Category: 49609-84-9

Electric Literature of C6H3Cl2NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Copper-catalyzed synthesis of 2-aminopyridylbenzoxazoles via domino reactions of intermolecular N-arylation and intramolecular O-arylation. Author is Lu, Ju-You.

A simple and general approach to nitrogen-containing heterocycles via copper-catalyzed domino reaction has been developed, and the corresponding 2-aminopyridylbenzoxazole derivatives I (Z = W = CH, N; R = Me, Et, Ph, etc.; R1 = H, 4-Me, 5-CF3, etc.; R2 = H, 4-Cl) were obtained in good to excellent yields using the readily available starting materials II ( X = Y= Br, Cl; Z = W = CH, N; R1 = H, 4-Me, 5-CF3, etc; R2 = H, 5-Cl) and amines RNH2 (R = Me, Et, Ph, etc.). This method possesses unique step economy features, and is of high tolerance towards various functional groups in the substrates.

Different reactions of this compound(2-Chloronicotinoyl chloride)Electric Literature of C6H3Cl2NO require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Formula: C6H3Cl2NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by ZnO.

An efficient method for the synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by nano-ZnO under solvent-free condition at room temperature was described. The method is compatible with a range of ethers including tricyclic ethers, tetracyclic ethers, pentacyclic ethers and hexacyclic ethers and have afforded the products with moderate to good yields. The ZnO could be reused up to three times and the product yield after three cycles is 87%.

Different reactions of this compound(2-Chloronicotinoyl chloride)Formula: C6H3Cl2NO require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 49609-84-9, is researched, SMILESS is O=C(Cl)C1=CC=CN=C1Cl, Molecular C6H3Cl2NOJournal, Article, Scientific Reports called Dual-active antifungal agents containing strobilurin and SDHI-based pharmacophores, Author is Zuccolo, Marco; Kunova, Andrea; Musso, Loana; Forlani, Fabio; Pinto, Andrea; Vistoli, Giulio; Gervasoni, Silvia; Cortesi, Paolo; Dallavalle, Sabrina, the main research direction is Pyricularia Sclerotinia strobilurin SDHi pharmacophore antifungal.Recommanded Product: 2-Chloronicotinoyl chloride.

Crop disease management often implies repeated application of fungicides. However, the increasing emergence of fungicide-resistant pathogens requires their rotation or combined use. Tank-mix combinations using fungicides with different modes of action are often hard to manage by farmers. An alternative and unexploited strategy are bifunctional fungicides, i.e. compounds resulting from conjugation of the pharmacophores of fungicides with different mechanisms of action. In this paper we describe a new approach to antifungal treatments based on the synthesis of dual agents, obtained by merging the strobilurin and succinate dehydrogenase inhibitor pharmacophores into a new entity. The compounds were tested against important fungal plant pathogens and showed good inhibition of Pyricularia oryzae and Sclerotinia sclerotiorum with activity comparable to com. fungicides. The inhibition of the cytochrome bc1 and the succinate dehydrogenase enzyme activity confirmed that the new mols. are endowed with a dual mechanism of action. These results were further supported by mol. modeling which showed that selected compounds form stable complexes with both cytochrome b subunit and succinate dehydrogenase enzyme. This work can be considered an important first step towards the development of novel dual-action agents with optimized structure and improved interaction with the targets.

Different reactions of this compound(2-Chloronicotinoyl chloride)Recommanded Product: 2-Chloronicotinoyl chloride require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.Recommanded Product: 2-Chloronicotinoyl chloride.

Twenty [1,2,4]triazolo[4,3-a]pyridines I (R = C6H5, 2-ClC6H4, 2-Cl,4-FC6H3, etc,) were designed, synthesized and screened as Smoothened (Smo) inhibitors. Four of these novel compounds exhibited directly bound to Smo protein with stronger binding affinity than Vismodegib (VIS). The new compounds exhibited broad anti-proliferative activity against cancer cell lines in vitro, especially triple-neg. breast cancer cells. Mechanistic studies demonstrated that I (R = 2,6-di-Cl-pyridine) markedly induced cell cycle arrest and apoptosis in MDA-MB-468 cells. Compound I (R = 2,6-di-Cl-pyridine) blocked Smo translocation into the cilia and reduced Smo protein and mRNA expression. Furthermore, the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1) was significantly inhibited. Finally, I (R = 2,6-di-Cl-pyridine) demonstrated greater anti-tumor activity in authors’ animal models than VIS with lower toxicity. Hence, these results support further optimization of this novel scaffold to develop improved Smo antagonists.

The article 《Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo》 also mentions many details about this compound(49609-84-9)Recommanded Product: 2-Chloronicotinoyl chloride, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]) to get more information.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Category: chiral-phosphine-ligands. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Photoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones. Author is Yang, De-Yong; Liu, Liang; Gu, Jia-Yi; He, Yan-Hong; Guan, Zhi.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

The article 《Photoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones》 also mentions many details about this compound(49609-84-9)Category: chiral-phosphine-ligands, you can pay attention to it, because details determine success or failure

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called N-Heterocarbene Palladium Complexes with Dianisole Backbones: Synthesis, Structure, and Catalysis, published in 2019-06-24, which mentions a compound: 49609-84-9, mainly applied to heterocarbene palladium complex dianisole preparation Suzuki coupling catalyst; crystal structure mol palladium complex dianisole heterocyclic carbene preparation, Formula: C6H3Cl2NO.

A series of palladium N-heterocyclic carbenes (NHCs), complexes C1-C5, bearing dianisole backbones and substituted N-aryl moieties have been synthesized and characterized. The electronic effect as well as the steric environment of the NHC ligands has been assessed. The synthesized palladium complexes were applied for Suzuki-Miyaura cross-coupling reactions under aerobic conditions. The relationship between the catalytic structure and catalytic performance was then extensively investigated. Upon optimizing the reaction conditions, the C4 was found to be highly efficient to catalyze the cross-coupling of (hetero)aryl chlorides with (hetero)arylboronic acids at a 0.1 mol % palladium loading.

After consulting a lot of data, we found that this compound(49609-84-9)Formula: C6H3Cl2NO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: 2-Chloronicotinoyl chloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3. Author is Ceballos, Javier; Schwalfenberg, Melanie; Karageorgis, George; Reckzeh, Elena S.; Sievers, Sonja; Ostermann, Claude; Pahl, Axel; Sellstedt, Magnus; Nowacki, Jessica; Carnero Corrales, Marjorie A.; Wilke, Julian; Laraia, Luca; Tschapalda, Kirsten; Metz, Malte; Sehr, Dominik A.; Brand, Silke; Winklhofer, Konstanze; Janning, Petra; Ziegler, Slava; Waldmann, Herbert.

Bioactive compound design based on natural product (NP) structure may be limited because of partial coverage of NP-like chem. space and biol. target space. These limitations can be overcome by combining NP-centered strategies with fragment-based compound design through combination of NP-derived fragments to afford structurally unprecedented “”pseudo-natural products”” (pseudo-NPs). The design, synthesis, and biol. evaluation of a collection of indomorphan pseudo-NPs that combine biosynthetically unrelated indole- and morphan-alkaloid fragments are described. Indomorphane derivative glupin (I) was identified as a potent inhibitor of glucose uptake by selectively targeting and upregulating glucose transporters GLUT-1 and GLUT-3. Glupin suppresses glycolysis, reduces the levels of glucose-derived metabolites, and attenuates the growth of various cancer cell lines. Our findings underscore the importance of dual GLUT-1 and GLUT-3 inhibition to efficiently suppress tumor cell growth and the cellular rescue mechanism, which counteracts glucose scarcity.

After consulting a lot of data, we found that this compound(49609-84-9)Recommanded Product: 2-Chloronicotinoyl chloride can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: 2-Chloronicotinoyl chloride. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Catalyst shuttling enabled by a thermoresponsive polymeric ligand: facilitating efficient cross-couplings with continuously recyclable ppm levels of palladium. Author is Wang, Erfei; Chen, Mao.

A polymeric monophosphine ligand WePhos has been synthesized and complexed with palladium(II) acetate [Pd(OAc)2] to generate a thermoresponsive pre-catalyst that can shuttle between water and organic phases, with the change being regulated by temperature The structure of the polymeric ligand was confirmed with matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) mass spectrometry and size-exclusion chromatog. (SEC) anal., as well as NMR (NMR) measurements. This polymeric metal complex enables highly efficient Pd-catalyzed cross-couplings and tandem reactions using 50 to 500 ppm palladium, and this can facilitate reactions that are tolerant to a broad spectrum of (hetero)aryl substrates and functional groups, as demonstrated with 73 examples with up to 99% isolated yields. Notably, 97% Pd remained in the aqueous phase after 10 runs of catalyst recycling experiments, as determined via inductively coupled plasma-at. emission spectrometry (ICP-AES) measurements, indicating highly efficient catalyst transfer. Furthermore, a continuous catalyst recycling approach has been successfully developed based on flow chem. in combination with the catalyst shuttling behavior, allowing Suzuki-Miyaura couplings to be conducted at gram-scales with as little as 10 ppm Pd loading. Given the significance of transition-metal catalyzed cross-coupling and increasing interest in sustainable chem., this work is an important step towards the development of a responsive catalyst.

After consulting a lot of data, we found that this compound(49609-84-9)Recommanded Product: 2-Chloronicotinoyl chloride can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 49609-84-9, is researched, Molecular C6H3Cl2NO, about Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor, the main research direction is germacrane sesquiterpenoid Aristolochia anticardiac fibrosis fibronectin alpha SMA Smad.Application of 49609-84-9.

A germacrane sesquiterpenoid library containing 30 compounds (2-31) was constructed by structural modification of a major component aristolactone (1) from the traditional Chinese medicine Aristolochia yunnanensis. Compound 11 was identified as a promising anticardiac fibrosis agent by systematic screening of this library. 11 could inhibit the expression of fibronectin (FN), α-smooth muscle actin (α-SMA), and collagens in transforming growth factor β 1 (TGFβ1)-stimulated cardiac fibroblasts at a micromolar level and ameliorate myocardial fibrosis and heart function in abdominal aortic constriction (AAC) rats at 5 mg/kg dose. Mechanistic study revealed that 11 inhibited the TGFβ/small mother against decapentaplegic (Smad) signaling pathway by targeting TGFβ type I receptor (IC50 = 14.9 ± 1.6 nM). The structure-activity relationships (SARs) study indicated that the unsaturated γ-lactone ring and oxidation of C-1 were important to the activity. These findings may provide a new type of structural motif for future anticardiac fibrosis drug development.

Although many compounds look similar to this compound(49609-84-9)Application of 49609-84-9, numerous studies have shown that this compound(SMILES:O=C(Cl)C1=CC=CN=C1Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application In Synthesis of 2-Chloronicotinoyl chloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ-opiate receptor 1 (OPRM1) expressing cells. Author is Hsu, Tom; Mallareddy, Jayapal R.; Yoshida, Kayla; Bustamante, Vincent; Lee, Tim; Krstenansky, John L.; Zambon, Alexander C..

Opioids are powerful analgesics acting via the human μ-opiate receptor (hMOR). Opioid use is associated with adverse effects such as tolerance, addiction, respiratory depression, and constipation. Two synthetic opioids, AH-7921 and U-47700 that were developed in the 1970s but never marketed, have recently appeared on the illegal drug market and in forensic toxicol. reports. These agents were initially characterized for their analgesic activity in rodents; however, their pharmacol. at hMOR has not been delineated. Thus, we synthesized over 50 chem. analogs based on core AH-7921 and U-47700 structures to assess for their ability to couple to Gαi signaling and induce hMOR internalization. For both the AH-7921 and U-47700 analogs, the 3,4-dichlorobenzoyl substituents were the most potent with comparable EC50 values for inhibition of cAMP accumulation; 26.49 ± 11.2 nmol L-1 and 8.8 ± 4.9 nmol L-1, resp. Despite similar potencies for Gαi coupling, these two compounds had strikingly different hMOR internalization efficacies: U-47700 (10μmol L-1) induced ∼25% hMOR internalization similar to DAMGO while AH-7921 (10μmol L-1) induced ∼5% hMOR internalization similar to morphine. In addition, the (R,R)-enantiomer of U-47700 is significantly more potent than the (S,S)-enantiomer at hMOR. In conclusion, these data suggest that U-47700 and AH-7921 analogs have high analgesic potential in humans, but with divergent receptor internalization profiles, suggesting that they may exhibit differences in clin. utility or abuse potential.

Although many compounds look similar to this compound(49609-84-9)Application In Synthesis of 2-Chloronicotinoyl chloride, numerous studies have shown that this compound(SMILES:O=C(Cl)C1=CC=CN=C1Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate