Category: 4020-99-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

To 100ml round-bottomed flask protected from light with aluminum foil, 3-isocyanato-2,4,6-trimethylbenzoyl chloride 3.0 g (13.4mmol) was taken, and after depressurization and purged with nitrogen, dry tetrahydrofuran 50ml was added and dissolved. To this solution, methoxydiphenylphosphine2.7ml (13mmol) was dropped at 65C , and the mixture was stirred for 1.5 hours. The solvent was evaporated under reduced pressure, azeotroped twice with hexane 50ml, and dried under reduced pressure, to give 3-isocyanato-2,4,6-trimethylbenzoyldiphenylphosphineoxidecrude product 5.5g. To 100ml round-bottomed flask protected from light with aluminum foil, methanol 20ml was taken, and after decompression and purged with nitrogen, the mixture was stirred at 40C. Here, 3-isocyanato-2,4,6-trimethylbenzoyldiphenylphosphineoxidecrude product 1.0g was added over 5 min to asolution dissolved in tetrahydrofuran 5ml under nitrogen atmosphere, and stirred at 40 C for 5 hours. After evaporation of the solvent under reduced pressure, under protection from light, it was purified by silica gel column chromatography to give the objective compound 1.0g (97% yield)., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KurarayNoritakeDentalCo., Ltd.; Tsuruta, Takahiro; Ishino, Hiroshige; (33 pag.)JP5688933; (2015); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 1000 ml by adding reaction bottle 99.5g (0.46mol) diphenyl methoxy phosphorus (? 99.5% purity) and 87.4g (0.51mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 10 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; Suzhou Chenghe Medical Company Chemistry Limited Company; Xia, Qiujing; (6 pag.)CN105439828; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In 1000 ml by adding reaction bottle 108g (0.5mol) diphenyl methoxy phosphorus (? 99.5% purity) and 86g (0.5mol) (content ? 99.2%) making between, to elevate temperature under stirring condition 50 C, and at this temperature thermal insulation 8 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Chenghe Medical Company Chemistry Limited Company; Xia, Qiujing; (5 pag.)CN105418677; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OMe)), trans-C763: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OMe) (0.556 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from dichloromethane/pentane at room temperature affording trans-C763 (1.35 g, 62.2%, >95% purity). ?H NMR (400 IVIFIz, CD2C12, ppm): oe18.37 (d, J= 11.2 Hz, 1H), 7.36-7.29 (m, 2H), 7.27 -7.15 (m, 8H), 7.06 -7.000 (m, 1H), 6.88 (s, 2H), 6.79 (s, 2H), 4.13 -3.87 (m,4H), 3.15 (d, J= 12.8 Hz, 3H), 2.56 (s, 6H), 2.37 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.10 (s, 3H),1.03 (s, 3H). 3?PNIVIR(161.8 IVIFIz, CD2C12, ppm): oe 134.4 (s)., 4020-99-9

4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

cis-RuC12(slMes)(phenylindenylidene)(Ph2P(OMe)), cis-C885: trans-C748? 2Py (27.18 g, 30 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed heptanes were added (5000 mL). Phosphinite Ph2P(OMe) (6.8 g, 31.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The mixture was stirred under N2 for 1 hr at ambient temperature (20 – 25 C). because there was some undissolved starting material, degassed CH2C12 (250 mL) was added and all solids were dissolved. The solution was passed through a silica plug (2.5? x 1.5?, D X H) and CH2C12 was used as eluent to remove the first red band of material, which was trans-C885. Then EtOAc was used as eluent to remove a second band that was concentrated and filtered providing brown crystals of cis-C885 (8.49 g). ?H NMR (400 MHz, CD2C12, ppm): oe 8.78 (dd, J = 8 Hz, J = 1 Hz, 1H), 7.52-7.24 (m, 8H), 7.13 – 6.89 (m, 9H), 6.75 (m, 2H), 6.43 (s, 1H), 6.40 (s, 1H), 6.24 (s, 1H), 6.11 (s, 1H), 3.98-3.63 (m, 4H), 3.66 (d, J = 10 Hz, 3H), 2.79 (s, 3H), 2.56 (s, 3H), 2.54 (s, 3H), 2.21 (s, 3H), 1.95 (s, 3H),1.66 (s, 3H). 3?P NIVIR (161.8 MHz, CD2C12, ppm): oe 133.3 (s), 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuC12(slMes)(CHPh)(Ph2P(OMe)), trans-C785: trans-C727 (4.35 g, 6.0 mmol) was dissolved in degassed CH2C12 (50 mL) with a magnetic stir bar under nitrogen in a round-bottomed flask. The flask was capped with a gas adaptor. Methyl diphenylphosphinite (2.6 g, 12 mmol) was syringed to the flask under nitrogen flow. The green solution turned brown immediately, which was continued to stir at room temperature for lh. The lights were removed under high vacuum, yielding a mixture of black oil and brown crystalline material. The flask was chilled by liquid nitrogen and the resulting solid was broken into small pieces with a spatula. Hexanes (50 mL) was added and the solvent was reduced by a rotary evaporator. The pink solid was collected by a frit funnel with vacuum filtration and washed with hexanes twice (2 x 25 mL). The solid was dried under high vacuum for 16h. Yield: 2.91g (62%). ?H NIVIR (400 IVIHz, C6D6, ppm): oe 19.33 (s, 1H, Ru=CH), 7.86 (d, J = 8 Hz, 2H), 7.33 (m, 4H), 7.13 (t, J = 8 Hz, 1H), 7.10 – 6.88 (m, 6H), 6.83 (s, 2H), 6.80 (m, 2H), 6.32 (s, 2H), 3.46 – 3.38 (m, 2H), 3.34 – 3.25 (m, 2H),3.29 (d, J = 12Hz, 3H), 2.79 (s, 6H), 2.39 (s, 6H), 2.17 (s, 3H), 1.90 (s, 3H). 3?P NIVIR (162 IVIHz, C6D6, ppm): oe 132.5 (s).

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 1 (0.153 mmol) was dissolved in 30 ml of hexane and 2 equivalents of the phosphine (61.8 mg, 0.30 mmol) was added. Thesolution was stirred for 60 min. The reaction mixture was taken to dryness under vacuum and the residue separated by thin layer chromatography using hexane:methylene chloride (4:1) as eluant. Compound 4e. Yellow solid. IR (CH2Cl2, nuCO, cm-1):2076(m), 2052(s), 2040(w), 2012(vs), 1997(s), 1984(w). NMR (CDCl3): delta 1H:-21.59 (d, 3JPH=2.7 Hz, M-H-M), 0.31 (s, SiMe3), 3.56 (s, P(OMe)Ph2),7.41-7.7 (m, P(OMe)Ph2); delta 31P{H}: 119.7; delta 29Si{1H}:1.69., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gonzalez-Lopez, Vianney; Torres-Sandoval, Indira; Carrasco-Gonzalez, Ana L.; Elias-Jimenez, Adonay; Leyva, Marco A.; Rosales-Hoz, Maria J.; Cruz-Borbolla, Julian; Zuno-Cruz, Francisco J.; Sanchez-Cabrera, Gloria; Jardinez, Christian; Inorganica Chimica Acta; vol. 492; (2019); p. 8 – 17;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Using the same stoichiometric ratio than in the previous reactions, the hexane solution was stirred at room temperature for 5 days. Then 5 mL of ethanol were added and the solution stirred for another 5 days. The solvent was then evaporated under vacuum and the residue purifiedby TLC. Compound 8d was obtained in 63% yield.

4020-99-9, As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Article; Gonzalez-Lopez, Vianney; Torres-Sandoval, Indira; Carrasco-Gonzalez, Ana L.; Elias-Jimenez, Adonay; Leyva, Marco A.; Rosales-Hoz, Maria J.; Cruz-Borbolla, Julian; Zuno-Cruz, Francisco J.; Sanchez-Cabrera, Gloria; Jardinez, Christian; Inorganica Chimica Acta; vol. 492; (2019); p. 8 – 17;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

As shown in Figure 1 Wittig reagent between methoxy benzyldiphenyloxy phosphate synthesis route.In a 1000 ml reaction flask, 108 g was added(0.5 mol) of diphenylmethoxyphosphine(Purity & gt; 99.5%) and 120 g (0.7 mol)M-methoxybenzyl chloride (content ? 99.2%),Stirring temperature conditions to 55 , and at this temperature for 8 hours, Paul finished cooling to 10 , directly into the next step reaction.

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Taicang Kastem New Material Co., Ltd; Li, Ruiqing; (5 pag.)CN105440075; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

cis-RuC12(slMes)(t-butylvinylidene)(Ph2P(OMe)), cis-C777v: trans-C 71 9v (5.0 g, 7.0 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed CH2C12 was added (40 mL). Phosphinite Ph2P(OMe) (2.26 g, 10.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The reaction was stirred under N2 for 60 mm at ambient temperature (20 – 25 C) yielding a yellow crystalline solid. The crude material was filtered, washed with heptanes and dried under high vacuum to provide a crude yellow solid (3.6 g). The crude yellow solid (1.6 g) was dissolved in degassed CH2C12 (2000 mL) and filtered through Celite. The filtrate was concentrated under high vacuum and the resulting solid was recrystallized in CH2C12/heptanes. The crystals were filtered and washed with heptanes and dried under high vacuum to yield a yellow solid. Yield: 1.3g. ?H NMR (400 IVIHz, CD2C12, ppm): oe 7.46 -7.41 (m, 1H), 7.39- 7.28 (m, 5H), 7.18 – 7.14 (m, 3H), 7.000 (s, 1H), 6.95 (s, 1H), 6.90 – 6.85 (m, 2H), 6.64 (s, 1H), 4.06 – 3.85 (m, 4H), 3.35 (d, J= 11 Hz, 3H), 2.80 (s, 3H), 2.77 (s, 3H) 2.40 (s, 6H), 2.33 (s, 3H), 2.09 (s, 3H), 1.93 (d, J= 5 Hz, 1H), 0.33 (s, 9H). 3?P NIVIR (161.8 IVIHz, C6D6, ppm): oe 135.15 (s)., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate