Category: 167693-62-1

Lloyd-Jones, Guy C.;Butts, Craig P. published 《Nickel(II) complexes bearing (phosphinoaryl)oxazoline ligands as pro-catalysts for Grignard cross-coupling》. The research results were published in《Tetrahedron》 in 1998.Synthetic Route of C25H26NOP The article conveys some information:

Ni(II) complexes bearing chiral (phosphinoaryl)oxazoline ligands, e.g., I, are pro-catalysts for cross-coupling of (Z)-styryl bromide with (1-phenylethyl)magnesium chloride. Under suitable conditions, there is a dynamic kinetic resolution resulting in moderate enantioselectivity. The nature of the substituent at the stereogenic center of the oxazoline ligand affects catalysis in two distinct ways: smaller substituents lead to improved rates and selectivities while polar substituents reverse the sense of asym. induction. The solid state structure of one [(phosphinoaryl)oxazoline]nickel(II) pro-catalyst was determined by single crystal x-ray diffraction. To complete the study, the researchers used (S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole (cas: 167693-62-1) .

(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole(cas: 167693-62-1) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Synthetic Route of C25H26NOP

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Koch, Guido;Lloyd-Jones, Guy C.;Loiseleur, Olivier;Pfaltz, Andreas;Pretot, Roger;Schaffner, Siliva;Schnider, Patrick;von Matt, Peter published 《Synthesis of chiral (phosphinoaryl)oxazolines, a versatile class of ligands for asymmetric catalysis》. The research results were published in《Recueil des Travaux Chimiques des Pays-Bas》 in 1995.Recommanded Product: 167693-62-1 The article conveys some information:

Enantiomerically pure 2-[2-(diphenylphosphino)aryl]oxazolines I (R = Ph, CHMe₂, CMe₃, CH₂Ph, isobutyl) are readily prepared from 2-bromobenzonitrile by transmetalation with BuLi, subsequent reaction with chlorodiphenylphosphine and conversion of the resulting phosphinoaryl nitrile to the oxazoline by treatment with a chiral amino alc. in the presence of ZnCl₂. An alternative synthesis is based on the ortho-metalation of 2-aryloxazolines followed by reaction with chlorodiphenylphosphine.(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole (cas: 167693-62-1) were involved in the experimental procedure.

(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole(cas: 167693-62-1) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Recommanded Product: 167693-62-1

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Giereth, Robin;Mengele, Alexander K.;Frey, Wolfgang;Kloss, Marvin;Steffen, Andreas;Karnahl, Michael;Tschierlei, Stefanie published 《Copper(I) Phosphinooxazoline Complexes: Impact of the Ligand Substitution and Steric Demand on the Electrochemical and Photophysical Properties》 in 2020. The article was appeared in 《Chemistry – A European Journal》. They have made some progress in their research.Recommanded Product: (S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole The article mentions the following:

Seven homoleptic Cu^I complexes based on hetero-bidentate PN̂ ligands were synthesized and comprehensively characterized. To study structure-property relations, the type, size, number and configuration of substituents at the phosphinooxazoline (phox) ligands were systematically varied. To this end, a combination of x-ray diffraction, NMR spectroscopy, steady-state absorption and emission spectroscopy, time-resolved emission spectroscopy, quenching experiments and cyclic voltammetry was used to assess the photophys. and electrochem. properties. Also, time-dependent d. functional theory calculations were applied to also analyze the excited state structures and characteristics. Surprisingly, a strong dependency on the chirality of the resp. PN̂ ligand was found, whereas the specific kind and size of the different substituents has only a minor impact on the properties in solution Most importantly, all complexes except C3 are photostable in solution and show fully reversible redox processes. Sacrificial reductants were applied to demonstrate a successful electron transfer upon light irradiation These properties render this class of photosensitizers as potential candidates for solar energy conversion issues. And (S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole (cas: 167693-62-1) was used in the research process.

(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole(cas: 167693-62-1) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Recommanded Product: (S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Computed Properties of C25H26NOPIn 2002, Fairlamb, Ian J. S.;Lloyd-Jones, Guy C.;Vyskocil, Stepan;Kocovsky, Pavel published 《Analysis of stereochemical convergence in asymmetric Pd-catalysed allylic alkylation reactions complicated by halide and memory effects》. 《Chemistry – A European Journal》published the findings. The article contains the following contents:

A quant. two-term description of memory effects arising in Pd-catalyzed allylic alkylation reactions formally proceeding through ‘meso’-type π-allylpalladium intermediates is presented. The utility of this description (stereochem. convergence (s.c.) and global enantiomeric excess (ee_g)) is demonstrated by application to a series of Pd-catalyzed allylic alkylation reactions involving racemic cyclopentenyl esters. Anal. of such reactions, by employing a range of enantiomerically pure monophosphine ligands, reinforces the conclusion that selectivities (enantiomeric excess (ee) values) obtained under standard ‘benchmark’ type conditions may be very misleading when powerful memory effects are operative. By comparison of s.c. and ee for a given ligand/solvent combination under a range of related conditions, however, one may predict the limiting (‘latent’) selectivity that will be obtained when the memory effect is negated. This technique is exemplified with one particular ligand [I; wherein Z = NMe₂] for which a number of strategies were employed to find conditions that negate the memory effect and reveal the limiting selectivity of the ligand. These conditions give a higher limiting global selectivity than that obtainable by using standard diastereoisomer equilibration methods such as added halide. Thus, the anal. of s.c. vs. ee_g also allows subtle changes in selectivity to be discerned. The difference in limiting selectivity (chloride vs. non-chloride conditions) is proposed to arise through the nucleophilic attack of neutral monodentate vs. cationic bidentate complexes I (wherein Z = NMe₂, OMe). The experimental procedure involved many compounds, such as (S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole (cas: 167693-62-1) .

(S)-2-(2-(Diphenylphosphanyl)phenyl)-4-isobutyl-4,5-dihydrooxazole(cas: 167693-62-1) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Computed Properties of C25H26NOP

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis