606-68-8| Page 2 of 4 | Chiral phosphine ligands

Wang, Yan-zi’s team published research in Journal of Membrane Science in 2016-09-15 | 606-68-8

Journal of Membrane Science published new progress about Biochemical reaction kinetics. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Safety of ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt.

Wang, Yan-zi; Zhao, Zhi-ping; Li, Man-feng; Chen, Yong-zhen; Liu, Wen-fang published the artcile< Development of a hollow fiber membrane micro-reactor for biocatalytic production of formate from CO2>, Safety of ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt, the main research area is hollow fiber membrane bioreactor formate carbon dioxide.

A hollow fiber membrane (HFM) micro-reactor was developed for the conversion of CO2 to formate for the first time by combining hydrophobic polymer HFMs as a gas distributor and modified polyethylene (PE) HFMs for enzyme immobilization in the same module. The effects of the ventilation mode, polymer type and parameters of bubbling membrane, gas velocity and configurational parameters of the HFM module on the reaction were investigated. Using HFM for aeration, the specific activity of enzyme increased, and the Michaelis constant decreased remarkably. For most membranes investigated, when the porosity and pore size of the aerating membrane increased, the reaction rate initially increased and later decreased. The maximum rate was achieved with PE when the porosity was 50% and the pore size was 0.625 μm. For the membranes made of the same type of polymer, a higher value for the contact angle corresponded with a higher reaction rate. Upgrading the number of bubbling HFMs and packing d. intensified the reaction. The optimum upstream gas velocity decreased as the bubbling HFM number increased. The HFM number for bearing enzyme and the height-diameter ratio of the module had no significant effects on the reaction. HFM-attached enzyme showed excellent reusability and storage stability.

Referemce:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Siu, Eulalia’s team published research in Biotechnology Progress in 2007-02-28 | 606-68-8

Biotechnology Progress published new progress about Electrochemical reduction. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Reference of 606-68-8.

Siu, Eulalia; Won, Keehoon; Park, Chan Beum published the artcile< Electrochemical Regeneration of NADH Using Conductive Vanadia-Silica Xerogels>, Reference of 606-68-8, the main research area is electorchem NADH regeneration vanadia silica xerogel.

Elec. conductive sol-gel matrixes have been first introduced in order to enhance the efficiency of electrochem. NADH regeneration systems for biocatalysis. Vanadia-silica mixed gels as conductive sol-gels were synthesized using vanadium (V) oxytripropoxide (VOTP) and tetra-Me orthosilicate (TMOS) as precursors. Direct electrochem. reductions of NAD+ were carried out in the presence of vanadia-silica xerogels using unmodified platinum electrodes. Vanadia-silica gels from higher ratios of VOTP to TMOS could effectively improve electrochem. generations of NADH from NAD+. Direct electrochem. regenerations of NADH were coupled to the synthesis of L-glutamate from α-ketoglutarate catalyzed by glutamate dehydrogenases (GDH). In this case, vanadia-silica gels were used as matrixes for enzyme encapsulation, as opposed to serving as additives. When GDH were entrapped in “”nonconductive”” silica gels, synthesized using only TMOS, in the control experiment, the initial supply of NADH exhausted quickly and a final conversion of 30% was obtained. However, the use of conductive vanadia-silica gels with encapsulated GDH resulted in complete conversion of α-ketoglutarate to L-glutamate. A turnover number of a cofactor was also enhanced 3-fold by the application of conductive vanadia-silica gels.

Saba, Tony’s team published research in ACS Catalysis in 2021-01-01 | 606-68-8

ACS Catalysis published new progress about Hydrogenation. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Formula: C21H27N7Na2O14P2.

Saba, Tony; Li, Jianwei; Burnett, Joseph W. H.; Howe, Russell F.; Kechagiopoulos, Panagiotis N.; Wang, Xiaodong published the artcile< NADH Regeneration: A Case Study of Pt-Catalyzed NAD+ Reduction with H2>, Formula: C21H27N7Na2O14P2, the main research area is TEM hydrogenation catalyst platinum; NAD hydrogenation NMR NADH platinum magnesium catalyst nicotinamide silica.

This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of NAD (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via byproduct quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net neg. charge under the reaction conditions, outperforms the neutral Pt/C and pos. charged Pt/MgO because of the favorable electrostatic attraction between the catalyst surface and pos. charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.

ACS Catalysis published new progress about Hydrogenation. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Formula: C21H27N7Na2O14P2.

Kishore, Nand’s team published research in Journal of Chemical Thermodynamics in 1999-02-28 | 606-68-8

Journal of Chemical Thermodynamics published new progress about Equilibrium constant. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Application of C21H27N7Na2O14P2.

Kishore, Nand; Holden, Marcia J.; Tewari, Yadu B.; Goldberg, Robert N. published the artcile< A thermodynamic investigation of some reactions involving prephenic acid>, Application of C21H27N7Na2O14P2, the main research area is thermodn prephenate dehydratase dehydrogenase.

Calorimetric enthalpies of reaction have been measured for the following enzyme-catalyzed reactions at the temperature 298.15 K: prephenate(aq) = phenylpyruvate(aq) + carbon dioxide(aq), prephenate(aq) + NADox(aq) + H2O(l) = 4-hydroxyphenylpyruvate(aq) + NADred(aq) + carbon dioxide(aq). Here, NADox and NADred are, resp., the oxidized and reduced forms of β-NAD. The enzymes that catalyze these resp. reactions, prephenate dehydratase and prephenate dehydrogenase, were prepared by expression of the appropriate plasmids using the techniques of mol. biol. The calorimetric measurements together with the equilibrium modeling calculations lead to a standard molar enthalpy change ΔrHom = -(126±5) kJ·mol-1 for the reference reaction: prephenate2-(aq) = phenylpyruvate-(aq) + HCO3-(aq). Similarly, ΔrHom = -(74±3) kJ·mol-1 for the reference reaction: prephenate2-(aq) + NADox-(aq) + H2O(l) = 4-hydroxyphenylpyruvate-(aq) + NADred2-(aq) + HCO3-(aq) + H+(aq). Both results pertain to T = 298.15 K and ionic strength I = 0. Benson estimates for the entropies lead to approx. values of the equilibrium constants K ≈ 1×1026 and K ≈ 1×1012, resp., for the above two reference reactions. (c) 1999 Academic Press.

Frattini, Domenico’s team published research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2019-12-25 | 606-68-8

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Carbon nanotubes. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, HPLC of Formula: 606-68-8.

Frattini, Domenico; Hyun, Kyuhuan; Kwon, Yongchai published the artcile< Direct electrochemistry of lactate dehydrogenase in aqueous solution system containing L(+)-lactic acid, β-nicotinamide adenine dinucleotide, and its reduced form>, HPLC of Formula: 606-68-8, the main research area is lactic acid nicotinamide adenine dinucleotide lactate dehydrogenase electrochem.

Using lactate dehydrogenase (LDH) for lactate detection in biosensors is fascinating but still challenging because in-situ bioelectrochem. sensors are still at the research stage due to the lack of reliable information about the direct electrochem. of systems not involving redox mediators. To provide reliable information, the direct electrochems. of aqueous solution systems containing L(+)-lactic acid (Lac), β-NAD (NAD+) and its reduced form (NADH) is investigated using (i) free-standing LDH and (ii) LDH immobilized on carbon nanotubes (CNT). Results show that there is one peak for NADH oxidation and one peak for the NAD+ reduction while the conversion of lactate is observed in the aqueous solution In addition, the peak for NADH oxidation may disappear or be shifted irreversibly. As a result, the detection of lactate relies on the type of solution The conventional mechanisms explaining these phenomena are too superficial and hard to interpret, thus, in this work, we suggest a new interpretation method explaining the empirical behavior of lactate detection. In this prospect, the role of chem. equilibrium related to the conversion of lactate into pyruvate that is catalyzed by LDH is important and this is sequentially elucidated, while the rate-determining step for lactate detection is suggested.

Ostrakhovitch, Elena A’s team published research in Neuroscience Letters in 2022-01-19 | 606-68-8

Neuroscience Letters published new progress about Cerebrospinal fluid. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Application of C21H27N7Na2O14P2.

Ostrakhovitch, Elena A.; Song, Eun-Suk; Macedo, Jessica K. A.; Gentry, Matthew S.; Quintero, Jorge E.; van Horne, Craig; Yamasaki, Tritia R. published the artcile< Analysis of circulating metabolites to differentiate Parkinson′s disease and essential tremor>, Application of C21H27N7Na2O14P2, the main research area is metabolites differentiate Parkinson disease essential tremor; Alpha-synuclein; Cerebrospinal fluid; Metabolomic analysis; Parkinson’s disease; Plasma.

Parkinson′s disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiol. We sought to determine whether an underlying metabolic pattern may differentiate ET from PD. Circulating metabolites in plasma and cerebrospinal fluid (CSF) were analyzed using gas chromatog.-mass spectroscopy. There were several disrupted pathways in PD compared to ET plasma including glycolysis, tyrosine, phenylalanine, tyrosine biosynthesis, purine and glutathione metabolism Elevated α-synuclein levels in plasma and CSF distinguished PD from ET. The perturbed metabolic state in PD was associated with imbalance in the pentose phosphate pathway, deficits in energy production, and change in NADPH, NADH and nicotinamide phosphoribosyltransferase levels. This work demonstrates significant metabolic differences in plasma and CSF of PD and ET patients.

Rzygalinski, Ignacy’s team published research in Electrophoresis in 2008-04-30 | 606-68-8

Electrophoresis published new progress about Capillary electrophoresis. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Electric Literature of 606-68-8.

Rzygalinski, Ignacy; Pobozy, Ewa; Drewnowska, Renata; Trojanowicz, Marek published the artcile< Enzymatic in-capillary derivatization for glucose determination by electrophoresis with spectrophotometric detection>, Electric Literature of 606-68-8, the main research area is glucose oxidation capillary electrophoresis oxidase peroxidase gluconolactone.

The following paper compares several procedures of in-capillary bienzymic derivatization with regard to glucose determination with the use of glucose oxidase and horseradish peroxidase. The procedures discussed below include continuous contact in the capillary, plug-plug injection, and sequential injection with incubation in the capillary inlet. The reaction of hydrogen peroxide catalyzed by peroxidase was performed using two different substrates. The best results were achieved for NAD, reduced disodium salt (NADH) acting both as a chromogenic reagent and a substrate for peroxidase, while the method employed was sequential injection and incubation at the capillary inlet. The LOD was estimated to be 25 nM with a linear response up to 0.1 μM.

Yang, Jing’s team published research in Catalysis Communications in 2012 | 606-68-8

Catalysis Communications published new progress about Biochemical fuel cells (hybrid photoelectrochem.). 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Reference of 606-68-8.

Yang, Jing; Wang, Kunqi; Liang, Liang; Feng, Ligang; Zhang, Yuwei; Sun, Bo; Xing, Wei published the artcile< A hybrid photoelectrochemical biofuel cell based on the photosensitization of a chlorophyll derivative on TiO2 film>, Reference of 606-68-8, the main research area is hybrid photoelectrochem biofuel cell photosensitization chlorophyll derivative titania film.

A hybrid photoelectrochem. biofuel cell is composed of a TiO2 film conductive glass electrode sensitized by a copper chlorophyll trisodium salt in combination with the platinized cathode and the electrolyte which contains redox mediator and enzyme as catalyst. The photovoltaic measurements indicate the optimal dye-adsorption time is 4 h and the incident photon-to-collected electron conversion efficiency is 16% at 400 nm. From the current-voltage curve the open-circuit voltage, short-circuit c.d., maximum power d. and overall energy conversion efficiency are 468 mV, 482 μA/cm2, 97 μW/cm2 and 9.7%, resp.

Gorbunova, Ioanna A’s team published research in Physical Chemistry Chemical Physics in 2020 | 606-68-8

Physical Chemistry Chemical Physics published new progress about Electronic transition dipole moment. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt.

Gorbunova, Ioanna A.; Sasin, Maxim E.; Beltukov, Yaroslav M.; Semenov, Alexander A.; Vasyutinskii, Oleg S. published the artcile< Anisotropic relaxation in NADH excited states studied by polarization-modulation pump-probe transient spectroscopy>, Recommanded Product: ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt, the main research area is beta NADH disodium salt excited state dynamics anisotropic relaxation.

We present the results of exptl. and theor. studies of fast anisotropic relaxation and rotational diffusion in the first electron excited state of biol. coenzyme NADH in water-ethanol solutions The experiments have been carried out by means of a novel polarization-modulation transient method and fluorescence polarization spectroscopy. For interpretation of the exptl. results a model of the anisotropic relaxation in terms of scalar and vector properties of transition dipole moments has been developed based on the Born-Oppenheimer approximation This model allows for the description of fast isotropic and anisotropic excited state relaxation under excitation of mols. by ultrafast laser pulses in transient absorption and upconversion experiments The results obtained suggest that the dynamics of anisotropic rovibronic relaxation in NADH under excitation with 100 fs pump laser pulses can be characterised by a single vibrational relaxation time τv lying in the range of 2-15 ps and a single rotation diffusion time τr lying in the range of 100-450 ps, both depending on ethanol concentration The dependence of the times τv and τr on the solution polarity (static permittivity) and viscosity has been determined and analyzed. Limiting values of the term {P2(cos θ)} describing the rotation of the transition dipole moment in the course of vibrational relaxation have been determined from experiments as a function of ethanol concentration and analyzed.

Wilson, Thomas A’s team published research in Electroanalysis in 2018 | 606-68-8

Electroanalysis published new progress about Amperometry. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Quality Control of 606-68-8.

Wilson, Thomas A.; Musameh, Mustafa; Kyratzis, Ilias L.; Zhang, Jie; Bond, Alan M.; Hearn, Milton T. W. published the artcile< Variation of Carbon Based Materials on the Electropolymerization of Tyramine>, Quality Control of 606-68-8, the main research area is carbon electropolymerization tyramine sensor NADH.

The electropolymerization of tyramine was studied using glassy C electrodes modified with six classes of C materials, C black, graphitized C, graphite, graphene oxide, CVD based multi-walled C nanotubes and arc discharged based multi-walled C nanotubes. These materials were characterized before and after electrodeposition of polytyramine (PT) by Raman spectroscopy, inductively coupled plasma optical emission spectrometry, cyclic voltammetry and amperometry. Previously, other groups established that impurities present in C materials, can play a critical role in electrocatalytic activity. The presence of graphitic basal plane C, rather than metallic impurities, is believed to initiate the formation of a redox active PT film that mediates the oxidation of NADH. The importance of graphitic basal plane C was supported by examining the impact of the graphitization of C black at 500-2000°. Graphitic basal plane C impurity is highly active and important with respect to the electrodeposition of a PT film that possesses significant catalytic activity towards the oxidation of NADH.

Electroanalysis published new progress about Amperometry. 606-68-8 belongs to class chiral-phosphine-ligands, and the molecular formula is C21H27N7Na2O14P2, Quality Control of 606-68-8.