Category: 6372-42-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

Potassium tetrachloropalladate(II) was prepared by the procedure described in [26]. Potassium chloride, 2 equiv, was added to a solution of palladium(II) chloride in 25 mL of distilled water with stirring over a period of 30 min. The mixture was cooled with ice, and yellowish-brown crystals of potassium tetrachloropalladate(II) separated in a few minutes. The crystals were collected by filtration and recrystallized from water containing a few drops of aqueous HCl. The complexes were prepared by adding 2 equiv of the corresponding phosphine in 15 mL of acetonitrile to a solution of 0.326 g of K2[PdCl4] in15 mL of water, followed by stirring. After 30 min, a solution of 2 equiv of N,N-dimethylthiourea in 15 mL of methanol was added, and the mixture was stirred for one hour. The resulting yellow or red solution was filtered, and the filtrate was kept at room temperature for three to five days. Slow evaporation of the acetonitrile-methanol solution afforded solid complex 1-3. The overall reaction is shown in Scheme 1.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Aziz; Sirajuddin; Munir; Tirmizi; Nadeem; Tahir; Sajjad; Russian Journal of General Chemistry; vol. 88; 3; (2018); p. 551 – 559;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: Under N2 atmosphere, NaOAc (4.0 equiv), PPh3 1a (0.5 mmol), PdCl2 (10.0 mol %), AgOOCCF3 (5.0 equiv), CH3CN (2.0 mL) and methyl acrylate 2a (0.6 mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60 C for 24 h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

A solution of silver thiocyanate (0.1146 g, 0.691 mmol) in pyridine (5 mL) was added to asolution of cyclohexyldiphenylphosphine (0.1854 g, 0.691 mmol) in acetonitrile (100 mL).The reaction was heated under reux for 2.5 h. The ltered solution was left to crystallizewhich resulted in an oily product. The oil was dissolved in acetonitrile followed by the removalof the excess of pyridine using a rotary evaporator. Again, an oily product was obtained afterthe acetonitrile evaporated to dryness. Small white crystals were obtained by placing theproduct on the rotary evaporator for 2 h at 95 C. The product yielded 0.2423 g (81%) witha m.p. of 161-164 C. Anal. Calcd for C38H42Ag2N2S2P2: C, 52.55; H, 4.87; N, 3.23; S, 7.38%.Found: C, 52.52; H, 4.96; N, 3.24; S, 7.06%. Solid FTIR (nu, in cm-1): 3045(w) nu(=C-H); 3002(w)nu(C-H); 2089(s) nu(SCN); 1477, 1433(m) nu(C=C); 1384(w); 1326, 1306(w); 1182, 1157(w); 1093(w)nu(P-C); 1025, 996(m) deltaasym (C-H); 848(w) delta(C-H)para; 742, 692(s) delta(C-H)meta. 1H NMR (400 MHz,CDCl3), (delta, in ppm): 1.25 (m, cyclohexyl); 1.51 (m, cyclohexyl); 2.30 (d, 3J(H-H) = 11.6 Hz,cyclohexyl); 7.30 (m, H-aromatic); 7.62 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz,CDCl3) (delta, in ppm): 25.73 (para C, cyclohexyl); 26.50 (d, 2J(P-C) = 13.9 Hz, cyclohexyl, ortho C); 28.88 (d, 3 J(P-C) = 6.9 Hz, cyclohexyl, meta C); 35.43 (d, 1J(P-C) = 17.7 Hz, cyclohexyl, ipsoC). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 9.07.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

fac-[Re(Hfaa)(CO)3(H2O)] (51mg; 0.1mmol) was dissolved in methanol (3ml) and PPh2Cy (27mg; 0.1mmol) dissolved in 2ml methanol was added. The solution was stirred for 6h at room temperature and the orange solution was left to crystallize. Crystals suitable for the collection with X-ray diffraction formed. Yield=48mg, 64%. IR (KBr, cm-1): nuCO=2024, 1949, 1907. 1H NMR (600MHz, CD2Cl2): delta 7.50-7.47 (m, 2H), 7.46-7.41 (m, 8H), 5.83 (s, 1H), 2.39 (tq, J=12.2, 2.8Hz, 1H), 2.13 (d, J=11.1Hz, 2H), 1.81-1.76 (m, 2H), 1.65 (d, J=13.3Hz, 1H), 1.41-1.31 (m, 2H), 1.03-0.92 (m, 3H). 13C NMR (600MHz, CD2Cl2): delta 195.41, 192.55, 177.60, 168.02, 134.07, 130.88, 128.60, 127.09, 116.98, 93.10, 35.39, 28.15, 26.99, 25.95. 31P NMR (300MHz, CD2Cl2): delta 32.18. UV-Vis: epsilon (lambdamax=350nm)=2783M-1cm-1. Anal. Calc. for C26H22F6O5PRe: C, 41.71; H, 3.37. Found: C, 41.75; H, 3.35.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Manicum, Amanda-Lee E.; Schutte-Smith, Marietjie; Visser, Hendrik G.; Polyhedron; vol. 145; (2018); p. 80 – 87;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

158.6 g (332.8 mmol in terms of sulfur trioxide) of fuming sulfuric acid containing 16.8% by mass of sulfur trioxide was placed in a 3-neck flask having an internal capacity of 300 mL, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line, and 35.03 g (130.54 mmol) of diphenylcyclohexylphosphine (hereinafter referred to as DPCHxP) was introduced thereinto for 1 hour. Further, the liquid temperature was controlled to a range of 25 C. to 30 C. After completion of the addition, the reaction was carried out at 50 C. for 7 hours. (0225) While controlling the liquid temperature to a range of 25 C. to 30 C., the reaction solution was diluted with 480 g of ion exchange water, and then transferred to a separatory funnel, and 250 g of toluene and 60 g of triisooctylamine were added thereto, followed by thoroughly mixing, thereby acquiring an organic phase. The organic phase was separated by adding 330 g of an aqueous 5%-by-mass sodium hydroxide solution to the organic phase. A lower phase was acquired and 76 g of an aqueous 20%-by-mass sulfuric acid solution was added dropwise thereto. Then, 70 g of toluene and 70 g of tetrahydrofuran were added thereto, followed by sufficiently mixing, thereby acquiring an organic phase. To the organic phase was added 15.85 g (156.63 mmol) of triethylamine, followed by stirring in the range of 20 C. to 30 C. for 1 hour. This liquid was concentrated until the liquid amount reached 50 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration through natural filtering, thereby acquiring 5.68 g of a white solid. (0226) 31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) delta: a (3-sulfonatophenyl)phenylcyclohexylphosphine triethylammonium salt as a mono-form showed a peak at -4.49 and an oxide formed by oxidation of the phosphorous atoms showed a peak at 32.76. (0227) The acquisition was a mixture including 5.32 g (11.83 mmol, 93.81% by mole) of a (3-sulfonatophenyl)phenylcyclohexylphosphine triethylammonium salt and 0.36 g (0.78 mmol, 6.19% by mole) of an oxide formed by oxidation of the phosphorous atoms. From the viewpoint that 5.68 g (12.61 mmol in terms of phosphorous atoms) of a desired product could be acquired using 35.03 g (130.54 mmol) of DPCHxP, the yield based on phosphorous atoms was 9.7%. This phosphorous compound was referred to as a ligand L.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; KURARAY CO., LTD.; YOSHIKAWA, Tatsuya; TSUJI, Tomoaki; (30 pag.)US2016/46549; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: To a solution of [Fe2(CO)6{mu-SCH2CH(CH2O2CCH3)S}] (0.044?g, 0.1?mmol) and tris(2-furyl)phosphine (0.023?g, 0.1?mmol) in CH2Cl2 (5?mL) was added a solution of Me3NO¡¤2H2O (0.011?g, 0.1?mmol) in MeCN (5?mL). The mixture was stirred at room temperature for 1?h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC separation using CH2Cl2/petroleum ether?=?1:1 (v/v) as eluent. From the main red band, 0.062?g (95%) of complex 2 was obtained as a red solid.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Chen, Fei-Yan; He, Jiao; Mu, Chao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Polyhedron; vol. 160; (2019); p. 74 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

Solid silver thiocyanate (0.0604 g, 0.36 mmol) was added to the solution of cyclohexyldiphenylphosphine(0.1922 g, 0.72 mmol) in ethanol (40 mL) and DMSO (30 mL). The reaction mixturewas placed under reux for 5.5 h followed by ltration. The ethanol was removed byevaporation. The ltrate was placed in the freezer which resulted in the solution freezing andupon melting small white crystals were isolated (0.0751 g, 30%), m.p. 190-193 C. Anal. Calcdfor C37H42Ag1N1S1P2: C, 63.25; H, 6.03; N, 1.99; S, 4.56%. Found: C, 62.91; H, 5.99; N, 1.74%. SolidFTIR (nu, in cm-1): 3050(w) nu(=C-H); 2929, 2845(m) nu(C-H); 2069(m) nu(SCN); 1480, 1432(m) nu(C=C);1328 (w); 1174 (w); 1095(w) nu(P-C); 1025, 998(s) deltaasym (C-H); 915, 886, 848, 733, 692(m) delta(C-H).1H NMR (400 MHz, CDCl3) (delta, in ppm): 1.19 (m, 10H, cyclohexyl); 1.62 (m, 12H, cyclohexyl); 2.40(d, 3J(H-H) = 9.2 Hz, cyclohexyl); 7.30 (t, 3 J(H-H) = 7.2 Hz, H-aromatic); 7.36 (t, 3J(H-H) = 7.2 Hz,H-aromatic); 7.49 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz, CDCl3) (delta, in ppm):25.72 (para C); 26.69 (d, 2J(P-C) = 9.7 Hz, cyclohexyl, C2); 29.16 (d, 3J(P-C) = 6.0 Hz, cyclohexyl,C3); 35.60 (d, 1J(P-C) = 11.2 Hz, cyclohexyl, C1); 128.80 (d, 3J(P-C) = 9.0 Hz, meta C, phenyl);130.17 (s, para C, phenyl); 131.23 (d, 1J(P-C) = 23.0 Hz, ipso C, phenyl); 133.69 (d, 2J(P-C) = 15.0 Hz, ortho C, phenyl). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 16.25.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: A mixture of AgBr (0.018g, 0.1mmol), diphenyl(p-tolyl) phosphine (P5) 0.028g (0.1mmol) and thiosemicarbazide (L1) 0.018g (0.2mmol) in 20ml of acetone/ methanol (1:1) was refluxed with continuous mechanical stirring overnight at 70C. The light yellow transparent solution obtained was filtered to avoid any impurity and slow addition of water resulted precipitation of final product. The product was collected by filtration, washed with water and dried. Again in situ transformation of L1 to L2 had taken place. Yield 0.078g, 89%. Anal. Calc. for C42H43AgBrN3P2S: C, 57.8; H, 4.9; N, 4.8. Found: C, 57.8; H, 4.9; N, 4.8%. IR cm-1: 3531 (w), 3479 (m), 3413 (m), 3119 (s), 2926 (s), 2842 (s), 1633 (s), 1608 (s), 1546 (m), 1456 (s), 1384 (s), 1148 (m), 1058 (s), 989 (ms), 819 (m), 767 (m), 666 (s), 521 (m).

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Altaf, Muhammad; Stoeckli-Evans, Helen; Cuin, Alexandre; Sato, Daisy Nakamura; Pavan, Fernando Rogerio; Leite, Clarice Queico Fujimura; Ahmad, Saeed; Bouakka, Mohammed; Mimouni, Mostafa; Khardli, Fatima Zahra; Hadda, Taibi Ben; Polyhedron; vol. 62; (2013); p. 138 – 147;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate