Category: 13440-07-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 4-bromophenylacetylene (0.088 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuCl (0.01 g, 0.1 mmol), tert-butyl peroxybenzoate(0.15 g, 1.5 mmol) and N-methylpyrrolidone(2 mL), 70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 81%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Into a round bottom flask was added (dichloroiodo)benzene (2, 0.15 mmol, 1.02 equiv), DCM (0.25 mL, 0.6M), and to this was added excess ethanol (0.1 mL, 10 equiv), followed by the secondary phosphine oxide (0.15 mmol, 1.0 equiv,). The reaction mixture was stirred at room temperature for the indicated length of time, then concentrated in vacuo and purified by column chromatography., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Eljo, Jasmin; Murphy, Graham K.; Tetrahedron Letters; vol. 59; 31; (2018); p. 2965 – 2969;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Weigh 0.2 mmol of (E)-1,3-diphenylpropene, 0.3 mmol of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone into a 15 mL pressure-resistant reaction tube and add magnetic stirring. The mixture was reacted with 2 mL of nitromethane at room temperature for 5 min, monitored by TLC, and then reacted with 0.4 mmol of bis(naphthalen-1-yl)phosphine oxide for 6 h. After completion of the reaction, it was extracted with 20 ml of sodium sulfite solution, 10 mL of ethyl acetate, dried over anhydrous sodium sulfate at 20 C for 10 minutes and filtered, and finally distilled under reduced pressure at -0.09 MPa at 40 C to remove organics. The product (E)-(1,3-diphenylallyl)bis(naphthalen-1-yl)phosphine oxide was obtained as a solvent in a yield of 96%., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Guangdong University of Technology; Wen Chunxiao; Chen Qian; Wang Xiaofeng; Yu Guodian; Huo Yanping; Zhang Kun; (15 pag.)CN108774263; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Solution of di(1-naphthyl)phosphine oxide (0.1 g) in chloroform (5 mL) was refluxed in air for 2 h. Then the solvent was distilled under reduced pressure and residue was dried in vacuum. Di(1-naphthyl)phosphinic acid was prepared in near quantitative yield. White powder, mp 198-201 C, FT-IR (KBr): 3055, 3008, 2955, 2922, 2854, 2632, 2289, 1955, 1646, 1619, 1591, 1568, 1505, 1456, 1432, 1382, 1334, 1212, 1178, 1152, 1025, 995, 951, 833, 800, 773, 753, 680, 566, 526, 479. 1H NMR (CDCl3): 9.58 (br, 1H, OH), 8.48 (d, J 8.5 Hz, 2H, H8), 8.16 (dd, J 16.3 and 7.2 Hz, 2H, H2), 7.92 (d, J 8.4 Hz, 2H, H4), 7.79 (d, J 8.1 Hz, 2H, H5), 7.40-7.36 (m, 4H, H6,7), 7.29 (t, J 7.7 Hz, 2H, H3). 13C NMR (CDCl3): 133.5 (d, J 11 Hz, C9), 133.4 (d, J 11 Hz, C8), 133.3 (d, J 2 Hz, C7), 132.7 (d, J 11 Hz, C10), 128.9 (d, J 137 Hz, C1), 128.7 (C4), 127.1 (C5), 126.6 (d, J 5 Hz, C3), 126.1 (C6), 124.5 (d, J 15 Hz, C2). 31P NMR (CDCl3): 37.3 ppm. MS m/z calcd for C20H15O2P: MS (M+ 315)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kuimov, Vladimir A.; Matveeva, Elena A.; Khutsishvili, Spartak S.; Vakul’skaya, Tamara I.; Sinegovskaya, Lidiya M.; Malysheva, Svetlana F.; Gusarova, Nina K.; Trofimov, Boris A.; Tetrahedron; vol. 73; 32; (2017); p. 4723 – 4729;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add in the reaction bottle4-phenylbutyne (0.065 g, 0.5 mmol), dinaphthyl phosphorus (0.30 g, 1 mmol),Cu(SCN)2 (0.0179 g, 0.1 mmol), tert-butyl peroxide (0.30 mL, 2 mmol) and water (2 mL),60oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 85%)., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Nitrophenylacetylene (0.077 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuBr2 (0.022 g, 0.1 mmol),Di-tert-butyl peroxide (0.45 g, 3 mmol),Reacts with acetone (2 mL) at 50oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 65%)., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

4-fluorophenylacetylene (0.060 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuSCN (0.012 g, 0.1 mmol),Tert-butyl alcohol peroxide (0.45 mL, 3 mmol) and toluene (2 mL),90oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 82%)., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 4-methoxycarbonylphenylacetylene to the reaction flask(0.080 g, 0.5 mmol), dinaphthylphosphoric acid(0.30 g, 1 mmol), CuBr (0.014 g, 0.1 mmol),Di-tert-butyl peroxide (0.30 g, 2 mmol),Reacts with water (2 mL) at 80oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 75%)., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

2-Trifluoromethylphenylacetylene (0.085 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuI2 (0.032 g, 0.1 mmol),Tert-butyl alcohol peroxide (0.45 mL, 3 mmol),And ethanol (2 mL),60oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 77%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cycloheptatriene 1 (19 mg, 0.2 mmol) in DCE (2 mL) was added DDQ (50 mg, 0.22 mmol) under N2 atmosphere. After stirring for 5 min at room temperature, diphenylphosphine oxide 2a (60 mg, 0.3 mmol) was then added, and the resulting mixture was stirred at room temperature for 9 h. The reaction was then quenched with saturated aqueous Na2SO3 solution (10 mL) and extracted with ethyl acetate (3¡Á10 mL). The extracts were combined and dried over anhydrous Na2SO4. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate (2:1) to afford the desired 3a (58 mg, 99%) as a white solid., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Wen, Chunxiao; Yu, Guodian; Ou, Yingcong; Wang, Xiaofeng; Zhang, Kun; Chen, Qian; Tetrahedron Letters; vol. 60; 19; (2019); p. 1345 – 1348;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate