Category: 6224-63-1

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a magnetically stirred solution of a N-formyl/thiourea (2 mmol) and a triarylphosphine (2 mmol) in dry EtOAc (10 mL) was added dropwise, a dialkyl acetylenedicarboxylate (2 mmol) in dry EtOAc (5mL) at room temperature over 10 min. The progress of the reaction was monitored by thin-layer chromatography with n-hexane-ethyl acetate(1:1 v/v) mixture as eluent. After completion of the reaction the solvent was removed under reduced pressure and the solid residue was washed with cold diethyl ether (2 ¡Á 5 mL) and the product was obtained., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Shams, Nasim; Mosslemin, Mohammad Hossein; Yazdani, Afshin; Anaraki-Ardakani, Hossein; Ghane, Javad; Journal of Chemical Research; vol. 40; 6; (2016); p. 351 – 353;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

Under inert gas protection, 344 mg of Fe2S2(CO)6 (1 mmol) and 20 mL of tetrahydrofuran solvent were added to the flask containing the stirring magnets.A dark red solution was obtained, and the obtained solution was cooled to -78 ¡ã C with a liquid nitrogen bath, and 2 mL of a lithium triethylborohydride (1M in THF) solution was slowly added under stirring.After reacting for 15 min, 0.18 mL of trifluoroacetic acid (2.2 mmol) was added and the reaction was continued for 15 min.Add 304 mg of P(C6H4-3-CH3)3 (1.0 mmol), stir at room temperature for 3 h, then add 630 mg of I-4-C6H4N(CH2Cl)2 (2 mmol) and 0.28 mL of triethylamine.The reaction was stirred at room temperature for 12 h. The tetrahydrofuran solvent was removed by rotary evaporation, and the residue was extracted with dichloromethane.Then, thin layer chromatography was carried out using a developing solvent of dichloromethane/petroleum ether in a volume ratio of 1:6, and the main ribbon was collected to obtain a model 3.

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; He Jiao; Wu Yu; Xie Ying; Jiang Jin; Sun Yanchun; Wang Zheng; Zou Like; Xie Bin; Gao Fan; Mu Chao; (11 pag.)CN109232665; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under a N2 atmosphere, phosphine ligand (2 mmol) (L) was added to a stirred solution of Co2(CO)8 (1 mmol) in tetrahydrofuran or toluene (10 mL). The reaction mixture was stirred for 1 h under CO bubbling at 50 ¡ãC. The organic solvent was evaporated under reduced pressure. The resulting solid was washed several times with diethyl ether and pentane, finally dried under vacuum to give the desired complex., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Ame?zquita-Valencia, Manuel; Rami?rez-Garavito, Ricardo; Toscano, Rube?n A.; Cabrera; Catalysis Communications; vol. 33; (2013); p. 29 – 33;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2mmol NaOH (0.080g) is dissolved in 10ml of methanol and 2mmol of carbon disulfide (CS2) (0.150g, 120mul, density=1.266g/ml) is then added. The clear solution is then added to a 10ml acetonitrile solution which contains 0.5mmol AgNO3 (0.085g) and 1mmol tri-aryl-phosphines (tpp: 0.262g (1), 0.304g, tptp and tmtp: 0.304g (2 and 3)). The mixture was stirred for 3h at 0¡ãC and the resulting yellow solution was filtered off. Colorless crystals of 1?3 suitable for X-ray analysis were grown from slow evaporation of the solution after 2days., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Banti, Christina N.; Kourkoumelis, Nikolaos; Tsiafoulis, Constantinos G.; Skoulika, Stavroula; Hadjikakou, Sotiris K.; Polyhedron; vol. 121; (2017); p. 115 – 122;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(7) (Tri(m-tolyl)phosphine-kappaP)(1-(2,4-dichlorobenzoyl)-3-(N-methylphenyl)thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.192?g (0.564?mmol) 1-(2,4-dichlorobenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 215-217?¡ãC. FTIR (cm-1); 3139(w), 2996(w), 2882(w), 1622(m), 1512(s), 1420(s), 1368(w), 1318(w), 1242(w), 1189(w), 1095(m), 1061(w), 1018(w), 988(w), 934(m), 910(s), 860(s), 784(s), 744(s), 692(s), 614(w). H NMR (300?MHz, CDCl3) delta 2.36 [(s, 9H, 3(-CH3)], 3.59 (s, 3H, N-CH3), 6.84-8.40 (m, 20H, ArH); 13C NMR (75.5?MHz, CDCl3) delta 21.6 (3C), 42.2 (C), 114.6 (C), 114.9 (C), 124.6 (C), 125.4 (C), 127.2 (2C), 127.5 (C),128.8 & 128.9 (d, 3C,13C-31P, 2J?=?12.0?Hz), 129.1(C), 129.3 (3C), 132.7 & 132.8 (d, 3C, 13C-31P, 3J?=?9.0?Hz), 134.7 & 134.9 (d, 3C, 13C-31P, 2J?=?11.5?Hz), 141.3 (3C), 151.1 (3C), 171.3 (1C, C=O), 173.9 (1C, C=S); 31P NMR (121.5?MHz, CDCl3) delta 32.87; Anal. Calc. for C36H32Cl3N2OPPdS (Mol. mass: 784.47) C, 55.12; H, 4.11; N, 3.57; S, 4.09. Found: C, 54.91; H, 3.99; N, 3.59; S, 4.03., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.23 methyl 2-phenyl-5-(3-methylphenyl)thiazole-4-carboxylate (4b) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 125 mg (81percent). 1H NMR (300 MHz, CDCl3) delta 2.41 (s, 3H), 3.86 (s, 3H), 7.23-7.34 (m, 4H), 7.44-7.46 (m, 3H), 7.96-7.99 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 165.0, 161.7, 145.6, 139.8, 137.0, 131.8, 129.6, 129.5, 129.2, 129.1, 128.0, 127.2, 126.0, 125.8, 51.3, 20.4 ppm., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(6) (Tri(m-tolyl)phosphine-kappaP)(1-(4-fluorobenzoyl)-3-(N-methylphenyl) thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.163?g (0.564?mmol) 1-(4-fluorobenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 192-194?¡ãC. FTIR (cm-1); 3142(w), 2998(w), 2879(w), 1617(m), 1509(s), 1422(s), 1362(w), 1310(w), 1244(w), 1192(w), 1090(m), 1064(w), 1020(w), 990(w), 940(m), 916(s), 864(s), 780(s), 746(s), 690(s), 619(w). H NMR (300?MHz, CDCl3) delta 2.30 [(s, 9H, 3(-CH3)],3.59 (s, 3H, N-CH3), 6.86-8.41 (m, 21H, ArH); 13C NMR (75.5?MHz, CDCl3) delta 21.3 (3C), 42.2 (C), 114.7 & 114.9 (2C, d, 13C-19F, 2J?=?19.7?Hz), 127.0 (C), 127.6 (C), 127.8 (C), 127.9 (C), 128.4 (C), 129.3 (C), 132.0 (C), 132.7 & 132.9 (2C, d, 13C-19F, 3J?=?10.6?Hz), 135.3 &137.9 (1C, d, 13C-19F, 1J?=?272.0?Hz), 135.4(C), 137.8 (C), 145.5 (C), 168.7 (C), 171.0 (1C, C=O), 173.8 (1C, C=S); 31P NMR (121.5?MHz, CDCl3) delta 34.80; Anal. Calc. for C36H33ClFN2OPPdS (Mol. mass: 733.57) C, 58.94; H, 4.53; N, 3.82; S, 4.37. Found: C, 58.99; H, 4.58; N, 3.89; S, 4.42.

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4.3.29 methyl 2-phenyl-5-(3-methylphenyl)oxazole-4-carboxylate ;(4i) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 117 mg (80percent). 1H NMR (300 MHz, CDCl3) delta 2.44 (s, 3H), 3.97 (s, 3H), 7.27 (d, J=7.7 Hz, 1H), 7.38 (t, J=7.7 Hz, 1H), 7.46-7.49 (m, 3H), 7.93-7.96 (m, 2H), 8.13-8.17 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 161.7, 158.7, 154.5, 137.2, 130.2, 130.1, 127.9, 127.8, 127.4, 126.9, 125.9, 125.4, 124.8, 51.4, 20.6 ppm., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

To a solution of P(3-Me-C6H4)3 (1.98 g, 6.50 mmol) in toluene (20 mL), a solution of 3c (1.51gm, 5.90 mmol) in toluene (10 mL) was added via cannula. After 4 hours, the clear yellow solution was evaporated to afford a yellow residue. The yellow residue was washed with a mixture of 1:3 toluene-hexanes (4 x 12 mL), yielding a yellow oil. The yellow oil was washed with ether (10 mL) to give white solid 8 (1.8 g, 60percent). 1H NMR (CDCl3): delta 7.71 (s, 1H, 6-CH of -C6H3SO3-), 7.68 (s, 3H, 2-CH of (3-CH3-C6H4)3P=NH-), 7.55 (m, 3H, 5-CH of (3-CH3-C6H4)3P=NH-), 7.32 (s, 3H, 4-CH and 6-CH of (3-CH3-C6H4)3P=NH-), 6.85 (d, J = 8.4, 1H, 4-CH of -C6H3SO3-), 6.39 (d, J = 8.4, 1H, 3-CH of -C6H3SO3-), 3.90 (t, 2H, CH of CH2CH2CH3), 2.35 (s, 9H, 3-CH3 of (3-CH3-C6H4)3P=NH-), 2.19 (s, 3H, J = 6.8, 5-CH3 of – CH3C6H3SO3-), 1.52 (m, 2H, CH of CH2CH2CH3), 0.78 (t, 3H, J = 7.4, CH of CH2CH2CH3). 31P NMR (CDCl3): delta 2.7. 13C NMR (CDCl3): delta 148.9, 138.4 (d, JPC = 11.6), 134.6, 133.1 (d, JPC = 9.3), 132.5 (d, JPC = 3.1), 131.5 (d, JPC = 2.3), 130.5 (d, JPC = 10.0), 129.8 (d, JPC = 2.3), 128.4 (d, JPC = 13.2), 126.5 (d, JPC = 24), 124.6, 122.5 (d, JPC = 10.8), 71.1, 22.4, 21.5, 20.2, 10.1. Anal. Calcd for C31H34NO3PS: C, 70.03; H, 6.45; N, 2.63. Found: C, 69.89; H, 6.32; N, 2.52., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Burns, Christopher T.; Shang, Suisheng; Thapa, Rajesh; Mashuta, Mark S.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4832 – 4835;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78percent).2

6224-63-1, The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate