Category: 240417-00-9

240417-00-9, 2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a nitrogen-purged glove box, a jar equipped with a stir bar was charged with 2- diphenylphosphino-2′-(N,N-dimethylamino)biphenyl (PhDavePhos, 0.75 g, 1.96 mmol) and toluene (20 mL). Mesitylcopper(I) (0.35 g, 1.92 mmol), dissolved in toluene (10 mL), was then added. After stirring at room temperature for about 5 minutes, pyrazole (0.14 g, 2.05 mmol) was added as a solid. The resulting mixture was at 100C, for 2 hours, with stirring. The solvent was mostly removed in vacuo, and the resulting mixture, in about 2 mL toluene, was precipitated with 40 mL hexanes. The solid was collected by filtration, and rinsed with hexanes. The white solid was dried under vacuum to yield the title complex (0.42 g), as an off white solid.

240417-00-9, The synthetic route of 240417-00-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DOW GLOBAL TECHNOLOGIES LLC; LAITAR, David S.; CLARK, Thomas P.; RACHFORD, Aaron A.; MUKHOPADHYAY, Sukrit; DE VRIES, Timothy S.; DEVORE, David D.; (31 pag.)WO2016/57441; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.

25 mL of Schlenk tube, and 2-diphenylphosphino-2 ‘- (N, N-dimethylamino) biphenyl was added to a solution of 76.3 mg (0.2 mmol), (1,5-cyclooctadiene) chloride2.5 mg of rhodium (I) dimer (2.5% of moles of raw material), and 32 mg of lithium tert-butoxide (0.4 mmol), argon was replaced three times, and 1 mL of 1,4-dioxane and 47.1 mg (0.3 mmol) of bromobenzene were added under argon. 120 C for 36 hours, cooled to room temperature and evaporated under reduced pressure. The solvent was separated on a 200-300 mesh silica gel column. The petroleum ether: Ester = 100: 1 and dried in vacuo to give 56.9 mg of product as a white solid in 62% yield,

240417-00-9 2-Diphenylphosphino-2’-(N,N-dimethylamino)biphenyl 2734939, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nanjing University; Qiu Xiaodong; Wang Minyan; Zhao Yue; Pu Xinghui; Hu Jiefeng; Shi Zhuangzhi; (26 pag.)CN106674279; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate