Category: 4559-70-0

New learning discoveries about 4559-70-0

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

4559-70-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: Under an argon atmosphere, the carbonyl compounds (0.24 mmol, 1.2 eq), TsNHNH2 (0.252 mmol, 1.26 eq) and anhydrous dioxane (2.0 mL) were successively added to a flame-dried Schlenk flask. The reaction was heated at 60 ?C with stirring for 30 minutes. After the solution cooled down to room temperature diphenyl phosphine oxide 1a (0.20 mmol, 1.0 eq), K2CO3 (0.60 mmol, 3.0 eq), and CuI (0.02 mmol, 10 mol %) were sequentially added to the system. The mixture was stirred to reflux. When the reaction was considered complete, as determined by TLC analysis, the reaction mixture was cooled to room temperature. Water was added to the mixture and extracted with ethyl acetate twice. The combined organic phase was washed with brine and dried over Na2SO4. The concentrated residue was purified by column chromatography over silica gel using petroleum ether/ethyl acetate (1:1) as eluent to get the product.

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Zi-Sheng; Zhou, Zhao-Zhao; Hua, Hui-Liang; Duan, Xin-Hua; Luo, Jian-Yi; Wang, Jia; Zhou, Ping-Xin; Liang, Yong-Min; Tetrahedron; vol. 69; 3; (2013); p. 1065 – 1068;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Simple exploration of 4559-70-0

4559-70-0, As the paragraph descriping shows that 4559-70-0 is playing an increasingly important role.

4559-70-0, Diphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of dicyclohexylcarbonyl peroxide (127 mg, 0.5 mmol), copper oxide (7.9 mg, 0.1 mmol), 3,4,7,8-tetramethyl-1,10-phenanthroline (11.8 mg, 0.05 mmol), dichloromethane (1 mL) and diphenylphosphoryl (50.5 mg, 0.25 mmol), stirred at 40 C, and monitored by TLC until the end of the reaction;The crude product obtained after the completion of the reaction was separated by column chromatography ( petroleum ether: acetone = 4:1) to give the desired product (yield: 77%).

4559-70-0, As the paragraph descriping shows that 4559-70-0 is playing an increasingly important role.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Tao Zekun; (13 pag.)CN110229187; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

New learning discoveries about 4559-70-0

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexylcarboxylic acid (136 mg, 1 mmol), 4-dimethylaminopyridine (DMAP, 18.3 mg, 0.15 mmol), dicyclohexylcarbodiimide (DCC, 340 mg, 1.65 mmol), and hydrogen peroxide to the reaction flask. (57 muL 1.9 mmol) and dichloromethane (5 mL), stirred at room temperature for 2 hours, filtered, and distilled off the solvent in the filtrate to obtain a concentrate;To the concentrate were added copper bromide (17.8 mg, 0.08 mmol), 6,6′-dimethyl-2,2′-bipyridine (14.7 mg, 0.08 mmol), and ethylene glycol dimethyl ether (1 mL). And diphenylphosphine (50.5 mg, 0.25 mmol), stirred at 60 oC, TLC monitoring until the end of the reaction;The crude product obtained after the reaction was separated by column chromatography (petroleum ether: acetone = 4: 1) to obtain the target product (yield 75%).

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate