Category: 166330-10-5

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Synthesis of the phosphine oxidesThe phosphine oxides were synthesized by oxidation ofthe corresponding phosphines. Calculated amounts of H2O2(30percent) were added slowly to the vigorously stirred THF solutionof the respective phosphine. Stirring was maintainedat room temperature for 2 h. After evaporation of THF, theresidue was treated with acetone-ethyl acetate to obtain therespective phosphine oxide product as a precipitate. The precipitatesthus obtained were filtered off and dried in a vacuum.All melting points were above 360 C with decomposition. DPEPO: 1H NMR (250 MHz, CDCl3): d = 7:75 ? 7:64(m, 9H, Phen-H), 7.42 (m, 13H, Phen-H), 7.05 ? 7.04 (t, 2H,Phen-H), 7.07 (t, 2H, Phen-H), 7.08 (t, 2H, Phen-H). ? MS(EI): m=z = 570. Yield 84percent., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pietraszkiewicz, Marek; Mal, Suraj; Pietraszkiewicz, Oksana; Gorski, Krzysztof; Chelwani, Nitin; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 69; 2; (2014); p. 239 – 247;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a Schlenk flask containing Cu(CH3CN)4*BF4 (0.032g,0.1 mmol) and DPEphos (0.054g, 0.1 mmol) was added CH2Cl2 (10 mL) under nitrogen atmosphere, and the solution (i) was stirred at room temperature (RT) for 4 h. A CH2Cl2 (10 mL) and CH3OH (10 mL) mixture solution of NHPIP (0.034 g, 0.1 mmol) and KOH (0.006 g, 0.1 mmol) was also stirred at room temperature (RT) for 4 h to give solution (ii). Then, (ii) was added into (i) by a syringe under nitrogen. After reaction of 48 h at RT, the solution was filtered and the solventwas removed by a rotary evaporator. The residue was dissolved in diethyl ether, and orange block crystals were obtained by the solvent evaporation method (0.080 g, 85percent). IR (nu, cm?1, Figure S1 (Supporting Information)): 3374 m, 2929 s, 2851 m, 1740 w, 1701 w, 1651 w, 1590 s, 1542 w, 1511 m, 1461 m, 1436 s, 1384 m, 1331 s, 1260 w, 1216 w, 1102 m, 1170 w, 1029 w, 859 w, 805 w, 734 m, 696 m. 1H NMR (400 MHz, [D6]DMSO, Figure S2): delta 8.94 (d, J = 8.1Hz, 2H), 8.58 (d, J = 8.5 Hz, 4H), 8.28 (d, J = 8.5 Hz, 2H), 7.66 (dd, J = 7.8, 4.7 Hz, 2H), 7.44 (t, J = 7.8 Hz, 2H), 7.31?7.22 (m, 6H), 7.18 (t, J = 7.4 Hz, 8H), 7.08 (t, J = 7.5Hz, 2H), 6.97 (d, J = 5.4 Hz, 8H), 6.62 (s, 2H). Anal. Calcd. for C55H38CuN5O3P2: C, 70.10; H, 4.06; N, 7.43percent. Found: C,71.2; H, 4.35; N, 7.62percent., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Xin Fang; Zhang, Xiao Yu; Li, Rong Fang; Feng, Xun; Bulletin of the Korean Chemical Society; vol. 37; 3; (2016); p. 282 – 286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

2.679 g (8.635 mmol) of Rh(COD)(acac) was mixed with 20 ml of MEK in a 0.1 litre Schlenk flask. To the resulting slurry was added by syringe 1.22 ml of neat 54percent wt tetrafluoroboric acid in diethylether (8.74 mmol) by syringe over a period of 2 minutes, resulting in a red solution. After 5 minutes, 1.17 ml (9.66 mmol) of 1,5-cyclooctadiene was added by syringe. The brown red slurry was stirred for 20 minutes. Then 4.65 g (8.635 mmol) of DPEPhos was added in 2 portions over a period of 3 minutes. A orange slurry resulted after 5 minutes. The stirred slurry was reduced by evaporating MEK solvent until a slurry of the cationic complex in about 10 ml of residual solvent was obtained. To this slurry was added 20 ml of ethanol. The resulting orange slurry was degassed and stirred at room temperature for 1 hour before being filtered and washed with 2×5 ml of cold ethanol. After drying overnight (1 mbar, 2O0C), gave 7.26 g of complex [Rh cod DPEPhos] BF4 with approximately 0.75 equivalents of ethanol , Yield = 98.5 percent (8.51 mmol)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; NEDDEN, Hans Guenter; WO2010/1173; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of Tetrakis(acetonitrile)copper(I) tetrafluoroborate ([Cu(NCCH3)4]BF4, 3.11 g, 33.0 mmol) and Bis[(2-diphenylphosphino)phenyl]ether (O[C6H4P(C6H5)2]2, DPEphos, 5.33 g, 33.0 mmol) in 300 ml of CH2Cl2 was stirred at room temperature for 3 h. Upon addition of 1,10-Phenanthroline (C12H8N2, phen, 1.78 g, 33.0 mmol) the clear solution turned bright yellow, remained clear, and was stirred for an additional 2 h. Approximately 900 ml of diethyl ether ((CH3CH2)2O) was added to the solution to precipitate a bright yellow solid. The solution containing the newly precipitated solid was then left in the refrigerator for one day. It was vacuum filtered using a medium frit, washed with diethyl ether and dried under vacuum. A bright yellow powder was isolated (yield: 8.00 g, 93 percent)., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Kubi?ek, Katharina; Thekku Veedu, Sreevidya; Storozhuk, Darina; Kia, Reza; Techert, Simone; Polyhedron; vol. 124; (2017); p. 166 – 176;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: PyIm-Cu(I) complexes P1?P4 were synthesized by the following route: [Cu(CH3CN)4](PF6) (0.124g, 0.4mmol) and POP (0.216g, 0.4mmol) reacted in dichloromethane (15ml) at 25¡ãC for 2h. Then, the corresponding PyIm ligand (0.4mmol) was dissolved in the degassed dichloromethane solution and injected into the mixed solution for 2h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1ml. Addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. And the product was recrystallized with ethanol., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Jinglan; Chai, Chaoyang; Xu, Shengxian; Zhao, Feng; Xia, Hongying; Wang, Yibo; Inorganica Chimica Acta; vol. 484; (2019); p. 237 – 244;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

A solution of the ligand DPEphos (0.355g, 0.66 mmol) in30 mL of dichloromethane was added drop by drop to a solution of CoCl2.6H2O (0.166g, 0.70 mmol) in 50 mL dichloromethane. The reaction mixture was refluxed under nitrogen for 1 h. After cooling the reaction mixture, the solvent was evaporated and the resultant solid mass was washed several times with ether and hexane. Finally, after drying under vacuum,a blue compound was obtained which was re-crystallized from dichloromethane. Yield: 90percent. Anal. Calcd. forC36H28Cl2OP2Co (percent): C, 64.69; H, 4.22, Co, 8.82; Found: C,64.12; H, 4.19; Co, 8.78; Selected peak assignments in MSESIm/z (percent): 1360 (5), [2M+Na]+; 1301 (30), [2M-Cl]+; 746(20), [M+2K]2+; 690 (30) [M+Na]+; 539 (50), [DPEphos]+;Selected IR frequencies (cm-1, KBr): 3051, 2985 (C-H);1485, 1435 (C=C); 1101 (C-O-C); 506 (Co-P); 336, 322 (Co-Cl) ); UV-Vis (CH2Cl2), max (nm): 246, 647, 713., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Sahu, Debojeet; Banik, Biplab; Borah, Malabika; Das, Pankaj; Letters in Organic Chemistry; vol. 11; 9; (2014); p. 671 – 676;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon protection, bis(2-diphenylphosphinophenyl)ether (Compound 2) 538 g, toluene solvent was added to the reaction vessel.700 mL, 8.8 mL of trifluoromethanesulfonic acid, 150 mL of acetone, the reaction system was heated to 200 C, and after 16 h of reaction, it was reduced toAt room temperature, after extraction, drying and recrystallization, the desired product 4,5-bisdiphenylphosphino-9,9-dimethyloxaxan (Compound 1) is obtained.549 g (yield 95%)., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Henan Academy Of Sciences Chemical Institute Co., Ltd.; Liu Tingting; Chen Hui; Zhou Duo; Zhao Shunwei; Li Yunfei; Yang Zhenqiang; Cui Fumin; Duan Zheng; Yang Ruina; (4 pag.)CN109942631; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: A solution of [Cu(CH3CN)4](ClO4) (35.3mg, 0.108mmol) and 1,2-bis(diphenylphosphino)ethane (dppe) (43.2mg, 0.108mmol) in CH2Cl2 (10mL) was stirred for 30min at room temperature. A solution of Hbmp (22.6mg, 0.108mmol) in CH2Cl2 (5mL) was added, and this mixture was stirred for another 2h to give a light-yellow solution. The solvent was evaporated to dryness at reduced pressure. The residue was dissolved in a mixture of acetone/dichloromethane (1:5 v/v), and slow diffusion of petroleum ether into the above solution gave light-yellow crystals of 2 (69.4mg, 0.090mmol, 83percent)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Di, Bao-Sheng; Chen, Jing-Lin; Luo, Yan-Sheng; Zeng, Xue-Hua; Qiu, Lu; He, Li-Hua; Liu, Sui-Jun; Wen, He-Rui; Polyhedron; vol. 119; (2016); p. 525 – 531;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: A mixture of Tetrakis(acetonitrile)copper(I) tetrafluoroborate ([Cu(NCCH3)4]BF4, 3.11 g, 33.0 mmol) and Bis[(2-diphenylphosphino)phenyl]ether (O[C6H4P(C6H5)2]2, DPEphos, 5.33 g, 33.0 mmol) in 300 ml of CH2Cl2 was stirred at room temperature for 3 h. Upon addition of 1,10-Phenanthroline (C12H8N2, phen, 1.78 g, 33.0 mmol) the clear solution turned bright yellow, remained clear, and was stirred for an additional 2 h. Approximately 900 ml of diethyl ether ((CH3CH2)2O) was added to the solution to precipitate a bright yellow solid. The solution containing the newly precipitated solid was then left in the refrigerator for one day. It was vacuum filtered using a medium frit, washed with diethyl ether and dried under vacuum. A bright yellow powder was isolated (yield: 8.00 g, 93 percent)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kubi?ek, Katharina; Thekku Veedu, Sreevidya; Storozhuk, Darina; Kia, Reza; Techert, Simone; Polyhedron; vol. 124; (2017); p. 166 – 176;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 0.0243 g CuSCN (0.2 mmol), 0.0464 g dpq(0.2 mmol) and 0.1077 g pop (0.2 mmol) were dissolved in the mixed solvents of 5 mL CH3OH and 5 mL CH2Cl2, stirred at room temperature for 6 h. The filtrate was evaporated slowly at room temperature for around 5 days to yield yellow crystalline products.Yield: 77%. Anal. Calc. for C51H36CuN5OP2S: C, 68.60; H, 4.03; N,7.80. Found: C, 66.60; H, 4.23; N, 7.60%. 1H NMR (600 MHz, DMSO,298 K): delta, ppm: 6.66-7.42 (m, pop-aromatic ring), 7.98-9.53 (m,dpq-heteroaromatic ring); 31P NMR (600 MHz, DMSO, 298 K): delta,ppm: 11.65 (s, pop). IR for 9 (KBr pellets, cm-1): 3425(w), 2048(vs), 1564(w), 1434(vs), 1386(s), 1218(s), 1122(m), 998(w), 753(s), 512(s), 420(w)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kuang, Xiao-Nan; Lin, Sen; Liu, Jian-Ming; Han, Hong-Liang; Liu, Min; Xin, Xiu-Lan; Yang, Yu-Ping; Li, Zhong-Feng; Jin, Qiong-Hua; Li, Si-Fan; Li, Yue-Xue; Feng, Yue-Bing; Polyhedron; vol. 165; (2019); p. 51 – 62;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate