Category: 63995-70-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

General procedure: Platinum complexes were synthetized by dissolving K2PtCl4 (8.3 mg, 0.02 mmol) in degassed deuterated water (2 mL). Three equiv. of the corresponding ligand (0.06 mmol) were added to the solution, which was then stirred for 15 min at room temperature under nitrogen. Studies in the presenceof RAME-beta-CD were conducted as follows: the required amount of cyclodextrin was introduced into500 L of the above solution. After 15 min of stirring, the solution was transferred into a NMR tube and analysed.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Ferreira, Michel; Bricout, Herve; Tilloy, Sebastien; Monflier, Eric; Molecules; vol. 22; 1; (2017);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

1 was labeled with99mTc by heating99mTc in a vehicle solution containing tricine and 3,3′,3″-phosphanetriyltris(benzenesulfonic acid) trisodium salt (TPPTS) in high purity and yield. Typically, 2 mug of 1 was mixed 5-10 mCi / 100 mu99iotaetaTau04, followed by addition of with 200 of the vehicle solution in a vial. The mixture was heated at 95 C for 10 min, and cooled to room temperature to yield the99mTc-labeled product as analyzed by radio- HPLC. Radio-HPLC analysis was performed using Waters RP-HPLC (Milford, MA) on a reverse-phase analytical column (Phenomenex, Jupiter 4 mu Proteo 90A, 250 x 4.6 mm, 4 micron) with a gradient from 10% to 70 % aqueous acetonitrile containing 25 mM ammonium formate at a flow rate of 1 mL/min over 40 min.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; YALE UNIVERSITY; THE UNITED STATES OF AMERICA as represented by THE DEPARTMENT OF VETERANS AFFAIRS; SADEGHI, Mehran; YE, Yunpeng; KIM, Hye-Yeong; HUANG, Henry (Yiyun); TOCZEK, Jakub; (85 pag.)WO2017/177144; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

[0139] Under argon atmosphere, tris(3-sulfonatophenyl)phosphine hydrate sodium salt (c) (42.6 mg, 0.075 mmol) and acetylacetonato iridium(1,5-cyclooctadiene) (10.0 mg, 0.025 mmol) were placed in a Schlenk flask. One-half milliliters of a degassed aqueous formic acid solution (98 vol %) was added thereto with a syringe, and the flask was tightly sealed, followed by stirring the resulting mixture at 60 C. for 1 hour. Thereafter, the aqueous formic acid solution was removed under reduced pressure, and the resultant was washed with ethanol, to obtain the iridium hydride complex C as white powder (46.6 mg). Spectroscopic Data of the Iridium Hydride Complex C: [0140] 1H NMR (D2O), delta: 6.97-8.00 (m, 24H), [fac: -10.64 (t, JH-P=18.4 Hz, 1H), -11.83 (ddd, JH-P=102.7, 20.4 Hz, JH-H=4.8 Hz, 2H)]

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY; Muranaka, Makoto; Oshiki, Toshiyuki; US2013/244865; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Compound 110: Os3(C0)10(CNh (20 mg, 0.022 mmol) was dissolved in dichloromethane (3 ml).HS(CH2)2NCH2(CsNHs)2 (1 eq) was then added and the reaction mixture was stirred at roomtemperature overnight. The solvent was removed and the crude material was purified by columnchromatography to obtain product precursor (110a) in 88% yield. Compound (110a) was thenfurther modified as summarized in Figure 1 to yield compound (110).

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MELVILLE, Chris R.; INBAR FESKE, Miriam; HERSCHLEB, Jill Lynden; JOHNS, Adam Matthew; GREENMAN, Kevin Lloyd; PARTYKA, David; ZALATAN, David; TOSTE, Dean F.; WO2014/14852; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Under argon protection,Add to 50mLSchlenk bottle1 ¡¤ 56 mmol of (SO3Na+) 3-R6,4 ¡¤ 73 mmol of [CH3 (EO) 42N + H = C (N (CH3) 2) 2] [CH3SO3-] and 25 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours, filtered,The filtrate was removed under reduced pressure to give an orange yellow viscous liquid acetonitrile, yield 96%.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

The labeling method was as follows: to a 10 mL vial was added tricine solution (0.5 mL, 80 mg/mLin saline), HYNIC-D1-FA2 solution (100 L, 1 mg/mL in PBS, pH 7.4), TPPTS (0.2 mL, 5 mg/mL insaline), SnCl2 solution (20 L, 2 mg/mL) in 0.1 N HCl and about 1 mL of 99mTcO4 (370 MBq) in saline.The vial was heated at 100 C for 30 min in a heating module. After cooling to room temperature,a sample of the resulting solution was purified and analyzed by Sep-Pak C18 cartridge and radio-HPLC.In further experiments, a kit formulation was developed for preparation of 99mTc-HYNIC-D1-FA2 usingthis ternary ligand system.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Guo, Zhide; Gao, Mengna; Song, Manli; Shi, Changrong; Zhang, Pu; Xu, Duo; You, Linyi; Zhuang, Rongqiang; Su, Xinhui; Liu, Ting; Du, Jin; Zhang, Xianzhong; Molecules; vol. 21; 6; (2016);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Under argon protection, add in a 50 mL Schlenk bottle(S03Na) 3-R6,4.73 mmol of [C6H5 (EO) 16N + H = C (N (CH3) 2) 2] [CH3SO3-] and (SO3Na)3-R6 10 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours, filtered and the filtrate was removed under reduced pressure to give an orange yellow viscous liquid in 90% yield.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Example 2 15 g of 4-chloro-3-nitrobenzaldehyde, 13.2 g of 4-carboxyphenylboronic anhydride, 10 g of sodium carbonate and a mixture of 50 mg of palladium as 22% strength aqueous chloride solution, 1 ml of water and 820 mg of a 0.6 M aqueous TPPTS solution together with 145 ml of ethylene glycol and 10 ml of water are placed under nitrogen in a reaction vessel and heated to boiling for 4 hours. 200 ml of water are added and the mixture is acidified with concentrated hydrochloric acid to pH 1-2, which results in precipitation of the product. Crystallization from isopropanol and drying under reduced pressure gives 18.4 g (84%) of 4′-formyl-6′-nitrobiphenyl-4-carboxylic acid as a yellow solid having a melting point of 227-235 C.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Clariant GmbH; US2001/20104; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

200 muL of a mixture containing TPPTS 5.0 mg, tricine 6.5 mg, disodium succinate 38.5 mg, succinic acid 12.7 mg and 30 mug of HYNIC-PEG4-E [PEG4-c(phg-isoDGRk)] 2 was added, and 0.5-1.0 mL was added. The Na99mTcO4 solution was heated in a 100 C water bath for 20 minutes in a vial. After the reaction was completed, it was cooled at room temperature for 5 minutes to prepare 99mTc-HYNIC-PEG4-E[PEG4-c(phg-isoDGRk)]2.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Peking University; Wang Fan; Shi Jiyun; Gao Hannan; (17 pag.)CN110101880; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Under argon protection,Add to 50mLSchlenk bottle1 ¡¤ 56 mmol of (SO3Na) 3-R6,4.73 mmol of [CH3 (EO) 16N + (C6H5CH2) = C (N (CH3) 2) 2] [CH3SO3-] and 10 mL of acetonitrile were added and the reaction mixture was stirred at room temperature for 72 hours, filtered,The filtrate was removed under reduced pressure to give an orange yellow viscous liquid acetonitrile,Yield 92%.

The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate