Category: 166330-10-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgCl (0.0286 g, 0.2 mmol) and DMF (2 ml) into the reaction flask. Stirring for 12 h, and then filtrating, the filtrate was slow evaporated at ambient temperature. 16 days later, colorless block shaped crystals were obtained. Yield: 22.5percent (0.0427 g). Anal. Calc.for (C103H95Ag2Cl2NO5P6): C, 65.14; H, 5.01; N, 0.74. Found: C,65.45; H, 4.94; N, 0.74percent. IR (cm-1, KBr pellets): 3436br, 3050m, 2924m, 2853m, 1950w, 1676vs, 1583m, 1565m, 1480s, 1461s, 146vs, 1385s, 1330m, 1311m, 1257s, 1223s, 1184m, 1161m, 1127m, 1094s, 1070s, 1026m, 997m, 878m, 801m, 747s, 696s,543w, 529w, 506s, 481m, 470m, 433w, 420w. 1H NMR (600 MHz,CDCl3): 2.90 (d, 4H, dppe), 3.48 (s, 6H, DMF), 6.76?7.28 (m, 76H,Ph), 8.02 (s, 1H, DMF). 31P {1H}NMR (243 MHz, CDCl3): 5.7 (br,dppe), 11.9 (br, d, JAg?P = 286.8 Hz, DPEphos)., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting precursor P – 1 (3.8 g, 10 mmol, 1.0 equivalent), silver oxide (1.2 g, 5 mmol, 50percent yield), solvent acetonitrile 50 ml are sequentially added into a 100 ml flask, 50 ¡ãC light reaction 12 hours; filter, collecting the filtrate, dryness, a colorless solid. The solid with thecopperpowder (0.64 g, 10 mmol, 1.0 equivalent) as for 100 ml flask, add anhydrous non-oxygen second grade nitrile 50 ml, stirring at the room temperature reaction 5 hours; add ligand POP (4.3 g, 8 mmol, 80percent yield), stirring at the room temperature reaction 3 hours; filter, to remove the insoluble solid, collecting the filtrate, reduced pressure drying, be light green solid, that is the crude product. The crude product is dissolved inmethylenechloridesolvent, slow volatilization of the solvent, a large number of colorless crystalline precipitation, filtration to obtain pure complex [(NHC – 1) Cu (POP)]+PF6-(7.2 G, 7.3 mmol), and the yield is 73percent., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Luoyang Normal College; Wang Zhiqiang; Zhang Zhiqiang; Xu Liancai; Sun Xiaojuan; Xu Chen; Li Hongmei; (21 pag.)CN104610285; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D1 (0.12 g, 0.4 mmol), copper powder (0.032 g, 0.5 mmol), and POP (0.22 g, 0.4 mmol) werereacted in CH3CN (5 mL) at 60 ¡ãC for 24 h. The resulting mixture was filtered through a plugof Celite and concentrated to 1 mL. Addition of Et2O (10 mL) to the filtrate afforded a paleyellow precipitate, which was collected, washed with Et2O, and recrystallized with ethanol.Yield: 0.29 g, 80percent. 1H NMR (400 MHz, DMSO) delta (ppm): 8.32 (s, 1H), 8.02 (t, J = 6.4 Hz, 3H), 7.53(s, 1H), 7.43?7.37 (m, 5H), 7.33 (d, J = 6.9 Hz, 5H), 7.26 (d, J = 6.7 Hz, 4H), 7.17?7.05 (m, 9H), 6.92 (s, 4H), 6.66 (s, 2H), 3.44 (s, 3H); 13C NMR (101 MHz, DMSO) delta (ppm): 157.93, 148.14,140.51, 133.66, 132.91, 132.38, 132.10, 131.80, 131.61, 131.42, 129.82, 128.73, 125.00, 124.72,123.83, 122.44, 120.47, 116.92, 112.23, 37.52; 31P NMR (162 MHz, DMSO) delta (ppm): ?8.80 (s),?143.57 (quint). HRMS (m/z, ESI+): Calcd for C45H37CuN3OP2 ([M]+) 760.1708; found 760.1723.Anal. Calcd for C45H37CuF6N3OP3 (906.25): C, 59.64; H, 4.12; N, 4.64. Found: C, 59.97; H, 4.47;N, 4.52., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Shaobo; Xu, Shengxian; Wang, Jinglan; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Coordination Chemistry; vol. 70; 4; (2017); p. 584 – 599;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: Dpa (0.0368 g, 0.2 mmol) and POP (0.0539 g, 0.1 mmol) wereadded into the stirring solution of AgClO4 (0.0208 g, 0.1 mmol),in a mixture of CH3CN (5 ml) and H2O (5 ml) at ambient temperature.The mixture was stirred for 6 h. The insoluble residues wereremoved by filtration, and the brown filtrate was evaporatedslowly at room temperature for about four days to yield whitecrystals. Yields: 42percent., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Zhang, Yan-Ru; Cui, Yang-Zhe; Jin, Qiong-Hua; Yang, Yu-Ping; Liu, Min; Li, Zhong-Feng; Bi, Kai-Lun; Zhang, Cun-Lin; Polyhedron; vol. 122; (2017); p. 86 – 98;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

[Cu(CH3CN)4]ClO4 (16.3mg, 0.050mmol) was added to a mixture of pipH (7.4mg, 0.025mmol) and POP (26.9mg, 0.050mmol) in DCM under a stream of dry argon by using Schlenk techniques and a vacuum-line system at room temperature. A lemon-yellow solution was obtained quickly and then stirred for 2h at room temperature. After filtration through the absorbent cotton, layering n-hexane dropwise onto the dichloromethane filtrate carefully produced the target product as yellow crystals a few days later. The sample was obtained in an 84.4percent yield (35.8mg) after being dried using infrared dry technique. Anal. Calc. for C90H67Cl2Cu2N5O10P4 (1a) (1697.307): C, 63.64; H, 3.98; N, 4.12. Found: C, 63.55; H, 3.95; N, 4.12percent. ESI-MS (m/z) (see Fig. S2): 1500.35 [Cu2(pip)(POP)2]+ (calcd 1500.28); 898.195 [Cu(pipH)(POP)]+ (calcd 898.192); 601.093 [Cu(POP)]+ (calcd 601.091). 1H NMR (400MHz, DMSO-d6, delta, ppm) (see Fig. S3): 15.25 (s, 1H, NH), 9.06 (d, J=8.0Hz, 2H), 8.94 (s, 1H), 8.84 (s, 0.5H), 8.78 (d, J=8.0Hz, 1H), 8.47 (s, 1H), 8.37 (d, J=8.0Hz, 1H), 8.24 (s, 1H), 8.03 (s, 1H), 7.92 (s, 0.5H), 7.70 (s, 1H), 7.48?7.01 (m, 40H), 6.84?6.67 (m, 16H). 31P NMR (400MHz, DMSO-d6, delta, ppm): ?11.34, ?13.30, ?19.47. Characteristic IR spectrum (KBr, cm?1): 1094s (ClO4?)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Niu, Yan-Wen; Liu, Xia; Zhao, Ling; Guo, Ya-Meng; Li, Wen-Xin; Ma, Miao-Miao; Li, Xiu-Ling; Polyhedron; vol. 157; (2019); p. 241 – 248;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: NHC?Cu(I) complexes 1?3 were synthesized by the following route: a solution of imidazolium salt (0.4mmol), copper powder (0.032g, 0.5mmol) and POP (0.22g, 0.4mmol) was reacted in CH3CN (5mL) at 60¡ãC for 24h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. The addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. The product was recrystallized with ethanol., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Shengxian; Wang, Jinglan; Liu, Shaobo; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Molecular Structure; vol. 1153; (2018); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC-Cu(I) complexes 1-3 were synthesized by the following route:a solution of imidazolium salt (0.4 mmol), copper powder (0.032 g,0.5 mmol) and POP (0.22 g, 0.4 mmol) reacted in CH3CN (5 mL) at60 C for 24 h. The resulting mixture was filtered through a plug ofCelite and concentrated to ca. 1 mL. Addition of Et2O (10 ml) to thefiltrate afforded a pale yellow precipitate, which was collected andwashed with Et2O. And the productwas recrystallized with ethanol., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Wang, Jinglan; Liu, Shaobo; Xu, Shengxian; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Organometallic Chemistry; vol. 846; (2017); p. 351 – 359;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried 10 mL screw-capped vial was charged with [(allyl)PdCl]2 (3.7 mg, 0.010 mmol),1a (0.12 g, 0.20 mmol) and toluene (1 mL) under a gentle stream of nitrogen. The vessel washeated at 140 C for 24 h followed by cooling. An aqueous solution of H2O2 (ca. 30%, a fewdrops) was added, and the mixture was stirred at room temperature for 1 h. The mixture wasfiltered through a short pad of silica gel, and the pad was washed with EtOAc. The filtrate wasevaporated, and the residue was purified by GPC to give 2a (70 mg, 93%) as a yellowish whitesolid., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Baba, Katsuaki; Masuya, Yoshihiro; Chatani, Naoto; Tobisu, Mamoru; Chemistry Letters; vol. 46; 9; (2017); p. 1296 – 1299;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of anhydrous FeCl3 (100 mg; 0.615 mmol)in 20 mL acetonitrile, a solution of the ligand DPEphos (662mg; 1.23 mmol) in 30 mL acetonitrile was added. The reaction mixture was refluxed under continuous flow of N2 for1h. The color of the solution turned dark brown from yellow.After cooling the reaction mixture, the solvent was evaporated and the resultant solid mass was washed several timeswith ether and hexane. Finally, after drying under vacuum, adark brown compound was obtained which was recrystallized from acetonitrile. Yield: 88percent; Anal. Calcd. forC72H56O2P4Cl3Fe: C, 69.78; H, 4.55; Fe, 4.51. Found: C,69.47; H, 4.58; Fe, 4.49, Selected peak assignments in MSESIm/z (percent): 1242 (10), [M-Cl+K]+; 1164 (40), [MPh+2H]2+; 539 (100), [DPEphos]+; Selected IR frequencies(cm-1, KBr): 3060 (C-H), 1481, 1438 (C=C); 1102 (C-O-C);545 (Fe-P); Far IR (Nujol): 387, 339, 314(Fe-Cl); UV-Vis(CH3CN), max (nm): 229, 272, 360.

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Sahu, Debojeet; Banik, Biplab; Borah, Malabika; Das, Pankaj; Letters in Organic Chemistry; vol. 11; 9; (2014); p. 671 – 676;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of HPDPH (35.5mg, 0.16mmol) in THF (6mL) was added NaH (60percent, 6.51mg, 0.16mmol) to form a yellow solution. After stirring for 10min, CuCl (15.87mg, 0.16mmol) and XANTPhos (92.85mg, 0.16mmol) were added. The yellow resulting solution was stirred overnight and filtered. The filtrate was layered with hexane to give yellow crystals which were suitable for an X-ray diffraction study.

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Ya-Ping; Hu, Xiao-Hui; Wang, Yi-Fan; Pan, Jun; Yi, Xiao-Yi; Polyhedron; vol. 102; (2015); p. 782 – 787;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate