Category: 161265-03-8

161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 161265-03-8, Recommanded Product: (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine)

Dinuclear organogold(i) complexes bearing uracil moieties: Chirality of Au(i)-Au(i) axis and self-assembly

The conjugation of dinuclear organogold(i) complexes with a bridging diphosphine ligand as an organometallic compound and the uracil derivative as a nucleobase was demonstrated to afford bioorganometallic conjugates. Single-crystal X-ray structure determination of the dinuclear organogold(i)-uracil conjugates revealed the assembly properties of gold(i) and the uracil moieties in the solid state. The crystal structure of (U6Au)2(mu-Xantphos) (U6 = 6-ethynyl-1-octyluracil) with Xantphos as the bridging diphosphine ligand revealed the presence of an intramolecular aurophilic Au(i)-Au(i) interaction. R- and S-enantiomers based on the Au(i)-Au(i) axis exist in the unit cell, which are connected alternately to form the hydrogen-bonded assembly through intermolecular hydrogen bonds between the uracil moieties. In the case of the dinuclear organogold(i) complex (U5Au)2(mu-Xantphos) (U5 = 5-ethynyl-1-octyluracil), both enantiomers were found to form homochiral RR and SS dimers, respectively, through pi-pi interactions between 5-ethynyl-uracil moieties. In the crystal packing, each dimer is assembled alternately to form the hydrogen-bonded assembly through intermolecular hydrogen bonds between the uracil moieties. As expected, the utilization of (R)-BINAP as a bridging diphosphine ligand with axial chirality induced the chirality of the Au(i)-Au(i) axis. The crystal structure of the dinuclear organogold(i) complex with (R)-BINAP (U6Au)2(mu-R-BINAP) confirmed the axial chirality of the Au(i)-Au(i) axis, forming a R,R-enantiomer, wherein each molecule is arranged through intermolecular hydrogen bonds between the uracil moieties to form a helical molecular arrangement.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine). In my other articles, you can also check out more blogs about 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Electric Literature of 161265-03-8, An article , which mentions 161265-03-8, molecular formula is C39H32OP2. The compound – (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) played an important role in people’s production and life.

The challenge of palladium-catalyzed aromatic azidocarbonylation: From mechanistic and catalyst deactivation studies to a highly efficient process

Azidocarbonylation of iodoarenes with CO and NaN3, a novel Heck-type carbonylation reaction, readily occurs in an organic solvent-H 2O biphasic system to furnish aroyl azides at room temperature and 1 atm. The reaction is catalyzed by Xantphos-Pd and exhibits high functional group tolerance. The catalyst deactivation product, [(Xantphos)PdI2], can be reduced in situ with PMHS to Pd(0) to regain catalytic activity. In this way, the catalyst loading has been lowered to 0.2% without any losses in selectivity at nearly 100% conversion to synthesize a series of aroyl azides in 80-90% isolated yield on a gram scale. Alternatively, the ArCON3 product can be used without isolation for further transformations in situ, e.g., to isocyanates, ureas, benzamides, and iminophosphoranes. A detailed experimental and computational study has identified two main reaction pathways for the reaction. For both routes, Ar-I oxidative addition to Pd(0) is the rate-determining step. In the presence of CO in excess, the Ar-I bond is activated by the less electron-rich Pd center of a mixed carbonyl phosphine complex. Under CO-deficient conditions, a slightly lower energy barrier pathway is followed that involves Ar-I oxidative addition to a more reactive carbonyl-free (Xantphos)Pd0 species. Mass transfer in the triphasic liquid-liquid-gas system employed for the reaction plays an important role in the competition between these two reaction channels, uniformly leading to a common aroyl azido intermediate that undergoes exceedingly facile ArCO-N 3 reductive elimination. Safety aspects of the method have been investigated.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 161265-03-8, help many people in the next few years., Electric Literature of 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Reference of 161265-03-8. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine). In a document type is Article, introducing its new discovery.

CuH-catalysed hydroamination of arylalkynes with hydroxylamine esters-a computational scrutiny of rival mechanistic pathways

An in-depth computational mechanistic probe of the CuH-mediated hydroamination of internal arylalkynes with an archetype hydroxylamine ester and hydrosilane by a (Xantphos)CuH catalyst (Xantphos ? {P^P} ? 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene) is presented. This first comprehensive computational study of the CuH-mediated electrophilic alkyne hydroamination has identified the most accessible pathway for the rival avenues for direct and reductive hydroamination. The mechanistic picture derived from smooth energy profiles obtained by employing a reliable computational protocol applied to a realistic catalyst model conforms to all available experimental data. The crucial vinyl-and alkylcopper intermediates were found to display a distinct chemodivergence in their reactivity towards amine electrophile and alcohol, which ensures the successful formation of alpha-branched alkylamines together with (E)-enamines. On the one hand, the vinylcopper is somewhat preferably approached by the alcohol, thereby rendering the reductive hydroamination avenue favourable in the presence of both amine electrophile and alcohol. In contrast, the greater kinetic demands for protonation versus electrophilic amination predicted for the alkylcopper prevents the reductive hydroamination avenue to become non-productive. Electronically modified hydroxylamine esters are found to influence the chemoselectivity in reactivity towards amine electrophile and alcohol achievable for the vinyl-and alkylcopper, thereby offering an opportunity for process improvement.

If you are interested in 161265-03-8, you can contact me at any time and look forward to more communication.Reference of 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application of 161265-03-8, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a patent, introducing its new discovery.

Efficient Copper-Catalyzed Multicomponent Synthesis of N-Acyl Amidines via Acyl Nitrenes

Direct synthetic routes to amidines are desired, as they are widely present in many biologically active compounds and organometallic complexes. N-Acyl amidines in particular can be used as a starting material for the synthesis of heterocycles and have several other applications. Here, we describe a fast and practical copper-catalyzed three-component reaction of aryl acetylenes, amines, and easily accessible 1,4,2-dioxazol-5-ones to N-acyl amidines, generating CO2 as the only byproduct. Transformation of the dioxazolones on the Cu catalyst generates acyl nitrenes that rapidly insert into the copper acetylide Cu-C bond rather than undergoing an undesired Curtius rearrangement. For nonaromatic dioxazolones, [Cu(OAc)(Xantphos)] is a superior catalyst for this transformation, leading to full substrate conversion within 10 min. For the direct synthesis of N-benzoyl amidine derivatives from aromatic dioxazolones, [Cu(OAc)(Xantphos)] proved to be inactive, but moderate to good yields were obtained when using simple copper(I) iodide (CuI) as the catalyst. Mechanistic studies revealed the aerobic instability of one of the intermediates at low catalyst loadings, but the reaction could still be performed in air for most substrates when using catalyst loadings of 5 mol %. The herein reported procedure not only provides a new, practical, and direct route to N-acyl amidines but also represents a new type of C-N bond formation.

If you are interested in 161265-03-8, you can contact me at any time and look forward to more communication.Application of 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Related Products of 161265-03-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine)

Bidentate Phosphines of Heteroarenes: 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene

Twofold lithiation of 9,9-dimethylxanthene with n-butyllithium and N,N,N’,N’-tetramethylethylenediamine (TMEDA) in boiling n-heptane followed by reaction with chlorodiphenylphosphine (Ph2PCl) yielded the title compound 4.The phosphine ligand was characterised by 1H NMR, 13C NMR, 31P NMR spectroscopy and single crystal X-ray structure analysis.The folded and deformed xanthene unit causes a remarkably short P…P distance of 4.1 Angstroem which in turn results in a large coupling 6JPP’ = 27.3 Hz.

If you are hungry for even more, make sure to check my other article about 161265-03-8. Related Products of 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a Article£¬once mentioned of 161265-03-8, Application In Synthesis of (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine)

Innovative Electrochemical Screening Allows Transketolase Inhibitors to Be Identified

Transketolases (TKs) are ubiquitous thiamine pyrophosphate (TPP)-dependent enzymes of the nonoxidative branch of the pentose phosphate pathway. They are considered as interesting therapeutic targets in numerous diseases and infections (e.g., cancer, tuberculosis, malaria), for which it is important to find specific and efficient inhibitors. Current TK assays require important amounts of enzyme, are time-consuming, and are not specific. Here, we report a new high throughput electrochemical assay based on the oxidative trapping of the TK-TPP intermediate. After electrode characterization, the enzyme loading, electrochemical protocol, and substrate concentration were optimized. Finally, 96 electrochemical assays could be performed in parallel in only 7 min, which allows a rapid screening of TK inhibitors. Then, 1360 molecules of an in-house chemical library were screened and one early lead compound was identified to inhibit TK from E. coli with an IC50 of 63 muM and an inhibition constant (KI) of 3.4 muM. The electrochemical assay was also used to propose an inhibition mechanism.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine). In my other articles, you can also check out more blogs about 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), name: (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine).

Effect of diphosphine ligands on ruthenium catalyzed asymmetric hydrogenation of ketones

A series of diphosphines including those that are configurationally flexible were examined in the Ru(II) catalyzed enantioselective hydrogenation of 1-acetonaphthone in the presence of a chiral diamine. These ligands were found to exert significant effects on both the activity and enantioselectivity of Ru(II)-diamine catalysts, with the ligand with the smallest bite angle yielding the lowest conversion and the one with largest bite angle yielding the lowest enantioselection.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine). In my other articles, you can also check out more blogs about 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application of 161265-03-8, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a patent, introducing its new discovery.

Palladium-catalysed hydroamidocarbonylation of 1,3-dienes

Herein, we report our recent result on the development of the selective catalytic method towards the synthesis of beta,gamma-unsaturated imides via Pd-catalysed hydroamidocarbonylation of conjugated dienes. Note that this reaction proceeds under acid additive free conditions. Various dienes, including those of high industrial value (e.g. isoprene, 1,3-butadiene), are shown to be compatible with our established method (28 examples, 40-99% yield), which leads to the corresponding beta,gamma-unsaturated imides in a highly efficient and atom-economic fashion.

If you are interested in 161265-03-8, you can contact me at any time and look forward to more communication.Application of 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a Article£¬once mentioned of 161265-03-8, SDS of cas: 161265-03-8

C – S coupling using a mixed-ligand Pd catalyst: A highly effective strategy for synthesizing arylthio-substituted heterocycles

C – S coupling: A variety of arylthio-substituted heterocycles can be prepared through C – S coupling of the corresponding halide-substituted heterocycles by using a mixed-ligand palladium catalyst, [Pd2(dba) 3]/ Xantphos/CyPF-tBu (see scheme; dba=dibenzylideneacetone). This catalytic system is extremely powerful and efficient, allowing even C – Cl bond activation.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.SDS of cas: 161265-03-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 161265-03-8, in my other articles.

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a Patent£¬once mentioned of 161265-03-8, Application In Synthesis of (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine)

A PROCESS FOR THE REDUCTION OF A TERTIARY PHOSPHINE OXIDE TO THE CORRESPONDING TERTIARY PHOSPHINE IN THE PRESENCE OF A CATALYST AND USE OF A TERTIARY PHOSPHINE FOR REDUCING A TERTIARY PHOSPHINE OXIDE IN THE PRESENCE OF A CATALYST

A process for the conversion of a tertiary phosphine oxide to the corresponding tertiary phosphine comprising reacting said tertiary phosphine oxide with a reducing tertiary phosphine, in the presence of a catalyst that catalyzes the conversion.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine). In my other articles, you can also check out more blogs about 161265-03-8

Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate