With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15929-43-8,Bis(4-(trifluoromethyl)phenyl)phosphine oxide,as a common compound, the synthetic route is as follows.
General procedure: To a mixture of 2-iodophenol (21c) (1.32 g, 6.00 mmol) and bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide (22) (2.85 g, 6.01 mmol) dissolved in CCl4 (30 mL) was added triethylamine (1.67 mL, 12.0 mmol) at 0 C. After stirring for 15 min at the same temperature, to the mixture was added an aqueous saturated solution of NH4Cl (40mL). The mixture was extracted with CH2Cl2 (50 mL ¡Á 3), and the combined organicextract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel100 g, n-hexane/EtOAc = 19/1 to 9/1) to give 2-iodophenyl bis(3,5-bis(trifluoromethyl)-phenyl)phosphinate (23c) (3.67 g, 5.30 mmol, 88.4%) as a colorless solid.
The synthetic route of 15929-43-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Nishiyama, Yoshitake; Kamada, Shuhei; Yoshida, Suguru; Hosoya, Takamitsu; Chemistry Letters; vol. 47; 9; (2018); p. 1216 – 1219;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate