Category: 17261-28-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, 2-(Diphenylphosphanyl)benzoic acid (0.50 g, 1.63 mmol) and 4-dimethylaminopyridine (DMAP, 20 mg, 0.163 mmol) were dissolved in CH2Cl2 (10 mL). Ethanol (0.29 mL, 4.89 mmol) was added, and the solution was placed under Ar(g) and cooled to 0¡ã C. N,N’-Diisopropylcarbodiimide (DIC, 0.25 mL, 1.63 mmol) was added dropwise, and the resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography, eluting with 10percent EtOAc(ethylacetate)/hexanes, to give phosphine 1a as a pale yellow solid (0.44 g, 1.32 mmol, 81percent yield). 2-(Diphenylphosphanyl)benzoic acid was purchased from Sigma-Aldrich (St. Louis, Mo.).Data for 1a: 1H NMR (400 MHz, CDCl3) delta=8.07 (m, 1H, Ar.), 7.44-7.25 (m, 12H, Ar.), 6.93 (m, 1H, Ar.), 4.22 (q, 2H, J=7.1 Hz, OCH2CH3), 1.21 (t, 3H, J=7.1 Hz, OCH2CH3). 13C NMR (100 MHz, CDCl3, 31P-coupled; 1H-decoupled, observed signals) delta=166.9, 140.8, 140.0, 138.1, 137.9, 134.8, 134.6, 134.3, 134.0, 133.8, 131.8, 130.6, 128.6, 128.5, 128.4, 128.2, 61.2, 14.0. 31P NMR (162 MHz, CDCl3) delta=-4.0. HRMS (ESI+) m/z calculated for (C21H20O2P)+ 335.1196, measured 335.1208.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Patent; Raines, Ronald Thaddeus; Myers, Eddie Leonard; US2010/125132; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.8 (1R,2S)-1-Phenyl-2-(pivalamido)propyl 2-(diphenylphosphinyl)benzoate 9d fx17 Purified by flash column chromatography (80/20, hexanes/EtOAc) to yield 0.256 g (20percent) of product as a yellow oil. [alpha]D23 = -12.7 (c 0.694, CHCl3). 1H NMR (500 MHz, CDCl3): delta 0.86 (d, J = 6.9 Hz, 3H), 1.04 (s, 9H), 4.35-4.41 (m, 1H), 6.00 (s, 1H), 6.02 (d, J = 3.7 Hz, 1H), 6.90-6.93 (m,1H), 7.14-7.26 (m, 16H), 7.31-7.39 (m, 3H), 8.04-8.07 (m, 1H). 13C NMR (100 MHz, CDCl3): delta 14.75, 27.58, 38.67, 49.00, 79.18, 126.62, 127.92, 128.38, 128.57, 128.63, 128.68, 128.73, 128.87, 130.90, 130.94, 132.31, 133.47, 133.66, 133.81, 133.96, 134.17, 134.79, 134.89, 135.00, 137.48, 137.58, 137.69, 139.58, 139.84, 166.33, 177.80. 31P NMR (162 MHz, CDCl3): delta -5.24. IR v (Nujol): 1717, 1652, 1398, 1378, 1251, 746, 697 cm-1. ESI HRMS for C33H34NO3P: calcd (M+H+) 524.2355; found 524.2353.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

To the reactor was added 2-diphenylphosphine benzoic acid (5.00 g 16.26 mmol) N-hydroxysuccinimide (3.74 g, 32.52 mmol) and DCC (6.71 g, 32.52 mmol) followed by dichloromethane (80.0 mL), stirred at room temperature for 12 hours, filtered through celite and rinsed with dichloromethane to give the filtrate. Steamed and purified by silica gel column chromatography to give the indicated product The product was pale yellow solid 2 (5.03 g, yield 77percent)., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Chemical Institute; Shi Yian; Liu Weigang; Pan Hongjie; Tian Hua; (25 pag.)CN105017172; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.6 (1R,2S)-2-(4-Nitrobenzamido)-1-phenylpropyl 2-(diphenylphosphinyl)benzoate 9b fx15 Purified by flash column chromatography (50/50, hexanes/ EtOAc) to yield 0.300 g (43percent) of product as a yellow oil. [alpha]D23 = -18.9 (c, 1.04 CHCl3). 1H NMR (500 MHz, CDCl3): delta 0.94 (d, J = 7.0 Hz, 3H), 4.61-4.68 (m, 1H), 6.29 (d, J = 2.8 Hz, 1H), 7.06-7.09 (m, 1H), 7.19-7.23 (m, 4H), 7.30-7.38 (m, 11H), 7.43-7.50 (m, 3 H), 7.99 (d, J = 8.8 Hz, 2 H), 8.05-8.08 (m, 1H), 8.18 (d, J = 8.8 Hz, 2H). 13C NMR (100 MHz, CDCl3): delta 13.95, 50.41, 79.33, 123.66, 126.10, 128.13, 128.49, 128.52, 128.59, 128.68, 128.75, 128.89, 129.08, 129.17, 130.78, 130.82, 132.42, 133.28, 133.46, 133.76, 133.96, 134.10, 135.11, 135.43, 135.66, 136.75, 136.81, 136.90, 137.15, 138.26, 138.48, 140.25, 149.43, 164.88, 167.33. 31P NMR (162 MHz, CDCl3): delta -5.39. IR v (cm-1, neat): 3068, 2982, 1717, 1660, 1524, 1346, 1250, 729, 698. ESI HRMS for C35H29N2O5P: calcd (M+H) 589.1892, found 589.1901.

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: The 1a? (439 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed in vacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-(benztriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol), followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 6 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried overNa2SO4. The solvent was removed in vacuo to afford the crude product as a colourless oil, which was purified by flash chromatography (20percent EtOAc in hexanes) yielding the precat. 1a as a white solid (514 mg, 82percent).

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Zheng, Xiaojun; Deng, Qifu; Hou, Qinglin; Zhang, Kaiqiang; Wen, Pushan; Hu, Shunqin; Wang, Haifei; Synthesis; vol. 50; 12; (2018); p. 2347 – 2358;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate