Category: 360048-63-1

Homogeneous Chiral Nickel-Catalyzed Asymmetric Hydrogenation of Substituted Aromatic α-Aminoketone Hydrochlorides through Dynamic Kinetic Resolution was written by Hibino, Takuya;Makino, Kazuishi;Sugiyama, Takaya;Hamada, Yasumasa. And the article was included in ChemCatChem in 2009.Application of 360048-63-1 This article mentions the following:

Asym. hydrogenation of aromatic amino ketones using homogeneous chiral nickel catalyst proceeds with high diastereoselectivity and excellent enantioselectivity via dynamic kinetic resolution In AcOH the hydrogenation proceeds diastereoselectively with retention of the configuration at the stereogenic center. In the experiment, the researchers used many compounds, for example, (1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1Application of 360048-63-1).

(1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1) belongs to chiral phosphine ligands. Although many reactions require more nucleophilic trialkylphosphines as catalysts, only a few chiral trialkylphosphines are available. Trivalent phosphorus compounds called phosphines have a tetrahedral electron-group geometry which makes them structurally analogous to amines.Application of 360048-63-1

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Enantioselective and Regio-divergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir was written by Thieme, Niels;Breit, Bernhard. And the article was included in Angewandte Chemie, International Edition in 2017.Formula: C42H56FeO2P2 This article mentions the following:

The rhodium-catalyzed atom-economic asym. N-selective intermol. addition of purine derivatives to terminal allenes is reported. Branched allylic purines were obtained in high yields, regioselectivity and outstanding enantioselectivity utilizing a Rh/Josiphos catalyst. Conversely, linear selective allylation of purines could be realized in good to excellent regio- and E/Z-selectivity with a Pd/dppf catalyst system. Furthermore, the new methodol. was applied to a straightforward asym. synthesis of carbocyclic nucleoside abacavir. In the experiment, the researchers used many compounds, for example, (1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1Formula: C42H56FeO2P2).

(1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1) belongs to chiral phosphine ligands. Phosphine-catalyzed asymmetric reactions are now powerful and versatile tools for the construction of C–C, C–N, C–O, and C–S bonds and for the syntheses of functionalized carbocycles and heterocycles. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.Formula: C42H56FeO2P2

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Cobalt-Catalyzed Asymmetric Addition of Silylacetylenes to 1,1-Disubstituted Allenes was written by Sawano, Takahiro;Ou, Keiyu;Nishimura, Takahiro;Hayashi, Tamio. And the article was included in Journal of Organic Chemistry in 2013.Product Details of 360048-63-1 This article mentions the following:

The asym. addition of silylacetylenes to 1,1-disubstituted allenes proceeded in the presence of a Co/chiral bisphosphine ligand to give the corresponding enynes with high enantioselectivity. E.g., reaction of (4-MeOC₆H₄)CMe:C:CH₂ with ⁱPr₃SiCCH in the presence of 5 mol% Co(OAc)₂·4H₂O/5 mol% dppe/50 mol% Zn in DMSO at 80° gave 89% yield of (4-MeOC₆H₄)CHMeC(:CH₂)CCSiⁱPr₃ (major isomer). The results of D-labeling experiments indicated that a H atom at the chiral center is originated from the terminal alkyne, and they were in good agreement with the proposed catalytic cycle where enantioselectivity is determined by the reaction of the proposed π-allylcobalt intermediate with the terminal alkyne. In the experiment, the researchers used many compounds, for example, (1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1Product Details of 360048-63-1).

(1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.Product Details of 360048-63-1

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Palladium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic 5,10-Dihydrophenazasilines via Enantioselective 1,5-Palladium Migration was written by Sato, Yosuke;Takagi, Chihiro;Shintani, Ryo;Nozaki, Kyoko. And the article was included in Angewandte Chemie, International Edition in 2017.Synthetic Route of C42H56FeO2P2 This article mentions the following:

A palladium-catalyzed asym. synthesis of silicon-stereogenic 5,10-dihydrophenazasilines was developed that proceeds via an unprecedented enantioselective 1,5-palladium migration. High enantioselectivity was achieved by employing 4,4′-bis(trimethylsilyl) (R)-Binap as the chiral ligand, and a series of mechanistic investigations were carried out to probe the catalytic cycle of this process. In the experiment, the researchers used many compounds, for example, (1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1Synthetic Route of C42H56FeO2P2).

(1R)-1-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]ferrocene (cas: 360048-63-1) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Synthetic Route of C42H56FeO2P2

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis