Category: 31181-89-2

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ) is researched.Name: 5-Chloropicolinaldehyde.Ayyash, Ahmed Neamah; Hammady, Ali Obaid published the article 《Synthesis and bioactivity screening of new 1,3-thiazolidin-4-one compounds bearing (thiadiazole/triazole) moieties》 about this compound( cas:31181-89-2 ) in Journal of Physics: Conference Series. Keywords: thiazolidinone thiadiazole triazole preparation antibacterial antifungal. Let’s learn more about this compound (cas:31181-89-2).

This article deals with synthesis, identification and biol. activity screening of 1,3-thiazolidin-4-ones bearing thiadiazoles/triazoles. New derivatives of 1,3-thiazolidin-4-ones have been obtained via cyclocondensation reaction of Schiff bases with thiolactic acid in presence of anhydrous zinc chloride. The synthesized compounds have been screened and investigated for their antimicrobial activities. Most of them exhibited excellent activity.

《Synthesis and bioactivity screening of new 1,3-thiazolidin-4-one compounds bearing (thiadiazole/triazole) moieties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloropicolinaldehyde)Name: 5-Chloropicolinaldehyde.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 31181-89-2, is researched, Molecular C6H4ClNO, about Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells, the main research direction is carbamothioylamino pyridinylcarboxamide preparation diastereoselective antitumor activity docking SAR; Apoptosis; Cell cycle; Proliferation; Prostate cancer; Thiosemicarbazone.Reference of 5-Chloropicolinaldehyde.

To discover novel anticancer agents with potent and low toxicity, a range of new thiosemicarbazone-indole analogs I [R = H, Me, Cl, OMe; R1 = H, Me, R2 = H, Me, OH, etc.; R3 = H, Me; X = N, C] based on lead compound II were designed and synthesized previously. Most compounds displayed moderate to high anticancer activities against five tested tumor cells (PC3, EC109, DU-145, MGC803, MCF-7). Specifically, the represented compound I [R = H, R1 = Me; R2 = Me, R3 = H] (III) possessed strong antiproliferative potency and high selectivity toward PC3 cells with the IC50 value of 0.054μM, compared with normal WPMY-1 cells with the IC50 value of 19.470μM. Preliminary mechanism research indicated that compound (III) could significantly suppress prostate cancer cells (PC3, DU-145) growth and colony formation in a dose-dependent manner. Besides, derivative (III) induced G1/S cycle arrest and apoptosis, which may be related to ROS accumulation due to the activation of MAPK signaling pathway. Furthermore, mol. (III) could effectively inhibit tumor growth through a xenograft model bearing PC3 cells and had no evident toxicity in vivo. Overall, based on the biol. activity evaluation, analog (III) can be viewed as a potential lead compound for further development of novel anti-prostate cancer drug.

《Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloropicolinaldehyde)Reference of 5-Chloropicolinaldehyde.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ) is researched.Name: 5-Chloropicolinaldehyde.Ayyash, Ahmed Neamah; Hammady, Ali Obaid published the article 《Synthesis and bioactivity screening of new 1,3-thiazolidin-4-one compounds bearing (thiadiazole/triazole) moieties》 about this compound( cas:31181-89-2 ) in Journal of Physics: Conference Series. Keywords: thiazolidinone thiadiazole triazole preparation antibacterial antifungal. Let’s learn more about this compound (cas:31181-89-2).

This article deals with synthesis, identification and biol. activity screening of 1,3-thiazolidin-4-ones bearing thiadiazoles/triazoles. New derivatives of 1,3-thiazolidin-4-ones have been obtained via cyclocondensation reaction of Schiff bases with thiolactic acid in presence of anhydrous zinc chloride. The synthesized compounds have been screened and investigated for their antimicrobial activities. Most of them exhibited excellent activity.

《Synthesis and bioactivity screening of new 1,3-thiazolidin-4-one compounds bearing (thiadiazole/triazole) moieties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloropicolinaldehyde)Name: 5-Chloropicolinaldehyde.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 31181-89-2, is researched, Molecular C6H4ClNO, about Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells, the main research direction is carbamothioylamino pyridinylcarboxamide preparation diastereoselective antitumor activity docking SAR; Apoptosis; Cell cycle; Proliferation; Prostate cancer; Thiosemicarbazone.Reference of 5-Chloropicolinaldehyde.

To discover novel anticancer agents with potent and low toxicity, a range of new thiosemicarbazone-indole analogs I [R = H, Me, Cl, OMe; R1 = H, Me, R2 = H, Me, OH, etc.; R3 = H, Me; X = N, C] based on lead compound II were designed and synthesized previously. Most compounds displayed moderate to high anticancer activities against five tested tumor cells (PC3, EC109, DU-145, MGC803, MCF-7). Specifically, the represented compound I [R = H, R1 = Me; R2 = Me, R3 = H] (III) possessed strong antiproliferative potency and high selectivity toward PC3 cells with the IC50 value of 0.054μM, compared with normal WPMY-1 cells with the IC50 value of 19.470μM. Preliminary mechanism research indicated that compound (III) could significantly suppress prostate cancer cells (PC3, DU-145) growth and colony formation in a dose-dependent manner. Besides, derivative (III) induced G1/S cycle arrest and apoptosis, which may be related to ROS accumulation due to the activation of MAPK signaling pathway. Furthermore, mol. (III) could effectively inhibit tumor growth through a xenograft model bearing PC3 cells and had no evident toxicity in vivo. Overall, based on the biol. activity evaluation, analog (III) can be viewed as a potential lead compound for further development of novel anti-prostate cancer drug.

《Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloropicolinaldehyde)Reference of 5-Chloropicolinaldehyde.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application In Synthesis of 5-Chloropicolinaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light. Author is Ahemed, Jakeer; Pasha, Jakeer; Rao D, Venkateshwar; Kore, Ranjith; Gade, Ramesh; Bhongiri, Yadagiri; Chetti, Prabhakar; Pola, Someshwar.

Synthesis of new Schiff′s base Zn-complexes for photo-oxidation of Me arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of Me arenes which are converted into its resp. aldehydes with moderate yields under visible light irradiation The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the Me groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of Me arenes is reported under visible-light-driven conditions.

《Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloropicolinaldehyde)Application In Synthesis of 5-Chloropicolinaldehyde.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloropicolinaldehyde(SMILESS: O=CC1=NC=C(Cl)C=C1,cas:31181-89-2) is researched.Formula: C54H45ClP3Rh. The article 《Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson’s disease therapy》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:31181-89-2).

We previously developed a novel series of vinyl sulfones as nuclear factor erythroid 2-related factor 2 (Nrf2) activators with therapeutic potential for Parkinson’s disease (PD). However, the previously developed lead compound (1) exhibited undesirable druglike properties. Here, we optimized vinyl sulfones by introducing nitrogen heterocycles to improve druglike properties. Among the synthesized compounds, 17e was the most promising drug candidate with good druglike properties. Compound 17e showed superior effects on Nrf2 activation in cell-based assays compared to compound 1 (17e: half-maximal effective concentration (EC50) = 346 nM; 1: EC50 = 530 nM). Compound 17e was further confirmed to induce expression of Nrf2-dependent antioxidant enzymes at both mRNA and protein levels. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of PD, 17e significantly attenuated loss of tyrosine hydroxylase-immunopos. dopaminergic neurons, suppressed microglial activation, and alleviated PD-associated motor dysfunction. Thus, 17e is a novel Nrf2 activator with excellent druglike properties and represents a potential therapeutic candidate for PD.

Different reactions of this compound(5-Chloropicolinaldehyde)Quality Control of 5-Chloropicolinaldehyde require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application In Synthesis of 5-Chloropicolinaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents. Author is Dong, Shiyang; Liu, Yanhua; Xu, Jun; Hu, Yue; Huang, Limin; Wang, Zengtao.

Background: Epilepsy is a serious and common neurol. disorder threatening the health of humans. Despite enormous progress in epileptic research, the anti-epileptic drugs present many limitations. These limitations prompted the development of more safer and effective AEDs. Methods: A series of N-substituted (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)- 2-thioxothiazolidin-4- one derivatives and 5-substituted-thioxothiazolidindione derivatives were designed, synthesized and tested for anticonvulsant activity against maximal electroshock (MES) and s.c. pentylenetetrazole (scPTZ). Neurotoxicity was determined by the rotarod test. Results: Among them, the most potent 4e displayed high protection against MES-induced seizures with an ED50 value of 9.7 mg/kg and TD50 value of 263.3 mg/kg, which provided 4e with a high protective index (TD50/ED50) of 27.1 comparable to reference antiepileptic drugs. 4e clearly inhibits the NaV1.1 channel in vitro. The mol. docking study was conducted to exploit the results. Conclusion: Stiripentol is a good lead compound for further structural modification. Compound 4e was synthesized, which displayed remarkable anticonvulsant activities, and the NaV1.1 channel inhibition was involved in the mechanism of action of 4e.

Different reactions of this compound(5-Chloropicolinaldehyde)Application In Synthesis of 5-Chloropicolinaldehyde require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Endoori, Srinivas; Gulipalli, Kali Charan; Bodige, Srinu; Shaikh, Arbaz Sujat; Vemula, Divya; Surapureddi, Sri Ramakrishna; Seelam, Nareshvarma published the article 《Design, synthesis, anti-cancer activity and in-silico studies of some novel 4,5-dihydroisoxazole-5-carboxamide derivatives》. Keywords: dihydroisoxazole carboxamide preparation SAR mol docking antitumor human.They researched the compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ).Formula: C6H4ClNO. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:31181-89-2) here.

A novel series of 4,5-dihydroisoxazole-5-carboxamide derivatives I (X = CH, N; R = Cl, CF3; R1 = cyclobutyl, cyclohexyl, benzoyl, etc.) were designed, synthesized and evaluated for their anti-cancer activity against two different human cancer cell lines. Most of the synthesized compounds showed anti-cancer activity with IC50 values ranging from 4.03 to 104.45μM. Further, few compounds were showed potent inhibitory activity against two cancer cell lines, with IC50 values close to that of standard drug. It is important to note that compound I (X = CH; R = CF3; R1 = 5-isopropyl-3-yl-isoxazole) was more potent than the standard drug cisplatin with IC50 values of 4.11 and 4.03μM against Hela cell line and MCF-7 cell line resp.

After consulting a lot of data, we found that this compound(31181-89-2)Formula: C6H4ClNO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Synthetic Route of C6H4ClNO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about One-Pot Transfer Hydrogenation Reductive Amination of Aldehydes and Ketones by Iridium Complexes “”on Water””.

An efficient and practical one-pot transfer hydrogenation reductive amination of aldehydes and ketones with amines has been developed by using iridium complexes as catalysts and formic acid as hydrogen source in aqueous solution, providing an environmentally friendly methodol. for the construction of a wide range of functionalized amine compounds in excellent yields (≈ 80%-95%). This effective methodol. can be scaled up to gram scale with 0.1 mol-% catalyst loading and also be employed in the synthesis of medical substances such as Meclizine.

Although many compounds look similar to this compound(31181-89-2)Synthetic Route of C6H4ClNO, numerous studies have shown that this compound(SMILES:O=CC1=NC=C(Cl)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ) is researched.Product Details of 31181-89-2.Yadav, Priya; Yadav, Manavi; Gaur, Rashmi; Gupta, Radhika; Arora, Gunjan; Rana, Pooja; Srivastava, Anju; Sharma, Rakesh K. published the article 《Fabrication of Copper-based Silica-coated Magnetic Nanocatalyst for Efficient One-pot Synthesis of Chalcones via A3 Coupling of Aldehydes-Alkynes-Amines》 about this compound( cas:31181-89-2 ) in ChemCatChem. Keywords: aromatic aldehyde aryl alkyne piperidine coupling isomerization hydrolysis diastereoselective; diaryl propenone preparation green chem. Let’s learn more about this compound (cas:31181-89-2).

The synthesized bioactive and pharmacol. important chalcone motifs by employing green and efficient silica-coated magnetically separable catalyst, Cu@DBM@ASMNPs was reported. The highly proficient nanocatalyst proved its invincibility for the solvent-free one-pot synthesis of chalcone moieties by A3 coupling of aldehydes-alkynes-amines in good to excellent yields. The fabricated Cu@DBM@ASMNPs was structurally and chem. analyzed by various techniques such as FT-IR, SEM, TEM, VSM, ICP-MS, ED-XRF and XPS. The programmed catalytic protocol was proceeded via isomerization-hydrolysis reaction of aldehydes and terminal alkynes. The present strategy offered much greener and efficacious synthesis of chalcones by adding benefits such as solvent-less synthetic protocol and much shorter reaction time. Other interesting and noteworthy features of this methodol. were broad substrate scope, mild reaction conditions, and reusability up to seven runs without significant loss of its catalytic activity which renders it an environmentally friendly and remarkable protocol from industrial point of view.

Compounds in my other articles are similar to this one(5-Chloropicolinaldehyde)Product Details of 31181-89-2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate