Category: 18437-78-0

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under inert gas protection conditions,To a flask equipped with a stirring magnet, 344 mg of Fe2S2(CO)6 (1 mmol) and 30 mL of tetrahydrofuran solvent were added.A dark red solution was obtained, and the resulting solution was cooled to -78 ¡ã C with a liquid nitrogen bath.2.1 mL of lithium triethylborohydride (1M in THF) solution was slowly added under stirring.After reacting for 15 min, 0.2 mL of trifluoroacetic acid (2.5 mmol) was added and the reaction was continued for 15 min.Add 348 mg of P(C6H4-4-F)3 (1.1 mmol), stir at room temperature for 3 h before adding788 mg of I-4-C6H4N(CH2Cl)2 (2.5 mmol) and 0.3 mL of triethylamine were stirred at room temperature for 12 h.The solvent of tetrahydrofuran was removed by rotary distillation, and the residue was extracted with dichloromethane, and then subjected to thin-layer chromatography using a solvent of dichloromethane/petroleum ether ratio of 1:5 to collect a main color band to obtain a model 2 .

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; He Jiao; Wu Yu; Xie Ying; Jiang Jin; Sun Yanchun; Wang Zheng; Zou Like; Xie Bin; Gao Fan; Mu Chao; (11 pag.)CN109232665; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under N2 atmosphere, NaOAc (4.0?equiv), PPh3 1a (0.5?mmol), PdCl2 (10.0?mol?percent), AgOOCCF3 (5.0?equiv), CH3CN (2.0?mL) and methyl acrylate 2a (0.6?mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60?¡ãC for 24?h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid. IR (KBr disk, cm?1): nuC?O 2052 (vs), 1983 (vs), 1976 (vs), 1937 (vs). 1H NMR (500MHz, CDCl3): 7.55?7.50 (m, 6H, PhH), 7.14 (t, J=8Hz, 6H, PhH), 1.93 (d, J=7Hz, 2H, SCH2), 1.19 (d, J=8Hz, 2H, SCH2) ppm. 31P{1H} NMR (200MHz, CDCl3, 85percent H3PO4): 61.45 (s) ppm. 13C{1H} NMR (125MHz, CDCl3): 214.52 (d, JP-C=8.4Hz, PFeCO), 209.66 (FeCO), 164.92, 162.91 (dd, JP-C=1.4Hz, JF-C=251.7Hz, p-PhC), 135.13, 134.03 (dd, JP-C=8.4Hz, JF-C=13.1Hz, o-PhC), 131.67, 131.34 (dd, JP-C=40.7Hz, JF-C=3.4Hz, i-PhC), 116.21, 116.05 (dd, JP-C=10.6Hz, JF-C=21Hz, m-PhC), 34.88 (d, JP-C=2.9Hz, SCH2) ppm. Anal. Calc. for C25H16F3Fe2O5PS2: C, 45.48; H, 2.44. Found: C, 45.54; H, 2.56., 18437-78-0

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Complex 1 was synthesized by the simultaneous and dropwise addition of tris-(4-fluorophenyl)phosphine(0.316 g, 1 mmol) in acetone and sodium 4-benzylpiperazine-1-carbodithioate (0.274 g, 1 mmol)in methanol to a methanolic suspension of palladium(II) chloride (0.177 g, 1 mmol). The reaction mixturewas refluxed for 5 h with constant stirring. The resulting orange-colored solution was filtered androtary evaporated to obtained orange solid (scheme 1). It was dried and re-dissolved in chloroform,and on slow evaporation needle-like crystals were obtained. Complexes 2 and 3 were synthesized bythe same method (scheme 1). Complex 1: Yield: 0.50 g (65percent), M.p. 198 ¡ãC. Mol. Wt: 709.47: Anal. Cald (found) for C30H27ClF3N2PPdS2:C, 50.78 (50.71); H, 3.84 (3.83); N, 3.95 (3.92); S, 9.04 (9.00): IR (4000?200 cm?1): 1492 v(C?N); 1010 v(CSSsym);378 v(Pd?S); 303 v(Pd?Cl); 245 v(Pd-P). 1H NMR {CDCl3, 300 MHz, delta (ppm)}: 3.40 (s, 2H, H4), 3.56 (t, 4H,H2, H2?, 3J1H, 1H = 5.1 Hz), 2.27 (t, 4H, H3, H3?, 3J1H, 1H = 5.1 Hz), 7.28?7.40 (m, 17H, H6, H6?, H7, H7?,H8, Hb, Hb?,Hc, Hc?). 13C NMR {CDCl3, 75 MHz, delta (ppm)}: 205.4 (C1); 51.8 (C2, C2?), 46.8 (C3, C3?); 62.5 (C4), 136.8 (C5),129.1 (C6, C6?), 128.2 (C7, C7?), 127.6 (C8), 163.2 (Ca), 115.9 (Cb, Cb?); 124.8 (Cc, Cc?), 165.7 (Cd).

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Zia-ur-Rehman; Journal of Coordination Chemistry; vol. 69; 20; (2016); p. 2999 – 3009;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: PR3 and NH4PF6 were added to a solution of fac-[RuCl3(NO)(P?N)] (1) in MeOH (5 mL) and the resulting orange suspensionwas refluxed for 3 h, except for the P(p-Me-C6H4)3 system whenreaction occurred at r.t. After being cooled to room temperature,the resulting yellow suspensions of complexes 3?5 were filteredto give a yellow solid that was washed with H2O (2 5 mL), MeOH(2 5 mL) and Et2O (2 5 mL), and then dried in vacuo. In the caseof complex 2, the reaction generated a clear yellow solution; thesolvent was removed in vacuo to give a yellow residue that wasthen largely dissolved in CH2Cl2 (5 mL), and the mixture wasfiltered through Celite. Addition of n-hexane (15 mL) yielded a yellowsolid that was then treated as described above. The mer, transisomerof 1 [6,7] could also be used as the precursor for synthesesusing the same methodology, which gave similar product yields., 18437-78-0

As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; da Silva, Juliana P.; Fagundes, Francisco D.; Back, Davi F.; Ellena, Javier; James, Brian R.; de Araujo, Marcio P.; Inorganica Chimica Acta; vol. 454; (2017); p. 40 – 45;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred and degassed solution of [Fe(h5-Cp)(CO)2I] (1 mmol)in dry acetone (30 mL) PR3 (1 mmol) was added. The reactionmixture was then irradiated under UV light (125 W) for 3e7 h (seebelow). The precipitate was separated by cannula-filtration and thesolvent was evaporated under vacuum. The residue was twicerecrystallized from dry dichloromethane/n-hexane and dark greenproducts are obtained.[Fe(h5-Cp)(CO)(PPh3)

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Pilon, Adhan; Girio, Patricia; Nogueira, Guilherme; Avecilla, Fernando; Adams, Harry; Lorenzo, Julia; Garcia, M. Helena; Valente, Andreia; Journal of Organometallic Chemistry; vol. 852; (2017); p. 34 – 42;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: Under N2 atmosphere, NaOAc (4.0?equiv), PPh3 1a (0.5?mmol), PdCl2 (10.0?mol?percent), AgOOCCF3 (5.0?equiv), CH3CN (2.0?mL) and methyl acrylate 2a (0.6?mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60?¡ãC for 24?h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the chloro derivative of pyridoxine 9 (1 equiv) in 30 ml of acetonitrile were added trisubstituted phosphine (1?5 equiv). The reaction mixture was refluxed for 7 h. Different workup procedures were used for preparation of phosphonium salts.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Pugachev, Mikhail V.; Shtyrlin, Nikita V.; Sapozhnikov, Sergey V.; Sysoeva, Lubov P.; Iksanova, Alfiya G.; Nikitina, Elena V.; Musin, Rashid Z.; Lodochnikova, Olga A.; Berdnikov, Eugeny A.; Shtyrlin, Yurii G.; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7330 – 7342;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 0.28 g (0.76 mmol) of iodo aminoester (S)-2-(t-butyloxycarbonylamino)allyl-4-iodobutanoate (III’) and 0.48 g (1.5 mmol) of [tri-(4- fluorophenyl) ]phosphine in THF was stirred 24h under argon at 80¡ãC. Then, 3 mL of toluene followed by 30 mL of diethyl ether were added to the mixture at room temperature. The white precipitate was filtered off and washed with 2 x 25 mL of diethyl ether and purified by chromatography with a mixture of acetone / petroleum ether (2 : 7) as eluent. The phosphonium salt (Il’d) was isolated in 63percent yield. Pale yellow solid. 31P NMR (121 MHz, CDCl3) : 5(ppm) = +26 (s)., 18437-78-0

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE BOURGOGNE; JUGE, Sylvain; BAYARDON, Jerome; REMOND, Emmanuelle; ONDEL-EYMIN, Marie-Joelle; WO2013/30193; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.25 methyl 2-phenyl-5-(4-fluorophenyl)thiazole-4-carboxylate (4e) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 118 mg (76percent). White solid, mp 126-128 ¡ãC; 1H NMR (300 MHz, CDCl3) delta 3.86 (s, 3H), 7.13 (t, J=8.6 Hz, 2H), 7.44-7.47 (m, 3H), 7.50-7.56 (m, 2H), 7.94-7.99 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 166.1, 165.0, 162.5, 161.7, 145.3, 140.9, 132.6, 131.9, 131.8, 130.7, 129.0, 126.8, 126.3, 126.2, 115.5, 115.3, 52.3 ppm; IR (KBr) 2944, 1721, 1528, 1468, 1343, 1224, 1200, 1007, 843, 762, 689 cm-1; HRMS (ESI) calcd for [C17H12FNO2S+H]+ 314.0646, found 314.0649.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate