Cu(I)-Ming-phos Catalyzed Enantioselective [3+2] Cycloadditions of Glycine ketimines to β-Trifluoromethyl Enones was written by Liu, Bing;Zhang, Zhan-Ming;Xu, Bing;Xu, Shan;Wu, Hai-Hong;Zhang, Junliang. And the article was included in Advanced Synthesis & Catalysis in 2018.Related Products of 2222798-18-5 This article mentions the following:
A catalytic asym. [3+2] cycloaddition of glycine ketimines with β-CF3 β,β-disubstituted enones was realized in the presence of a chiral copper(I)/Ming-Phos complex. This method provided an access to construct highly functionalized pyrrolidines e.g.,I, bearing three contiguous stereocenters, which including a trifluoromethylated all-carbon quaternary stereocenter. The features of this reaction included high chemo-, diastereo-, enantioselectivity (up to > 20:1 cr, > 20:1 dr, 98% ee), readily available starting materials, well functional-group tolerance and mild reaction conditions. Control experiments demonstrated that the fluoro-substituent was crucial for the reactivity. In the experiment, the researchers used many compounds, for example, (R)-N-((R)-(2-(Diphenylphosphino)phenyl)(phenyl)methyl)-N,2-dimethylpropane-2-sulfinamide (cas: 2222798-18-5Related Products of 2222798-18-5).
(R)-N-((R)-(2-(Diphenylphosphino)phenyl)(phenyl)methyl)-N,2-dimethylpropane-2-sulfinamide (cas: 2222798-18-5) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.Related Products of 2222798-18-5
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis