Category: 40400-13-3

Category: chiral-phosphine-ligands. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Selenenate Anions (PhSeO-) as Organocatalyst: Synthesis of trans-Stilbenes and a PPV Derivative. Author is Zheng, Zhipeng; Trofymchuk, Oleksandra S.; Kurogi, Takashi; Varela, Elena; Mindiola, Daniel J.; Walsh, Patrick J..

The selenenate anion (RSeO-) is introduced as an active organocatalyst for the dehydrohalogenation coupling of benzyl halides to form trans-stilbenes. It is shown that RSeO- is a more reactive catalyst than the previously reported sulfur analogs (sulfenate anion, RSO-) and selenolate anions (RSe-) in the aforementioned reaction. This catalytic system was also applied to the benzylic-chloromethyl-coupling polymerization (BCCP) of a bis-chloromethyl arene to form ppv (poly(p-phenylene vinylene))-type polymers with high yields, Mn (average mol. weight) up to 13,000 and D (dispersity) of 1.15.

Compounds in my other articles are similar to this one(1-(Bromomethyl)-2-iodobenzene)Category: chiral-phosphine-ligands, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Thiophene Derivative-Loaded Nanoparticles Mediate Anticancer Activity Through the Inhibition of Kinases and Microtubule Assembly, published in 2021-07-31, which mentions a compound: 40400-13-3, mainly applied to thiophene nanoparticle anticancer kinase inhibition microtubule assembly; Antimitotic drugs; Caspase activity; Cell cycle arrest; Microtubule assembly; Nanoparticles; Tetrahydrobenzo[b]thiophenes; Tubulin polymerization, COA of Formula: C7H6BrI.

Different tetrahydrobenzo[b]thiophene derivatives are explored as new tubulin polymerization destabilizers to arrest tumor cell mitosis. A series of compounds incorporating the tetrahydrobenzo[b]thiophene scaffold are synthesized, and their biol. activities are investigated. The cytotoxicity of each of the synthesized compounds is assessed against a range of cell lines. Specifically, the benzyl urea tetrahydrobenzo[b]thiophene derivative, 1-benzyl-3-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)urea (BU17), is identified as the most potent compound with broad-spectrum antitumor activity against several cancer cell lines. The potential mechanism(s) of action are investigated where dose-dependent G2/M accumulation and A549 cell cycle arrest are detected. Addnl., A549 cells treated with BU17 express enhanced levels of caspase 3 and 9, indicating the induction of apoptosis. Furthermore, it is found that BU17 inhibits WEE1 kinase and targets tubulin by blocking its polymerization BU17 is also formulated into PLGA nanoparticles, and it is demonstrated that BU17-loaded nanoparticles can significantly enhance antitumor activity compared to the soluble counterpart.

Compounds in my other articles are similar to this one(1-(Bromomethyl)-2-iodobenzene)COA of Formula: C7H6BrI, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-2-iodobenzene( cas:40400-13-3 ) is researched.Product Details of 40400-13-3.Chang, Chenyang; Zhang, Huihui; Wu, Xinxin; Zhu, Chen published the article 《Radical trifunctionalization of hexenenitrile via remote cyano migration》 about this compound( cas:40400-13-3 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: hexenenitrile radical trifunctionalization remote cyano migration. Let’s learn more about this compound (cas:40400-13-3).

A novel radical-mediated trifunctionalization of hexenenitriles via the strategy of remote functional group migration is disclosed. A portfolio of functionalized hexenenitriles are employed as substrates. After difunctionalization of the unactivated alkenyl part via remote cyano migration, the in situ formed radical intermediate is captured by an azido radical, thus enabling the trifunctionalization. The reaction features mild conditions and broad functional group compatibility, leading to valuable products bearing multiple useful groups. This protocol further extends the scope of remote functional group migration.

Compounds in my other articles are similar to this one(1-(Bromomethyl)-2-iodobenzene)Product Details of 40400-13-3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

SDS of cas: 40400-13-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. Author is Lee, Sujin; Cil, Onur; Haggie, Peter M.; Verkman, Alan S..

The chloride/bicarbonate exchanger SLC26A3 (down-regulated in adenoma, DRA) is expressed mainly in colonic epithelium where it dehydrates the stool by facilitating the final step of chloride and fluid absorption. SLC26A3 inhibition has predicted efficacy in various types of constipation including that associated with cystic fibrosis. We previously identified, by high-throughput screening, 4,8-dimethylcoumarin inhibitors of murine slc26a3 with IC50 down to ∼150 nM. Here, we synthesized a focused library of forty-three 4,8-dimethylcoumarin analogs. Structure-activity studies revealed the requirement of 4,8-dimethylcoumarin-3-acetic acid for activity. The most potent inhibitors were produced by replacements at C7, including 3-iodo- (4az(I)) and 3-trifluoromethyl- (4be(II)), with IC50 of 40 nM and 25 nM, resp. Pharmacokinetics in mice showed predicted therapeutic concentrations of I for >72 h following a single 10 mg/kg oral dose. I at 10 mg/kg fully normalized stool water content in a loperamide-induced mouse model of constipation. The favorable inhibition potency, selectivity within the SLC26 family and pharmacol. properties of I support its further preclin. development.

As far as I know, this compound(40400-13-3)SDS of cas: 40400-13-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Synthetic Route of C7H6BrI. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Intramolecular Homolytic Substitution Enabled by Photoredox Catalysis: Sulfur, Phosphorus, and Silicon Heterocycle Synthesis from Aryl Halides. Author is Garrido-Castro, Alberto F.; Salaverri, Noelia; Maestro, M. Carmen; Aleman, Jose.

Aryl radical generation and manipulation constitutes a long-standing challenge in organic synthesis. Photocatalytic single-electron reduction of aryl halides was established as a premier activation pathway to reach these intermediates. The current study integrates the conceptual simplicity of the classical intramol. homolytic substitution with the practicality of the modern photocatalytic approach. Predicated on an efficient metal-free dehalogenation of aryl halides under mild organo-photoredox conditions, sulfur, phosphorus, and silicon heteroatoms capture the C(sp2)-centered radical in an intramol. fashion.

This literature about this compound(40400-13-3)Synthetic Route of C7H6BrIhas given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-2-iodobenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Cobalt-Catalyzed Dearomatization of Indoles via Transfer Hydrogenation To Afford Polycyclic Indolines.Electric Literature of C7H6BrI.

A cobalt-catalyzed dearomatization of indoles via transfer hydrogenation with HBpin and H2O was developed. This reaction offered a straightforward platform to access hexahydropyrido[1,2-a]indoles in high regio- and chemoselectivity. A preliminary reaction mechanism was proposed on the basis of deuterium-labeling experiments, and a cobalt hydride species was involved in the reaction.

This literature about this compound(40400-13-3)Electric Literature of C7H6BrIhas given us a lot of inspiration, and I hope that the research on this compound(1-(Bromomethyl)-2-iodobenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Name: 1-(Bromomethyl)-2-iodobenzene. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Direct Formation of 2-Substituted 2H-Indazoles by a Pd-Catalyzed Reaction between 2-Halobenzyl Halides and Arylhydrazines.

A direct and operationally simple method for the regioselective synthesis of 2-aryl-substituted 2H-indazoles is reported. The Pd-catalyzed reaction between easily available 2-bromobenzyl bromides and arylhydrazines employing Cs2CO3 as the base and t-Bu3PHBF4 as the ligand in DMSO at 120°C in a sealed tube delivers the 2-substituted-2H-indazoles in a single synthetic step with yields up to 79%. The new method is based on a regioselective intermol. N-benzylation followed by intramol. N-arylation and oxidation

In addition to the literature in the link below, there is a lot of literature about this compound(1-(Bromomethyl)-2-iodobenzene)Name: 1-(Bromomethyl)-2-iodobenzene, illustrating the importance and wide applicability of this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Nickel-Catalyzed Reductive Arylalkylation via a Migratory Insertion/Decarboxylative Cross-Coupling Cascade, the main research direction is nickel catalyst reductive arylalkylation migratory insertion decarboxylative coupling cascade.Formula: C7H6BrI.

Reported is a nickel-catalyzed reductive arylalkylation of unactivated alkenes tethered to aryl iodides with redox active N-hydroxyphthalimide esters as the alkyl source through successful merging of migratory insertion and decarboxylative cross-coupling in a cascade. This new method avoids the use of pregenerated organometallic reagents and thus enables the synthesis of diverse benzene-fused carbo- and heterocyclic compounds with high tolerance of a wide range of functional groups.

In addition to the literature in the link below, there is a lot of literature about this compound(1-(Bromomethyl)-2-iodobenzene)Formula: C7H6BrI, illustrating the importance and wide applicability of this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Computed Properties of C7H6BrI. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Bromomethyl)-2-iodobenzene, is researched, Molecular C7H6BrI, CAS is 40400-13-3, about Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C-H insertion of donor/donor carbenes. Author is Nickerson, Leslie A.; Bergstrom, Benjamin D.; Gao, Mingchun; Shiue, Yuan-Shin; Laconsay, Croix J.; Culberson, Matthew R.; Knauss, Walker A.; Fettinger, James C.; Tantillo, Dean J.; Shaw, Jared T..

Using donor/donor carbenes and Rh2(R-PTAD)4 as a catalyst, a collection of isochroman substrates I (R1 = Me, 4-NCC6H4, 4-MeOC6H4, 3-pyridyl, R2 = 4-MeOC6H4; R1 = Ph, R2 = MeCC, H2C:CMe, PhCH:CH, Ph, etc.) was synthesized in good yields with excellent diastereo- and enantioselectivity from the corresponding hydrazones II, and no rearrangement products were observed Furthermore, this procedure was applied to the first synthesis of tetrahydroisoquinolines via C-H insertion. In one case, a Stevens rearrangement product was isolated at elevated temperature from a carbamate-protected amine substrate, and computational evidence suggested formation through a free ylide not bound to rhodium.

In addition to the literature in the link below, there is a lot of literature about this compound(1-(Bromomethyl)-2-iodobenzene)Computed Properties of C7H6BrI, illustrating the importance and wide applicability of this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Advanced Synthesis & Catalysis called Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade, Author is Cai, Jinhui; Wang, Zhen-Kai; Zhang, Yun-Hao; Yao, Fei; Hu, Xu-Dong; Liu, Wen-Bo, which mentions a compound: 40400-13-3, SMILESS is BrCC1=C(I)C=CC=C1, Molecular C7H6BrI, Application of 40400-13-3.

A palladium-catalyzed intramol. α-arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2-naphthols, e.g., 1-(3-hydroxynaphthalen-2-yl)ethan-1-one, is reported. With ortho-bromobenzyl-substituted α-fluoroketones RCH2C(F)(C(O)R2)C(O)R1 (R = 2-bromophenyl, 2-bromopyridin-3-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc., R1 = Me, Et, Ph, R2 = Et, OMe, OEt, Ot-Bu) as the substrates and palladium acetate/triphenylphosphine as the catalyst system, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields. The applications of the strategy are demonstrated by the synthesis of useful building blocks, such as naphtha[2,3-b]furan, naphthol AS-D, and ligands/catalysts.

In addition to the literature in the link below, there is a lot of literature about this compound(1-(Bromomethyl)-2-iodobenzene)Application of 40400-13-3, illustrating the importance and wide applicability of this compound(40400-13-3).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate