Category: 1365531-84-5

Meng, Fanke;Haeffner, Fredrik;Hoveyda, Amir H. published 《Diastereo- and enantioselective reactions of bis(pinacolato)diboron, 1,3-enynes, and aldehydes catalyzed by an easily accessible bisphosphine-Cu complex》 in 2014. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Reference of (R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl The article mentions the following:

Catalytic enantioselective multicomponent processes involving bis(pinacolato)diboron B₂(pin)₂, 1,3-enynes RCCCH:CH₂ (R = Ph, aryl, 3-thienyl, 1-cyclohexenyl, TIPSOCMe₂, Et₃Si), and aldehydes R¹CHO (R¹ = aryl, 3-benzo[b]thienyl, cinnamyl, cyclohexenyl, PhCH₂CH₂) resulting in chiral bis(homopropargyl) diols R¹CH(OH)CH(CH₂OH)CCR are disclosed; the resulting compounds contain a primary C-B(pin) bond, as well as alkyne- and hydroxyl-substituted tertiary carbon stereogenic centers. A critical feature is the initial enantioselective Cu-B(pin) addition to an alkyne-substituted terminal alkene. This and other key mechanistic issues have been investigated by DFT calculations Reactions are promoted by the Cu complex of a com. available enantiomerically pure bis-phosphine and are complete in 8 h at ambient temperature; products are generated in 66-94% yield (after oxidation or catalytic cross-coupling), 90:10 to >98:2 diastereomeric ratio, and 85:15-99:1 enantiomeric ratio. Aryl-, heteroaryl-, alkenyl-, and alkyl-substituted aldehydes and enynes can be used. Utility is illustrated through catalytic alkylation and arylation of the organoboron products as well as applications to synthesis of fragments of tylonolide and mycinolide IV.(R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl (cas: 1365531-84-5) were involved in the experimental procedure.

(R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl(cas: 1365531-84-5) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.Reference of (R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Gonzalez-Esguevillas, Maria;Pascual-Escudero, Ana;Adrio, Javier;Carretero, Juan C. published 《Highly selective copper-catalyzed asymmetric [3+2] cycloaddition of azomethine ylides with acyclic 1,3-dienes》 in 2015. The article was appeared in 《Chemistry – A European Journal》. They have made some progress in their research.COA of Formula: C48H28F24O4P2 The article mentions the following:

The first examples of the catalytic asym. 1,3-dipolar cycloaddition of azomethine ylides with acyclic activated 1,3-dienes/1,3-enynes was described. Under copper catalysis, a selective cycloaddition at the terminal γ,δ-C=C bond was observed In addition, depending on the ligand used, either the exo or endo adduct of pyrrolidines e.g.I [Ar = C₆H₅, 4-MeC₆H₄, 2-BrC₆H₄, etc.] could be obtained with high selectivity. Under appropriate reaction conditions, the acyclic 1,6-addition product was detected, suggesting a stepwise mechanism. The resulting pyrrolidines were suitable substrates for further access to polycyclic systems, as highlighted by the preparation of hexahydrochromeno[4,3-b]pyrrole and the tetracyclic core of the alkaloid gracilamine.(R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl (cas: 1365531-84-5) were involved in the experimental procedure.

(R)-2,2′-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl(cas: 1365531-84-5) is a compound of chiral-phosphine-ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge.COA of Formula: C48H28F24O4P2

Reference:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis