Category: 50777-76-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, Under inert gas protection,50 mL of Schlenk reaction tube was added2,9-dimethyl-4,7-bis (2-thienyl) -1,10-phenanthroline (0.187 g, 0.5 mmol)2- (diphenylphosphino) benzaldehyde (0.291 g, 1 mmol) andPotassium carbonate (50 mmol),Add deoxygenated toluene (20 mL)Rose to 100 ¡ã C for 12 h,Cooled to room temperature, 50 mL of water was added to the reaction solution, the solid was precipitated and filtered,The filtered solid was recrystallized from 1 mL of crystalline solvent methanol,To give the title product 335 mg, yield 73percent

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Patent; Zhejiang University of Technology; Luo Shuping; Yu Zhejian; Chen Hao; Xia Liangmin; Wang Mingming; Wu Qingan; (8 pag.)CN106749411; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

To a mixture of o-(diphenylphosphino)benzaldehyde (0.86 g, 3.0 mmol) and anhydrous Na2SO4 (10.0 g, 70.0 mmol) in CH2Cl2 (25 mL) was added (R,R)-2-(2,5-dimethyl-pyrrol-1-yl)-cyclohexylamine (0.68 g, 3.5 mmol). The mixture was stirred at room temperature for 3 days. The resulting solution was filtrated and the solvent was removed under vacuum to obtain a yellow solid (R,R)-1 (1.30 g, 93percent yield). Anal. for C31H33N2P: 464.58 g/mol; [alpha]D20 = -36.0 (c 1.0, CH2Cl2)., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

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Article; Zeng, Li; Wu, Fang; Li, Yan-Yun; Dong, Zhen-Rong; Gao, Jing-Xing; Journal of Organometallic Chemistry; vol. 762; (2014); p. 34 – 39;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9,50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, Fluorene (16.62 g, 0.1 mol) was added to a solution of (3.9 g, 0.17 mol) sodium in 200-mL ethanol, the mixture was kept at 60 ¡ãC then a solution of (29 g, 0.1 mol) 2-diphenylphosphino benzaldehyde in 40-mLethanol was added dropwise. The mixture turned red after 2 h then the reaction was cooled and the solids were crystallized from dichloromethane?hexane. Yield: 85percent, m.p.:153 ¡ãC.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Nemati Kharat, Ali; Rajabi Kouchi, Fereshteh; Tamaddoni Jahromi, Bahareh; Journal of Coordination Chemistry; vol. 69; 1; (2016); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

To a solution of 6 (60 mg, 0.15 mmol) in dried and deoxygenated CH2Cl2 (5 mL) under agron atmosphere, were added CuSO4 (71.8 mg, 0.45 mmol) and diphenylphosphinobenzaldehyde 7 (48.6 mg, 0.17 mmol). After 7 hrs, the reaction mixture was filtered via canula and the solvent was evaporated. The mixture was purified by column chromatography Ethyl acetate: Hexanes: triethylamine (1 : 2: 0.02) affording 8 (100 mg, quant.) as a colorless oil. [alpha]D20: -32.7 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 8.58 (d, 1H, J = 3.8 Hz, NCHPh), 7.82-7.81 (m, 2H, arom), 7.63-7.17 (m, 22H, arom, triazol), 6.87-6.84 (m, 1H, arom), 5.64 (s, 1H, PhCHOO), 5.60 (d, 1H, J = 8.5 Hz, H-1), 4.38 (m, 1H, H-6), 4.13-4.04 (m, 2H, H-2, H-5), 3.89-3.85 (m, 2H, H-3,H-6)’, 3.80-3.74 (m, 1H, H-4). 13C-NMR (125 MHz, CDCl3): delta = 164.9, 164.8, 147.3, 138.7, 138.5, 138.4, 138.3, 137.7, 137.6, 136.9, 134.2 134.1, 133.7, 133.5, 130.6, 130.2, 129.3, 128.8, 128.7, 128.6, 128.5, 128.5, 128.4, 128.3, 126.3, 125.8, 119.7, 102.1, 87.2, 79.8, 72.4, 69.8, 68.3. 31P-NMR (121.4 MHz, CDCl3) : delta = 10.69 ppm. HMRS: Calcd for C40H36N4O4P [M]: 667.24770, found: 667.24770 (0.4 ppm)., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Khiar, Noureddine; Navas, Raquel; Ferna?ndez, Inmaculada; Tetrahedron Letters; vol. 53; 4; (2012); p. 395 – 398;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: In a Schlenk tube under nitrogen, alpha-D-pyranose 5-8 (2.1 mmol) and 2-(diphenylphosphino)benzaldehyde (621 mg, 2.1mmol) were stirred in toluene (40 mL) at 60 ¡ãC for 12 h. After concentration, the residue was purified by flash column chromatography on silica gel.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Szulc, Izabela; Ko?odziuk, Robert; Zawisza, Anna; Tetrahedron; vol. 74; 13; (2018); p. 1476 – 1485;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate