Category: 31181-89-2

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates.Recommanded Product: 5-Chloropicolinaldehyde.

In this study, structure-activity relationship based on thiosemicarbazone derivatives (E)-R1C(S)NHN=C(R2)(R3) (I) (R1 = phenylamino, Ph, cyclohexylamino, morpholin-4-yl, etc.; R2 = H, Me; R3 = Ph, pyridin-2-yl, 3,4,5-trimethoxyphenyl, etc.) was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds (I).HCl [R1 = piperazin-1-yl, R2 = H, R3 = 2-hydroxyphenyl (II); R1 = 4-methylpiperazin-1-yl, R2 = H, R3 = 2-hydroxyphenyl (III)] exhibited excellent activity against 10 NDM-pos. isolate clin. isolates in reversing MEM resistance. Further studies demonstrated that compounds II and III were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44μmol/L, resp. Mol. docking speculated that compounds II and III were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities were found even at concentrations of 1000 mg/mL against red blood cells. In vivo exptl. results showed that a combination of MEM and compound III was markedly effective in treating infections caused by NDM-1 pos. strain and prolonging the survival time of sepsis mice. The finding showed that compound III might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug.

In some applications, this compound(31181-89-2)Recommanded Product: 5-Chloropicolinaldehyde is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about In vivo potent BM635 analogue with improved drug-like properties.SDS of cas: 31181-89-2.

Herein an efficient method was reported for the design, synthesis, biol. evaluation, pharmacokinetic anal. as well as in vivo TB mouse efficacy studies of novel (2-methyl-1H-pyrrol-3-yl)methanamines I [R = Me, 4-i-PrC6H4, 4-F3CC6H4, etc.; R1 = i-Pr, cyclohexyl, 4-FC6H4, etc.; R2 = 4-morpholinyl, 3-hydroxy-1-piperidyl, 3-methoxy-1-piperidyl] from 2-methyl-1H-pyrroles, formaldehyde and amines under Mannich reaction conditions. These BM635 analogs I showed improved physicochem. properties and excellent antimycobacterial activity. This hit-to-lead campaign led to the identification of a new compound I [R = 4-i-PrC6H4, R1 = i-Pr, R2 = 4-morpholinyl] that showed excellent activity (MIC = 0.15 μM; SI = 133) against drug-sensitive Mycobacterium tuberculosis strains as well as efficacy in a murine model of TB infection.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 31181-89-2, is researched, Molecular C6H4ClNO, about Tandem Strecker/C(sp3)-H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH4SCN as a cyanating agent, the main research direction is azarene arylmethylamine ammonium thiocyanate iodine pentoxide promoter Strecker oxidation; cyano imidazopyridine preparation.Electric Literature of C6H4ClNO.

An I2O5 promoted tandem Strecker/C(sp3)-H amination reaction of pyridine-2-carboxaldehydes, benzylamines and NH4SCN was reported. This multicomponent reaction that allowed the single-step construction of biol. important cyano-functionalized imidazo[1,5-a]pyridines with mol. diversity was realized for the first time. Moreover, the use of safe and easy-to-handle NH4SCN as a surrogate cyanating agent made this protocol appealing for potential applications.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers, the main research direction is mechanistic reaction covalent assembly metal mediated hemi aminal ethers.Formula: C6H4ClNO.

The use of reversible covalent bonding in a four-component assembly incorporating chiral alcs. was recently reported to give a method for determining the enantiomeric excess of the alcs. via CD spectroscopy. Experiments that probe the mechanism of this assembly, which consists of 2-formylpyridine (2-PA), dipicolylamine (DPA), Zn(II) and alcs. to yield zinc complexes of tren-like ligands, are presented. The studies focus upon the mechanism of conversion of a hemi-aminal (1) to a hemi-aminal ether (3), thereby incorporating the fourth component. It was found that mol. sieves along with 3 to 4 equiv of alc. are required to drive the conversion of 1 to 3. Attempts to isolate an intermediate in this reaction via addition of strong Lewis acids led to the discovery of a five-membered ring pyridinium salt (5), but upon exposure to Zn(II) and alcs. gave different products to the assembly. This was interpreted to support the intermediacy of an iminium species. Kinetic studies reveal that the conversion of 1 to 3 is zero-order in alc. in large excesses of alc., supporting rate-determining formation of an intermediate prior to reaction with alc. Further, the magnitudes of the rate constants for interconversion of 1 and 3 are similar, supporting the notion that there are similar rate-determining steps (rds) for the forward and reverse reactions. Hammett plots show that the rds involves creation of a neg. charge (interpreted as the loss of pos. charge), supporting the notion that the decomplexation of Zn(II) from the assemblies to generate apo-forms of 1 and 3 is rate-determining The individual mechanistic conclusions are combined to create a qual. reaction coordinate diagram for the interconversion of 1 and 3.

When you point to this article, it is believed that you are also very interested in this compound(31181-89-2)Formula: C6H4ClNO and due to space limitations, I can only present the most important information.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Zhong, Ying-Ying; Chen, Hui-Sheng; Wu, Pan-Pan; Zhang, Bing-Jie; Yang, Yang; Zhu, Qiu-Yan; Zhang, Chun-Guo; Zhao, Su-Qing published an article about the compound: 5-Chloropicolinaldehyde( cas:31181-89-2,SMILESS:O=CC1=NC=C(Cl)C=C1 ).COA of Formula: C6H4ClNO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:31181-89-2) through the article.

Considerable interest has been attracted in oleanolic acid and its analogs because of their hypoglycemic activity. In this study, a series of novel oleanolic acid analogs against α-glucosidase were synthesized and their biol. activities were evaluated in vitro and in vivo. In vitro α-glucosidase inhibition activity results indicated that most of the designed analogs exhibited prominent inhibition activities, especially compounds I [R = 4-MeC6H4, 2,4-(MeO)2C6H3, 4-MeOC6H4, 3-ClC6H4] (II) which have IC50 values of 0.33 ± 0.01, 0.98 ± 0.06, 0.69 ± 0.01 and 0.72 ± 0.21 μM, resp. Enzyme kinetic studies on the most potent compounds reveled that derivatives II were noncompetitive inhibitors. Moreover, the docking studies were carried out to prove that the four compounds could interact with the hydrophobic region of the active pocket and form hydrogen bonds to enhance the binding affinity of them with the α-glucosidase. The cytotoxicity evaluation assay demonstrated a high level of safety profile of the active compounds II against normal 3T3 cell line. Furthermore, the in vivo actual pharmacol. potential studies on derivatives II showed that the hypoglycemic effects of them were comparable to that of pos. control, acarbose.

If you want to learn more about this compound(5-Chloropicolinaldehyde)COA of Formula: C6H4ClNO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(31181-89-2).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

He, Zhangxu; Qiao, Hui; Yang, Feifei; Zhou, Wenjuan; Gong, Yunpeng; Zhang, Xinhui; Wang, Haojie; Zhao, Bing; Ma, Liying; Liu, Hong-min; Zhao, Wen published the article 《Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent》. Keywords: thiosemicarbazone diastereoselective preparation antitumor activity SAR cytotoxicity apoptosis; Apoptosis; Migration; Proliferation; Selectivity; Thiosemicarbazone.They researched the compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ).HPLC of Formula: 31181-89-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:31181-89-2) here.

A series of novel thiosemicarbazone derivatives I [R1 = Ph, benzyl, phenylethyl,etc.; R2 = 2-pyridyl, 3-methyl-2-pyridyl, 4-methyl-2-pyridyl,etc.; R3 = H, Me] containing indole fragment were designed and synthesized. Most compounds exhibited excellent antiproliferative activity against PC3, MGC803 and EC109 cell lines with low micromolar IC50 (0.14-12μM). Especially, compound I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] can selectively inhibit PC3 cells in three tested tumor cells with IC50 value of 0.14 μM, which was attributed to a synergistic effect after introducing indole fragment into the TSC structure. Meanwhile, compound I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] displayed more selectivity in PC3 cells toward two normal WPMY-1 and GES-1 cell lines, compared to those of 3-AP and DPC. It was also found that I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] can effectively inhibit PC3 cell proliferation, colonization and induce apoptosis. Compound I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] may significantly suppress migration and invasion by blocking the EMT process but had no effect on cell cycle. Collectively, this findings indicated that I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] with structure of thiosemicarbazone containing indole may serve as a useful anticancer lead for further optimization and development.

If you want to learn more about this compound(5-Chloropicolinaldehyde)HPLC of Formula: 31181-89-2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(31181-89-2).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: 5-Chloropicolinaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Facile One Pot Multi-Component Solvent-Free Synthesis of 2,4,5-Trisubstituted Imidazoles Using “”Green”” and Expeditious Ionic Liquid Catalyst under Microwave Irradiation. Author is Sonyanaik, B.; Ashok, K.; Rambabu, S.; Ravi, D.; Kurumanna, A.; Madhu, P.; Sakram, B..

Acetic acid functionalized poly(4-vinylpyridinium) bromide is a highly efficient and recyclable catalyst for the construction of 2,4,5-trisubstituted imidazole derivatives I (Ar = Ph, 3-indolyl, 5-methylpyridin-2-yl, etc.) by a three-component condensation of benzyl with various aldehydes ArCHO and ammonium acetate under solventless conditions. The microwave initiated process leads to anal. pure compounds within 2-5 min. The advantages of this “”green”” methodol. are cost-effectiveness, simple procedure, low energy consumption, no involvement of organic solvents, safe operation, clean reaction profile, high yields, and recyclability of the catalyst.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Electric Literature of C6H4ClNO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C-H Borylation of Benzyl-2-Pyridines at Room Temperature. Author is Yang, Yuhuan; Gao, Qian; Xu, Senmiao.

A convenient and ligand-free Ir-catalyzed dehydrogenative ortho C-H borylation of benzyl-2-pyridines was developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)]2. The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities.

Here is a brief introduction to this compound(31181-89-2)Electric Literature of C6H4ClNO, if you want to know about other compounds related to this compound(31181-89-2), you can read my other articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate