Category: 607-01-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: The phosphine ligand (PPh2R and PPhR2; R=Me or Et) (0.5mmol) was directly added to the solution of the starting complex [PtCl(sac)(COD)] (COD=1,5-cyclooctadiene) (0.25mmol, 0.13g) in the mixture of MeCN and MeOH (1:1, 10mL). The reaction mixture was refluxed for 24h. Then, the solvents were removed by a rotary evaporator and the white solids were washed with diethyl ether and a small amount of cold EtOH. The solids were dissolved in a mixture containing water, MeCN and MeOH (1:1:1). The crystals of 2, 3 and 4 were obtained from the evaporation of the solutions after three or four weeks at r.t., 607-01-2

Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Icsel, Ceyda; Yilmaz, Veysel T.; Cevatemre, Buse; Aygun, Muhittin; Ulukaya, Engin; Journal of Inorganic Biochemistry; vol. 195; (2019); p. 39 – 50;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Accurately weighed ethyl diphenylphosphine (123 muL, 0.6 mmol),1,10-Phenanthroline (0.4698 g, 2.4 mmol) was added to a 25 mL Schlenk reaction flask.Then 3,5-dimethyl iodobenzene (144 muL, 0.9 mmol) was added and the solvent was dichloromethane (2 mL).The reaction was carried out at 75 C for 30 h. After the reaction,Extract with ethyl acetate/water and dry the organic phase with anhydrous sodium sulfate.The solvent was removed under reduced pressure.Separation of silica gel column using petroleum ether/ethyl acetate as eluentThe yield of the product was 40%., 607-01-2

The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To acetone solution of (diphenylphosphino) ethane (dppe) (0.398 g, 1 mmol) was added 4-nitrophenacyl bromide (0.256 g, 1.05 mmol)and the resulting mixture was stirred for 12 h at room temperature. The resulting yellow solution was filtered off, washed with petroleum diethyl ether, and dried under vacuum. Yield: 0.49 g, 75%; m. p.:220-222 C. Anal. Calc. for C34H30BrNO4P2: C, 62.02; H, 4.59; N, 2.13. Found: C, 62.27; H, 4.61; N, 2.15%. Selected IR absorption in KBr (cm-1): 1684 (nuC=O), 1191 (nuP=O). 31P{1H} NMR (CDCl3): deltaP = 19.45 (d, PCH2, 3JPP = 58.37); 31.66 (d, P(O)Ph2, 3JPP = 54.82). 1H NMR (CDCl3): deltaH = 2.83 (m, 2H, CH2); 3.82 (m, 2H, CH2); 6.32 (d, 1H, PCH2CO, 2JPH = 12.25), 6.52 (d, 1H, PCH2CO, 2JPH = 12.00); 7.18-8.37 (m, 24H, Ph). 13C{1H} NMR (CDCl3): deltaC = 18.06 (t, CH2, 1JPC = 26.03); 36.32 (pseudot, PCH2CO, 1JPC = 29.13); 116.03-134.95 (Ph); 191.31 (s, CO).

607-01-2, Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Samiee, Sepideh; Kooti, Nadieh; Gable, Robert W.; Journal of Molecular Structure; vol. 1129; (2017); p. 319 – 324;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Under nitrogen gas protection, 344 mg of Fe2S2(CO)6 (1 mmol) and 20 mL of tetrahydrofuran solvent were added to a flask equipped with a stirrer magnet.A dark red solution was obtained and the resulting solution was cooled down to -80C in a liquid nitrogen bath.2.2 mL of lithium triethylborohydride (1M in THF) was added slowly with stirring.After 15 minutes of reaction, 0.2 mL of trifluoroacetic acid was added and the reaction was continued for 10 minutes.Add 0.2 mL of formaldehyde solution (37%wt) and raise the reaction to room temperature.After stirring the reaction for 2 h, 235 mg of Ph2PCH2CH3 (1.1 mmol) was added.After stirring for 11h at room temperature, the tetrahydrofuran solvent was removed by rotary evaporation.Add 20 mL of methylene chloride and 1 mL of concentrated sulfuric acid and continue stirring for 20 h.20 mL of water was added and the layers were separated. The dichloromethane in the organic layer was removed by rotary evaporation.The residue was extracted with methylene chloride, and then thin layer chromatography was performed using a developing solvent having a methylene chloride/petroleum ether volume ratio of 1:3. The main red band was collected to obtain a model 3 with a yield of 24%.

607-01-2, As the paragraph descriping shows that 607-01-2 is playing an increasingly important role.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; Zou Like; Mu Chao; Deng Chenglong; Wu Yu; Zhao Peihua; Xie Bin; Luo Qiang; (10 pag.)CN106674288; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compound 1a (30mg, 0.026mmol) and PPh3 (13mg, 0.052mmol) were added together in acetone (15cm3). The mixture was stirred for 24, and after concentration the resulting precipitate was filtered off and recrystallised from dichloromethane/hexane. Yield: 54.35%. Found C: 61.3, H: 4.8; N: 1.9; C42H41NClFeO2PPd (820.47g/mol) requires C: 61.5, H: 5.0, N: 1.7. IR numax/cm-1: 1598m (C=N), 308b (Pd-Cl). NMR 1H (CDCl3): deltaH=8.39 (d, 1H, HC=N, 4J(PH) 8.8) 6.88 (b, 2H, C6H2), 5,41 (s, 1H, CHO2), 4.28 [d, 1H, H3, 3J 2.4Hz], 4.14, 3.86, 2.08, 1.34 (m, 6H, CH2), 3.98 (s, 5H, C5H5), 3.35 [d, 1H, H4, 3J 2.4Hz], 2.46 (s, 3H, Me), 2.28 (s, 3H, Me), 2.26 (s, 3H, Me). NMR 31P (CDCl3): deltaP=36.4 s.

607-01-2, The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Martinez, Javier; Marino, Marta; Caamano, Marcelo; Teresa Pereira, Ma; Ortigueira, Juan M.; Gayoso, Eduardo; Lopez-Torres, Margarita; Vila, Jose M.; Journal of Organometallic Chemistry; vol. 740; (2013); p. 92 – 97;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Accurately weighed ethyl diphenylphosphine (123 muL, 0.6 mmol),4-bromobiphenyl (0.1399 g, 0.6 mmol),Potassium monohydrogen phosphate (0.4050 g, 3 mmol) was added to a 25 mL Schlenk reaction flask, followed by solvent toluene (2 mL).The reaction was carried out at 50 C for 8 h.After the reaction was completed, it was extracted with ethyl acetate/water.The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated.Using petroleum ether/ethyl acetate as the eluent,Separated by silica gel column,The yield of the product was 50%., 607-01-2

As the paragraph descriping shows that 607-01-2 is playing an increasingly important role.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: 2-Chloromethylbenzothiazole (1) (0.183 g, 0.001 mol) andpotassium iodide (KI) (0.166 g, 0.001 mol) were taken intoa round bottomed flask containing 20 mL of THF. Thereaction mixture was stirred for 3 h at 40C. After completionof the reaction as checked by TLC, cooled the reactionmass to RT and then filtered to remove the salt (KCl),resulted in iodo compound, 2-(iodomethyl) benzo[d]thiazole(2). The filtrate was transferred into a flask and sodiumazide (NaN3) (0.065 g, 0.001 mol) was added. The reactionmixture was stirred at 25-30C for 3 h to form an intermediate,2-azidomethylbenzothiazole (3). The reaction mixturewas filtered to remove the salt, NaI, and filtrate was takenfor the next step.Triphenylphosphine (4a) (0.262 g, 0.001mol) was added to 3under N2 atmosphere. The reaction mixture was stirred at 65-70C for 4 h and the progress of the reaction was monitored byTLC using ethylacetate: n-hexane (2:3) as an eluent. After completionof the reaction, the solvent was removed from the reactionmixture in a rotaevaporator to get the crude product and itwas purified by column chromatography using ethylacetate:nhexane(1:4) to obtain pure product, N-(1,3-Benzothiazol-2-ylmethyl)-N-(1,1,1-triphenyl-lambda5-phosphanylidene) amine (5a).The same procedure was adopted for the synthesis of remainingtitle compounds and the physical data of these compounds aresummarized in Table 1., 607-01-2

Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Madhava; Subramanyam; Thaslim Basha; Jawahar Babu; Naga Raju; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 16 – 21;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate