Category: 719-80-2

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: By analogy with 18a from solution alpha-chloroether 16a (1.25 g, 3.8 mmol) in Et2O (1mL) and ethyl diphenylphosphinite 17(0.87 g, 3.8 mmol) compound 18b in 77 % yield (1.44 g) was obtained, m.p. 146-148 C((isooctane).1H NMR (400 MHz, CDCl3, 20 C): delta 3.37(s, 3H, OMe), 5.02 (d, 2JPH= 13.3 Hz, 1H, PCH), 6.56 (s, 1H, CHBr2), 7.15-8.05 (m, 14H, C6H4, 2Ph) ppm. 13C NMR (100.61 MHz, CDCl3, 20 C): delta 40.7 (CHBr2), 59.0 (d, 3JPC= 12.48 Hz, OMe), 83.1 (d, 1JPC= 86.52 Hz, PCH), 128.4, 128.5, 128.6, 128.7, 129.4, 130.3, 130.6, 131.7, 131.8 (CH-aromatic), 128.8, 128.9, 132.3, 132.5, 132.6, 133.2, 135.4, 135.5, 135.6,135.7, 142.5, 142.6 (C-aromatic). 31P NMR (162 MHz, CCl4,20 C): delta 28.2 ppm. Anal. Calcd for C21H19Br2O2P: C, 51.04; H, 3.88; Br, 32.34; P, 6.27. Found: C, 50.81; H, 3.77; Br, 32.18; P, 6.14.

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Gazizov, Mukattis B.; Ivanova, Svetlana Yu.; Bagauva, Liliya R.; Khairullin, Rafail A.; Musin, Rashid Z.; Tetrahedron Letters; vol. 57; 2; (2016); p. 210 – 212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, 2.90 grams (12 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzaldehyde (prepared according to Stokker, Jour. Med. Chem. Vol. 29 p.170, 1986) was reduced with 0.454 grams (12 mmol) of sodium borohydride in ethanol (20 mL) at 0 C. The reaction was stirred 1 hr, quenched with aqueous ammonium chloride and the mixture extracted with ether. The organic portion was dried (MgSO4) and concentrated to give 2.90 grams of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl alcohol as an oil which solidified on standing. The crude solid was treated with 1.31 mL of thionyl chloride and heated on a steam bath for 1 hour. After cooling to room temperature, the crude mixture was taken up in water and extracted with ether. The ether was washed with water and dried(MgSO4), and concentrated to give an oily residue which was purified by silica gel chromatography (25% methylene chloride/ 75% hexane) to give 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride as a solid. 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150C for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111C).

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; EP948335; (2007); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2., 719-80-2

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, EXAMPLE 7 Diphenyl(1-ureidobutyl)phosphine oxide STR15 When a mixture of 0.50 mole of ethyl diphenylphosphinite 0.55 mole of n-butyraldehyde, and 0.25 mole of urea in 150 ml of chlorobenzene is warmed at 110 C. for 3 hr, there is only a slow reaction. The mixture is cooled to room temperature and 0.25 mole of acetic acid is added dropwise in ~10 minutes. The temperature increases to 65 during this addition; the urea dissolves and then a white solid product separates. The addition of another 0.25 mole of acetic acid causes no additional heat of reaction. The reaction mixture is warmed at 65-80 for 9.5 hr and filtered, giving 44.4g. Recrystallization from ethylene glycol gives 26.5g of a white solid: mp 241-244; 31 P nmr (CF3 CO2 H) -44.4 ppm; ms M+ = 316 (theory 316). Anal. Calcd for C17 H21 N2 O2 P: N, 8.85; P, 9.79. Found: N, 8.62; P, 9.94.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Monsanto Company; US4036913; (1977); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

The reaction flask was evacuated to -0.098 MPa using a vacuum pump.Under this condition will be 23.02gDiphenylethoxyphosphine and 18.26g2,4,6-trimethylbenzoyl chloride was added to the reaction flask, and the reaction was started at a temperature of 40 C.During the reaction, the temperature was raised by 10 C every 20 minutes until the temperature was raised to 90 C.Then react at a constant temperature of 90 C for 8 h.The exhaust gas generated during the reaction is removed by vacuum to the ethyl chloride recovery system and used.After the reaction, 50% ethanol was added to crystallize.33.13 g of the target product TPO were obtained. The purity of the product was 99.2% and the yield was 95.1%., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Shaoxing Shangyu Yirui Chemical Co., Ltd.; Li Kunwu; (6 pag.)CN109336925; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, Preparation Example 206,7,8-Trifluoro-4-thiophenyl-3 (diphenylphosphorylmethyl)-quinoline (B13); A solution of G13 (5.2 g, 13.4 mmol) and ethyl diphenylphosphinite (6.2 ml, 27 mmol) in toluene (25 ml) was refluxed for 2 h during which time the precipitated solid developed. After cooling to room temperature, the solid was isolated by filtration and washed with toluene. The product was then dried to obtain the title compound (6.6 g, 96.9% yield), mp: 244-245 C.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY; US2011/46379; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: 2-Chloromethylbenzothiazole (1) (0.183 g, 0.001 mol) andpotassium iodide (KI) (0.166 g, 0.001 mol) were taken intoa round bottomed flask containing 20 mL of THF. Thereaction mixture was stirred for 3 h at 40C. After completionof the reaction as checked by TLC, cooled the reactionmass to RT and then filtered to remove the salt (KCl),resulted in iodo compound, 2-(iodomethyl) benzo[d]thiazole(2). The filtrate was transferred into a flask and sodiumazide (NaN3) (0.065 g, 0.001 mol) was added. The reactionmixture was stirred at 25-30C for 3 h to form an intermediate,2-azidomethylbenzothiazole (3). The reaction mixturewas filtered to remove the salt, NaI, and filtrate was takenfor the next step.Triphenylphosphine (4a) (0.262 g, 0.001mol) was added to 3under N2 atmosphere. The reaction mixture was stirred at 65-70C for 4 h and the progress of the reaction was monitored byTLC using ethylacetate: n-hexane (2:3) as an eluent. After completionof the reaction, the solvent was removed from the reactionmixture in a rotaevaporator to get the crude product and itwas purified by column chromatography using ethylacetate:nhexane(1:4) to obtain pure product, N-(1,3-Benzothiazol-2-ylmethyl)-N-(1,1,1-triphenyl-lambda5-phosphanylidene) amine (5a).The same procedure was adopted for the synthesis of remainingtitle compounds and the physical data of these compounds aresummarized in Table 1.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Madhava; Subramanyam; Thaslim Basha; Jawahar Babu; Naga Raju; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 16 – 21;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Equimolar mixture of chloride 2a and respective phosphite or phosphinite 3 in benzene was kept at room temperature for 12 h. Solvent was evaporated in vacuo, solid residue was triturated with petroleum ether. In case of reaction of 2a with phosphinite 3c the precipitated phosphine oxide 4c was separated by filtration and washed with benzene. 4.5.3. [1-(Benzyloxycarbonylamino)-2,2,3,3-tetrafluoropropyl](dipheny)phosphine oxide 4c. Yield 59%; mp 177-179 C. 1H NMR (CDCl3): delta = 4.96 (d, 1H, 2JHH = 12 Hz, PhCHA), 5.03 (d, 1H, 2JHH = 12 Hz, PhCHB), 5.34 (m, 1H, CHP), 5.53 (d, 1H, 3JHH = 10 Hz, NH), 6.27 (tt, 1H, 2JHF = 54, 3JHF = 5 Hz, HCF2), 7.2-7.9 (m, 15H, Ph) ppm. 19F NMR (CDCl3): delta = -120.4 (m, 1F, CFAFB), -120.6 (m, 1F, CFAFB), -139.2 (d, 1F, 2JFH = 54 Hz, HCFAFB), -139.5 (d, 1F, 2JFH = 54 Hz, HCFAFB) ppm. 31P NMR (CDCl3): delta = 29.1 ppm. 13? NMR (CDCl3) (selected signals): delta = 51.81 (dt, 1JCP = 74, 2JCF = 24 Hz, CHP), 66.50 (CH2), 109.43 (dt, 1JCF = 252, 2JCF = 30 Hz, HCF2), 156.34 (C=O) ppm. Anal. calcd for C23H20F4NO3P: C, 59.36; H, 4.33; N, 3.01. Found: C, 59.67; H, 4.43; N, 3.17., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Onys’ko, Petro P.; Zamulko, Kateryna A.; Kyselyova, Olena I.; Yelenich, Ivanna P.; Rassukana, Yuliya V.; Journal of Fluorine Chemistry; vol. 185; (2016); p. 191 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, B (the ratio of reagents 3 : 1 in a toluene solution).Compound3b (0.81 g, 78%) was obtained from a mixture of solutions of ester1b (1.15 g, 4.5 mmol) in toluene (3 mL) and compound 2 (0.39 g,1.5 mmol) in toluene (3 mL) (20-25 C, 48 h) , m.p. 209-211 C(toluene).

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gazizov; Ismagilov; Shamsutdinova; Tarakanova; Karimova; Russian Chemical Bulletin; vol. 65; 12; (2016); p. 2943 – 2947; Izv. Akad. Nauk, Ser. Khim.; vol. 65; 12; (2016); p. 2943 – 2947,5;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150 C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111 C.).

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US5969017; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate