Category: 40400-13-3

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-2-iodobenzene(SMILESS: BrCC1=C(I)C=CC=C1,cas:40400-13-3) is researched.Application In Synthesis of 5-Chloropicolinaldehyde. The article 《Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:40400-13-3).

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known cure. Aggregates of the nuclear protein TDP-43 have been recognized as a hallmark of proteinopathy in both familial and sporadic cases of ALS. Post-translational modifications of this protein, include hyperphosphorylation, cause disruption of TDP-43 homeostasis and as a consequence, promotion of its neurotoxicity. Among the kinases involved in these changes, cell division cycle kinase 7 (CDC7) plays an important role by directly phosphorylating TDP-43. In the present manuscript the discovery, synthesis, and optimization of a new family of selective and ATP-competitive CDC7 inhibitors based on 6-mercaptopurine scaffold are described. Moreover, we demonstrate the ability of these inhibitors to reduce TDP-43 phosphorylation in both cell cultures and transgenic animal models such as C. elegans and Prp-hTDP43 (A315T) mice. Altogether, the compounds described here may be useful as versatile tools to explore the role of CDC7 in TDP-43 phosphorylation and also as new drug candidates for the future development of ALS therapies.

Here is just a brief introduction to this compound(40400-13-3)Computed Properties of C7H6BrI, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Synthetic Route of C7H6BrI. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about A case of chain propagation: α-aminoalkyl radicals as initiators for aryl radical chemistry. Author is Constantin, Timothee; Julia, Fabio; Sheikh, Nadeem S.; Leonori, Daniele.

The generation of aryl radicals from the corresponding halides by redox chem. was generally considered a difficult task due to their highly neg. reduction potentials. The α-aminoalkyl radicals can be used as both initiators and chain-carriers for the radical coupling of aryl halides with pyrrole derivatives, a transformation often employed to evaluate new highly reducing photocatalysts. The mode of reactivity obviates for the use of strong reducing species and was also competent in the formation of sp2 C-P bonds. Mechanistic studies have delineated some of the key features operating that trigger aryl radical generation and also propagate the chain process.

Here is just a brief introduction to this compound(40400-13-3)Synthetic Route of C7H6BrI, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Palladium-Catalyzed Synthesis of 6H-Dibenzo[c,h]chromenes and 5,6-Dihydrobenzo[c]phenanthridines: Application to the Synthesis of Dibenzo[c,h]chromene-6-ones, Benzo[c]phenanthridines, and Arnottin I.Formula: C7H6BrI.

6H-Dibenzo[c,h]chromenes, e.g. I, and N-tosyl-5,6-dihydrobenzo[c]phenanthridines II [R1 = H, 9-Cl, 8-CO2Me; R2 = H, 2-F, 2-Br, etc.] were synthesized via Pd-catalyzed domino reactions of acetylenic substrates involving intramol. trans-oxo/amino palladation onto the triple bond followed by nucleophilic addition of the intermediate to a tethered cyano/aldehyde. The scope of this reaction was extended through one step conversion of some of the products to 6H-dibenzo[c,h]chromen-6-ones and benzo[c]phenanthridines. Utilization of this methodol. led to a formal total synthesis of the natural product arnottin I.

Here is just a brief introduction to this compound(40400-13-3)Formula: C7H6BrI, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: 1-(Bromomethyl)-2-iodobenzene. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about An Efficient Route to Isochromene Derivatives via Cascade Radical Cyclization and Radical-Radical Coupling. Author is Yu, Kaili; Li, Minyan; Deng, Guogang; Liu, Chunxiang; Wang, Jing; Liu, Zhengfen; Zhang, Hongbin; Yang, Xiaodong; Walsh, Patrick J..

Isochromene synthesis is generally limited to cyclization of Ph propargyl ether precursors under transition metal catalyzed conditions. Herein, authors present a novel disconnection that rapidly constructs isochromene derivatives I (R1 = H, 7-Me, 7-F, etc.; R2 = H, Me, C6H5; R3 = H, Me) and II (Ar = 4-MeC6H4, 4-FC6H4, 2-pyridyl, etc.) through a cascade radical cyclization strategy. Generation of aryl radicals by SET reduction of 2-iodo benzyl allenyl ethers is followed by radical cyclization to construct the isochromene core with formation of an allylic radical. The allylic radical then undergoes coupling with the azaallyl radical to give products in good to excellent yields. The elaborated 2-iodo Ph propargyl ether precursors can be used to construct isochromenes bearing various functional groups.

Here is just a brief introduction to this compound(40400-13-3)Recommanded Product: 1-(Bromomethyl)-2-iodobenzene, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Obul, Mamateli; Wang, Xincheng; Zhao, Jiangyu; Li, Gen; Aisa, Haji Akber; Huang, Guozheng published the article 《Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus》. Keywords: influenza B virus rupestonic acid kidney cell; Artemisia rupestris; Benzylation; Influenza virus; Rupestonic acid.They researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).Safety of 1-(Bromomethyl)-2-iodobenzene. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:40400-13-3) here.

Influenza viruses are responsible for seasonal epidemics and occasional pandemics, which cause significant morbidity and mortality. Although several drugs (adamantanes and neuraminidase inhibitors) are available in the market, the worldwide spread of drug-resistant influenza strains poses an urgent need for novel antiviral drugs. Artemisia rupestris L. is a folk medicine used to treat cold. In this paper, we structurally modified rupestonic acid, a bioactive component of A. rupestris, to synthesize a series of 2-substituted rupestonic acid Me esters (3a-3o). Their structures were fully characterized by 1H NMR, 13C NMR, HRMS spectra. Among them, compounds 3b and 3c exhibited potent activities against influenza H1N1 with micromolar IC50 values and might serve as new lead compounds for the treatment of influenza.

Here is just a brief introduction to this compound(40400-13-3)Safety of 1-(Bromomethyl)-2-iodobenzene, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Shan, Xiang-Huan; Zheng, Hong-Xing; Yang, Bo; Tie, Lin; Fu, Jia-Le; Qu, Jian-Ping; Kang, Yan-Biao published the article 《Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay》. Keywords: nitrile alkylaryl halide copper catalyst oxidative heterocyclization; indole preparation.They researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).Computed Properties of C7H6BrI. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:40400-13-3) here.

The combination of base-promoted benzylic C-H cleavage and copper-catalyzed carbanion-radical redox relay was reported. Catalytic amount of naturally abundant and inexpensive copper salt, such as copper(II) sulfate, was used for anion-radical redox relay without any external oxidant. By avoiding using N-O/N-N homolysis or radical initiators to generate iminyl radicals, this strategy realized modular synthesis of N-H indoles and analogs from abundant feedstocks, such as toluene and nitrile derivatives, and also enabled rapid synthesis of large scale pharmaceuticals.

Here is just a brief introduction to this compound(40400-13-3)Computed Properties of C7H6BrI, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: 1-(Bromomethyl)-2-iodobenzene. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Three-Component Synthesis of 2-Substituted Thiobenzoazoles Using Tetramethyl Thiuram Monosulfide (TMTM) as Thiocarbonyl Surrogate.

A metal-free synthesis of 2-benzyl/allyl-substituted thiobenzoazoles was developed starting from tetra-Me thiuram monosulfide (TMTM) which served as thiocarbonyl surrogate. By using 2-aminophenols (or 2-aminothiophenols, or 1,2-phenylenediamines) and TMTM as starting materials, 2-mercaptobenzoazoles could be synthesized efficiently. The subsequent C-S bond formation with benzyl/allyl halides gave the final products (2-benzyl/allyl-substituted thiobenzoazoles) with good to excellent yields. The metal-free conditions, inexpensive and easily available starting materials, and broad substrate scope are the advantageous features of this protocol.

Here is just a brief introduction to this compound(40400-13-3)Recommanded Product: 1-(Bromomethyl)-2-iodobenzene, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Intramolecular palladium(II)/(IV) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group, published in 2019, which mentions a compound: 40400-13-3, mainly applied to indane aldehyde preparation; tertiary aldehyde arylation palladium imine catalyst, Application In Synthesis of 1-(Bromomethyl)-2-iodobenzene.

Palladium catalyzed β-C(sp3)-H activation of tertiary aldehydes RCH2C(R1)(R2)CHO [R = 2-Br-5-ClC6H3, 2-IC6H4, 2-Br-4-H3COC6H3, etc.; R1 = Me, Et, n-Pr; R2 = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R4 = H, 5-F, 4-Cl, 5-CF3, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step.

Here is just a brief introduction to this compound(40400-13-3)Application In Synthesis of 1-(Bromomethyl)-2-iodobenzene, more information about the compound(1-(Bromomethyl)-2-iodobenzene) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Catalysts called Gold(I)-Catalyzed Tandem Synthesis of Polycyclic Dihydroquinazolinones, Author is Sun, Jingyang; Song, Yoona; Ryu, Jae-Sang, which mentions a compound: 40400-13-3, SMILESS is BrCC1=C(I)C=CC=C1, Molecular C7H6BrI, HPLC of Formula: 40400-13-3.

A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds such as I was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones such as I.

Compound(40400-13-3)HPLC of Formula: 40400-13-3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bromomethyl)-2-iodobenzene), if you are interested, you can check out my other related articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Abdullaha, Mohd; Ali, Mehboob; Kour, Dilpreet; Mudududdla, Ramesh; Khajuria, Parul; Kumar, Ajay; Bharate, Sandip B. published the article 《Tetramethoxystilbene Inhibits NLRP3 Inflammasome Assembly via Blocking the Oligomerization of Apoptosis-Associated Speck-like Protein Containing Caspase Recruitment Domain: In Vitro and In Vivo Evaluation》. Keywords: tetramethoxystilbene preparation oligomerization.They researched the compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ).Recommanded Product: 40400-13-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:40400-13-3) here.

Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1β (IL-1β). Various inflammatory diseases involve the activation of inflammasome complexes; thus, the intervention in complex formation via small mols. offers a new therapeutic opportunity. The structure-guided design and synthesis of a series of methoxystilbenes and methoxy-2-phenylnaphthalenes identified new inhibitors of NLRP3 inflammasome complex. The tetramethoxystilbene 4o and trimethoxy 2-phenylnaphthalene 1t inhibit the release of a mature form of IL-1β in J774A.1 cells with IC50 values of 1.39 and 2.07μM, resp. Mechanistic investigation revealed that tetramethoxystilbene 4o blocks the oligomerization of apoptosis-associated speck-like protein (ASC), which is the vital step in the formation of NLRP3 inflammasome assembly, thus preventing the activation of caspase-1 and the IL-1β release. Treatment of LPS+ATP challenged mice with 20 mg/kg of 4o significantly suppressed the levels of IL-1β. The data presented herein warrant further investigation of methoxystilbenes in disease-specific models of inflammatory diseases.

Compound(40400-13-3)Recommanded Product: 40400-13-3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bromomethyl)-2-iodobenzene), if you are interested, you can check out my other related articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate