Category: 24171-89-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A benzene solution (20 mL) of 1 (30 mg, 0.054 mmol) and PTh3 (15 mg, 0.054 mmol) was refluxed for 12 h. The solvent was removed under reduced pressure and the residue chromatographed by TLC on silica gel. Elution with cyclohexane/CH2Cl2 (9:1, v/v) developed three bands. The faster band was unreacted 1 (6 mg), while the second band afforded [Fe2(CO)5(PTh3)(mu-Th)(mu-PTh2)] (2b) (12 mg, 27%) as an orange powder. Spectroscopic data for this band before crystallization showed the presence of a second complex (ca. 10%) that was assigned as [Fe2(CO)5(PTh3)(mu-O=C-Th)(mu-PTh2)] (3b). Recrystallization of the mixture from hexane/CH2Cl2 at 4C gave a crystalline product from which a crystal of [Fe2(CO)5(PTh3)(mu-O=C-Th)(mu-PTh2)] (3b) was selected for crystallography. The third band gave a small amount (ca. 2 mg) of a yellow solid, tentatively identified as [Fe2(CO)6(PTh3)(eta1-Th)(mu-PTh2)]. Spectral data: IR(m(CO), CH2Cl2): 2059 vs, 2018 vs, 1998 s, 1975 w, 1958 br and1895 w. 1H NMR (CDCl3): d 7.88 (d, J 2, 1H), 7.77 (s, 2H), 7.62 (d,J 6, 3H), 7.53 (br, 1H), 7.35 (s, 3H), 7.10 (s, 3H), 6.95 (br, 2H) 6.76(br, 1H), 6.55 (br, 1H), 6.17 (br, 1H). 31P{1H} NMR (CDCl3): d137.0 (d, J 48, P), 40.0 (d, J 48, 1P). Spectral data for 2b: Anal.Calc. for C29H18Fe2O5P2S6: C, 42.87; H, 2.23%. Found: C, 42.91; H,2.25%. IR (m(CO), CH2Cl2): 2038 vs, 1990 s, 1977 sh and 1948 wcm1 1H NMR (CDCl3): d 7.64 (d, J 2.0, 1H), 7.57 (m, 4H), 7.42 (d,J 2.0, 1H), 7.22 (m, 3H), 7.09 (m, 5H), 6.75 (t, J 4.0, 1H) 6.63 (t, J4.0, 1H), 6.37 (m, 1H), 4.79 (d, J 2.0, 1H). 31P{1H} NMR (CDCl3): d92.3 (d, J 24, 1P), 35.0 (d, J 24, 1P). Spectral data for 3b: IR(m(CO), CH2Cl2): 2036 vs, 1981 s, 1952 w and 1934 w cm1.31P{1H} NMR (CDCl3): d 71.7 (d, J 100, 1P), 33.2 (d, J 100, 1P)., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Rahaman, Ahibur; Alam, Fakir Rafiqul; Hossain, Md. Kamal; Abdel-Magied, Ahmed F.; Ghosh, Shishir; Tocher, Derek A.; Haukka, Matti; Kabir, Shariff E.; Nordlander, Ebbe; Hogarth, Graeme; Inorganica Chimica Acta; vol. 430; (2015); p. 208 – 215;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A CH2Cl2 solution (30 mL) of [Fe3(CO)12] (200 mg, 0.40 mmol) and PTh3 (111 mg, 0.40 mmol) was heated to reflux for 12 h. The solvent was removed under reduced pressure and the residue chromatographed by TLC on silica gel. Elution with hexane/CH2Cl2 (v/v 9:1) developed two bands [Fe2(CO)6(mu-eta1,eta2-Th)(mu-PTh2)] (3) (160 mg, 72%) as light orange crystals and [Fe2(CO)5(mu-eta1,eta2-Th)(mu-PTh2)(PTh3)] (4) (6 mg, 2%) as deep orange crystals., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Conference Paper; Rahaman, Ahibur; Alam, Fakir Rafiqul; Ghosh, Shishir; Haukka, Matti; Kabir, Shariff E.; Nordlander, Ebbe; Hogarth, Graeme; Journal of Organometallic Chemistry; vol. 730; (2013); p. 123 – 131;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of [Fe2(CO)6{mu-SCH2CH(CH2O2CCH3)S}] (0.044?g, 0.1?mmol) and tris(2-furyl)phosphine (0.023?g, 0.1?mmol) in CH2Cl2 (5?mL) was added a solution of Me3NO¡¤2H2O (0.011?g, 0.1?mmol) in MeCN (5?mL). The mixture was stirred at room temperature for 1?h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC separation using CH2Cl2/petroleum ether?=?1:1 (v/v) as eluent. From the main red band, 0.062?g (95%) of complex 2 was obtained as a red solid., 24171-89-9

24171-89-9 Tri(thiophen-2-yl)phosphine 90384, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Fei-Yan; He, Jiao; Mu, Chao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Polyhedron; vol. 160; (2019); p. 74 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Analogous to the reaction described above, Ru3(CO)12 (100 mg, 0.156 mmol) and PTh3 (44 mg, 0.157 mmol) in THF (20 mL) were treated with a few drops of Na[Ph2CO] in THF and the solution was stirred at 25 C for 30 min. Workup and chromatographic separation as described above afforded 1 (58 mg, 42%), 2 (15 mg, 8%), and 3 (7 mg, 3%)., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Uddin, Md Miaz; Begum, Noorjahan; Ghosh, Shishir; Sarker, Jagodish C.; Tocher, Derek A.; Hogarth, Graeme; Richmond, Michael G.; Nordlander, Ebbe; Kabir, Shariff E.; Journal of Organometallic Chemistry; vol. 812; (2016); p. 197 – 206;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of [Fe2(CO)6(mu-SCH2CH2S)] (0.037 g, 0.1 mmol) and tricyclohexylphosphine (0.028 g, 0.1 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h, and then, the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 1:3 (v/v) as eluent. From the main red band, 0.042 g (68%) of complex 2 was obtained as a red solid., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yan, Lin; Li, Ao; Xiao, Qi-Min; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Transition Metal Chemistry; vol. 44; 5; (2019); p. 483 – 489;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A hexane solution (30 mL) of 4 (20 mg, 0.23 mmol) and PTh3 (10 mg, 0.035 mmol) was heated to reflux for 1 h during, during which time the color of the solution changed from pale yellow to orange. The solvent was then removed under reduced pressure and the residue was subjected to TLC on silica gel. Elution with hexane/CH2Cl2 (7:3, v/v) developed only one band that corresponded to 5 (16 mg, 61%)., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uddin, Md Miaz; Begum, Noorjahan; Ghosh, Shishir; Sarker, Jagodish C.; Tocher, Derek A.; Hogarth, Graeme; Richmond, Michael G.; Nordlander, Ebbe; Kabir, Shariff E.; Journal of Organometallic Chemistry; vol. 812; (2016); p. 197 – 206;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,6-Bis(chloromethyl)-3-hydroxypyridine hydrochloride (5) (0.20 g, 0.88 mmol) was added to a solution of tris(2-thienyl)phosphine (0.98 g, 3.50 mmol) in acetonitrile (40 mL) and the mixture was refluxed for 48 h. Then, the solvent was evaporated in vacuo, the dry residue was dissolved in chloro- form and washed with water. The aqueous filtrate was dried in vacuo, and recrystallized from acetone. The yield was 0.10 g (15%), a white crystalline compound, m.p. 176-178 C. 1H NMR (DMSO-d6), d: 5.00 (d, 2 H, CH2P, J = 15.3 Hz); 5.11 (d, 2 H, CH2P, J = 15.7 Hz); 7.10, 7.34 (AB-system, 2 H, PyH, J = 8.4 Hz); 7.47-7.49 (m, 3 H, P(2-thien)3); 7.51-7.53 (m, 3 H, P(2-thien)3); 7.89 (dd, 3 H, P(2-thien)3, J1= 8.3 Hz, J2= 3.6 Hz); 7.97 (dd, 3 H, P(2-thien)3, J1= 8.3 Hz, J2= 3.6 Hz); 8.47-8.50 (m, 6 H, P(2-thien)3); 11.33 (s, 1 H, OH). 13C NMR (DMSO-d6), d: 20.92 (s, CH2P); 25.93 (d, CH2P, J = 54.4 Hz); 119.25 (d, Cthien, J = 86.5 Hz); 123.89 (s, CPyr); 124.71 (s, CPyr); 129.64 (d, Cthien, J = 13.4 Hz); 131.00 (d, Cthien, J = 10.1 Hz); 133.74 (d, Cthien, J = 10.2 Hz); 135.23 (d, Cthien, J = 2.1 Hz); 137.02 (s, CPyr); 138.01 (CPyr); 139.45 (d, Cthien, J = 12.7 Hz); 153.09 (t, CPyr, J = 5.1 Hz). 31P NMR (DMSO-d6), d: 4.07; 4.31. HRMS, found: m/z 340.4863 [M – 3 Cl – H]2+. C31H26NOP2S6Cl2. Calculat- ed: [M – 3 Cl – H] = 340.4863., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Shtyrlin; Vafina; Pugachev; Khaziev; Nikitina; Zeldi; Iksanova; Shtyrlin, Yu. G.; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 537 – 545; Izv. Akad. Nauk, Ser. Khim.; 2; (2016); p. 537 – 545,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

To a solution of the chloro derivative of pyridoxine 9 (1 equiv) in 30 ml of acetonitrile were added trisubstituted phosphine (1-5 equiv). The reaction mixture was refluxed for 7 h. Different workup procedures were used for preparation of phosphonium salts., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Pugachev, Mikhail V.; Shtyrlin, Nikita V.; Sapozhnikov, Sergey V.; Sysoeva, Lubov P.; Iksanova, Alfiya G.; Nikitina, Elena V.; Musin, Rashid Z.; Lodochnikova, Olga A.; Berdnikov, Eugeny A.; Shtyrlin, Yurii G.; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7330 – 7342;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H)., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

2-Chloromethyl-3-hydroxypyridine hydrochloride (4) (0.40 g, 2.22 mmol) was added to a solution of tris- (2-thienyl)phosphine (0.93 g, 3.32 mmol) in acetonitrile (40 mL) and the mixture was refluxed for 12 h. Then, the solvent was evaporated in vacuo, the dry residue was dissolved in chloroform and washed with water. The aqueous layer was separated, dried in vacuo, and recrystallized from acetone. The yield was 0.24 g (24%), a white crystalline compound, m.p. 197-198 C. 1H NMR (DMSO-d6), d: 5.29 (d, 2 H, CH2P, J = 14.4 Hz); 7.22 (ABX-system, 1 H, 5-PyH, J1 = 8.0 Hz, J2= 4.6 Hz); 7.34 (ABX- system, 1 H, 4-PyH, J = 8.0 Hz); 7.49 (m, 3 H, P(2-thien)3 (thien means thienyl)); 7.91 (ABX-system, 1 H, 6-PyH, J = = 4.6 Hz); 7.97 (dd, 3 H, P(2-thien)3, J1 = 8.3 Hz, J2 = 3.4 Hz); 8.45 (t, 3 H, P(2-thien)3, J = 4.6 Hz); 10.83 (s, 1 H, OH). 13C NMR (DMSO-d6), d: 32.92 (d, CH2P, J = 64.3 Hz); 120.00 (d, Cthien, J = 112.2 Hz); 122.70 (s, CPyr); 124.62 (s, CPyr); 129.99 (d, Cthien, J = 16.2 Hz); 137.83 (d, Cthien, J = 3.9 Hz); 138.53 (s, CPyr); 140.51 (d, Cthien, J = 4.1 Hz); 141.98 (d, CPyr, J = 12.1 Hz); 152.36 (d, CPyr, J = 8.0 Hz). 31P NMR (DMSO-d6), d: 10.68. HRMS, found: m/z 388.0048 [M – 2 Cl – H]+. C18H16NOPS3Cl2. Calculated: [M – 2 Cl – H] = 388.0048., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shtyrlin; Vafina; Pugachev; Khaziev; Nikitina; Zeldi; Iksanova; Shtyrlin, Yu. G.; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 537 – 545; Izv. Akad. Nauk, Ser. Khim.; 2; (2016); p. 537 – 545,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate