Category: 5931-53-3

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The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5931-53-3 is helpful to your research., Application In Synthesis of Diphenyl(o-tolyl)phosphine

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5931-53-3, Name is Diphenyl(o-tolyl)phosphine, molecular formula is C19H17P. In a Article£¬once mentioned of 5931-53-3, Application In Synthesis of Diphenyl(o-tolyl)phosphine

Phosphorus-31 NMR studies of several phosphines in the solid state

Phosphorus-31 NMR powder spectra and high resolution MAS spectra have been obtained for a number of solid phosphines under conditions of high-power proton decoupling and cross-polarization.The principal components of the 31P chemical shift tensor obtained from static powder spectra or slow MAS spectra are discussed in terms of the known structures of many of the phosphines. he CP/MAS 31P NMR spectra are used to determine the number of crystallographycally nonequivalent molecules in the unit cell.The NMR results are consistent with data available from X-ray diffraction.In one case there is evidence of polymorphism.Key words: 31P NMR of solid phosphines, principal components of 31P chemical shift tensors, crystallographic nonequivalence from 31P CP/MAS NMR.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5931-53-3 is helpful to your research., Application In Synthesis of Diphenyl(o-tolyl)phosphine

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The Absolute Best Science Experiment for 5931-53-3

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5931-53-3 is helpful to your research., 5931-53-3

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5931-53-3, Name is Diphenyl(o-tolyl)phosphine, molecular formula is C19H17P. In a Article£¬once mentioned of 5931-53-3, 5931-53-3

Phosphorus-31 NMR studies of several phosphines in the solid state

Phosphorus-31 NMR powder spectra and high resolution MAS spectra have been obtained for a number of solid phosphines under conditions of high-power proton decoupling and cross-polarization.The principal components of the 31P chemical shift tensor obtained from static powder spectra or slow MAS spectra are discussed in terms of the known structures of many of the phosphines. he CP/MAS 31P NMR spectra are used to determine the number of crystallographycally nonequivalent molecules in the unit cell.The NMR results are consistent with data available from X-ray diffraction.In one case there is evidence of polymorphism.Key words: 31P NMR of solid phosphines, principal components of 31P chemical shift tensors, crystallographic nonequivalence from 31P CP/MAS NMR.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5931-53-3 is helpful to your research., 5931-53-3

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 5931-53-3

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5931-53-3,5931-53-3, Diphenyl(o-tolyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar amounts of KSeCN (5.8 mg, 0.04 mmol) andeither diphenyl(ortho-tolyl)phosphane (11.1 mg, 0.04 mmol)or dicyclohexyl(ortho-tolyl)phosphane (11.5 mg, 0.04 mmol)were dissolved in the minimum amount of MeOH (10 ml). TheKSeCN solution was added dropwise (over a period of 5 min)to the phosphane solution with stirring at room temperature.Slow evaporation of the solvent afforded the title compoundsas colourless crystals suitable for single-crystal X-ray studies.Analytical data for I, 31P {H} NMR (CDCl3, 161.99 MHz):32.03 [t, 1J(31P-77Se) = 714 Hz]

The synthetic route of 5931-53-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Davis, Wade L.; Muller, Alfred; Acta Crystallographica Section C: Structural Chemistry; vol. 75; (2019); p. 1310 – 1318;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

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5931-53-3,5931-53-3, Diphenyl(o-tolyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 33 [(2-Methylphenyl)diphenylphosphoranylidene]carbamic acid, ethyl ester A solution of 1.0 g of (2-methylphenyl)diphenylphosphine in 30 ml of ether was treated with 4 ml of 1M ethyl carbonazidate in ether. The mixture was allowed to stand 48 hours, then repeatedly concentrated and finally treated with fresh ether and refrigerated, giving 930 mg of the desired compound, mp 113-114 C.

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Reference£º
Patent; American Cyanamid Company; US4767749; (1988); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

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5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

A solution prepared by dissolving 0.86 g (3.1 mmol) of diphenyl (2-toluyl) phosphine in 5 ml of chloroform was charged into a 30 mL eggplant flask equipped with a stirrer, cooled in an ice bath, and filtered dropwise. 6.1 g (62 mmol) of 34.5% aqueous hydrogen peroxide was dropped from the funnel and stirred for 40 minutes. After separating the organic layer with a separatory funnel, the aqueous layer was washed 5 times with 5 ml of chloroform. The obtained organic layer was dried over magnesium sulfate, and then chloroform was distilled off, followed by vacuum drying to obtain crude diphenyl (2-toluyl) phosphine oxide as a yellow solid. The obtained crude diphenyl (2-toluyl) phosphine oxide was dissolved in ethyl acetate / n-hexane and recrystallized and purified to give a white solid of diphenyl (2-toluyl) phosphine oxide.0. 91 g (3.1 mmol) were obtained.

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Reference£º
Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

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5931-53-3,5931-53-3, Diphenyl(o-tolyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This procedure is in accordance with Csar et. al. [16] . Addition of nBuLi in hexanes (10.4 mmol, 1.60 M) to a 100-mL flask charged with CH3C6H4-o-PPh2 (2.40 g, 8.69 mmol), 30 mL ether, 3 mL pentane and 1.60 mL TMEDA resulted in precipitation of orange microcrystals, and the mixture was stirred at 23 C for 18 h. Filtration of the precipitate yielded the title compound as orange crystals (2.757 g, 80%). 1H NMR (C6D6): delta 1.66 (4H, s), 1.83 (12H, s), 6.23 (1H, t, 7 Hz), 6.77 (1H, t, 7 Hz), 7.03 (1H, m), 7.11 (3H, m), 7.18 (4H, m), 7.60 (4H, t, 7 Hz). 13C NMR (C6D6): delta 45.10, 56.26, 107.84, 120.28, 128.51, 128.55, 128.63, 129.36, 133.34, 134.66, 134.86, 137.25, 168.69. 31P NMR (C6D6): delta -15.52 (s).

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Reference£º
Article; Jacobs, Brian P.; Wolczanski, Peter T.; MacMillan, Samantha N.; Journal of Organometallic Chemistry; vol. 847; (2017); p. 132 – 139;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

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5931-53-3 Diphenyl(o-tolyl)phosphine 80040, achiral-phosphine-ligands compound, is more and more widely used in various.

5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

80 g (199.8 mmol in terms of sulfur trioxide) of fuming sulfuric acid containing 20% by mass of sulfur trioxide was placed in a 3-neck flask having an internal capacity of 200 ml, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line, and 27.65 g (100.07 mmol) of diphenyl(2-methylphenyl)phosphine (hereinafter referred to as a DPOTP) was added thereto for 1 hour. Further, the liquid temperature was controlled to a range of 25 C. to 30 C. After completion of the addition, the reaction was carried out at the same temperature for 2 hours. (0220) While controlling the liquid temperature to a range of 25 C. to 30 C., the reaction solution was diluted with 600 g of ion exchange water and then transferred to a separatory funnel, and 250 g of toluene and 250 g of tetrahydrofuran were added thereto, thereby acquiring an organic phase. To the organic phase was added 20 g of an aqueous 20%-by-mass sodium hydroxide solution to separate the organic phase, thereby acquire a lower phase. The lower phase was concentrated until the liquid amount reached 95 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration by natural filtering, thereby acquiring 23.53 g of a pale yellow solid. (0221) To this acquisition was added 120 g of ion exchange water to obtain an aqueous solution, and then 24 g of an aqueous 50%-by-mass sulfuric acid solution was added dropwise thereto. Further, 70 g of toluene and 70 g of tetrahydrofuran were added thereto, followed by sufficiently mixing, thereby acquiring an organic phase. To the organic phase was added 10.52 g (103.96 mmol) of triethylamine, followed by stirring in the range of 20 C. to 30 C. for 1 hour. This liquid was concentrated until the liquid amount reached 50 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration by natural filtering, thereby acquiring 15.36 g of a pale yellow solid. (0222) 31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) delta: a diphenyl(6-methyl-3-sulfonatophenyl)phosphine triethylammonium salt as a mono-form showed a peak at -13.19, and an oxide formed by oxidation of the phosphorous atoms showed a peak at 28.73. (0223) The acquisition was a mixture including 14.63 g (31.98 mmol, 95.42% by mole) of a diphenyl(6-methyl-3-sulfonatophenyl)phosphine triethylammonium salt and 0.73 g (1.54 mmol, 4.58% by mole) of an oxide formed by oxidation of the phosphorous atoms. From the viewpoint that 15.36 g (33.52 mmol in terms of phosphorous atoms) of a desired product could be acquired using 27.65 g (100.07 mmol in terms of phosphorous atoms) of DPOTP, the yield based on phosphorous atoms was 33.5%. This phosphorous compound was referred to as a ligand K.

5931-53-3 Diphenyl(o-tolyl)phosphine 80040, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; KURARAY CO., LTD.; YOSHIKAWA, Tatsuya; TSUJI, Tomoaki; (30 pag.)US2016/46549; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

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The synthetic route of 5931-53-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

To a Schlenk flask charged with a solution of [Ph2P(o-tolyl)] (1 g, 3.61 mmol) in hexane (40 mL),tetramethylethylenediamine, TMEDA (0.54 mL, 3.61 mmol) and nBuLi (1.44 mL of a hexane solution,3.61 mmol) were added at -78 C with stirring. The reaction mixture was then kept at 0 C for 16 h,after which it was filtered and dried under reduced pressure yielding an extremely air and moisturesensitive yellow-orange solid. Crystals for the X-ray experiment were obtained from benzene. Yield:(1.24 g, 86%). m.p.: 146-148 C. 1H NMR (500 MHz, C6D6, 298 K): delta 7.57 (m, 4H, CH arom), 7.36 (m, 1H,CH arom), 7.16 (m, 1H, CH arom), 7.09 (m, 3H, CH arom), 7.03 (m, 2H, CH arom), 6.99 (m, 1H, CH arom),6.73 (m, 1H, CH arom), 6.19 (m, 1H, CH arom), 2.35 (br, 2H, CH2Li), 1.85 (s, 12H, CH3N), 1.65 (s, 4H,CH2N). 13C{1H} NMR (100.68 MHz, C6D6, 298 K): delta 43.71 (d, CH2-Li, 3JP,C = 17.5 Hz), 45.57 (s, CH3N),56.87 (s, CH2N), 108.12 (s, CH, o-tolyl), 120.68 (s, CH, o-tolyl), 127.94 (s, CH, Phenyl), 128.03 (d, CH,3JP,C = 7.4 Hz, Phenyl), 128.3 (s, CH, o-tolyl), 128.80 (s, CH, Phenyl), 132.79, (s, CH, o-tolyl), 133.9 (d, CH,2JP,C = 20.1 Hz, o-tolyl), 134.2 (s, CH, 2JP,C = 17.5 Hz, Phenyl), 136.27 (d, C-P, 1JP,C = 12.57 Hz, o-tolyl),136.66 (d, C-P, 1JP,C = 11.3 Hz, Phenyl), 157.5 (d, C-P, 1JP,C = 26.39 Hz, o-tolyl). 31P{1H} NMR (161.92MHz, C6D6, 298 K): delta 15.30 (s, w1/2 4 Hz).). 7Li NMR (155.45 MHz, C6D6, 298 K): delta 1.59 (s). IR(KBr/cm-1): 3059 (m), 2962 (m), 1585 (m), 1470 (m), 1434 (m), 1258 (m), 1176 (m), 1088 (m), 1026 (m),803 (m), 742 (s), 693 (s), 551 (m), 511 (m).

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Reference£º
Article; Rufino-Felipe, Ernesto; Mu Oz-Hernandez, Miguel-Angel; Montiel-Palma, Virginia; Molecules; vol. 23; 1; (2018);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate