606-68-8| Page 3 of 4 | Chiral phosphine ligands

Ludwig, Janet C’s team published research in Chemico-Biological Interactions in 1980-04-30 | 606-68-8

Chemico-Biological Interactions published new progress about Drug-metabolizing enzymes Role: BIOL (Biological Study). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Related Products of 606-68-8.

Ludwig, Janet C.; Misiorowski, Ronald L.; Chvapil, Milos; Seymour, Michael D. published the artcile< Interaction of zinc ions with electron carrying coenzymes NADPH and NADH>, Related Products of 606-68-8, the main research area is zinc NADH drug metabolism inhibition.

The substrate for the drug-oxidizing system, NADPH, binds to Zn2+, but NADH does not. Equilibrium gel filtration and acid titrations of Zn2+ and NADPH tetrasodium salt indicated a molar ratio of metal to nucleotide of 2:1 and a formation constant of 106.75. 31P-NMR, UV, and fluorescence spectra of the complex indicated the possible binding sites of Zn2+ to NADPH. Since Zn2+ is known to inhibit the metabolism of drugs by mixed function oxidases in liver microsomes, the formation of the Zn2+-NADPH complex suggests the mechanism by which Zn2+ may inhibit the drug-oxidizing system.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Tominaga, Masato’s team published research in Electrochemistry Communications in 2013-06-30 | 606-68-8

Electrochemistry Communications published new progress about Carbon nanotubes (oxygenated). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Product Details of C21H27N7Na2O14P2.

Tominaga, Masato; Iwaoka, Ayako; Kawai, Daisuke; Sakamoto, Shingo published the artcile< Correlation between carbon oxygenated species of SWCNTs and the electrochemical oxidation reaction of NADH>, Product Details of C21H27N7Na2O14P2, the main research area is oxygenated carbon nanotube correlation electrochem oxidation NADH.

The correlation between carbon oxygenated species as a defect in single-walled carbon nanotubes (SWCNTs) and the oxidation reaction behavior of the reduced form of β-nicotinamide dinucleotide (NADH) was investigated. The two main oxidation peaks of NADH at the SWCNTs were due to adsorbed and diffused species, resp. The peak current ratio showed a good relationship to the intensity ratio of the G-band/D-band obtained from the Raman spectra of the SWCNTs.

Ward, Richard A’s team published research in Journal of Medicinal Chemistry in 2012-04-12 | 606-68-8

Journal of Medicinal Chemistry published new progress about Antitumor agents. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Electric Literature of 606-68-8.

Ward, Richard A.; Brassington, Claire; Breeze, Alexander L.; Caputo, Alessandro; Critchlow, Susan; Davies, Gareth; Goodwin, Louise; Hassall, Giles; Greenwood, Ryan; Holdgate, Geoffrey A.; Mrosek, Michael; Norman, Richard A.; Pearson, Stuart; Tart, Jonathan; Tucker, Julie A.; Vogtherr, Martin; Whittaker, David; Wingfield, Jonathan; Winter, Jon; Hudson, Kevin published the artcile< Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation>, Electric Literature of 606-68-8, the main research area is lactate dehydrogenase A inhibitor preparation lead generation SAR.

Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate, utilizing NADH as a cofactor. It has been identified as a potential therapeutic target in the area of cancer metabolism In this manuscript we report our progress using fragment-based lead generation (FBLG), assisted by x-ray crystallog. to develop small mol. LDHA inhibitors. Fragment hits were identified through NMR and SPR screening and optimized into lead compounds with nanomolar binding affinities via fragment linking. Also reported is their modification into cellular active compounds suitable for target validation work.

Tyagi, Anudishi’s team published research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 2018-07-31 | 606-68-8

Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis published new progress about Acute myeloid leukemia. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, COA of Formula: C21H27N7Na2O14P2.

Tyagi, Anudishi; Pramanik, Raja; Vishnubhatla, Sreenivas; Ali, Safdar; Bakhshi, Radhika; Chopra, Anita; Singh, Archna; Bakhshi, Sameer published the artcile< Pattern of mitochondrial D-loop variations and their relation with mitochondrial encoded genes in pediatric acute myeloid leukemia>, COA of Formula: C21H27N7Na2O14P2, the main research area is acute myeloid leukemia mitochondrial DNA D loop variation pediatric; AML; D-loop; Mitochondrial DNA; Variations.

Role of mitochondrial DNA variations, particularly in D loop region, remains investigational in acute myeloid leukemia (AML). Consecutive 151 pediatric AML patients were prospectively enrolled from June 2013 to August 2016, for evaluating pattern of variations in mitochondrial D-loop region and to determine their association, if any, with expression of mitochondrial-encoded genes. For each patient, D-loop region was sequenced on baseline bone marrow, buccal swab and mother′s blood sample. Real time PCR was used for relative gene expression of four mitochondrial DNA encoded genes viz. Nicotinamide-adenine-dineucleotide-dehydrogenase subunit 3 (ND3), Cytochrome-B (Cyt-B), Cytochrome c oxidase-I (COX1) and ATP-synthetase F0 subunit-6 (ATP6). Total 1490 variations were found at 237 positions in D-Loop; 1206 (80.9%) were germline and 284 (19.1%) were somatic. Positions 73-263 were identified as a probable hotspot region. G bases appeared to be most stable nucleotide (least number of single base substitutions) whereas T appeared to be most susceptible to variations with germline T-C being the commonest. Gene expression of Cyt-B was found to be significantly higher for any variation (somatic or germline) at positions 16,192 and 16,327 while it was significantly lower for variations at positions 16,051 and 207. Any variation at positions 152, 207 and 513 significantly decreased COX1 expression while those at positions 16,051 and 152 attenuated ATP6 expression. This first study evaluated type and overall pattern of D-loop variations in AML, and also showed that some of these variations in D loop region might have an effect on the mitochondrial-encoded genes which is new and valuable information in AML genomics.

Jolin, Trinidad’s team published research in Biochemical Journal in 1971 | 606-68-8

Biochemical Journal published new progress about Deiodination. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt.

Jolin, Trinidad; Morreale de Escobar, Gabriella published the artcile< Deiodination of L-thyroxine and its activity on the oxidation in vitro of reduced nicotinamide adenine dinucleotide by peroxidase plus hydrogen peroxide>, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt, the main research area is thyroxine deiodination NADH oxidation; peroxidase peroxide NADH thyroxine.

When L-thyroxine [51-48-9] activated the oxidation of disodium NADH [606-68-8] by horseradish peroxidase (EC 1.11.1.7) + hydrogen peroxide [7722-84-1], little removal of phenolic ring iodine [7553-56-2] atoms became apparent until most of the NADH had been oxidized, after which it increased markedly. This extensive deiodination was accompanied by loss of the ability of thyroxine to catalyze the oxidation of NADH by peroxidase + H2O2. ICN [506-78-5], but not I2 or thyronine [1596-67-4], catalyzed NADH oxidn in both the presence and absence of peroxidase + H2O2. Thyroxine + peroxidase + H2O2 were comparable with ICN alone in their effects on NADH oxidation The obvious results that the active moiety is the halogen liberated from thyroxine or ICN were not directly supported by some of the results obtained by measuring the degree of deiodination of thyroxine in the system. Possible explanations of these apparently contradictory conclusions were discussed.

Wangler, Anton’s team published research in Journal of Chemical Thermodynamics in 2019-01-31 | 606-68-8

Journal of Chemical Thermodynamics published new progress about Cosolvents. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Related Products of 606-68-8.

Wangler, Anton; Loll, Rouven; Greinert, Thorsten; Sadowski, Gabriele; Held, Christoph published the artcile< Predicting the high concentration co-solvent influence on the reaction equilibria of the ADH-catalyzed reduction of acetophenone>, Related Products of 606-68-8, the main research area is acetophenone alc dehydrogenase catalyst cosolvent effect reduction equilibrium.

The use of co-solvents for the enhancement of the reaction parameters reaction rate, yield and enantioselectivity is an established optimization strategy in biotechnol. To determine the influence of co-solvents on even one of these reaction parameters requires a great amount of exptl. data. Thus, predictive and phys. sound models are desired to decrease the amount of exptl. effort. This work aims at providing such a framework, which was applied to the ADH (alc. dehydrogenase)-catalyzed reduction of acetophenone at 303.15 K and 1 bar in water (neat) and under the influence of up to 20 wt-% of polyethylene glycol (PEG) and 15 wt-% trisodium citrate (Na3Cit). In a first step, the equilibrium composition was measured at constant pH. It was then shown that high concentration of PEG or Na3Cit changed the equilibrium position significantly (up to a factor of 13) compared to neat reaction mixtures To be able to predict this strong co-solvent influence on the reaction equilibrium, the exptl. determined equilibrium compositions of the neat reaction were converted into a thermodn. equilibrium constant Kth using the activity coefficients γi of the reacting agents. The latter were predicted by electrolyte perturbed-chain statistical associating fluid theory (ePC-SAFT). These finally allowed quant. predicting the high concentration co-solvent influence on the equilibrium position.

Ludvik, J’s team published research in Analytica Chimica Acta in 1988-06-15 | 606-68-8

Analytica Chimica Acta published new progress about Adsorption. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Category: chiral-phosphine-ligands.

Ludvik, J.; Volke, J. published the artcile< Evidence for a radical intermediate in the anodic oxidation of reduced nicotinamide adenine dinucleotides obtained by electrogenerated chemiluminescence>, Category: chiral-phosphine-ligands, the main research area is electrooxidation product reduction nicotinamide adenine dinucleotide; adenine derivative electrochemiluminescence; chemiluminescence adenine derivative; radical intermediate redox reaction adenine derivative.

Electrogenerated chemiluminescence is used to show that the radicals NAD• and NADP• are intermediates in the electrooxidation of NADH and NADPH at a Pt anode in anhydrous or partly aqueous (up to 15 volume%) DMSO. An ECE mechanism seems to predominate. The use of DMSO proved to be very convenient, with the advantage of enabling electrogenerated chemiluminescence to be obtained in partly aqueous media even with ionic substances as substrates. The method is useful in proving the existence of unstable radical intermediates in redox processes, even for relatively large mols. such as NADH and NADPH.

Analytica Chimica Acta published new progress about Adsorption. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Category: chiral-phosphine-ligands.

Xing, Xiu’s team published research in New Journal of Chemistry in 2022 | 606-68-8

New Journal of Chemistry published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Reference of 606-68-8.

Xing, Xiu; Liu, Yan; Shi, Ming-Liang; Li, Kun; Fan, Xin-Yue; Wu, Zhong-Liu; Wang, Na; Yu, Xiao-Qi published the artcile< Preparation of chiral aryl alcohols: a controllable enzymatic strategy via light-driven NAD(P)H regeneration>, Reference of 606-68-8, the main research area is rhodamine B labeled UiO 67 immobilized enzyme catalyst preparation; alc preparation enantioselective; ketone reduction photochem enzyme catalyst.

Controllable and mild photoenzymic production of chiral alcs. RCH(OH)R1 [R = Ph, 4-pyridyl, 2-naphthyl, etc.; R1 = H, Me, CH2CO2Me, etc.] was realized by coupling a versatile photochem. NAD(P)H regeneration system with (R)- or (S)-selective ketoreductases. The efficiency of NAD(P)H regeneration was improved using a rhodium functionalized metal organic framework, namely Rh-UiO-67, to adjust and control electron transport and electron utilization. Furthermore, six different ketoreductases could be successfully immobilized on Rh-UiO-67 and combined with the light-driven NAD(P)H regeneration system to produce chiral aryl alcs. Various chiral alcs. with complementary (R)- and (S)-conformations could be constructed by this method with high yields (97%) and excellent stereoselectivity (>99% ee).

Mao, Menglei’s team published research in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022-06-01 | 606-68-8

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Adsorbents. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Application of C21H27N7Na2O14P2.

Mao, Menglei; Zhai, Tingting; Meng, Lingding; Meng, Zihui; Liu, Wenfang published the artcile< Controllable preparation of mesoporous silica and its application in enzyme-catalyzed CO2 reduction>, Application of C21H27N7Na2O14P2, the main research area is controllable mesoporous silica enzyme catalyzed CO2 reduction.

Enzymic conversion of CO2 to high-value chems. is a significant route for the utilization of greenhouse gases in mild, high-selectivity and environment-friendly way, however, conversion efficiency is not yet satisfying. Here, mesoporous silica (mSiO2) nanoparticles with controllable structure were prepared and modified by polydopamine (PDA) and polyethyleneimine (PEI), which were then used in an integrated process for CO2 capture and conversion to formate for the first time. The effects of structure parameters of mSiO2 and modification conditions on its application properties were investigated. The results show that in a range of 230 ∼ 500 nm, SiO2 particles with smaller size exhibited better intensifying effect, while the optimal size was 410 nm for mSiO2 with the same etching extent, attributed to a higher sp. surface area. mSiO2 itself was a robust CO2 adsorbent and the addition of 0.01 g mSiO2(410) enabled CO2 conversion to be accelerated 11.94 times compared to free enzyme. After modification, with 0.05 g PDA/PEI-mSiO2(340) and PDA/PEI-mSiO2(410), the enzyme reaction was expedited up to 24 and 30.8 times of the system without particles due to an enhanced CO2 uptake, as a collaborative result of mesoporous structure and amino-functionalization. Following that, PDA/PEI-mSiO2(410) was used as the carrier for the co-immobilization of formate dehydrogenase and carbonic anhydrase, which could retain 86.7% activity after use for 10 times and 55.2% activity after 21 days at 4°C, while 29.6% for free enzymes.

Tewari, Yadu B’s team published research in Journal of Chemical Thermodynamics in 1996-10-31 | 606-68-8

Journal of Chemical Thermodynamics published new progress about Entropy. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, COA of Formula: C21H27N7Na2O14P2.

Tewari, Yadu B.; Goldberg, Robert N. published the artcile< Thermodynamics of reactions catalyzed by L-iditol 2-dehydrogenase: The xylose assimilation pathway>, COA of Formula: C21H27N7Na2O14P2, the main research area is iditol dehydrogenase reaction thermodn xylose assimilation.

Apparent equilibrium constants and calorimetric enthalpies of reaction have been measured for the following enzyme-catalyzed (L-iditol 2-dehydrogenase) biochem. reactions in phosphate buffer at pHs near 7.5 and at the temperature 298.15 K D-sorbitol(aq) + NADox(aq) = D-fructose(aq) + NADred(aq), L-iditol(aq) + NADox(aq) = L-sorbose(aq) + NADred(aq), xylitol(aq) + NADox(aq) = D-xylulose(aq) + NADred(aq). Here, NADox is β-nicotinamide-adenine dinucleotide (oxidized form) and NADred is β-nicotinamide-adenine dinucleotide (reduced form). The results are used to calculate equilibrium constants and standard molar enthalpies, entropies, and Gibbs free energies for reference reactions involving specific species. Standard formation properties and standard transformed formation properties of the biochem. reactants are also calculated The thermodn. of the xylose assimilation pathway is summarized.