Category: 13689-20-8

New learning discoveries about 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: In a sealed tube containing a solution of the phosphine oxide derivative (5 mmol) in anhydrous toluene (1 M) was added InBr3 (1 mol %, 0.05 mmol) and the TMDS (1.5 equiv, 7.5 mmol) under an argon atmosphere. The reaction mixture was stirred at 100 C during 7-40 h depending on the substrate (the reaction was monitored by 31P NMR). After complete consumption of the reagent the mixture was kept under argon in the sealed tube and cooled to 0 C. A solution of BH3.SMe2 (2 M in THF, 1 equiv) was then slowly added. After 1 h at room temperature, 31P NMR analysis of an aliquot indicates complete conversion to phosphine borane adduct. The crude was poured in an erlenmeyer flask and silica gel was carefully added while stirring. When silica gel was added in the reaction mixture, a slightly exothermic reaction was observed. The reaction mixture was then filtered on silica gel and washed several times with ethyl acetate. After evaporation of the ethyl acetate, the residue was purified by flash chromatography on silica gel with pure cyclohexane to afford the desired phosphine-borane., 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc; Tetrahedron; vol. 68; 15; (2012); p. 3151 – 3155;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

13689-20-8, Cyclohexyldiphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add cyclohexyldiphenylphosphine (28.4 mg, 0.1 mmol), copper triflate (3.6 mg, 0.01 mmol),Tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), the mixture was stirred at 80oC;TLC follows the reaction to completion;The crude product obtained after the reaction was recrystallized from toluene to obtain the target product (yield 82%). The analytical data of the product are as follows:, 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Some tips on 13689-20-8

As the paragraph descriping shows that 13689-20-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexyldiphenylphosphine oxide (28.4 mg, 0.1 mmol) to the reaction flask.Copper triflate (3.6 mg, 0.01 mmol), tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), and the mixture was stirred at 80 C;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was recrystallized from toluene to give the desired product (yield: 82%)., 13689-20-8

As the paragraph descriping shows that 13689-20-8 is playing an increasingly important role.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Tao Zekun; (13 pag.)CN110229187; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Analyzing the synthesis route of 13689-20-8

13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexyldiphenylphosphine (28.4 mg, 0.1 mmol), copper triflate (3.6 mg, 0.01 mmol),Tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), the mixture was stirred at 80oC;TLC follows the reaction to completion;The crude product obtained after the reaction was recrystallized from toluene to obtain the target product (yield 82%). The analytical data of the product are as follows:, 13689-20-8

13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

13689-20-8, Cyclohexyldiphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a screw capped vial with a spinvane triangular-shaped Teonstir bar were added indicated arylphosphine oxide (0.20 mmol),[IrCp*Cl2]2 (3.2 mg, 0.0040 mmol, 2.0 mol %), AgNTf2 (6.6 mg,0.017 mmol, 8.5 mol %), O,O-dipivaloyl-L-tartaric acid (2.6 mg,0.040 mmol), 1,2-dichloroethane (0.5 mL), and p-toluenesulfonylazide (43.4 mg, 0.22 mmol) under atmospheric conditions. Thereaction mixture was stirred in a pre-heated oil bath at 60 C for18 h, and then ltered through a pad of Celite washing with EtOAc(10 mL3). Solvents were removed under reduced pressure and theresidue was puried by column chromatography to give the ami-dated product. Enantiomeric excess (ee) of amidated products ofthe crude reaction mixture was determined by chiral HPLC analysisusing ChiralPak IB-3 column with ethanol/hexane as eluents. 4.8.4. Compound 5d. White solid; mp 225e227 C; 1H NMR(600 MHz, CDCl3) d 11.52 (s,1H), 7.80 (dd, J8.5, 4.0 Hz,1H), 7.69 (d,J8.2 Hz, 2H), 7.65e7.58 (m, 2H), 7.50 (td, J7.4,1.6 Hz,1H), 7.42 (td,J7.7, 2.9 Hz, 2H), 7.41e7.34 (m, 1H), 7.20 (ddd, J12.4, 7.7, 1.6 Hz,1H), 7.07 (d, J8.0 Hz, 2H), 7.06e7.00 (m,1H), 2.30 (s, 3H), 2.21e2.11(m,1H),1.82e1.76 (m,1H),1.76e1.66 (m, 2H),1.60 (ddd, J12.3, 6.2,3.2 Hz, 1H), 1.55e1.37 (m, 3H), 1.26e1.16 (m, 3H); 13C NMR(150 MHz, CDCl3) d 144.4,143.1,136.8,132.7 (d, JCP2.3 Hz),131.8 (d,JCP2.7 Hz), 131.1 (d, JCP96.5 Hz), 130.8 (d, JCP9.9 Hz), 130.7 (d,JCP8.9 Hz, 2C), 129.3 (2C), 128.6 (d, JCP11.4 Hz, 2C), 127.2 (s, 2C),122.9 (d, JCP11.6 Hz), 120.3 (d, JCP7.0 Hz), 116.2 (d, JCP90.3 Hz),37.2 (d, JCP72.9 Hz), 26.1 (d, JCP10.2 Hz), 26.0 (d, JCP10.2 Hz),25.5, 24.2 (d, JCP2.9 Hz), 23.8 (d, JCP2.7 Hz), 21.4; 31P NMR(243 MHz, CDCl3) d 44.1; IR (diamond) 2930, 2853, 2807, 2746,1594,1573,1491,1448,1439,1418,1339,1266,1161,1131,1106,1089,943, 872, 812, 779, 712, 695 cm1; HRMS (EI) m/z calcd forC25H28NO3PS [M]: 453.1528, found: 453.1526.

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gwon, Donghyeon; Park, Sehoon; Chang, Sukbok; Tetrahedron; vol. 71; 26-27; (2015); p. 4504 – 4511;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Analyzing the synthesis route of 13689-20-8

13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: To a solution of tertiary phosphine oxides 2 (0.4mmol) in CH2Cl2 (2mL) was added oxalyl chloride (0.4mmol) dropwise at room temperature under an argon atmosphere. After 30min, HEH (1mmol) was added to the mixture in one portion as well as TEA (3mmol). The mixture was stirred for another 2h at 40C, and then diluted with H2O (10mL). The resulting mixture was extracted with CH2Cl2 repeatedly. The extracts were dried (anhydrous Na2SO4) and evaporated. The crude product was purified by column chromatography on silica gel using ethyl acetate/petroleum ether to afford the pure product.

13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Zhang, Tong-Xin; Zhang, Wei-Xi; Luo, Mei-Ming; Chinese Chemical Letters; vol. 25; 1; (2014); p. 176 – 178;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate