Category: 49609-84-9

Safety of 2-Chloronicotinoyl chloride. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Highly efficient palladium-catalyzed cross-coupling of diarylborinic acids with arenediazoniums for practical diaryl synthesis. Author is Wang, Fengze; Wang, Chen; Sun, Guoping; Zou, Gang.

A highly efficient cross-coupling of cost-effective diarylborinic acids with both isolatable and latent arenediazoniums, i.e. tetrafluoroborates and aryltriazenes, resp., has been developed with a practical palladium catalyst system under base-free conditions in open flask at room temperature A variety of electronically and sterically various biaryls, in particular, those bearing a coordinative ortho-substituent, could be obtained in good to excellent yields by using 0.3 mol% palladium acetate as catalyst. Features of the protocol including cost-effectiveness of diarylborinic acids, efficacy to heteroatom ortho-substituted substrates and high chemoselectivity to aryl chlorides have been clearly demonstrated in practical synthesis of fungicide Boscalid (I).

There are many compounds similar to this compound(49609-84-9)Safety of 2-Chloronicotinoyl chloride. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The amine-catalysed Suzuki-Miyaura-type coupling of aryl halides and arylboronic acids, published in 2021-01-31, which mentions a compound: 49609-84-9, mainly applied to aromatic hydrocarbon preparation chemoselective; aryl halide arylboronic acid Suzuki coupling reaction; amine catalyst preparation, Category: chiral-phosphine-ligands.

A robust and chemoselective organocatalytic Suzuki-Miyaura-type coupling of aryl halides viz. Me 2-(4-bromophenyl)propanoate, Me 2-(4-chlorophenyl)propanoate, 5-bromopyrimidine, etc. with arylboronic acids viz. phenylboronic acid, naphthalen-2-ylboronic acid, furan-3-ylboronic acid, etc. catalyzed by amines, e.g. 2-methyl-N1,N3-di-o-tolylbenzene-1,3-diamine was reported. The utility and scope of this reaction were demonstrated by the synthesis of several com. relevant small mols. viz. Me 2-([1,1′-biphenyl]-4-yl)propanoate, Me 2-(4-(naphthalen-2-yl) phenyl)propanoate, 5-(furan-3-yl)pyrimidine, etc. and a selection of derivatives of pharmaceutical drugs e.g., Boscalid.

There are many compounds similar to this compound(49609-84-9)Category: chiral-phosphine-ligands. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

SDS of cas: 49609-84-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors. Author is Liu, Hong-Min; Suo, Feng-Zhi; Li, Xiao-Bo; You, Ying-Hua; Lv, Chun-Tao; Zheng, Chen-Xing; Zhang, Guo-Chen; Liu, Yue-Jiao; Kang, Wen-Ting; Zheng, Yi-Chao; Xu, Hai-Wei.

A series of new indole derivatives were designed and synthesized based on a lead compound obtained by a high-throughput screening with our inhouse compound library. Among the synthetic compounds, compound I was characterized as a potent LSD1 inhibitor with an IC50 of 1.230 μM and inhibited the proliferation of THP-1 cells effectively. And most importantly, this was the first irreversible LSD1 inhibitor that is not derived from monoamine oxidase inhibitors. Hence, the discovery of compound I may serve as a proof of concept work for AML treatment.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloronicotinoyl chloride(SMILESS: O=C(Cl)C1=CC=CN=C1Cl,cas:49609-84-9) is researched.HPLC of Formula: 31181-89-2. The article 《Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:49609-84-9).

In this study, novel potent pyrimidine derivatives I (R1 = SMe, SO2Me; R2 = [2-(pyridin-3-ylformamido)ethyl]aminyl, 3-Cl-4-FC6H3NH, 4-aminopiperidin-1-yl, etc.; R3 = [4-(morpholin-4-yl)phenyl]aminyl, C6H5NH, 3-Br-4-FC6H3NH, etc.) as core assembly modulators were synthesized and their antiviral effects were evaluated in in vitro and in vivo biol. experiments One of the synthesized derivatives, compound I (R1 = SO2Me; R2 = 4-aminopiperidin-1-yl; R3 = 3-Cl-4-F-C6H3NH) displayed potent inhibitory effects in the in vitro assays (52% inhibition in the protein-based assay at 100 nM and an IC50 value of 181 nM in the serum HBV DNA quantification assay). Moreover, treatment with compound I (R1 = SO2Me; R2 = 4-aminopiperidin-1-yl; R3 = 3-Cl-4-F-C6H3NH) for 5 wk significantly decreased serum levels of HBV DNA levels (3.35 log reduction) in a human liver-chimeric uPA/SCID mouse model, and these effects were significantly increased when I (R1 = SO2Me; R2 = 4-aminopiperidin-1-yl; R3 = 3-Cl-4-F-C6H3NH) was combined with tenofovir, a nucleotide analog inhibitor of reverse transcriptase used for the treatment of HBV infection.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 49609-84-9, is researched, Molecular C6H3Cl2NO, about Synthesis and Pharmacological Activity of 3-Phenoxybenzoic Acid Derivatives, the main research direction is phenoxybenzoic acid derivative preparation glucokinase protein glycation PPAR.SDS of cas: 49609-84-9.

3-Phenoxybenzoic acid derivatives were synthesized. Their pharmacol. activity was studied. Several compounds, in particular 2-cyanoprop-2-yl 3-phenoxybenzoate, were found to exhibit peroxisome proliferator-activated receptor γ agonist activity and to be capable of activating glucokinase and inhibiting protein glycation. The studied compounds did not influence dipeptidyl peptidase-4 activity.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

HPLC of Formula: 49609-84-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis, crystal structure and fungicidal activity of 2-chloro-N-(o-tolylcarbamoyl)nicotinamide. Author is Mi, Li-Jing; Qiao, Wang; Tan, Cheng-Xia; Weng, Jian-Quan; Liu, Xing-Hai.

The title compound, 2-chloro-N-(o-tolylcarbamoyl)nicotinamide (C14H12ClN3O2) was synthesized, and its structure was confirmed by 1H NMR, H RMS and X-ray diffraction. It crystallized in the monoclinic system, space group P21/n with a = 7.8356(7), b = 12.7949(8), c = 13.6326(10) Å, β = 91.929(7)°, V = 1365.97(18) Å3, Z = 4, the final R = 0.0416 and wR = 0.0971 for 2467 observed reflections with I > 2σ(I). The preliminary biol. test showed that the title compound had certain fungicidal activities.

From this literature《Synthesis, crystal structure and fungicidal activity of 2-chloro-N-(o-tolylcarbamoyl)nicotinamide》,we know some information about this compound(49609-84-9)HPLC of Formula: 49609-84-9, but this is not all information, there are many literatures related to this compound(49609-84-9).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Related Products of 49609-84-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Development of novel 2-substituted acylaminoethylsulfonamide derivatives as fungicides against Botrytis cinerea. Author is Wang, Minlong; Du, Ying; Liu, Chunhui; Yang, Xinling; Qin, Peiwen; Qi, Zhiqiu; Ji, Mingshan; Li, Xinghai.

Botrytis cinerea is an economically important fungal pathogen with a host range of over 200 plant species. Unfortunately, gray mold disease caused by B. cinerea has not been effectively controlled because of its high risk for fungicide resistance development. As a part of our ongoing efforts to develop novel sulfonamides as agricultural fungicides against Botrytis cinerea, we introduced 2-aminoethanesulfonic acid (taurine) substructure, designed and synthesized a series of novel 2-substituted acylaminoethylsulfonamides. The newly synthesized sulfonamides were evaluated in vitro and in vivo for their fungicidal activity against Botrytis cinerea, of which the 2-ethoxyacetylamide derivative (V-A-12, (I) EC50 = 0.66 mg·L-1) exhibited the highest potency in vitro and superior fungicidal activity compared with procymidone (EC50 = 1.06 mg·L-1). In vivo bioassay indicated that compound I could be effective for the control of tomato gray mold. Moreover, the structure-activity relationship of these sulfonamides was analyzed by establishing a three-dimensional quant. structure-activity relationship (3D-QSAR) model, which can provide guidance for the development of sulfonamides as fungicides. Finally, the effeicacy of sulfonamide derivatives was again verified in the activity evaluation against resistant Botrytis cinerea strains. These results further enhance the development value of 2-substituted acylaminoethylsulfonamides to control the tomato gray mold.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Fully Automated Chemical Synthesis: Toward the Universal Synthesizer, published in 2020-10-16, which mentions a compound: 49609-84-9, mainly applied to apparatus AutoSyn automated synthesis pyrimidine imatinib ibuprofen warfarin, Category: chiral-phosphine-ligands.

Automated peptide and oligonucleotide synthesizers enabled a revolution in mol. biol. and helped pave the way to modern synthetic biol. Similarly, fully automated synthetic chem. could herald a new wave of innovation in biol. and materials sciences by greatly facilitating access to known and novel mols. Here, we report on an automated multistep chem. synthesizer, AutoSyn, that makes milligram-to-gram-scale amounts of virtually any drug-like small mol. in a matter of hours and demonstrate its versatility with the synthesis of ten known drugs. Of the FDA-approved small-mol. drugs for which we were able to compute a synthetic route, 87% are predicted to be synthesized on AutoSyn. Moreover, AutoSyn enables digital synthesis protocols that ensure the reproducibility and transferability of synthesis protocols from one lab to another. If this follows the same evolution as automated peptide and DNA syntheses, it will lead to an exponential increase in chem. innovation across biol. and material sciences.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

COA of Formula: C6H3Cl2NO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition. Author is Sun, Chiyu; Zhang, Dajun; Luan, Tian; Wang, Youbing; Zhang, Wenhu; Lin, Lin; Jiang, Meihua; Hao, Ziqian; Wang, Ying.

Aberrant hedgehog (Hh) signaling is implicated in the development of a variety of cancers. Smoothened (Smo) protein is a bottleneck in the Hh signal transduction. The regulation of the Hh signaling pathway to target the Smo receptor is a practical approach for development of anticancer agents. We report herein the design and synthesis of a series of 2-methoxybenzamide derivatives as Hh signaling pathway inhibitors. The pharmacol. data demonstrated that compound 21 possessed potent Hh pathway inhibition with a nanomolar IC50 value, and it prevented Shh-induced Smo from entering the primary cilium. Furthermore, mutant Smo was effectively suppressed via compound 21. The in vitro antiproliferative activity of compound 21 against a drug-resistant cell line gave encouraging results.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells.Recommanded Product: 2-Chloronicotinoyl chloride.

Sodium taurocholate cotransport polypeptide (NTCP) plays an important role in the development of hepatitis and acts as a switch to allow hepatitis virus to enter hepatic cells. As the entry receptor protein of hepatitis virus, NTCP is also an effective target for the treatment of hepatocellular carcinoma. Herein, twenty-five benzamide analogs were synthesized based on the virtual screening design and their anti-proliferative activities against HepG2 cells were evaluated in vitro. Compound I was found to be promising, with an IC50 value of 2.8μM. The apoptosis induced by I was characterized by the regulation of markers, including an increase in Bax, cleaved-caspase 3, and cleaved-PARP proteins, and a decrease in Bcl-2 protein. Mol. docking and mol. dynamics (MD) simulation confirmed that compound I can bind tightly to NTCP. Western blot anal. also showed that NTCP was inhibited. Altogether, these results indicate that compound I acts as a novel NTCP inhibitor to induce apoptosis in HepG2 cells.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate