Category: 17261-28-8

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

After dissolving 3-amino-2-naphthol (0.159 g, 1.0 mmol), 2 (diphenylphosphino) benzoic acid (0.306 g, 1.0 mmol) and paratoluenesulfonicacid (0.190 g, 1.0 mmol) in 30 ml of toluene,The mixture was stirred at 150 under N2 (g) air flow for 15 hours.The product was separated into H2O and toluene layers using H2O,after toluene layer only collected separately dissolved in minimum amount of CHCl3 and the solvent evaporated in evaporator was performed by a silica gel column (Merck 60, 70-230 mesh).The column was prepared using a solution of CHCl3: ethyl acetate in a volume ratio of 5: 1 (v: v),The extracted product was recrystallized with CHCl3 and ethyl acetate in a volume ratio of 5: 2. The recrystallized product was dissolved in 10 ml of CH2Cl2,While stirring, 2 ml of H2O2 (30percent) was slowly added dropwise and the reaction was allowed to proceed overnight.The product was separated into a H2O layer and a CH2Cl2 layer using H2O,The CH2Cl2 layer alone was collected and the solvent was evaporated by evaporator and 2- (2-diphenylphosphoryl) phenyl) naphtho [2,3-d] oxazole (2-PPN),obtained.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Inje university industry-academic cooperation foundation; Lee, Bum-Jong; Kim, Ik-Hwan; Kang, Eun-Guk; Kim, Kyung-Hyun; (23 pag.)KR101581821; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: To a diethyl ether solution (20 mL) of AgCF3SO3 (51 mg,0.2 mmol) was added the corresponding phosphinobenzoic acid(61 mg, 0.2 mmol), and the reaction stirred for 2 h protected fromthe light. The insoluble compounds were filtered off, washed anddried. A second fraction was obtained by evaporation ca. 2 ml and addition of hexane. Compounds 1?2 were obtained as whitesolids. Yield of 1: 78 mg, 70percent. Anal. Calc. for C40H30Ag2F6O10P2S2:C, 42.65; H, 2.68; N, 0. Found: C, 42.37; H, 2.75; N, 0percent. 1H NMR(d6-acetone): d 8.37 (d, JHH = 7.6 Hz, 1H, H6), 7.76 (td, JHH = 7.6 Hz,JHP = 1.4 Hz, 1H, H5), 7.70 (td, JHH = 7.6 Hz, JHP = 1.4 Hz, 1H, H4),7.59?7.45 (m, 10H, Ph), 7.04 (t, JHP = JHH = 7.8 Hz, 1H, H3). 1HNMR (50 C, d6-acetone): d 12.49 (brs, 1H, COOH), 8.40 (ddd,JHH = 7.5 and 1.5 Hz, JHP = 4.4 Hz, 1H, H6), 7.82 (t, JHH = 7.5 Hz, 1H,H5), 7.77 (t, JHH = 7.5 Hz, 1H, H4), 7.60?7.43 (m, 10H, Ph),6.94 (ddd, JHP = 9.2 and 1.2 Hz, JHH = 7.5 Hz, 1H, H3). 19F NMR(d6-acetone): 77.58 (s). 31P NMR (d6-acetone): 15.6 (brs).31P NMR (50 C, d6-acetone): 15.5 (d, 1J107Ag?31P = 736 and1J109Ag?31P = 849 Hz). IR (KBr): 3060 m(O?H), 1673 m(CO), 1257,1223, 1209, 635 (CF3SO3) cm?1. Yield of 2: 91 mg, 81percent. Anal. Calc.for C20H15AgF3O5PS: C, 42.65; H, 2.68; N, 0. Found: C, 42.60; H,2.84; N, 0percent. 1H NMR (d6-acetone): d 11.5 (brs, 1H, COOH), 8.13(d, JHH = 8.0 Hz, 2H, H2), 7.68?7.55 (m, 12H, H3+Ph). 1H NMR(50 C, d6-acetone): d 12.54 (brs, 1H, COOH), 8.15 (dd, JHP =1.6 Hz, JHH = 8.4 Hz, 2H, H2), 7.68?7.53 (m, 12H, H3+Ph). 19F NMR(d6-acetone): 77.6 (s). 31P NMR (d6-acetone): 14.5 (d, 1JAg?P =721 Hz). 31P NMR (50 C, d6-acetone): 13.8 (d, 1J107Ag-31P = 690and 1J109Ag-31P = 795 Hz). IR (KBr): 3054 m(O?H), 1687 m(CO),1223, 635 (CF3SO3) cm1.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Miguel-Coello, Ana B.; Bardaji, Manuel; Inorganica Chimica Acta; vol. 423; PA; (2014); p. 219 – 224;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate