Category: 146960-90-9

146960-90-9, 1,1′-Bis(dicyclohexylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

537 mg (1.73 mmol) of Rh(COD)(acac) was mixed with 10ml of MEK in a small Schlenk flask. To the resulting slurry was added by syringe 0.23 ml of 48% aqueous tetrafluoroboric acid (1.76 mmol) over a period of 2 minutes, resulting in a red solution. After 10 minutes, 0.1 ml (0.83 mmol) of 1 ,5-cyclooctadiene was added by syringe. The brown red slurry was stirred for 20 minutes and then 1g of 1,1′-bis-(dicyclohexylphosphino)ferrocene (DCyPFC) (1.73 mmol) was added. A clear red solution resulted. The stirred solution was then reduced by evaporating MEK solvent. Removal of the ketone solvent was continued until a slurry of the cationic complex in about 3 ml of residual solvent was obtained. To this slurry was added 3 ml of ethanol. The resulting orange slurry was degassed and stripped to about 4 ml of ethanol/MEK. The remaining thick slurry was stirred at room temperature for 1 hour before being filtered and washed with 2×2 ml of cold ethano.. After drying overnight (1 mbar, 2O0C), gave 1.44 g of complex [Rh cod DCyPFC] BF4 , Yield = 95.4 % (1.65 mmol)., 146960-90-9

The synthetic route of 146960-90-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; NEDDEN, Hans Guenter; WO2010/1173; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146960-90-9,1,1′-Bis(dicyclohexylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

Example 21 Preparation of[DCyPFc RuCI2AMPY] Into a 200 mL stirred glass reactor are introduced 3.2 g of RuCI2(PPh3)3and 2.32 g of DCyPFc as solids followed by 100 mL of nitrogen saturated MEK. Stirring is started immediately and the slurry is stirred for 28 hours.3P{ H} NMR analysis of a NMR sample obtained by diluting a sample from the reaction mixture with C6D6shows that all DCyPFc has reacted and that the only free phosphine is PPh3released from RuCI2(PPh3)3.To the intermediate slurried in MEK is added 0.42 g of AMPY after dilution in 10 ml of MEK over the period of 10 minutes. The reaction mixture is stirred for 60 hours. The obtained thick slurry of a tan brown product is suction filtered using a Buechner funnel and filter paper until a wet cake of product is obtained. Washing with MEK is continued until the MEK filtrate is uncoloured. The yellow product is dried at 10 mbar, 30C for 48 hours. A sample was slurried in IPA and again filtered.The identity of the solid is confirmed by a combination of H and3P{ H} NMR analysis. By3P{ H} NMR analysis 2 isomers with delta = 51 ppm (major broad resonance) and delta = 48 ppm (minor broad resonance) are visible. The AMPY resonances for the major complex are delta = 9.94 (d), 7.73 (t), 7.40 (t), 7.35 (t) (all integration as 0.75 H) 5.07 (s, 1 .5 H), the AMPY resonances for the minor complex are delta = 9.80 (d), 8.06 (t), 7.93 (t), 7.64 (t) (all integration as 0.25 H), 5.01 (s, 0.5 H). The 2 x 4 CH resonances of ferrocene are at delta = 4.23 (m), 4.08 (m). The remaining resonances of the cyclohexyl – resonances (44) are a broad series of multiplets at delta = 2.2 – 0.94 ppm., 146960-90-9

The synthetic route of 146960-90-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; FACCHETTI, Sarah; NEDDEN, Hans; WO2015/79207; (2015); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

146960-90-9, 1,1′-Bis(dicyclohexylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,1′-Bis(dicyclohexylphosphino)ferrocene (dcpf) (0.578 g, 1.0 mmol) was added to a solution of silver(I) cyanide (0.134 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture at room temperature. The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h in dark. Slowly, the colour ofthe solution changed from light yellowish orange to dark yellowish orange colour. The resulting solution was evaporated to dryness to give a yellowish orange solid which was then extracted with dichloromethane (20 mL). The addition of diethyl ether (100 mL) to this solution led to yellow needle shaped diffraction quality crystals. These were separated and washed with hexane and dried. Yield: (0.846 g, 50 %). Anal. Calc. for C72H104N4P4Ag4Fe2: C, 51.06; H,6.15; N, 3.31. Found: C, 51.28; H, 6.34; N, 3.43. IR (cm-1, KBr): nu = 3401, 2926, 2852, 2368, 2345, 2129(CN), 1740, 1444, 1240, 1165, 1109, 1036, 850, 625, 480. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K):4.43 (s, 8H, C5H4), 4.18 (s, 8H, C5H4), 2.71-1.34 (m, 88H, Cy). 31P{1H}:delta 56.6 (sbr). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 272 (14,719), 478 (30,674). ESI-MS (m/z): 1692.8 (M+)., 146960-90-9

As the paragraph descriping shows that 146960-90-9 is playing an increasingly important role.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate