Category: 17261-28-8

17261-28-8. Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 17261-28-8, Name is 2-(Diphenylphosphino)benzoic acid,introducing its new discovery.

Phosphines: Preparation, reactivity and applications

The annual survey of the literature relating to the chemistry of traditional phosphines containing only P-C and P-H bonds published during 2017 is presented. It includes the the synthesis of new phosphines classified according to the used synthetic approachs, the data concerning the reactivity of phosphines excluding metal complexation (mainly the attack of phosphorus at carbon or other atoms and the formation of P(v) derivatives of phosphines) and the application of phosphines in organocatalysis and other fields of chemistry or adjacent sciences.

17261-28-8, If you are hungry for even more, make sure to check my other article about 17261-28-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 17261-28-8, Name is 2-(Diphenylphosphino)benzoic acid, molecular formula is C19H15O2P.

Fast reductive ligation of S-nitrosothiols

(Chemical Equation Presented) “Nitroso” knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 17261-28-8 is helpful to your research., 17261-28-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

To a solution of 2-diphenylphosphinobenzoic acid (67 mg, 0.22 mmol) in dry CH2Cl2 (5 mL) under an argon atmosphere N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide (50 mg, 0.26 mmol), hydroxybenzotriazole (36 mg, 0.26 mmol), and (1R,5S)-(-)-cytisine (50 mg, 0.26 mmol) were added at room temperature. The mixture was stirred at room temperature for 24 h and then was directly subjected to flash column chromatography (silica gel, CH2Cl2/CH3OH = 50:1) to give 104 mg (99percent yield) of 3 as a white solid; m.p. 126-128 ¡ãC. [alpha]D20 = -198.4 (c 0.64, CHCl3). 1H NMR (600 MHz, CDCl3, 253 K): 1:0.9 mixture of rotamers; signals for B-chair conformer: delta = 7.40-7.38 (m, 2H, Har), 7.37-7.34 (m, 1H, 10-H), 7.35-7.33 (m, 2H, Har), 7.32-7.30 (m, 3H, Har), 7.24-7.21 (m, 1H, Har), 7.20-7.16 (m, 3H, Har), 7.10 (dt, JH,H = 7.5, 0.6 Hz, 1H, Har), 7.06-7.02 (m, 1H, Har), 6.61 (dd, JH,H = 9.1, 1.2 Hz, 1H, 9-H), 6.15 (ddd, JH,H = 7.6, 3.6, 0.7 Hz, 1H, Har), 5.88 (dd, JH,H = 6.8, 1.0 Hz, 1H, 11-H), 4.85 (d, JH,H = 12.4 Hz, 1H, 4-Heq), 4.26 (d, JH,H = 15.6 Hz, 1H, 6-H), 3.90 (dd, JH,H = 15.6, 6.4 Hz, 1H, 6-H), 3.32 (d, JH,H = 12.7 Hz, 1H, 2-Heq), 2.94 (d, JH,H = 12.4 Hz, 1H, 4-Hax), 2.87 (brs, 1H, 1-H), 2.76 (dd, JH,H = 12.7, 1.6 Hz, 1H, 2-Hax), 2.61 (brs, 1H, 5-H), 2.05-1.92 (m, 2H, 13-H) ppm; resolved signals for A-chair conformer: delta = 7.45-7.42 (m, 1H, Har), 7.06-7.02 (m, 1H, Har), 7.37-7.34 (m, 1H, 10-H), 6.94 (ddd, JH,H = 7.5, 3.3, 0.6 Hz, 1H, Har), 6.54 (dd, JH,H = 9.0, 1.1 Hz, 1H, 9-H), 6.19 (dd, JH,H = 6.8, 0.7 Hz, 1H, 11-H), 4.75 (d, JH,H = 12.8 Hz, 1H, 2-Heq), 4.11 (d, JH,H = 15.6 Hz, 1H, 6-H), 3.74 (dd, JH,H = 15.6, 6.0 Hz, 1H, 6-H), 3.50 (d, JH,H = 12.6 Hz, 1H, 4-Heq), 3.20 (brs, 1H, 1-H), 3.04 (dd, JH,H = 12.8, 1.9 Hz, 1H, 2-Hax), 2.98 (d, JH,H = 12.6 Hz, 1H, 4-Hax), 2.32 (brs, 1H, 5-H), 2.05-1.92 (m, 2H, 13-H) ppm. 13C NMR (150.9 MHz, CDCl3, 253 K): signals for B-chair conformer: delta = 170.15 (Cq, C=O, amide), 163.19 (Cq, C=O, lactam), 148.16 (CH, 12-C), 141.27 (d, J31P,13C = 33.7 Hz, Cq, Car), 138.61 (CH, 10-C), 135.82 (d, J31P,13C = 9.9 Hz, Cq, Car), 135.70 (d, J31P,13C = 9.4 Hz, Cq, Car), 134.26 (d, J31P,13C = 20.7 Hz, 2 CH, Car), 134.00 (CH, Car), 133.63 (Cq, CCO), 133.06 (d, J31P,13C = 18.8 Hz, 2 CH, Car), 129.96 (CH, Car), 129.09 (CH, Car),129.03 (CH, Car), 128.56 (d, J31P,13C = 6.8 Hz, 2 CH, Car), 128.53 (d, J31P,13C = 7.8 Hz, 2 CH, Car), 128.29 (CH, Car), 126.06 (d, J31P,13C = 7.5 Hz, 1 CH, Car), 117.66 (CH, 9-C), 105.61 (CH, 11-C), 53.13 (d, J31P,13C = 1.8 Hz, CH2, 2-C), 49.01 (CH2, 6-C), 47.22 (CH2, 4-C), 34.37 (CH, 1-C), 26.93 (CH, 5-C), 25.72 (CH2, 13-C) ppm; signals for A-chair conformer: delta = 170.21 (Cq, C=O, amide), 163.26 (Cq, C=O, lactam), 148.18 (CH, 12-C), 141.65 (d, J31P,13C = 33.9 Hz, Cq, Car), 139.50 (CH, 10-C), 135.52 (d, J31P,13C = 8.5 Hz, Cq, Car), 135.42 (d, J31P,13C = 8.9 Hz, Cq, Car), 134.04 (d, J31P,13C = 20.3 Hz, 2 CH, Car), 134.04 (CH, Car), 133.76 (Cq, CCO), 133.03 (d, J31P,13C = 18.8 Hz, 2 CH, Car), 129.96 (CH, Car), 128.87 (CH, Car), 128.55 (CH, Car), 128.49 (CH, Car), 128.31 (d, J31P,13C = 6.5 Hz, 2 CH, Car), 128.27 (d, J31P,13C = 6.3 Hz, 2 CH, Car), 126.23 (d, J31P,13C = 7.9 Hz, 1 CH, Car), 117.19 (CH, 9-C), 106.42 (CH, 11-C), 52.23 (d, J31P,13C = 2.2 Hz, CH2, 4-C), 48.47 (CH2, 6-C), 48.30 (CH2, 2-C), 34.17 (CH, 1-C), 27.26 (CH, 5-C), 25.86 (CH2, 13-C) ppm. 31P{1H} NMR (242.92 MHz, CDCl3, 253 K): signal for B-chair conformer: delta = -14.07 ppm; signal for A-chair conformer: delta = -13.75 ppm. IR (KBr): nu = 3050, 2925, 2854, 1657, 1639, 1580, 1546, 1434, 1424, 1306, 1243, 745, 673 cm-1. MS (ESI): m/z = 479 (100, [M + 1]+), 289 (63). C30H27N2O2P (478.52): calcd. C 75.30, H 5.69, N 5.85, found C 75.63, H 5.81, N 5.96., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Philipova, Irena; Stavrakov, Georgi; Vassilev, Nikolay; Nikolova, Rositsa; Shivachev, Boris; Dimitrov, Vladimir; Journal of Organometallic Chemistry; vol. 778; (2015); p. 10 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, A mixture of DCMOH (156.2 mg, 0.5 mmol), 2-(diphenylphosphino)benzoic acid (183.8 mg, 0.6 mmol), N,N?-dicyclohexylcarbodiimide(288.9 mg, 1.4 mmol) and 4-dimethylaminopyridine (61.1 mg, 0.5 mmol) in anhydrousdichloromethane was stirred at room temperature for 12 h.The residue was filtrated, washed with brine, and extractedwith dichloromethane. The organic layer was dried overanhydrous Na2SO4 and concentrated. The residue was purifiedby silica gel chromatography with dichloromethane/methanol (15:1, v/v) to give DCMHNO as a brown solid(195 mg, 65%). 1H NMR (400 MHz, CDCl3) delta 8.91 (dd, J1=8.4 Hz, J2=1.2 Hz, 1H), 8.31-8.22 (m, 1H), 7.76-7.72 (m,1H), 7.63-7.52 (m, 4H), 7.50-7.42 (m, 3H), 7.41-7.27 (m,10H), 7.06-6.98 (m, 3H), 6.86 (s, 1H), 6.75 (d, J=15.9 Hz,1H). 13C NMR (101 MHz, CDCl3) delta 164.94, 157.26, 152.81,152.32, 152.21, 141.67, 141.39, 137.85, 137.55, 137.44,134.71, 134.52, 134.16, 133.95, 132.76, 132.28, 131.40,128.96, 128.86, 128.65, 128.58, 128.39, 126.02, 125.84,122.49, 118.79, 118.63, 117.84, 116.71, 115.62, 106.98,63.05. HRMS (MALDI-TOF): m/z: [M+K]+ calcd. forC39H25KN2O3P+: 639.1234; found: 639.1444. m.p.232-234 C.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Wang, Jianguo; Zhu, Wenping; Li, Chunbin; Zhang, Pengfei; Jiang, Guoyu; Niu, Guangle; Tang, Ben Zhong; Science China Chemistry; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: Triphenylphosphite (2.25g, 7.25mmol) was added portionwise to a stirred mixture of the corresponding amino acid methyl ester hydrochloride (7.15mmol), 2-(diphenylphosphanyl)benzoic acid (2.19g, 7.15mmol), and pyridine (30mL) at 100¡ãC under an argon atmosphere. The reaction mixture was stirred at this temperature for 6h. The excess of pyridine was removed under vacuum. The resulting residue was dissolved in chloroform, washed with water (3 times), saturated aqueous solution of NaHCO3 (3 times), and again with water (2 times). The organic layer was separated, dried over anhydrous Na2SO4, and evaporated to dryness. The resulting residue was purified by column chromatography on silica gel (eluent EtOAc?hexane (1:2)) to give ligands 5a,b as white crystalline solid. 4.2.4.1 Methyl (2R)-2-{[2-(diphenylphosphanyl)benzoyl]amino}-3-(methylsulfanyl)propanoate 5a Yield: 1.25 g (40percent). Mp: 105?108¡ãC. 31P{1H} (121.49 MHz, CDCl3): delta ?9.31 ppm. 1H NMR (400.13 MHz, CDCl3): delta 2.11 (s, 3H, SMe), 2.93 (d, 2H, CH2, 3JHH=5.0 Hz), 3.79 (s, 3H, OMe), 4.92 (dt, 1H, CH, 3JHH=7.6 Hz, 3JHH=5.0 Hz), 6.87 (br d, 1H, NH, 3JHH=7.6 Hz), 7.02 (ddd, 1H, H(C3), 3JHH=7.7 Hz, 3JHP=4.0 Hz, 4JHH=0.8 Hz), 7.29?7.39 (m, 11H, HAr), 7.43 (dt, 1H, H(C5), 3JHH=7.5 Hz, 4JHH=1.2 Hz), 7.70 (ddd, 1H, H(C6), 3JHH=7.5 Hz, 4JHP=3.8 Hz, 4JHH=1.2 Hz) ppm. 13C{1H} NMR (100.61 MHz, CDCl3): delta 16.33 (s, SMe), 36.45 (s, CH2S), 52.04 and 52.64 (both s, OMe and CH), 127.66 (d, C3, 2JCP=4.6 Hz), 128.53 (d, m-C in PPh, 3JCP=6.9 Hz), 128.58 (d, m-C in PPh, 3JCP=6.8 Hz), 128.62 (s, C4 or C5), 128.75 and 128.78 (both s, p-C in PPh2), 130.60 (s, C5 or C4), 133.79 (d, o-C in PPh, 2JCP=3.8 Hz), 133.99 (d, o-C in PPh, 2JCP=3.7 Hz), 134.45 (s, C6), 137.09 (d, C2, 1JCP=22.2 Hz), 137.28 (d, ipso-C in PPh, 1JCP=11.3 Hz), 137.33 (d, ipso-C in PPh, 1JCP=11.0 Hz), 140.15 (d, C1, 2JCP=24.3 Hz), 168.37 (s, C(O)NH), 171.26 (s, C(O)OMe) ppm. IR (KBr, nu/cm?1): 498(w), 518(w), 697(m), 749(s), 999(vw), 1027(vw), 1090(w), 1126(vw), 1159(w), 1176(w), 1214(m), 1258(w), 1311(w), 1434(m), 1459(w), 1479(w), 1520(br, m) (C(O)NH), 1560(vw), 1584(w), 1649(s) (nuC=O in C(O)NH), 1744(s) (nuC=O in C(O)OMe), 2850(vw), 2917(w), 2950(w), 3051(w), 3295(br, w) (nuNH). Anal. Calc. for C24H24NO3PS: C, 65.89; H, 5.53; N, 3.20. Found: C, 66.03; H, 5.49; N, 3.14percent.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Churusova, Svetlana G.; Aleksanyan, Diana V.; Rybalkina, Ekaterina Yu.; Nelyubina, Yulia V.; Peregudov, Alexander S.; Klemenkova, Zinaida S.; Kozlov, Vladimir A.; Polyhedron; vol. 143; (2018); p. 70 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.5 (1R,2S)-2-Benzamido-1-phenylpropyl 2-(diphenylphosphinyl)benzoate 9a fx14 Purified by recrystallization in CH2Cl2/hexanes to yield 0.702 g (71percent) of product as a white solid. [alpha]D23 = -5.9 (c 1.04, CHCl3). Mp = 77-81 ¡ãC. 1H NMR (400 MHz, CDCl3): delta 0.93 (d, J = 7.0 Hz, 3H), 4.64-4.71 (m, 1H), 6.22 (d, J = 2.9 Hz, 1H), 7.03-7.05 (m, 1H), 7.07 (dd, J = 8.8, 2.5 Hz, 1H), 7.20-7.49 (m, 20H), 7.83 (d, J = 8.3 Hz, 2H), 8.08 (m, 1H). 13C NMR (100 MHz, CDCl3): delta 14.45, 49.63, 79.55, 126.20, 127.28, 127.30, 127.99, 128.48, 128.50, 128.59, 128.66, 128.74, 128.93, 129.00, 130.92, 130.96, 131.38, 132.26, 133.34, 133.53, 133.97, 134.17, 134.63, 134.96, 135.44, 135.67, 137.02, 137.11, 137.15, 137.25, 137.39, 138.57, 138.80, 166.77, 167.03. 31P NMR (162 MHz, CDCl3): delta -5.64. IR v (cm-1, Nujol mull): 1722, 1627, 1247, 753, 695. ESI HRMS for C35H30NO3P: calcd (M+H) 544.2042; found 544.2042., 17261-28-8

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

To a solution of 2-(diphenylphosphino)benzoic acid (375 mg, 1.23 mmol) in DMF (10 mL) in 0 C. DIPEA (0.4 mL, 2.234 mmol), Compound 1 (640 mg, 1.117 mmol) and HATU (640 mg, 1.675 mmol) was added. The reaction was continued by stirring at RT for 12 h and the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with water and stirred for 15 minutes. The precipitated solid was filtered off, washed with water and dried in vacuo. Purification of the crude product by column chromatography on silica gel (100-200 mesh) using methanol in DCM (0.5: 9.5) as eluent gave the detector according to the invention as a pale yellow solid (320 mg; 33.20%). Mito-1 was obtained., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Korea University Research Management System; Seon U-gyeong; Sang Ka-peu-rae-sa-deu-beu-heu-ni-ya; Kim Jong-seung; (17 pag.)KR2019/85401; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N,N’-Dicyclohexylcarbodiimide (163 mg, 0.79 mmol) and 4-dimethylaminopyridine (5 mg, 0.039 mmol) were added to a solution of 2-(diphenylphosphino)benzoic acid (220.0 mg, 0.72 mmol) in anhydrous CH2Cl2 (30 mL) under argon with stirring at room temperature. After 30 min, fluorescein monomethyl ether (249 mg, 0.72 mmol) was added and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and cold acetone was added to dissolve the crude product. The insoluble urea by-product was removed by filtration. The filtrate was concentrated and the residue was purified by silica gel column chromatography (EtOAc /pet.ether=1:2) to provide 1 as a pale yellow solid (280 mg, 61percent)., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Miao, Zhengrui; Reisz, Julie A.; Mitroka, Susan M.; Pan, Jia; Xian, Ming; King, S. Bruce; Bioorganic and Medicinal Chemistry Letters; vol. 25; 1; (2015); p. 16 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, The 1a? (439 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed in vacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-(benztriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol), followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 6 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried overNa2SO4. The solvent was removed in vacuo to afford the crude product as a colourless oil, which was purified by flash chromatography (20percent EtOAc in hexanes) yielding the precat. 1a as a white solid (514 mg, 82percent). Mp. 93?95 ¡ãC [alpha]D30 = +20.8 (c 1.20, CH2Cl2); 1H NMR (400 MHz, CDCl3): delta = 7.63?7.61 (m, 2 H), 7.38?7.18 (m, 15 H), 7.12?6.98 (m, 8 H), 6.71 (d, J = 8.0 Hz, 1 H), 5.08 (dd, J = 11.2, 3.6 Hz, 1 H), 4.53 (dd, J = 8.4, 5.6 Hz, 1 H), 3.68 (d, J =11.2, 1 H), 2.12 (s, 6 H), 2.12?2.04 (m, 1 H), 0.84 (d, J = 7.2 Hz, 3 H), 0.82 (d, J = 7.2 Hz, 3H); 13C NMR (100 MHz, CDCl3): delta (C-P coupling not removed) = 171.1, 168.7, 141.2, 141.0, 140.5, 137.6, 137.5, 137.4, 136.6, 136.4, 134.5, 133.9, 133.8, 133.7, 132.1, 130.3, 129.7, 128.7, 128.6, 128.5, 128.5, 128.4, 127.9, 127.7, 127.7, 127.5, 127.5, 126.9, 73.2, 58.5, 54.8, 40.5, 31.8, 19.1, 18.0; 31P NMR (162 MHz, CDCl3) delta = ? 10.2; HRMS (ESI): calcd. for C40H43N3O2P [M+H]+ 628.3093, found 628.3095.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zheng, Xiaojun; Deng, Qifu; Hou, Qinglin; Zhang, Kaiqiang; Wen, Pushan; Hu, Shunqin; Wang, Haifei; Synthesis; vol. 50; 12; (2018); p. 2347 – 2358;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, Compound 1 (386 mg, 1 mmol), 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), DIEA (129 mg, 1 mmol), and 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3- tetramethyluronium hexafluorophosphate (HATU) (380 mg, 1 mmol) were dissolved in anhydrous CH2Cl2. The reaction mixture was stirred at room temperature for 12 h under argon atmosphere, tracked with TLC. And then the mixture was poured into water and extracted with CH2Cl2. The organic layer was separated, washed with saturated salt water, and dried over Na2SO4. The solvent was evaporated and the crude product of 2 was purified by column chromatography over silica gel, and eluted with CH2Cl2/petroleum ether (15:1) gave 2 as white solid (235 mg, 35percent). MP: 210 – 212 oC. 1H NMR (400 MHz, CDCl3) delta (ppm) 8.02 (d, J = 7.5 Hz, 1H), 7.70 – 7.59 (m, 4H), 7.40 – 7.17 (m, 15 H), 6.96 – 6.93 (m, 1H), 6.54 (d, J = 8.9 Hz, 1H), 6.44 (d, J = 2.4 Hz, 1H), 6.35 (dd, J = 8.8 Hz, 2.4 Hz, 1H), 6.26 (d, J = 2.1 Hz, 1H), 3.36 (q, J = 7.0 Hz, 4H), 1.17 (t, J = 7.0 Hz, 6H). 13C NMR (100 MHz, CDCl3): 169.69, 167.09, 153.27, 152.84, 149.74, 148.67, 141.36, 141.11, 135.04, 134.40, 134.21 134.17, 134.11, 134.01, 133.97, 133.90, 132.98, 130.58, 129.67, 129.49, 129.18, 128.99, 128.92, 128.84, 128.77, 128.69, 128.56, 128.51, 126.97, 124.97, 124.25 123.59, 119.44, 118.90, 117.61, 108.51, 104.77, 97.68, 83.99, 44.60, 12.63. 31P NMR (161.9 MHz, CDCl3) delta (ppm): -10.268. HRMS: calcd. m/z 675.2413 [M + H]+; m/z 1349.4747 [2M + H]+, found m/z 675.2419 [M + H]+; m/z 1349.4761 [2M + H]+.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Huang, Kun; He, Song; Zeng, Xianshun; Tetrahedron Letters; vol. 58; 20; (2017); p. 2004 – 2008;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate