Category: 50777-76-9

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: (S)-2-{[4-(Methoxycarbonylpropyl]phenyl)aminocarbonyl}indoline (3; 676 mg, 2 mmol) and 2-(diphenylphosphino)benzaldehyde (2a;1.16 g, 4 mmol) were dissolved in MeOH (5 mL). The reaction mixture was heated to 80 ¡ãC in a sealed tube for 48 h. After cooling to r.t., the mixture was extracted with EtOAc and concentrated. The resulting residue was chromatographed on silica gel (eluent:acetone/hexane = 1:2) to give colorless fine prisms; yield: 840 (69percent); mp 115?117 ¡ãC; [alpha]D21 ?169 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 7.71 (d, J = 6.5 Hz, 1 H), 7.43?7.13 (m,18 H), 6.97?6.91 (m, 3 H), 4.37 (d, J = 8.5 Hz, 1 H), 3.64 (s, 3 H), 3.53 (d,J = 16.5 Hz, 1 H), 3.09 (dd, J = 8.5, 16.5 Hz, 1 H), 2.52 (t, J = 7.5 Hz, 2 H),2.26 (t, J = 7.5 Hz, 2 H), 1.85 (quin, J = 7.5 Hz, 2 H).13C NMR (126 MHz, CDCl3): delta = 174.1, 173.6, 142.3?113.5 (Carom, overlapped), 81.4 (d, JC,P = 25.9 Hz), 64.1, 51.3, 34.3, 33.1, 31.4, 26.1. 31P{1H} NMR (202 MHz, CDCl3): delta = ?18.9 (s).MS (ESI-TOF): m/z = 633 [M + Na]+.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uozumi, Yasuhiro; Matsuura, Yutaka; Suzuka, Toshimasa; Arakawa, Takayasu; Yamada, Yoichi M. A.; Synthesis; vol. 49; 1; (2017); p. 59 – 68;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

3-phenylpropyl-1-amine (344 ml;2.41 mmol) in 10 mL of toluene was added drop-wise to a mixtureof (2-(diphenylphosphino))-benzaldehyde (0.7 g; 2.41 mmol) andanhydrous magnesium sulfate (1.6 g) in toluene (10 mL). The reactionwas stirred under reflux for 3 h. Resulting in a light yellowmixture. After filtration a yellow oil was obtained upon eliminationof the solvent under reduced pressure. Twice the treatment withhexane (10 mL) resulted in a purification of the product, whichhowever did not crystallize. Yield: 97percent. 1H NMR (CDCl3, 298 K,300 MHz): d (ppm) 8.86 (d, J 4,65 Hz, 1H, HCN-), 7.98e7.94(m, 1H, aromatic), 7.38e7.04 (m, 17H, aromatic), 6,87-6,83 (m, 1H,aromatic), 3.48 (t, J 6.65 Hz, 2H, NCH2-), 2.44e2.39 (m, 2H,-CH2-Ph), 1.84e1.75 (m, 2H, -CH2-). 31P{1H} (CDCl3, 298 K):d (ppm)13.80. ESI-MS (CHCl3 after treatment of H2O2) m/z:424.2 [OPN3 H]., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wajda-Hermanowicz, Katarzyna; Kochel, Andrzej; Wrobel, Robert; Journal of Organometallic Chemistry; vol. 860; (2018); p. 30 – 48;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 0.32 g (1.61 mmol) of the compound [1], 0.47 g (1.61 mmol) of 2- (diphenylphosphino) benzaldehyde, 1.5 g (1.61 mmol) of Amberlyst 15 (0.11 g), 15 mL of toluene were added, and the mixture was allowed to react at 80 ¡ã C. for 8 hours. The reaction solution was filtered, and the filtrate was evaporated under reduced pressure to give 0.61 g (yield: 80percent) of the target compound (hereinafter referred to as the compound [3]) represented by the following formula [3].

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsui Chemicals; Ishii, Seiichi; Ichikawa, Shinichiro; Fujita, Otomo Toshinori; (49 pag.)JP2018/162230; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, Under argon a solution of 2-(ethylthio)ethanamine (0.36 g, 3.44 mmol) in THF (3 ml) is added to a solution of 2-(diphenylphosphino)benzaldehyde (1.00 g, 3.44 mmol) in THF (10 ml). After stirring for 12 h at 72 ¡ãC the reaction mixture is cooled to 0 ¡ãC, DCM (3 ml) is added and the solvents are evaporated under vacuo. SNP-ligand N-(2- (diphenylphosphino)benzylidene)-2-(ethylthio)ethan-amine is obtained as an orange solid (1.20 g, 92percent). Analytical data: 1H-NMR (400 MHz, CDCl3): 8.92 (d, 7=4.80, 1H), 8.00 (m, 1H), 7.41 (m, 1H), 7.38-7.28 (m, 11H), 6.91 (m, 1H), 3.70 (dt, 7=1.26, 7.07, 2H), 2.62 (t, 7=7.33, 2H), 2.50 (q, 7=7.33, 2H), 1.23 (t, 7=7.33, 3H). 13C-NMR (400 MHz, CDCl3): 161.12, 139.67, 137.93, 136.96, 136.87, 134.42, 133.77, 130.74, 129.28, 129.01, 128.13, 61.64, 32.56, 26.49, 15.28. 31P-NMR (500 MHz, CDCl3): -13.55 (s, IP). GC/MS: 377 (6percent, M+), 348 (54percent, [M-29]+), 288 (100percent), 226 (20percent), 208 (14percent), 183 (28percent), 165 (14percent), 107 (11percent), 89 (34percent), 61 (14percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GIVAUDAN SA; GEISSER, Roger Wilhelm; OETIKER, Juerg Daniel; SCHROeDER, Fridtjof; WO2015/110515; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate