Category: 50777-76-9

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, A mixture of 0.14 g (0.48 mmol) 2-(diphenylphosphino)benzaldehyde and 0.05 g (0.48 mmol) ethyl carbazate was dissolved, by heating, in 25 mL ethanol. pH of the mixture was adjusted to ?4 with a hydrochloric acid. The mixture was heated at 56 ¡ãC for 60 min. The reaction solution was left to stand at room temperature while the colourless crystals separated from the solution. Yield 0.15 g (83percent). Mp 164-166 ¡ãC. IR (vs-very strong, s-strong, m-medium, w-weak): 3253 (w), 3189 (w), 3049 (m), 2974 (w), 1729 (m), 1707 (s), 1550 (s), 1458 (w), 1435 (w), 1385 (w), 1247 (vs), 1178 (w), 1092 (w), 1055 (m), 763 (w), 744 (w), 696 (m), 657 (w), 499 (w). HRMS (ESI) of C22H21N2O2P found for (M+H+) 377.1384, calcd (m/z) for (M+H+) 377.1414.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Milenkovic?, Milica; Bacchi, Alessia; Cantoni, Giulia; Radulovic?, Sinis?a; Gligorijevic?, Nevenka; Arandelovic?, Sandra; Sladic?, Dus?an; Vujc?ic?, Miroslava; Mitic?, Dragana; Andelkovic?, Katarina; Inorganica Chimica Acta; vol. 395; (2013); p. 33 – 43;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: All syntheses were carried out in the same fashion. Each reaction was monitored by TLC for 24 h to determine when the starting materials had been consumed. All TLC analyses were run on Selecto Scientific flexible silica gel-coated plates containing a fluorescent indicator and were developed using a hexanes-ethyl acetate (4:1) solution as the eluent. The following procedure is representative of the synthesis of all chalcones (see [Chart 1] and [Chart 2] for structures): A 25-mL round-bottomed flask was charged with the appropriate derivatives of both acetophenone (3 mmol) and benzaldehyde (3 mmol), and mixed with 10 mL of 95percent EtOH. The mixture was then stirred magnetically while being gently heated (in a 30 ¡ãC water bath) until both starting materials dissolved. In a separate flask, NaOH (3.5 mmol) was added to 10-mL of an ethanol-water (1:1) and the mixture was stirred magnetically until the solid dissolved. The NaOH solution was then added dropwise (using a Pasteur pipet) to the ethanolic solution of acetophenone and benzaldehyde described above. In most cases, the reaction mixture turned yellow and solidified within a few minutes. Ice water (2 mL) was added to the flask and the mixture was stirred vigorously. The solid was collected on a Hirsch funnel, washed with cold water, and air-dried overnight. The purity of the crude product was determined at this point using a combination of TLC analysis, melting point measurement, and 1H NMR spectroscopy. In case of an oily product, the reaction mixture was extracted with two 10-mL portions of CH2Cl2 and the organic phase was collected, dried over Na2SO4, and removed using a rotary evaporator. The purity of the oily product was then determined as described above. All impure products (solid or oil) were purified by column chromatography using Merck Silica gel (grade 60, 230-400 mesh) and 4:1 hexanes-ethyl acetate as eluent. In case of a solid, chromatographic separation was followed by recrystallization from either methanol or ethanol-water mixture. In all cases, the purity of the final product was checked again as described above; the spectral characteristics were found to be in good general agreement with those found in the literature.4 The organic chalcones prepared for this study were either pale-yellow solids or oils of the same color (as specified); the ferrocenyl analogs were reddish-orange solids or oils. For each of the reported compounds below, the 1H NMR data is presented as delta (multiplicity, integral ratio), and the IR data as nuCO, nuCC. The following percent yield and physical data are for new chalcones prepared for this study. Data for other chalcones (not given below) have been reported elsewhere[4], [5] and [6] and are also available online as Supplementary data., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Attar, Saeed; O’Brien, Zachary; Alhaddad, Hasan; Golden, Melissa L.; Caldero?n-Urrea, Alejandro; Bioorganic and Medicinal Chemistry; vol. 19; 6; (2011); p. 2055 – 2073;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, In a test cylinder containing a coolant, the molecular sieve 4 is activated. The solution of L(+)-leucine (65.5 mg, 0.5 mmol, 1 eq.) and potassium hydroxide (28 mg, 0.5 mmol, 1 eq.) in degassed anhydrous methanol (2 mL per mmol) is added. Orthodiphenylphosphine-benzaldehyde (145 mg, 0.5 mmol, 1 eq.) is then added and the mixture is kept under vigorous agitation for 3 hours at 40¡ã C. The solvent is then evaporated. The potassium iso-leucine phosphinoazomethinylate (Ib-K) is obtained in the form of a yellowish solid (209 mg, 95percent). The RMN characteristics of this compound are as follows:RMN 1H: (400 MHz, CD3DO) delta (ppm): 8.88 (d, H,PJ=5.5 Hz, 1H, H1); 8.06-8.02 (m, 1H, H9); 7.28-7.07 (m, 12H, H7, H8, H10-19); 6.72-6.69 (m, 1H, H5); 3.70 (dd 2J=4.4 Hz, 2J=9.7 Hz, 1H, H2); 1.55 (qd, 3J=4.4 Hz, 2J=9.7 Hz, 2H, H3); 0.89 (m, 1H, H4); 0.62 (d, 3J=6.6 Hz, 3H, H5′); 0.51 (d, 3J=6.4 Hz, 3H, H5)RMN 31P: (162 MHz, CD3DO) delta (ppm): -14.59 (s, 1P)RMN 13C: (100 MHz, CD3DO) delta (ppm): 180.90 (10, C20); 161.59 (1C, C1); 141.42 (1C, C21); 139.32 (1C, C24); 139.13 (10, C23); 138.0 (10, C6); 137.74 (1C, C22); 135.8 (4C, C10,14,15,19) 134.33 (1C, C9); 131.87-129.13 (8C, C7,8,11-13,166-18); 76.94 (1C, C2); 44.54 (10, C4); 25.7 (1C, C5); 24.3 (1C, C5′); 21.9 (1C, C3)

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Patent; Mauduit, Marc; Rix, Diane; Crevisy, Christophe; Wencel, Joanna; US2010/267956; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes. (E)-N-(2-(Diphenylphosphino)benzylidene)-2-methoxyaniline(2) Yield: 449 mg (66percent); m.p.: 108?109 C.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate