Category: 6372-42-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

An acetonitrile solution (5 mL) of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) was slowly added to a dichloromethane solution (5 mL) of cyclohexyldiphenylphosphine (0.027 g, 0.10 mmol) and compound 1 (0.040 g, 0.10 mmol). The resulting mixture was immediately turned from red to dark brown. After 1 h, the solvent was concentrated on an evaporator. The brown residue was purified by TLC (petroleum ether: CH2Cl2 = 4: 1) to give compound 2 (0.046 g, yield 72%) from the main red band. IR (KBr disc, cm-1): nuC?O 2044 (vs), 1983 (vs), 1973 (vs), 1925 (m). 1H NMR (500 MHz, CDCl3): 7.71 (s, 2H, PhH), 7.62 (s, 2H, PhH), 7.47, 7.45 (2s, 6H, PhH), 2.31 (s, 2H, CyH), 2.18 (s, 2H, CyH), 1.84 (s, 2H, SCH2), 1.70 (s, 1H, SCH), 1.39 (s, 2H, CyH), 1.28 (m, 2H, CyH), 1.14-1.03 (m, 3H, CyH), 0.79 (s, 3H, CH3) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85% H3PO4): 65.14 (s) ppm. 13C{1H} NMR (125 MHz, CDCl3): 216.18 (d, JP-C = 9 Hz, PFeCO), 215.94 (d, JP-C = 8.5 Hz, PFeCO), 210.45 (FeCO), 135.29 (d, JP-C = 33.9Hz, i-PhC), 133.40 (d, JP-C = 9.6Hz, o-PhC), 132.86 (d, JP-C = 10 Hz, o-PhC), 130.08 (s, p-PhC), 128.20 (t, JP-C = 8.9 Hz, m-PhC), 54.32 (SCH), 41.12 (SCH2), 40.95, 40.85, 28.90, 27.43, 27.35, 25.99 (CyC), 29.58 (CH2CH3), 14.05 (CH3) ppm. Anal. Calcd. for C27H29Fe2O5PS2: C, 50.65; H, 4.57. Found:C, 50.79; H, 4.34%.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Zhong-Qing; Li, Yu-Long; Liu, Xing-Hai; Liu, Xu-Feng; Yan, Lin; Yang, Jun; Journal of Sulfur Chemistry; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Evren, Enes; Ozdemir, Ismail; Inorganica Chimica Acta; vol. 500; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78%).2

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

Solid silver thiocyanate (0.0478 g, 0.29 mmol) was added to the solution of cyclohexyldiphenylphosphine(0.3031 g, 1.13 mmol) in acetonitrile (100 mL). The reaction mixture was heatedunder reux for 16 h. The solution was ltered hot and the solvent was reduced to ~10 mL by means of evaporation. The solution was transferred to a small vial and it was left to crystallizefrom which small white cubic crystals were isolated (0.3002 g, 84%), m.p. 173-176 C.Anal. Calcd for C55H63AgNSP3: C, 68.04; H, 6.54; N, 1.44; S, 3.30%. Found: C, 68.35; H, 6.56; N,1.39; S, 3.37%. Solid FTIR (nu, in cm-1): 3047(w) nu(C-H)aromatic; 2934, 2851(m) nuasym(C-H); 2360,2341(w); 2050(m) nu(SCN); 1479, 1461, 1446, 1432(m) nu(C=C)aromatic; 1328, 1309; 1268; 1193,1182, 1155; 1096(m) nu(P-C); 1071, 1024, 998(s) delta(C-H); 916(w); 885, 851, 741, 732 697(m)delta(C-H)aromatic. 1H NMR (400 MHz, CDCl3) (delta, in ppm): 1.27 (m, 14H, cyclohexyl), 1.67 (m, 14H,aromatic); 2.30 (d, 3J(H-H) = 8.0 Hz, 3H, H1); 7.30 (m, 17H, H-aromatic), 7.44 (t, 3J(H-H) = 8.0 Hz,11H, H-aromatic). 13C{H} NMR (100 MHz, CDCl3) (delta, in ppm): 25.94 (C4, cyclohexyl); 26.75 (d,1J(P-C) = 12.5 Hz, C1, cyclohexyl); 29.30 (d, 2J(P-C) = 10.4 Hz, C2, cyclohexyl); 35.61 (C3,cyclohexyl); 128.60 (d, 2J(P-C) = 8.3 Hz, ortho C, phenyl); 129.606 (para C, phenyl); 133.16 (d,3J(P-C) = 5.5 Hz, meta C, phenyl); 133.67 (d, 1J(P-C) = 16.3 Hz, ipso C, phenyl). 31P{H} NMR(161 MHz, CDCl3) (delta, in ppm): 9.32. 1H NMR (400 MHz, (CD3)2SO) (delta, in ppm): 1.14 (m, 14H,cyclohexyl), 1.59 (d, 3J(H-H) = 10.8 Hz, 3H, H1); 7.40 (m, 17H, H-aromatic), 7.59 (t, 2J(H-H) = 8.0 Hz, 11H, H-aromatic). 13C{H} NMR (100 MHz, (CD3)2SO) (delta, in ppm): 25.46 (C4,cyclohexyl); 25.81 (d, 1J(P-C) = 12.7, C1, cyclohexyl); 28.74 (d, 2J(P-C)=10.9, C2, cyclohexyl);33.97 (d, 3J(P-C) = 8.4 Hz, C3, cyclohexyl); 128.60 (d, 2J(P-C) = 8.6 Hz, meta C, phenyl); 129.64(para C, phenyl); 132.96 (d, 3J(P-C) = 13.7 Hz, ortho C, phenyl); 133.47 (d, 1J(P-C) = 16.6, ipsoC, phenyl). 31P{H} NMR (161 MHz, (CD3)2SO) (delta, in ppm): 9.04.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Evren, Enes; Ozdemir, Ismail; Inorganica Chimica Acta; vol. 500; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

0.86 g (2.30×10″3 moles) of trichlorotris(tetrahydrofuran)vanadium [VCI3(THF)3], 20 ml of toluene and, subsequently, 2.40 g (9.0×10″3 moles) of dipheny(cyclohexyl)phosphine (P/V molar ratio = 4) were placed into a 100 ml tailed flask. The mixture obtained was left, under vigorous stirring, at room temperature, for 60 minutes and, then, heated under reflux for 1 hour. The suspension obtained was filtered in the hot (60C) and the fraction collected was concentrated, under vacuum, at room temperature. Subsequently, drop by drop, under stirring, about 50 ml of pentane were added, obtaining the precipitation of a dark powder. After about 3 hours, everything was filtered and the solid light blue/gray residue obtained was washed with pentane (50 ml) and dried, under vacuum, at room temperature, obtaining 1.30 g (conversion with respect to starting [VCI3(THF)3] = 81.4%) of complex VCI3(PCyPh2)2 (molecular weight = 693.97 gxmol”1). (0157) Elementary analysis [found (calculated)] C: 62.40% (62.31%); H: 6.30% (6.10%); CI: 15.50% (15.33%); P: 9.0% (8.93%); V: 7.20% (7.34%)

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Patent; VERSALIS S.P.A.; RICCI, Giovanni; LEONE, Giuseppe; SOMMAZZI, Anna; FORNI, Alessandra; MASI, Francesco; (110 pag.)WO2016/128812; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

A large amount of phosphorescent cuprous complex CuI (2-PBO) (PPh 2 Cy) crystal the preparation of the sample: weighing 0.5mmol CuI of dissolved in 12 ml in acetonitrile, weighing 0.5 diphenyl cyclohexyl phosphine biligand dissolved in 10 ml of methylene chloride, the two kind of solution mixing, and stirring to make fully undergo coordination reaction to obtain the colorless solution A; then weighing 0.5mmol the 2-PBO biligand dissolved in 10 ml of acetonitrile, then to add the solution of the above-mentioned solution in A, and stirring to make fully undergo coordination reaction, finally the resulting orange-yellow reaction the fluid turns on lathe steams remove all solvent, vacuum drying, the obtained product is orange yellow crystal, yield 94% (to cu meter).

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; China University of Metrology; Chai, Wenxiang; Zhu, Qiumeng; Song, Li; Chen, Gang; Guo, Bing; Chen, Zhi; Qin, Laishun; (9 pag.)CN105777785; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: In a sealed tube containing a solution of the phosphine oxide derivative (5 mmol) in anhydrous toluene (1 M) was added InBr3 (1 mol %, 0.05 mmol) and the TMDS (1.5 equiv, 7.5 mmol) under an argon atmosphere. The reaction mixture was stirred at 100 C during 7-40 h depending on the substrate (the reaction was monitored by 31P NMR). After complete consumption of the reagent the mixture was kept under argon in the sealed tube and cooled to 0 C. A solution of BH3.SMe2 (2 M in THF, 1 equiv) was then slowly added. After 1 h at room temperature, 31P NMR analysis of an aliquot indicates complete conversion to phosphine borane adduct. The crude was poured in an erlenmeyer flask and silica gel was carefully added while stirring. When silica gel was added in the reaction mixture, a slightly exothermic reaction was observed. The reaction mixture was then filtered on silica gel and washed several times with ethyl acetate. After evaporation of the ethyl acetate, the residue was purified by flash chromatography on silica gel with pure cyclohexane to afford the desired phosphine-borane.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc; Tetrahedron; vol. 68; 15; (2012); p. 3151 – 3155;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: A 20mL scintillation vial was charged with 1equiv of NCr(NiPr2)2I (1) [42], 110 acetonitrile (3mL), and a Teflon-coated stir bar. This mixture was stirred at room temperature giving a dark red-orange solution. Separately, a solution of 111 AgSbF6 (1equiv) was prepared in acetonitrile (1-2mL). The AgSbF6 solution was then added dropwise to the stirred solution of 1. Upon addition, copious amounts of off-white precipitate formed, and the solution became dark brown. The resultant mixture was stirred for 20min after complete addition of the Ag solution. The mixture was then filtered over Celite to remove the precipitate. The dark brown solution of 2 collected was once again stirred at room temperature and a solution of PR3 (1-2equiv) in acetonitrile (1-2mL) was added. (1equiv of the phosphine was used if it was a solid or high-boiling liquid phosphine that is difficult to remove by recrystallization. 2equiv of phosphine were used if PR3 is a low-boiling liquid easily removed in vacuo.) Upon addition of PR3, the solution quickly became yellow-orange. The reaction solution was stirred for 1h at room temperature. The volatiles were then removed in vacuo to give a dark residue. This residue was rinsed with small aliquots of cold Et2O (3¡Á1mL) to remove any unreacted 1. The residue was once more dried in vacuo. The residue was dissolved in a minimal amount of CH2Cl2 or CHCl3 and layered with Et2O or pentane. The layered solution was then stored overnight at -35C to yield yellow-orange X-ray quality crystals.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Aldrich, Kelly E.; Billow, Brennan S.; Staples, Richard J.; Odom, Aaron L.; Polyhedron; vol. 159; (2019); p. 284 – 297;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate