh benzyl diphenylphosphine (138.2 g, 0.5 mol), dimethyl carbonate (135.1 g, 1.5 mol),Benzene (68.3 g, 25%) and 80%-Cs2O/SiO2 catalyst (1.37 g, 0.5%) were added to a stainless steel autoclave,The air in the reaction vessel was replaced by N2, and the temperature was raised to 160 C for 8 hours.After completion of the reaction, the cooling water was cooled to 65 C, and the catalyst was recovered by filtration, and the unreacted raw materials and solvent were distilled off under reduced pressure.The product was washed with n-hexane and then dried under vacuum at 60 C for 5 hours to give benzyldiphenylmethylmethyl carbonate (164.9 g) in a yield of about 90%.The methyl carbonate quaternary phosphonium salt benzyl diphenyl methyl carbonate hydrazine (55.0 g, 0.15 mol) was weighed and dissolved in dichloromethane (137.5 g).Trifluoromethanesulfonic acid (22.5 g, 0.15 mol) was added, and the mixture was refluxed under magnetic stirring at 50 C for 3 hours.After completion of the reaction, the solvent was removed by distillation under reduced pressure to give 62.8 g of benzyldiphenylmethyltrifluoromethanesulfonate ionic liquid, yield of about 95%.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; China Daily Expenses Chemical Institute Co., Ltd.; Geng Tao; Duan Shengfu; Jiang Yajie; Ju Hongbin; Wang Yakui; (8 pag.)CN108440595; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, A 100 mL round-bottomed flask was charged with 2.4 g of benzyl diphenyl phosphine, 1.4 g of benzylpyridine iridium(III) dichloro bridge dimer, 1.83 g of sodium carbonate and 100 mL of 2-ethoxyethanol. The reaction was stirred and heated at 135 C. for 6 h under nitrogen while protected from light with aluminum foil. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure(20 mmHg). A light brown solution was obtained and further purified by flash column chromatography on silica gel using dichloromethane and hexanes mixture as the eluent yielding 2 g (78%) of pure mer isomer was obtained.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Tsai, Yui-Yi; Barone, Michael S.; Tamayo, Arnold; Thompson, Mark E.; US2005/258742; (2005); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-(tert-butyl)-1H-1,2,4-triaz ol-5-yl)pyridine (59 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of EA and n-hexane (EA:n-hexane=1:2 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E3 (44% yield; 73 mg). The reaction scheme for producing the complex E3 is represented as follows: The spectrum analysis for the complex E3 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 8.97 (d, J=7.2 Hz, 1H), 8.05 (s, 1H), 7.84-7.89 (m, 4H), 7.52-7.56 (m, 3H), 7.46-7.50 (m, 4H), 7.17 (d, J=6.8 Hz, 1H), 6.97-6.79 (m, 2H), 6.78 (dd, J=2.2, 6 Hz, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.48 (s, 9H), 1.31 (s, 9H), 31P NMR (200 MHz, CD2Cl2, 298 K) delta 36.32, FAB-MS m/z 728.1 [M+1]+, 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 3-(4-(tert-butyl)pyridin-2-yl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-2H-4,7-methanoindazole (70 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of ethyl acetate (hereinafter referred as EA) and n-hexane (EA:n-hexane=1:3 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a white crystalline product, referred to as complex E1 (77.4% yield; 137 mg). The reaction scheme for producing the complex E1 is represented as follows: The spectrum analysis for the complex E1 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 8.97 (d, J=8.1 Hz, 1H), 7.84 (dd, J=10.4, 18.3 Hz, 4H), 7.38-7.51 (m, 8H), 7.06-7.07 (m, 2H), 6.94 (t, J=7.2 Hz, 1H), 6.47 (dd, J=1.8, 6 Hz, 1H), 3.73 (d, J=11.2 Hz, 2H), 2.97 (d, J=3.7 Hz, 1H), 2.08-2.14 (m, 1H), 1.80-1.86 (m, 1H), 1.43-1.47 (m, 1H), 1.41 (s, 3H), 1.25 (s, 9H), 0.97 (s, 3H), 0.84-0.88 (m, 1H), 0.81 (s, 3H) ppm, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.38 ppm, FAB-MS m/z 779.7 [M+1]+, 7650-91-1

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-(tert-butyl)-1H-pyrazol-5-yl)pyridine (59 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:hexane=1:1 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E2 (59.9% yield; 98.9 mg). The reaction scheme for producing the complex E2 is represented as follows: The spectrum analysis for the complex E2 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 9.05 (d, J=7.6 Hz, 1H), 7.86-7.91 (m, 3H), 7.62 (d, J=2.0 Hz, 1H), 7.46-7.54 (m, 5H), 7.26-7.31 (m, 2H), 7.17 (d, J=7.0 Hz, 1H), 6.98-7.11 (m, 4H), 6.60 (s, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.44 (s, 9H), 1.28 (s, 9H) ppm, 31P NMR (200 MHz, CD2Cl2, 298 K) delta 36.68 ppm, FAB-MS m/z 727.7 [M+1]+

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, General procedure: General procedures for the synthesis of 2-6: To a solution of 1 (0.2mmol) and monophosphines (0.2mmol) in MeCN, a solution of Me3NO¡¤2H2O (0.2mmol) in MeCN was added. The mixture was stirred at room temperature for 1h (Scheme 3 ). Then the solvent was removed on a rotary evaporator and the residue was subjected to TLC by using CH2Cl2/ petroleum ether as eluent. From the main red band, 2-6 were obtained as red solids with high yields, varying from 67% to 96%. Although complex 2 was reported in the literature [14], we prepared it by a different method and further studied its electrochemical and photochemical properties

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Li, Rui-Xia; Liu, Xu-Feng; Liu, Ting; Yin, Yi-Bing; Zhou, Ying; Mei, Shun-Kang; Yan, Jing; Electrochimica Acta; vol. 237; (2017); p. 207 – 216;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

1. “A”REACTION. BENZYIDIPHENYLPHOSPHINE (APPROXIMATELY 1. 0 G or 3.6 mmol ; Strem CHEMICALS), IrCI3* nH2O (APPROXIMATELY 0.52 g or 1.7 mmol ; available from Johnson Matthey Inc. of West DEPTFORD, NEW Jersey), and ethoxyethanol (approximately 15 ml ; ALDRICH, degassed) can be stirred at approximately 130C for approximately 45 minutes under nitrogen. The yellow precipitate may be isolated by filtration and dried under vacuum to yield approximately 0.78 g of the intermediate product. 31P NMR (202 MHz, CD2CI2, 296 K): -38.83. 2. “B”reaction. The product from the A reaction (approximately 0.30 g) can be combined with the sodium salt of 2,4-pentanedione (approximately 0.59 g or 0.48 mmol ; prepared from the corresponding acid and sodium hydride (both from ALDRICH)) and 2-ethoxyethanol (approximately 15 mL; ALDRICH), and the contents can be stirred under nitrogen at approximately 130C for approximately one hour. The volatile components can then be removed in vacuo, and the product may be purified from the resulting crude off-white solid via silica gel flash chromatography with CH2CI2 as the eluting solvent. The product (approximately 35 mg) may be isolated as a white solid that exhibits blue luminescence under 254 and 365 nm illumination. 31P NMR (202 MHz, CD2CI2, 296 K): -5.28.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; E.I. du Pont de Nemours and Company; WO2004/16710; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, To a white suspension of P(CH2C6H5)Ph2 (2.08 g, 7.53 mmol) in toluene (20 mL) in a 300 mL Kjeldahl flask, added dropwise a yellow solution of 3c (1.83 g, 7.17 mmol) in toluene (20 mL) at 25 oC. The combined mixture became a clear yellow solution immediately. After stirring for 15 minutes effervescence was observed. The solution was stirred for 4 hours and it remained a clear yellow solution. Removal of the solvent under vacuum afforded a yellow viscous material which was redissolved with CH2Cl2 (20 mL). The resulting clear yellow solution was transferred via cannula over to a suspension of [PyH][BF4] (1.29 g, 7.17 mmol) in CH2Cl2 (20 mL). The Kjeldahl flask was rinsed with CH2Cl2 (2×20 mL) and the rinsing solution was transferred to the reaction flask via cannula. Pyridine (0.9 mL, 10.8 mmol) was added to the white suspension in CH2Cl2 and the reaction mixture was refluxed for 12 hours. After cooling the reaction to 25 oC, a clear yellow solution was observed and the volatiles were removed under vacuum. The resulting viscous residue was washed with diethyl ether (4 x 40 mL) to give a yellow gum. The gum was purified by column chromatography using silica gel (80 g) and CH2Cl2. The column was eluted with CH2Cl2 (200 mL), CH2Cl2-MeOH 98:2 (500 mL), CH2Cl2-MeOH 95:5 (500 mL), CH2Cl2-MeOH 90:10 (500 mL), and CH2Cl2-MeOH 80:20 (500 mL). The fractions (100 mL) were analyzed by UV-Vis, and those that contained the product were combined and dried under vacuum, affording white foam. The foam was treated with CH2Cl2 (100 mL) and diethyl ether (300 mL) to afford a white precipitate. Filtration of the precipitate followed by diethyl ether washes (40 mL) afforded 17 (2.17g, 66%) as a white powder. 1H NMR ((CD3)2SO): delta 9.66 (d, JPH = 10.4, 1H, -P=NH-), 7.97 (m, 4H, 2,6-CH of -(C6H5)2P=NH-), 7.82 (m, 2H, 4-CH of -(C6H5)2P=NH-), 7.70 (m, 4H, 3,5-CH of -(C6H5)2P=NH-), 7.54 (s, 1H, -CH of C6H3SO3), 7.20-7.28 (m, 3H, 2,6- and 4-CH of -C6H5CH2P=NH-), 7.10 (m, 3,5-CH of -C6H5CH2P=NH-), 6.91 (dd, J = 8.0, 1.6, 1H, 4-CH of -C6H3SO3-), 6.64 (d, J = 8.0, 1H, 3-CH of -C6H3SO3-), 5.00 (d, JPH = 14.0, -CH2P=NH-), 2.21 (s, 3H, 5-CH3 of -C6H3SO3-). 1H NMR (CD2Cl2): delta 9.68 (d, JPH = 10.4, 1H, -P=NH-), 7.71-7.85 (m, 7H, 6-CH of -C6H3SO3-, 3,5-CH of -(C6H5)2P=NH-, and 2,6-CH of -C6H5CH2P=NH-), 7.62 (, m, 4H, 2,6-CH of -C6H5CH2P=NH ), 7.28 (m, 1H, 4-CH of -C6H5CH2P=NH), 7.20 (t, J = 7.6, 3,5-CH of -C6H5CH2P=NH-), 6.96 (m, 2H, 4-CH of -(C6H5)2P=NH-), 6.79 (dd, J = 8.4, 2.0, 1H, 4-CH of -C6H3SO3-), 6.34 (d, J = 8.4, 1H, 3-CH of -C6H3SO3-), 4.27 (d, JPH = 14.0, -CH2P=NH-), 2.23 (s, 3H, 5-CH3 of -C6H3SO3-). 31P NMR ((CD3)2SO): delta 35.9. 31P NMR (CD2Cl2): delta 36.1. 13C NMR ((CD3)2SO): delta 137.0 (d, JPC = 7.8), 135.6 (d, JPC = 3.1, para-CH of -(C6H5)2P=NH-), 133.1 (d, JPC = 10.8, ortho-CH of -(C6H5)2P=NH-), 132.7, 132.4, 131.1, 131.0 (d, JPC = 3.1), 130.4 (d, , JPC = 10.8, meta-CH of -(C6H5)2P=NH-), 129.3 (d, JPC = 3.1), 128.5, 128.4, 128.0 (d, JPC = 10.0, ipso C of -C6H5CH2P=NH-), 120.5 (d, JPC = 96.8, ipso C of -(C6H5)2P=NH-), 119.5 (d, JPC = 3.9), 30.9 (d, JPC = 56.5, -CH2P=NH-), 20.5. Anal. Calcd for C26H24NO3PS: C, 67.66; H, 5.24; N, 3.03. Found: C, 67.86; H, 5.33; N, 2.91.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Burns, Christopher T.; Shang, Suisheng; Thapa, Rajesh; Mashuta, Mark S.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4832 – 4835;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate