Category: 40400-13-3

Reference of 1-(Bromomethyl)-2-iodobenzene. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Development of the “”Diverted Heck”” Reaction for the Synthesis of Five-Membered Rings. Author is Breitwieser, Kevin; Chen, Peter.

The diverted Heck reaction is a potent method to synthesize cyclopropanes from electron-rich olefins and iodomethyl trifluoroborate. Nevertheless, it is not mechanistically limited to the three-membered rings. The synthesis of five-membered rings using bifunctional substrates with a halide moiety and an organometallic group is described. Also, the reactions of the resp. B and Sn-based substrates are further studied and optimized.

From this literature《Development of the “”Diverted Heck”” Reaction for the Synthesis of Five-Membered Rings》,we know some information about this compound(40400-13-3)Reference of 1-(Bromomethyl)-2-iodobenzene, but this is not all information, there are many literatures related to this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Quality Control of 1-(Bromomethyl)-2-iodobenzene. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Intramolecular Palladium-Catalyzed Ring Opening of Oxabenzonorbornadienes with C1-Tethered Aryl Halides. Author is Koh, Samuel; Pounder, Austin; Brown, Elizabeth; Tam, William.

The novel intramol. ring opening of oxabenzonorbornadienes with C1-tethered aryl halides was investigated using palladium catalysts to form fused tetracyclic frameworks. The reaction was generally found to synthesize 1,2-dihydronaphthalen-1-ol products with mild selectivity but was capable of synthesizing dehydrated naphthalene products in excellent yield and selectivity. Substituent effects on oxabenzonorbornadiene and on the iodoarene were explored along with the effects of varying tether length, where an efficient reaction was observed in nearly all cases. A total of 16 examples are reported with yields ranging from 0 to 96%.

From this literature《Intramolecular Palladium-Catalyzed Ring Opening of Oxabenzonorbornadienes with C1-Tethered Aryl Halides》,we know some information about this compound(40400-13-3)Quality Control of 1-(Bromomethyl)-2-iodobenzene, but this is not all information, there are many literatures related to this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.He, Jun; Xue, Yuhang; Han, Bo; Zhang, Chunzhu; Wang, You; Zhu, Shaolin researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).Product Details of 40400-13-3.They published the article 《Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes》 about this compound( cas:40400-13-3 ) in Angewandte Chemie, International Edition. Keywords: chiral amine synthesis pyrox nickel catalyzed asym reductive carboamination; pyrox nickel catalyzed reductive carboamination alkene benzoyl hydroxylamine; alkenes; asymmetric catalysis; carboamination; nickel; synthetic methods. We’ll tell you more about this compound (cas:40400-13-3).

Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis.

From this literature《Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes》,we know some information about this compound(40400-13-3)Product Details of 40400-13-3, but this is not all information, there are many literatures related to this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-2-iodobenzene(SMILESS: BrCC1=C(I)C=CC=C1,cas:40400-13-3) is researched.Category: chlorides-buliding-blocks. The article 《Copper-catalyzed direct C-H arylselenation of 4-nitro-pyrazoles and other heterocycles with selenium powder and aryl iodides. Access to unsymmetrical heteroaryl selenides》 in relation to this compound, is published in RSC Advances. Let’s take a look at the latest research on this compound (cas:40400-13-3).

A one-pot, Cu-catalyzed direct C-H arylselenation protocol using elemental Se and aryl iodides was developed for nitro-substituted, N-alkylated pyrazoles, imidazoles and other heterocycles including 4H-chromen-4-one. This general and concise method allows one to obtain a large number of unsym. heteroaryl selenides bearing a variety of substituents. The presence of the nitro group was confirmed to be essential for the C-H activation and can also be used for further functionalisation and manipulation. Several examples of heteroannulated benzoselenazines were also synthesized using the developed synthetic protocol.

From this literature《Copper-catalyzed direct C-H arylselenation of 4-nitro-pyrazoles and other heterocycles with selenium powder and aryl iodides. Access to unsymmetrical heteroaryl selenides》,we know some information about this compound(40400-13-3)Name: 1-(Bromomethyl)-2-iodobenzene, but this is not all information, there are many literatures related to this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 40400-13-3, is researched, Molecular C7H6BrI, about Cyclohepta[b]thiophenes as Potential Antiproliferative Agents: Design, Synthesis, In Vitro, and In Vivo Anticancer Evaluation, the main research direction is cyclohepta thiophene derivative preparation cancer.Formula: C7H6BrI.

Several thiophene featuring compounds are known for their promising antiproliferative activity. Prompted by the urgent need to identify new potent anticancer agents, 16 compounds of benzamides, benzylamines, and urea analogs incorporating a cyclohepta[b]thiophene scaffold were synthesized and biol. evaluated with a cell proliferation assay using the A549 nonsmall cell lung cancer cell line. Compound 17 demonstrated both potent and broad-spectrum anticancer activity with submicromolar 50% growth inhibition (GI50) values. It also showed superior antiproliferative activity (vs nocodazole) in OVACAR-4, OVACAR-5, CAKI-1, and T47D cell lines with GI50 values of 2.01 (vs 22.28), 2.27 (vs 20.75), 0.69 (vs 1.11), and 0.362 (vs 81.283) μM, resp. Addnl., compound 17 displayed minimal cytotoxicity based on 50% lethal concentration (LC50) values toward all tested cell lines. Further cell-based mechanistic studies of compound 17 revealed its ability to induce cell cycle arrest of A549 cells as evidenced by dose dependent G2/M accumulation. Furthermore, induction of early apoptosis along with activation of caspase 3, 8, and 9 were confirmed in A549 cells treated with compound 17. Targeting tubulin polymerization may explain the mechanism of the antiproliferative activity of compound 17 based on cell cycle anal., detected apoptosis, and in vitro inhibition of tubulin polymerization In vitro data were further supported by in vivo antitumor efficacy studies of compound 17 in a CT26 murine model for which the results showed a reduction in the tumor growth compared to untreated mice. Overall, compound 17 has the potential to function as a promising candidate for further development of potent anticancer chemotherapeutics.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Computed Properties of C7H6BrI. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Phenalenannulations: Three-Point Double Annulation Reactions that Convert Benzenes into Pyrenes. Author is Kawade, Rahul Kisan; Hu, Chaowei; Dos Santos, Nikolas R.; Watson, Noelle; Lin, Xinsong; Hanson, Kenneth; Alabugin, Igor V..

3-Point annulations, or phenalenannulations, transform a benzene ring directly into a substituted pyrene by “”wrapping”” two new cycles around the perimeter of the central ring at three consecutive carbon atoms. This efficient, modular, and general method for π-extension opens access to non-sym. pyrenes and their expanded analogs, e.g., I. Potentially, this approach can convert any aromatic ring bearing a -CH2Br or a -CHO group into a pyrene moiety. Depending upon the workup choices, the process can be directed towards either tin- or iodo-substituted product formation, giving complementary choices for further various cross-coupling reactions. The two-directional bis-double annulation adds two new polyaromatic extensions with a total of six new aromatic rings at a central core.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

SDS of cas: 40400-13-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Long-lived, strongly emissive, and highly reducing excited states in Mo(0) complexes with chelating isocyanides. Author is Herr, Patrick; Glaser, Felix; Buldt, Laura A.; Larsen, Christopher B.; Wenger, Oliver S..

Newly discovered tris(diisocyanide)molybdenum(0) complexes are Earth-abundant isoelectronic analogs of the well-known class of [Ru(α-diimine)3]2+ compounds with long-lived 3MLCT (metal-to-ligand charge transfer) excited states that lead to rich photophysics and photochem. Depending on ligand design, luminescence quantum yields up to 0.20 and microsecond excited state lifetimes are achieved in solution at room temperature, both significantly better than those for [Ru(2,2′-bipyridine)3]2+. The excited Mo(0) complexes can induce chem. reactions that are thermodynamically too demanding for common precious metal-based photosensitizers, including the widely employed fac-[Ir(2-phenylpyridine)3] complex, as demonstrated on a series of light-driven aryl-aryl coupling reactions. The most robust Mo(0) complex exhibits stable photoluminescence and remains photoactive after continuous irradiation exceeding 2 mo. Our comprehensive optical spectroscopic and photochem. study shows that Mo(0) complexes with diisocyanide chelate ligands constitute a new family of luminophores and photosensitizers, which is complementary to precious metal-based 4d6 and 5d6 complexes and represents an alternative to nonemissive Fe(II) compounds This is relevant in the greater context of sustainable photophysics and photochem., as well as for possible applications in lighting, sensing, and catalysis.

When you point to this article, it is believed that you are also very interested in this compound(40400-13-3)SDS of cas: 40400-13-3 and due to space limitations, I can only present the most important information.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

HPLC of Formula: 40400-13-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes. Author is Yuan, Zhenbo; Feng, Ziwen; Zeng, Yuye; Zhao, Xiaobin; Lin, Aijun; Yao, Hequan.

A palladium-catalyzed asym. reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β-hydrogen atoms, was realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibited good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jin, Ming; Yin, Shi-fu; Yang, Shang-Dong researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).SDS of cas: 40400-13-3.They published the article 《Bismuth(III)-Catalyzed Sequential Enamine-Imine Tautomerism/2-Aza-Cope Rearrangement of Stable β-Enaminophosphonates: One-Pot Synthesis of β-Aminophosphonates》 about this compound( cas:40400-13-3 ) in Organic Letters. Keywords: beta aminophosphonate preparation tandem condensation Cope rearrangement phosphonoaldehyde amine; tandem condensation aza Cope rearrangement phosphonoaldehyde homoallylamine preparation aminophosphonate; bismuth triflate catalyst tandem condensation aza Cope rearrangement phosphonoaldehyde. We’ll tell you more about this compound (cas:40400-13-3).

Bismuth triflate-catalyzed condensation of phosphonoaldehydes OHCCHR1P(O)(OR2)2 with homoallylic amine H2NCPh2CH2CH:CH2 gives β-aminophosphonates I (3a-o; R1 = substituted benzyl, H, allyl, cinnamyl, iBu, cyclopropyl; R2 = Et iPr) via tandem aza-Cope rearrangement. A novel catalytic tautomeric transformation of a β-enaminophosphoryl and 2-aza-Cope rearrangement sequence has been successfully applied to the one-pot synthesis of β-aminophosphonates with high efficiency and good tolerance. In this tandem reaction, Bi(OTf)3 exhibits unique activities and promotes both of enamine-imine tautomerism and 2-aza-Cope rearrangement.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

HPLC of Formula: 40400-13-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Difluorocarbene-derived trifluoromethylselenolation of benzyl halides.

Cu-Promoted difluorocarbene-derived trifluoromethylselenolation of benzyl halides RX [R = C6H5(CH2)2, naphthalen-2-ylmethyl, (3,4-dichlorophenyl)methyl, etc.; X = Cl, Br] with the Ph3P+CF2CO2-/Se/F- system is described. Three new carbon-heteroatom bonds, a Se-CF2 bond, SeCF2-F bond, and C-SeCF3 bond, were sequentially formed in the reaction. This work represents the first trifluoromethylselenolation protocol involving an external fluoride for the generation of the key intermediate, CF3Se- anion.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate